专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009010477A8 PIPERIDINE-4-ACETIC ACID DERIVATIVES AND THEIR USE 审中-公开
公开(公告)号：WO2009010477A8
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059136
申请日：2008-07-11
申请人： EUROSCREEN S.A. , HUCK, Jacques , OOMS, Frédéric , PARCQ, Julien , REGEREAU, Yannick , HOVEYDA, Hamid, R. , DUTHEUIL, Guillaume
发明人： HUCK, Jacques , OOMS, Frédéric , PARCQ, Julien , REGEREAU, Yannick , HOVEYDA, Hamid, R. , DUTHEUIL, Guillaume
IPC分类号： A61K31/445 , A61K31/4468 , A61K31/453 , A61K31/4535 , A61K31/4545 , C07D211/34 , C07D211/58 , C07D211/96 , C07D405/12 , C07D409/12 , A61P29/00 , A61P31/18 , A61P37/00 , A61P11/06 , A61P11/00
摘要： The present invention is directed to compounds of formula (I) compositions comprising them and their use.

2. 发明申请

WO2009010478A2 USE OF PIPERIDINE DERIVATIVES AS AGONISTS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开
标题翻译：哌啶衍生物作为趋化因子受体激动剂的应用
公开(公告)号：WO2009010478A2
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059137
申请日：2008-07-11
申请人： EUROSCREEN S.A. , HUCK, Jacques , OOMS, Frédéric , TYRCHAN, Christian , HOVEYDA, Hamid, R.
发明人： HUCK, Jacques , OOMS, Frédéric , TYRCHAN, Christian , HOVEYDA, Hamid, R.
IPC分类号： C07D211/58 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/445 , A61K31/4523 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P17/00 , A61P19/00 , A61P29/00
CPC分类号： C07D211/58 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is directed to novel piperidinc derivatives and to the use of piperidine derivatives of formula (I) as agonists of chemokine receptor activity.
摘要翻译：本发明涉及新的哌啶-1-酮衍生物以及式（I）的哌啶衍生物作为趋化因子受体活性激动剂的用途。

3. 发明申请

WO2009010479A2 NOVEL HETEROCYCLIC METHYLENE PIPERIDINE DERIVATIVES AND THEIR USE 审中-公开
标题翻译：新型杂环甲基哌啶衍生物及其用途
公开(公告)号：WO2009010479A2
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059138
申请日：2008-07-11
申请人： EUROSCREEN S.A. , HUCK, Jacques , OOMS, Frédéric , REGEREAU, Yannick
发明人： HUCK, Jacques , OOMS, Frédéric , REGEREAU, Yannick
IPC分类号： C07D413/06 , C07D401/06 , C07D413/14 , A61K31/4523 , A61K31/4525 , A61K31/454 , A61P1/00 , A61P17/00 , A61P19/00 , A61P31/00 , A61P35/00 , A61P11/00
CPC分类号： C07D413/06 , C07D401/06 , C07D413/14
摘要： The present invention is directed to compounds of formula (I) compositions comprising them and their use.
摘要翻译：本发明涉及包含它们的式（I）化合物及其用途。

4. 发明申请

WO2009010480A1 1-{2-[(DIPHENYL)AMINO]-ETHYL}-PIPERIDINE-4-CARBOXYLIC ACID BENZYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS CCR5 AGONISTS FOR THE TREATMENT OF IMMUNE AND INFLAMMATORY DISEASES 审中-公开
标题翻译： 1- {2 - [（二苯基）氨基] - 乙基} - 哌啶-4-羧酸苯甲酰胺衍生物及相关化合物作为CCR5治疗免疫和炎症疾病的药物
公开(公告)号：WO2009010480A1
公开(公告)日：2009-01-22
申请号：PCT/EP2008/059139
申请日：2008-07-11
申请人： EUROSCREEN S.A. , HUCK, Jacques , OOMS, Frédéric , PARCQ, Julien
发明人： HUCK, Jacques , OOMS, Frédéric , PARCQ, Julien
IPC分类号： C07D211/62 , A61K31/4465 , A61P37/00
CPC分类号： C07D211/62 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to pharmaceutically active piperidine derivatives and their use as agonists of CC chemokine receptor activity, more specifically of CCR5 activity. Chemokines are chemotactic cytokines which play an important role in immune and inflammatory responses.
摘要翻译：本发明涉及药学活性哌啶衍生物及其作为CC趋化因子受体活性的激动剂的用途，更具体地涉及CCR5活性。趋化因子是在免疫和炎症反应中起重要作用的趋化性细胞因子。

5. 发明申请

WO2004043951A1 PYRAZOLE DERIVATIVES AS MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS 审中-公开
标题翻译：作为过氧化物酶促反应物受体的调节剂的吡唑衍生物
公开(公告)号：WO2004043951A1
公开(公告)日：2004-05-27
申请号：PCT/EP2003/011855
申请日：2003-10-24
申请人： CAREX SA , HUCK, Jacques , SALADIN, Régis , SIERRA, Michael
发明人： HUCK, Jacques , SALADIN, Régis , SIERRA, Michael
IPC分类号： C07D409/04
CPC分类号： C07D413/14 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention relates to compounds, compositions and methods useful for modulating nuclear receptors activity in cells, and for treating and/or preventing various diseases and conditions mediated by said nuclear receptors, including metabolic or cell proliferative disorders. According to particular aspects, the present invention relates to compounds, compositions and methods useful for modulating activities of the Peroxisome Proliferator Activated Receptors (PPARs) and for treating and/or preventing various disease and conditions mediated by said nuclear receptors. More specifically, it relates to Peroxigome Proliferator Activated Receptor-gamma (PPAR-gamma) ligands, which are useful in the modulation of blood glucose levels and in the increase of insulin sensitivity in patients in need thereof. The properties of the compounds and compositions of the invention make these PPAR ligands particularly useful in the treatment of those diseases and conditions including diabetes, atherosclerosis, hyperglycemia, dyslipidemia, obesity, syndrome X, insulin resistance, hypertension, neuropathy, microvascular diseases (e.g. retinopathy, nephropathy), macrovascular diseases (e.g. myocardial infarction, stroke, heart failure) in mammals.
摘要翻译：本发明涉及可用于调节细胞中核受体活性以及治疗和/或预防由所述核受体介导的各种疾病和病症（包括代谢或细胞增殖性疾病）的化合物，组合物和方法。根据具体方面，本发明涉及可用于调节过氧化物酶体增殖剂活化受体（PPAR）的活性并用于治疗和/或预防由所述核受体介导的各种疾病和病症的化合物，组合物和方法。更具体地说，本发明涉及可用于调节血糖水平和增加需要的患者胰岛素敏感性的过氧化物增生物激活受体-γ（PPAR-γ）配体。本发明化合物和组合物的性质使得这些PPAR配体特别可用于治疗那些疾病和病症，包括糖尿病，动脉粥样硬化，高血糖症，血脂异常，肥胖症，X综合症，胰岛素抵抗，高血压，神经病，微血管疾病（例如视网膜病变，肾病），哺乳动物的大血管疾病（如心肌梗塞，中风，心力衰竭）。

6. 发明申请

WO2004037248A2 MODULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ACTIVITY 审中-公开
标题翻译：过氧化物酶促反应物激活受体活性的调节
公开(公告)号：WO2004037248A2
公开(公告)日：2004-05-06
申请号：PCT/EP2003/011710
申请日：2003-10-22
申请人： CAREX SA , HUCK, Jacques , SALADIN, Régis , SIERRA, Michael , KLOTZ, Evelyne
发明人： HUCK, Jacques , SALADIN, Régis , SIERRA, Michael , KLOTZ, Evelyne
IPC分类号： A61K31/415
CPC分类号： C07D413/14 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/14
摘要： The present invention relates to compounds, compositions and methods useful for modulating nuclear receptors activity in cells, and for treating and/or preventing various diseases and conditions mediated by said nuclear receptors, including metabolic or cell proliferative disorders. According to particular aspects, the present invention relates to compounds, compositions and methods useful for modulating activities of the Peroxisome Proliferator Activated Receptors (PPARs) and for treating and/or preventing various diseases and conditions mediated by said nuclear receptors. More specifically, it relates to Peroxisome Proliferator Activated Receptor-gamma (PPAR-gamma) ligands, which are useful in the modulation of blood glucose levels and in the increase of insulin sensitivity in patients in need thereof. The properties of the compounds and compositions of the invention make these PPAR ligands particularly useful in the treatment of those diseases and conditions including diabetes, atherosclerosis, hyperglycemia, dyslipidemia, obesity, syndrome X, insulin resistance, hypertension, neuropathy, microvascular diseases (e.g. retinopathy, nephropathy), macrovascular diseases (e.g. myocardial infarction, stroke, heart failure) in mammals.
摘要翻译：本发明涉及可用于调节细胞中核受体活性以及用于治疗和/或预防由所述核受体介导的各种疾病和病症（包括代谢或细胞增殖性疾病）的化合物，组合物和方法。根据具体方面，本发明涉及可用于调节过氧化物酶体增殖剂活化受体（PPAR）的活性并用于治疗和/或预防由所述核受体介导的各种疾病和病症的化合物，组合物和方法。更具体地，本发明涉及过氧化物酶体增殖物激活受体-γ（PPAR-γ）配体，其可用于调节血糖水平和在有需要的患者中增加胰岛素敏感性。本发明化合物和组合物的性质使得这些PPAR配体特别可用于治疗那些疾病和病症，包括糖尿病，动脉粥样硬化，高血糖症，血脂异常，肥胖症，X综合症，胰岛素抵抗，高血压，神经病，微血管疾病（例如视网膜病变，肾病），哺乳动物的大血管疾病（如心肌梗塞，中风，心力衰竭）。

7. 发明公开

EP2173715A2 USE OF PIPERIDINE DERIVATIVES AS AGONISTS OF CHEMOKINE RECEPTOR ACTIVITY 审中-公开
标题翻译： PIPERIDINYLDERIVATEN作为趋化因子受体活性的激动剂的用途
公开(公告)号：EP2173715A2
公开(公告)日：2010-04-14
申请号：EP08756797.0
申请日：2008-07-11
申请人： Euroscreen S.A.
发明人： HUCK, Jacques , OOMS, Frédéric , TYRCHAN, Christian , HOVEYDA, Hamid R.
IPC分类号： C07D211/58 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/445 , A61K31/4523 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61P11/00 , A61P17/00 , A61P19/00 , A61P29/00
CPC分类号： C07D211/58 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is directed to novel piperidinc derivatives and to the use of piperidine derivatives of formula (I) as agonists of chemokine receptor activity.

8. 发明公开

EP2164491A1 PIPERIDINE-4-ACETIC ACID DERIVATIVES AND THEIR USE 审中-公开
标题翻译：哌啶-4-醋酸衍生物及其
公开(公告)号：EP2164491A1
公开(公告)日：2010-03-24
申请号：EP08756798.8
申请日：2008-07-11
申请人： Euroscreen S.A.
发明人： HUCK, Jacques , OOMS, Frédéric , PARCQ, Julien , REGEREAU, Yannick , HOVEYDA, Hamid, R. , DUTHEUIL, Guillaume
IPC分类号： A61K31/445 , A61K31/4468 , A61K31/453 , A61K31/4535 , A61K31/4545 , C07D211/34 , C07D211/58 , C07D211/96 , C07D405/12 , C07D409/12 , A61P29/00 , A61P31/18 , A61P37/00 , A61P11/06 , A61P11/00
CPC分类号： A61K31/445 , A61K31/4468 , A61K31/453 , A61K31/4535 , A61K31/4545 , C07D211/34 , C07D401/12 , C07D413/12 , C07D451/02 , Y02A50/411
摘要： The present invention is directed to compounds of formula I compositions comprising them and their use.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式