专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1465989A4 GROWTH FACTOR MODIFIED PROTEIN MATRICES FOR TISSUE ENGINEERING 有权转让
标题翻译：生长因子修改组织重建PROTEINMATRIZES（组织工程）
公开(公告)号：EP1465989A4
公开(公告)日：2005-03-16
申请号：EP02792510
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： HUBBELL JEFFREY A , LUTOLF MATTHIAS , SCHENSE JASON , JEN ANNA
IPC分类号： A61K47/00 , A61K47/48 , A61L27/22 , C07K14/635
CPC分类号： A61L27/225 , A61K38/00 , A61L27/227 , C07K14/635 , C07K2319/00
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.

2. 发明申请

WO03052091A8 GROWTH FACTOR MODIFIED PROTEIN MATRICES FOR TISSUE ENGINEERING 审中-公开
标题翻译：生长因子改良组织工程蛋白质矩阵
公开(公告)号：WO03052091A8
公开(公告)日：2003-08-07
申请号：PCT/US0241114
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： HUBBELL JEFFREY A , LUTOLF MATTHIAS , SCHENSE JASON , JEN ANNA
IPC分类号： C12N5/06 , A61K33/06 , A61K38/00 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K19/00 , C12N9/10
CPC分类号： A61K9/0024 , A61L27/225 , A61L27/227 , C07K14/635 , C07K2319/00
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.
摘要翻译：将蛋白质掺入用于组织修复，再生和/或重塑和/或药物递送的蛋白质或多糖基质中。可以掺入蛋白质，使其通过降解基质，通过酶作用和/或扩散来释放。如实施例所示，一种方法是通过共价或非共价方法将肝素与基质结合，形成肝素基质。然后肝素将肝素结合生长因子非共价结合到蛋白质基质上。或者，可以构建融合蛋白，其包含交联区域，例如因子XIIIa底物和天然蛋白质序列。当需要长期药物递送时，例如在神经再生的情况下，在基质和生物活性因子之间引入可降解的键可能是特别有用的，其中期望在空间上改变作为再生的功能的药物释放速率，例如快速靠近生物组织界面，并进一步向进入损伤区更慢。额外的益处包括递送系统内的总药物剂量越少，释放的空间调节，允许在最大的细胞活动时释放更多百分比的药物。

3. 发明专利

DE60225185T2 未知
公开(公告)号：DE60225185T2
公开(公告)日：2009-02-19
申请号：DE60225185
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： HUBBELL JEFFREY A , LUTOLF MATTHIAS , SCHENSE JASON , JEN ANNA
IPC分类号： A61K47/00 , C12N5/06 , A61K33/06 , A61K38/00 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61K47/48 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K19/00 , C12N9/10
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.

4. 发明专利

CA2470419A1 GROWTH FACTOR MODIFIED PROTEIN MATRICES FOR TISSUE ENGINEERING 未知
公开(公告)号：CA2470419A1
公开(公告)日：2003-06-26
申请号：CA2470419
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： JEN ANNA , SCHENSE JASON , LUTOLF MATTHIAS
IPC分类号： C12N5/06 , A61K33/06 , A61K38/00 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K19/00 , C12N9/10
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.

5. 发明专利

ES2301697T3 MATRICES DE PROTEINA MODIFICADA CON FACTOR DE CRECIMIENTO PARA INGENIERIA DE TEJIDOS. 未知
公开(公告)号：ES2301697T3
公开(公告)日：2008-07-01
申请号：ES02792510
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： HUBBELL JEFFREY A , LUTOLF MATTHIAS , SCHENSE JASON , JEN ANNA
IPC分类号： A61K47/00 , C12N5/06 , A61K33/06 , A61K38/00 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61K47/48 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K19/00 , C12N9/10
摘要： Un péptido de fusión, caracterizado porque comprende: un primer dominio que comprende PTH y un segundo dominio que comprende un dominio del substrato covalentemente degradable.

6. 发明专利

AT386545T 未知
公开(公告)号：AT386545T
公开(公告)日：2008-03-15
申请号：AT02792510
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： HUBBELL JEFFREY , LUTOLF MATTHIAS , SCHENSE JASON , JEN ANNA
IPC分类号： A61K47/00 , C12N5/06 , A61K33/06 , A61K38/00 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61K47/48 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K19/00 , C12N9/10
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.

7. 发明专利

DE60225185D1 未知
公开(公告)号：DE60225185D1
公开(公告)日：2008-04-03
申请号：DE60225185
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： HUBBELL JEFFREY A , LUTOLF MATTHIAS , SCHENSE JASON , JEN ANNA
IPC分类号： A61K47/00 , C12N5/06 , A61K33/06 , A61K38/00 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61K47/48 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K19/00 , C12N9/10
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.

8. 发明专利

AU2002358272A1 GROWTH FACTOR MODIFIED PROTEIN MATRICES FOR TISSUE ENGINEERING 未知
公开(公告)号：AU2002358272A1
公开(公告)日：2003-06-30
申请号：AU2002358272
申请日：2002-12-18
申请人： ETH ZUERICH , UNIV ZUERICH , HUBBELL JEFFREY A
发明人： SCHENSE JASON , JEN ANNA , HUBBELL JEFFREY A , LUTOLF MATTHIAS
IPC分类号： C12N5/06 , A61K33/06 , A61K38/00 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/635 , C07K19/00 , C12N9/10
摘要： Proteins are incorporated into protein or polysaccharide matrices for use in tissue repair, regeneration and/or remodeling and/or drug delivery. The proteins can be incorporated so that they are released by degradation of the matrix, by enzymatic action and/or diffusion. As demonstrated by the examples, one method is to bind heparin to the matrix by either covalent or non-covalent methods, to form a heparin-matrix. The heparin then non-covalently binds heparin-binding growth factors to the protein matrix. Alternatively, a fusion protein can be constructed which contains a crosslinking region such as a factor XIIIa substrate and the native protein sequence. Incorporation of degradable linkages between the matrix and the bioactive factors can be particularly useful when long-term drug delivery is desired, for example in the case of nerve regeneration, where it is desirable to vary the rate of drug release spatially as a function of regeneration, e.g. rapidly near the living tissue interface and more slowly farther into the injury zone. Additional benefits include the lower total drug dose within the delivery system, and spatial regulation of release which permits a greater percentage of the drug to be released at the time of greatest cellular activity.

9. 发明专利

JP2009102383A Growth factor-modified protein matrix for tissue engineering 审中-公开
标题翻译：用于组织工程的生长因子修饰蛋白质矩阵
公开(公告)号：JP2009102383A
公开(公告)日：2009-05-14
申请号：JP2009005240
申请日：2009-01-13
申请人： Eidgenoessische Technische Hochschule Zuerich , Univ Zuerich , イジュノシッヒテクニッヒホッフシューラチューリッヒ , ウニヴェルジテート・チューリッヒUniversitaet Zuerich
发明人： HUBBELL JEFFREY A , LUTOLF MATTHIAS , SCHENSE JASON , JEN ANNA
IPC分类号： C07K14/635 , C12N5/06 , A61K33/06 , A61K38/00 , A61K38/17 , A61K38/22 , A61K38/23 , A61K38/48 , A61K47/34 , A61K47/42 , A61K47/48 , A61L27/22 , A61P19/08 , A61P43/00 , C07K14/745 , C07K19/00 , C12N9/10
CPC分类号： A61K9/0024 , A61L27/225 , A61L27/227 , C07K14/635 , C07K2319/00
摘要： PROBLEM TO BE SOLVED: To incorporate a protein into a protein or polysaccharide matrix for use in tissue repair, regeneration and/or remodelling and/or drug delivery. SOLUTION: The protein can be incorporated so that it is released by degradation of the matrix, by enzymatic activation and/or diffusion. As demonstrated by the examples, one method involves binding of heparin to the matrix by either a covalent or non-covalent method to form a heparin-matrix. The heparin then non-covalently binds a heparin-binding growth factor to the protein matrix. Alternatively, a fusion protein which contains a crosslinking region such as a factor XIIIa substrate and a native protein sequence can be constructed. Incorporation of a degradable linkage between the matrix and a bioactive factor can be particularly useful when long-term drug delivery is desired (for example in the case of nerve regeneration). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：将蛋白质掺入用于组织修复，再生和/或重塑和/或药物递送的蛋白质或多糖基质中。解决方案：可以掺入蛋白质，以便通过酶活化和/或扩散来降解基质来释放蛋白质。如实施例所示，一种方法包括通过共价或非共价方法将肝素与基质结合以形成肝素 - 基质。然后肝素将肝素结合生长因子与蛋白质基质非共价结合。或者，可以构建含有诸如因子XIIIa底物和天然蛋白质序列之类的交联区域的融合蛋白质。当需要长期药物递送时（例如在神经再生的情况下），在基质和生物活性因子之间引入可降解的键可以是特别有用的。版权所有（C）2009，JPO＆INPIT

10. 发明专利

NO20042357L 未知
公开(公告)号：NO20042357L
公开(公告)日：2004-07-13
申请号：NO20042357
申请日：2004-06-07
申请人： ETH ZUERICH
发明人： LUETOLF MATTHIAS , SCHENSE JASON CHARLES , JEN ANNA , HUBBELL JEFFREY ALAN
IPC分类号： A61K47/48 , A61L27/18 , A61L27/00 , A61L27/26 , A61L27/52 , A61L31/04 , C08G65/329 , C08G65/332 , C08G65/334 , C08G81/00 , C08H1/00 , C08L71/02 , A61K47/00
摘要： Biomaterial comprises a three dimensional polymeric network obtainable from the reaction of at least a first and second precursor molecule. The first precursor molecule is at least a trifunctional, branched component comprising at least three arms substantially similar in molecular weight and the second precursor molecule is at least a bifunctional component The ratio of equivalent weight or the functional groups of the first and second precursor molecule is in a range of between 0.9 and 1.1. The molecular weight of the arms of the first precursor molecule. the molecular weight of the second precursor molecule and the functionality of the branching points are selected so that the water content of the polymeric networks is between the equilibrium weight % and 92 weitht of the total weight of the polymeric network after completion of water uptake. The present invention teaches a way to improve characteristics of synthetic matrices which are useful for wound healing applications.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式