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1. 发明专利

JP2009112314A Method and composition for treating disorder 审中-公开
标题翻译：治疗疾病的方法和组合
公开(公告)号：JP2009112314A
公开(公告)日：2009-05-28
申请号：JP2009043222
申请日：2009-02-25
申请人： Epeius Biotechnologies Corp , エペイウスバイオテクノロジーズコーポレイション
发明人： GORDON ERLINDA M , HALL FREDERICK L
IPC分类号： C12N15/09 , A01N63/00 , A61K20060101 , A61K35/76 , A61K38/00 , A61K38/45 , A61K48/00 , A61K49/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P41/00 , A61P43/00 , C07H21/04 , C07K14/47 , C12N15/63 , C12N15/85 , C12N15/867
CPC分类号： C07K14/4738 , A61K48/00 , C12N15/85 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2800/108 , C12N2810/85
摘要： PROBLEM TO BE SOLVED: To provide an improved vector so as to enable a targeted delivery system to be used in a clinical setting, and to provide a system for producing the improved vector. SOLUTION: A method and a composition for producing a targeted delivery vector are provided. Such a vector is useful for treating neoplastic disorders. Furthermore, a protocol for administering a targeted delivery vector in a clinical setting so as to achieve a curative effect is provided. Besides, "targeted" virus and non-virus particles, for example, retrovirus vector particles, adenovirus vector particles, adeno-related virus vector particles, herpes virus vector particles and pseudovirus, e.g. associated with vesicular stomatitis virus G protein (VSV-G), are provided. A non-virus vector containing a virus protein as a part of Virosome, or other proteoliposome gene transfer vector(s), are also provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供改进的载体，以便能够在临床环境中使用目标递送系统，并提供用于生产改良载体的系统。提供了一种用于产生靶向递送载体的方法和组合物。这种载体可用于治疗肿瘤性疾病。此外，提供了用于在临床环境中施用靶向递送载体以达到疗效的方案。此外，“靶向”病毒和非病毒颗粒，例如逆转录病毒载体颗粒，腺病毒载体颗粒，腺相关病毒载体颗粒，疱疹病毒载体颗粒和假病毒，例如。与水泡性口炎病毒G蛋白（VSV-G）相关。还提供了含有病毒蛋白作为病毒颗粒的一部分的非病毒载体或其他蛋白脂质体基因转移载体。版权所有（C）2009，JPO＆INPIT

2. 发明申请

WO2012009703A3 TARGETED NANOPARTICLES FOR CANCER AND OTHER DISORDERS 审中-公开
标题翻译：针对癌症和其他疾病的靶向纳米颗粒
公开(公告)号：WO2012009703A3
公开(公告)日：2013-08-08
申请号：PCT/US2011044288
申请日：2011-07-15
申请人： EPEIUS BIOTECHNOLOGIES CORP , HALL FREDERICK L , GORDON ERLINDA M
发明人： HALL FREDERICK L , GORDON ERLINDA M
IPC分类号： A01N63/00
CPC分类号： A61K38/1709 , A61K38/193 , A61K38/2013 , A61K38/45 , C07K2319/33 , C12N2740/13022 , C12N2740/13043 , C12N2740/13071 , C12N2810/857
摘要： Targeted gene therapeutic systems are provided for the treatment of cancer, including viral particles. The viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastatic sites. Localized dosing regimens are provided to treat diseases such as cancer.
摘要翻译：提供靶向基因治疗系统用于治疗癌症，包括病毒颗粒。将病毒颗粒工程化以将治疗或诊断试剂特异性递送至疾病部位，例如癌症转移部位。提供局部给药方案来治疗癌症等疾病。

3. 发明申请

WO2008054826A2 PATHOTROPIC TARGETED GENE DELIVERY SYSTEM FOR CANCER AND OTHER DISORDERS 审中-公开
标题翻译：癌症和其他疾病的PATHTROPIC靶向基因递送系统
公开(公告)号：WO2008054826A2
公开(公告)日：2008-05-08
申请号：PCT/US2007023305
申请日：2007-11-05
申请人： EPEIUS BIOTECHNOLOGIES CORP , HALL FREDERICK L , LEVY JOHN P , REED REBECCA A , GORDON ERLINDA M
发明人： HALL FREDERICK L , LEVY JOHN P , REED REBECCA A , GORDON ERLINDA M
IPC分类号： A61K48/00 , C12N15/85 , C12N15/86 , C12N15/867
CPC分类号： A61K31/7088 , A61K35/76 , A61K38/1709 , A61K38/193 , A61K38/45 , A61K48/00 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2810/85 , A61K2300/00
摘要： Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastic sites. Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.
摘要翻译：提供了向嗜性（疾病寻找）靶向基因递送的系统，包括具有极高滴度的病毒颗粒。具体而言，病毒颗粒被工程化以特异性地将治疗剂或诊断剂递送至疾病部位，如癌变位点。还提供个性化的给药方案以有效地治疗诸如癌症之类的疾病，并减少不良副作用。

4. 发明专利

AU2008221564A1 Methods and Compositions for Treating Disorders 未知
公开(公告)号：AU2008221564A1
公开(公告)日：2008-10-16
申请号：AU2008221564
申请日：2008-09-19
申请人： EPEIUS BIOTECHNOLOGIES CORP
发明人： GORDON ERLINDA M , HALL FREDERICK L
IPC分类号： A01N63/00 , C12N15/09 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K48/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P27/02 , A61P27/12 , A61P35/00 , A61P35/04 , A61P43/00 , C07H21/04 , C07K14/47 , C12N5/06 , C12N7/00 , C12N15/12 , C12N15/63

5. 发明公开

EP2077862A4 PATHOTROPIC TARGETED GENE DELIVERY SYSTEM FOR CANCER AND OTHER DISORDERS 有权转让
标题翻译： PATHOTROPISCHES靶向基因传递系统癌症和其他疾病
公开(公告)号：EP2077862A4
公开(公告)日：2011-03-09
申请号：EP07867361
申请日：2007-11-05
申请人： EPEIUS BIOTECHNOLOGIES CORP
发明人： HALL FREDERICK L , LEVY JOHN P , REED REBECCA A , GORDON ERLINDA M
IPC分类号： A61K48/00 , A01K67/00 , C12N15/00 , C12N15/63 , C12N15/85 , C12N15/867
CPC分类号： A61K31/7088 , A61K35/76 , A61K38/1709 , A61K38/193 , A61K38/45 , A61K48/00 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2810/85 , A61K2300/00
摘要： Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastic sites. Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.

6. 发明公开

EP1619951A4 METHODS AND COMPOSITIONS FOR TREATING DISORDERS 有权转让
标题翻译：方法和组合物疾病治疗
公开(公告)号：EP1619951A4
公开(公告)日：2007-11-28
申请号：EP04760083
申请日：2004-04-21
申请人： EPEIUS BIOTECHNOLOGIES CORP
发明人： GORDON ERLINDA M , HALL FREDERICK L
IPC分类号： A01N63/00 , A61K20060101 , A61K48/00 , C07H21/04 , C07K14/47 , C12N15/63 , C12N15/85 , C12N15/867
CPC分类号： C07K14/4738 , A61K48/00 , C12N15/85 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2800/108 , C12N2810/85

7. 发明专利

AU2013251291A1 Pathotropic targeted gene delivery system for cancer and other disorders 未知
公开(公告)号：AU2013251291A1
公开(公告)日：2013-11-21
申请号：AU2013251291
申请日：2013-11-04
申请人： EPEIUS BIOTECHNOLOGIES CORP
发明人： GORDON ERLINDA M , REED REBECCA A , LEVY JOHN P , HALL FREDERICK L
IPC分类号： A61K48/00 , A01K67/00 , C12N15/00 , C12N15/63 , C12N15/85 , C12N15/867
摘要： H:\kII\Interwoven\NRPortbl\DCC\KLL\5790989_I.DOC-4/11/2013 Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastic sites. Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.

8. 发明专利

AU2013251289A1 PATHOTROPIC TARGETED GENE DELIVERY SYSTEM FOR CANCER AND OTHER DISORDERS 未知
公开(公告)号：AU2013251289A1
公开(公告)日：2013-11-21
申请号：AU2013251289
申请日：2013-11-04
申请人： EPEIUS BIOTECHNOLOGIES CORP
发明人： GORDON ERLINDA M , REED REBECCA A , LEVY JOHN P , HALL FREDERICK L
IPC分类号： A61K48/00 , A01K67/00 , C12N15/00 , C12N15/63 , C12N15/85 , C12N15/867
摘要： Abstract: Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic 5 agents to a disease site, such as cancer metastic sites, Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.

9. 发明专利

ES2366617T3 METODOS Y COMPOSICIONES PARA EL TRATAMIENTO DE TRANSTORNOS. 未知
公开(公告)号：ES2366617T3
公开(公告)日：2011-10-21
申请号：ES04760083
申请日：2004-04-21
申请人： EPEIUS BIOTECHNOLOGIES CORP
发明人： GORDON ERLINDA M , HALL FREDERICK L
IPC分类号： A01N63/00 , A61K20060101 , A61K48/00 , C07H21/04 , C07K14/47 , C12N15/63 , C12N15/85 , C12N15/867
摘要： Método para producir un vector de administración dirigida que comprende partículas retrovirales para inhibir la metástasis tumoral, comprendiendo dicho método las siguientes etapas: A) transfección transitoria de una célula productora con: i) un primer plásmido que comprende una secuencia de ácido nucleico que codifica la proteína anfotrópica de envoltura 4070A modificada para contener un dominio de enlace de colágeno, en el que la secuencia de ácido nucleico está enlazada operativamente a un promotor, y en el que el dominio de enlace de colágeno comprende la secuencia de aminoácido Gly-His-Val-Gly-Trp-Arg-Glu-Pro-Ser-Phe Met-Ala-Leu-Ser-Ala-Ala obtenida a partir del dominio D2 del factor de von Willebrand; ii) un segundo plásmido, que comprende: (a) una secuencia de ácido nucleico enlazada operativamente a un promotor, y en el que la secuencia codifica un polipéptido retroviral gag-pol, (b) una secuencia de ácido nucleico enlazada operativamente a un promotor, y en el que la secuencia codifica un polipéptido que confiere resistencia a medicamentos a la célula productora, (c) un origen de SV40 de replicación; iii) un tercer plásmido, que comprende: (a) una secuencia heteróloga de ácido nucleico enlazada operativamente a un promotor, y en el que la secuencia codifica un polipéptido de diagnóstico o terapéutico, (b) secuencias de repetición terminal larga 5'y 3'(LTRs), (c) una secuencia de empaquetado retroviral Ψ (d) un promotor CMV antepuesto a la LTR 5' (e) una secuencia de ácido nucleico enlazada operativamente a un promotor, y en el que la secuencia codifica un polipéptido que confiere resistencia a medicamentos a la célula productora, (f) un origen de SV40 de replicación, en el que la célula productora es una célula humana que expresa un antígeno grande T de SV40; B) cultivar las células productoras según A) en condiciones que permitan la producción de vectores de administración dirigida y su liberación en los sobrenadantes del cultivo; (C) aislar e introducir los sobrenadantes en un sistema de colector de bucle cerrado que comprende una bolsa tipo flexboy® y un sistema de colector, en el que la bolsa tipo flexboy está formada por una película coextrusionada de tres capas que consta de una capa de contacto con el fluido fabricada con etil vinil acetato, una barrera al gas de Etilen vinil alcohol y una capa exterior de etil vinil acetato para la recolección de las partículas virales; (D) recogida y concentración de los vectores de administración dirigidos, y (E) tratamiento de dichos vectores de administración dirigidos con un agente de degradación del ADN que no provoque una pérdida de la potencia del vector.

10. 发明专利

CA2522359C PATHOTROPIC RETROVIRAL VECTOR USED TO DELIVER DIAGNOSTIC OR THERAPEUTIC COMPOSITIONS 未知
公开(公告)号：CA2522359C
公开(公告)日：2013-09-24
申请号：CA2522359
申请日：2004-04-21
申请人： EPEIUS BIOTECHNOLOGIES CORP
发明人： GORDON ERLINDA M , HALL FREDERICK L
IPC分类号： C12N15/63 , A01N63/00 , A61K20060101 , A61K48/00 , C07H21/04 , C07K14/47 , C12N15/85 , C12N15/867
摘要： Methods and compositions for producing targeted delivery vectors are provided. Such vectors are useful for treating neoplastic disorders. Also provided are protocols for administering targeted delivery vectors in a clinical setting such that a therapeutic effect is achieved.

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