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1. 发明公开

EP2324849A3 Selective immune down regulation (SIDR) mediated transplantation processes 有权
标题翻译：选择性免疫抑制方法移植
公开(公告)号：EP2324849A3
公开(公告)日：2013-03-06
申请号：EP10184243.3
申请日：2000-07-17
申请人： ENZO THERAPEUTICS, INC.
发明人： Rabbani, Elazar , Roy-Chowdhury, Jayanta , Engelhardt, Dean L. , Ilan, Yaron
IPC分类号： A61K35/38 , A61P1/00 , A61P37/00
CPC分类号： A61K39/292 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/12 , A61K2035/122 , A61K2035/124 , A61K2039/542 , A61K2039/545 , A61K2039/57 , C12N2730/10134
摘要： This invention provides for unique immune modulation applications in transplantation processes, as well as in disease intervention and prevention directed to graft-versus-host rejection as well eliminating undesirable immunological effects resulting from immunization and vaccination. Also provided are treatments for other diseases, including Crohn's disease, primary schlerosing cholangitis, primary biliary cirrhosis, atheroschlerosis, etc. This invention also provides unique compositions for carrying out such processes.

2. 发明公开

EP2324849A2 Selective immune down regulation (SIDR) mediated transplantation processes 有权
标题翻译： SelektiveImmununterdrückungverfahrenzur Crohns Krankheit
公开(公告)号：EP2324849A2
公开(公告)日：2011-05-25
申请号：EP10184243.3
申请日：2000-07-17
申请人： ENZO THERAPEUTICS, INC.
发明人： Rabbani, Elazar , Roy-Chowdhury, Jayanta , Engelhardt, Dean L. , Ilan, Yaron
IPC分类号： A61K39/00 , A61K35/12 , A61P37/06
CPC分类号： A61K39/292 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/12 , A61K2035/122 , A61K2035/124 , A61K2039/542 , A61K2039/545 , A61K2039/57 , C12N2730/10134
摘要： This invention provides for unique immune modulation applications in transplantation processes, as well as in disease intervention and prevention directed to graft-versus-host rejection as well eliminating undesirable immunological effects resulting from immunization and vaccination. Also provided are treatments for other diseases, including Crohn's disease, primary schlerosing cholangitis, primary biliary cirrhosis, atheroschlerosis, etc. This invention also provides unique compositions for carrying out such processes.
摘要翻译：本发明提供在移植过程中的独特免疫调节应用，以及针对移植物抗宿主排斥的疾病干预和预防，以及消除由免疫接种和疫苗接种引起的不良免疫效应。还提供了其他疾病的治疗，包括克罗恩病，原发性硬化性胆管炎，原发性胆汁性肝硬化，动脉粥样硬化等。本发明还提供用于进行这些方法的独特组合物。

3. 发明授权

EP2324849B1 Selective immune down regulation (SIDR) for Crohn's disease 有权
标题翻译：克罗恩病选择性免疫抑制方法
公开(公告)号：EP2324849B1
公开(公告)日：2016-03-30
申请号：EP10184243.3
申请日：2000-07-17
申请人： ENZO THERAPEUTICS, INC.
发明人： Rabbani, Elazar , Roy-Chowdhury, Jayanta , Engelhardt, Dean L. , Ilan, Yaron
IPC分类号： A61K35/38 , A61K39/00 , A61P1/00 , A61P37/00
CPC分类号： A61K39/292 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/12 , A61K2035/122 , A61K2035/124 , A61K2039/542 , A61K2039/545 , A61K2039/57 , C12N2730/10134
摘要： This invention provides for unique immune modulation applications in transplantation processes, as well as in disease intervention and prevention directed to graft-versus-host rejection as well eliminating undesirable immunological effects resulting from immunization and vaccination. Also provided are treatments for other diseases, including Crohn's disease, primary schlerosing cholangitis, primary biliary cirrhosis, atheroschlerosis, etc. This invention also provides unique compositions for carrying out such processes.

4. 发明公开

EP1072271A3 Selective immune down regulation (SIDR) mediated transplantation processes 审中-公开
标题翻译：选择性免疫下调（SIDR）介导的移植过程
公开(公告)号：EP1072271A3
公开(公告)日：2001-10-04
申请号：EP00115423.6
申请日：2000-07-17
申请人： ENZO THERAPEUTICS, INC.
发明人： Rabbani, Elazar , Ilan, Yaron , Roy-Chowdhury, Jayanta , Engelhardt, Dean L.
IPC分类号： A61K39/00 , A61K35/12 , A61P37/06
CPC分类号： A61K39/292 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/12 , A61K2035/122 , A61K2035/124 , A61K2039/542 , A61K2039/545 , A61K2039/57 , C12N2730/10134
摘要： This invention provides for unique immune modulation applications in transplantation processes, as well as in disease intervention and prevention directed to graft-versus-host rejection as well eliminating undesirable immunological effects resulting from immunization and vaccination. Also provided are treatments for other diseases, including Crohn's disease, primary schlerosing cholangitis, primary biliary cirrhosis, atheroschlerosis, etc. This invention also provides unique compositions for carrying out such processes.
摘要翻译：本发明在移植过程中以及针对移植物抗宿主排斥的疾病干预和预防中提供了独特的免疫调节应用，并消除了由免疫和疫苗接种导致的不希望的免疫效应。还提供了治疗其他疾病的方法，包括克罗恩氏病，原发性硬化性胆管炎，原发性胆汁性肝硬化，动脉粥样硬化等。本发明还提供了用于实施这些方法的独特组合物。

5. 发明公开

EP1068799A2 Biological models capable of exhibiting secondary disease manifestations 审中-公开
标题翻译： Biologisches Modell mit derFähigkeitzur Manifestationen einerSekundärkrankheit
公开(公告)号：EP1068799A2
公开(公告)日：2001-01-17
申请号：EP00114901.2
申请日：2000-07-14
申请人： ENZO THERAPEUTICS, INC.
发明人： Brown, Jennifer June , Rabbani, Elazar , Donegan, James J. , Roy-Chowdhury, Jayanta
IPC分类号： A01K67/027
CPC分类号： A01K67/027 , A01K2227/106 , A01K2267/0337 , C12N2730/10111 , C12N2740/15011 , C12N2770/24211
摘要： This invention provides novel animal models for a human pathogen that is capable of exhibiting analogous secondary disease manifestation. Other animal models for a human pathogen are provided by this invention which are capable of exhibiting analogous secondary disease manifestations and are also capable of responding to therapeutic or preventive measures to such secondary disease manifestations. Other animal models for human retrovirus infections are provided including lower primates and primate excluding any members of the order Anthropoidea. Compositions, drugs, products and procedures for therapeutic and diagnostic applications derived from the animal models of this invention are also described and provided.
摘要翻译：本发明提供了能够表现出类似的次级疾病表现的人类病原体的新型动物模型。用于人类病原体的其它动物模型由本发明提供，其能够表现出类似的二次疾病表现，并且还能够对这种继发性疾病表现作出应对治疗或预防措施。提供其他用于人类逆转录病毒感染的动物模型，包括不包括任意顺式杀虫剂成员的低灵长类动物和灵长类动物。还描述和提供了衍生自本发明的动物模型的用于治疗和诊断应用的组合物，药物，产品和程序。

6. 发明公开

EP2301567A1 Selective immune down regulation (SIDR) for transplantation 失效
标题翻译： Selektive Immunherunterregulierung（SIDR）zur Transplantation
公开(公告)号：EP2301567A1
公开(公告)日：2011-03-30
申请号：EP10184206.0
申请日：1998-02-26
申请人： ENZO THERAPEUTICS, INC.
发明人： Roy-Chowdhury, Jayanta , Ilan, Yaron , Rabbani, Elazar , Engelhardt, Dean
IPC分类号： A61K39/00 , A61P37/06
CPC分类号： A61K48/00 , A61K35/12 , A61K35/74 , A61K38/00 , A61K39/0008 , A61K39/001 , A61K2039/542
摘要： Novel immune modulating processes are provided in which the immunological state of a subject including mature subjects, mammals and humans, are down regulated in a selective manner, and as a subset in a dominant manner. The novel immunological state termed SIDR for selective immune down regulation is usefully applied to the immunological modulation or regulation of gene delivery components, artificially expressed genes, gene delivery systems and expression products of artificially introduced genes by such delivery systems, and infectious agents. SIDR is also useful when combined with other immune modulating treatments such as general immune suppression and anti-apoptosis. SIDR may also be used to selectively down regulate the immune response system of a subject to a wide variety of noncellular immunogenic components and to native antigens. Other processes for producing immune suppression by administering macromolecules or compounds to a subject so as to obtain or effect SIDR are also provided. Kits for carrying out the novel processes are also provided.
摘要翻译：提供了新的免疫调节过程，其中包括成熟受试者，哺乳动物和人的受试者的免疫状态以选择性方式下调，并以主要方式作为子集。用于选择性免疫调节的称为SIDR的新型免疫学状态有效地应用于免疫调节或调节基因递送成分，人工表达的基因，基因递送系统和通过这种递送系统人工引入的基因的表达产物和感染因子。当与其他免疫调节治疗如一般免疫抑制和抗凋亡组合时，SIDR也是有用的。 SIDR也可用于选择性地将受试者的免疫应答系统下调到多种非细胞免疫原性组分和天然抗原。还提供了通过向受试者施用大分子或化合物以获得或影响SIDR来产生免疫抑制的其它方法。还提供了用于执行新颖过程的套件。

7. 发明公开

EP1068799A3 Biological models capable of exhibiting secondary disease manifestations 审中-公开
标题翻译：有能力以继发性疾病的表现的生物模型
公开(公告)号：EP1068799A3
公开(公告)日：2007-10-17
申请号：EP00114901.2
申请日：2000-07-14
申请人： ENZO THERAPEUTICS, INC.
发明人： Brown, Jennifer June , Rabbani, Elazar , Donegan, James J. , Roy-Chowdhury, Jayanta
IPC分类号： A01K67/027 , A61K38/00 , C12N5/06 , A61K39/00
CPC分类号： A01K67/027 , A01K2227/106 , A01K2267/0337 , C12N2730/10111 , C12N2740/15011 , C12N2770/24211
摘要： This invention provides novel animal models for a human pathogen that is capable of exhibiting analogous secondary disease manifestation. Other animal models for a human pathogen are provided by this invention which are capable of exhibiting analogous secondary disease manifestations and are also capable of responding to therapeutic or preventive measures to such secondary disease manifestations. Other animal models for human retrovirus infections are provided including lower primates and primate excluding any members of the order Anthropoidea. Compositions, drugs, products and procedures for therapeutic and diagnostic applications derived from the animal models of this invention are also described and provided.

8. 发明公开

EP1072271A2 Selective immune down regulation (SIDR) mediated transplantation processes 审中-公开
标题翻译： SelektiveImmununtdrückungverfahrenzur移植
公开(公告)号：EP1072271A2
公开(公告)日：2001-01-31
申请号：EP00115423.6
申请日：2000-07-17
申请人： ENZO THERAPEUTICS, INC.
发明人： Rabbani, Elazar , Ilan, Yaron , Roy-Chowdhury, Jayanta , Engelhardt, Dean L.
IPC分类号： A61K39/00 , A61K35/12 , A61P37/06
CPC分类号： A61K39/292 , A61K38/00 , A61K39/0005 , A61K39/0008 , A61K39/001 , A61K39/12 , A61K2035/122 , A61K2035/124 , A61K2039/542 , A61K2039/545 , A61K2039/57 , C12N2730/10134
摘要： This invention provides for unique immune modulation applications in transplantation processes, as well as in disease intervention and prevention directed to graft-versus-host rejection as well eliminating undesirable immunological effects resulting from immunization and vaccination. Also provided are treatments for other diseases, including Crohn's disease, primary schlerosing cholangitis, primary biliary cirrhosis, atheroschlerosis, etc. This invention also provides unique compositions for carrying out such processes.
摘要翻译：本发明提供在移植过程中的独特免疫调节应用，以及针对移植物抗宿主排斥的疾病干预和预防，以及消除由免疫接种和疫苗接种引起的不良免疫效应。还提供了其他疾病的治疗，包括克罗恩病，原发性硬化性胆管炎，原发性胆汁性肝硬化，动脉粥样硬化等。本发明还提供用于进行这些方法的独特组合物。

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