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1. 发明申请

WO03020749A2 NCAM BINDING COMPOUNDS 审中-公开
标题翻译： NCAM结合化合物
公开(公告)号：WO03020749A2
公开(公告)日：2003-03-13
申请号：PCT/DK0200574
申请日：2002-09-04
申请人： ENKAM PHARMACEUTICALS AS , ROENN LARS CHRISTIAN BIILMANN , OLSEN MARIANNE , BEREZIN VLADIMIR , BOCK ELISABETH , POULSEN FLEMMING MARTIN , HOLM ARNE VALDEMAR , SOROKA VLADISLAV , OESTERGAARD SOEREN
发明人： ROENN LARS CHRISTIAN BIILMANN , OLSEN MARIANNE , BEREZIN VLADIMIR , BOCK ELISABETH , POULSEN FLEMMING MARTIN , HOLM ARNE VALDEMAR , SOROKA VLADISLAV , OESTERGAARD SOEREN
IPC分类号： C12N5/02 , A61K38/00 , A61L27/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P13/12 , A61P15/00 , A61P17/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07K4/00 , C07K7/00 , C07K7/06 , C07K14/00
CPC分类号： C07K7/06
摘要： The present invention concerns an NCAM (neural cell adhesion molecule) binding compound capable of stimulating NCAM signalling and/or interfering with cell adhesion. The compound is a peptide having a sequence of the formula L1-A-L2-B-L3-C-L4, wherein A,B or Cis any amino acid residue, with the proviso that at least B or C is an acidic amino acid residue, and at least A, B, or C is a hydrophobic amino acid residue or Y, or A, B or C is any amino acid residue, with the proviso that at least B or C is an basic amino acid residue, and at least A, B, or C is a hydrophobic amino acid residue or Y, and L1, L2, L3 and L4 is individually selected from a chemical bond or an amino acid sequence having n amino acid residues, wherein n is an integer of from 0 to 5. According to the invention the compound may be used for the manufacture of a medicament for the treatment of normal, degenerated or damaged NCAM presenting cells, such as in various diseases or conditions of the central and peripheral nervous system.
摘要翻译：本发明涉及能够刺激NCAM信号传导和/或干扰细胞粘附的NCAM（神经细胞粘附分子）结合化合物。该化合物是具有式L1-A-L2-B-L3-C-L4的序列的肽，其中A，B或任何氨基酸残基，条件是至少B或C是酸性氨基酸并且至少A，B或C是疏水性氨基酸残基或Y或A，B或C是任何氨基酸残基，条件是至少B或C是碱性氨基酸残基，并且在至少A，B或C是疏水性氨基酸残基或Y，L1，L2，L3和L4分别选自具有n个氨基酸残基的化学键或氨基酸序列，其中n为0的整数根据本发明，该化合物可用于制备用于治疗正常，退化或损伤的NCAM呈递细胞的药物，例如在中枢和外周神经系统的各种疾病或病症中。

2. 发明申请

WO0018801A3 NCAM BINDING COMPOUNDS 审中-公开
标题翻译： NCAM结合化合物
公开(公告)号：WO0018801A3
公开(公告)日：2000-07-13
申请号：PCT/DK9900500
申请日：1999-09-23
申请人： ROENN LARS CHRISTIAN B , BOCK ELISABETH , HOLM ARNE , OLSEN MARIANNE , OESTERGAARD SOEREN , JENSEN PETER H , POULSEN FLEMMING M , SOROKA VLADISLAV , RALETS IGOR , BEREZIN VLADIMIR
发明人： ROENN LARS CHRISTIAN B , BOCK ELISABETH , HOLM ARNE , OLSEN MARIANNE , OESTERGAARD SOEREN , JENSEN PETER H , POULSEN FLEMMING M , SOROKA VLADISLAV , RALETS IGOR , BEREZIN VLADIMIR
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08
CPC分类号： C07K14/70503 , A61K38/00
摘要： The invention provides novel compounds which are capable to stimulate the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to pharmaceutical compositions, medicaments and methods for treatment of normal, degenerated and damaged NCAM presenting cells.
摘要翻译：本发明提供能够刺激来自呈现神经细胞粘附分子（NCAM）的细胞的增殖和/或生长的新型化合物。此外，本发明涉及用于治疗正常，退化和损伤的NCAM呈递细胞的药物组合物，药物和方法。

3. 发明专利

AU761451B2 NCAM binding compounds 未知
公开(公告)号：AU761451B2
公开(公告)日：2003-06-05
申请号：AU5727499
申请日：1999-09-23
申请人： RONN LARS CHRISTIAN B , BOCK ELISABETH , HOLM ARNE , OLSEN MARIANNE , OSTERGAARD SOREN , JENSEN PETER H , POULSEN FLEMMING M , SOROKA VLADISLAV , RALETS IGOR , BEREZIN VLADIMIR
发明人： RONN LARS CHRISTIAN B , BOCK ELISABETH , HOLM ARNE , OLSEN MARIANNE , OSTERGAARD SOREN , JENSEN PETER H , POULSEN FLEMMING M , SOROKA VLADISLAV , RALETS IGOR , BEREZIN VLADIMIR
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08 , A61K38/17 , C07K7/06 , C07K14/435
摘要： The invention provides novel compounds which are capable of stimulating the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to methods for treatment of normal, degenerated and damaged NCAM presenting cells.

4. 发明专利

AU5727499A Ncam binding compounds 未知
公开(公告)号：AU5727499A
公开(公告)日：2000-04-17
申请号：AU5727499
申请日：1999-09-23
申请人： BEREZIN VLADIMIR , BOCK ELISABETH , HOLM ARNE , JENSEN PETER H , OLSEN MARIANNE , OSTERGAARD SOREN , POULSEN FLEMMING M , RALETS IGOR , RONN LARS CHRISTIAN B , SOROKA VLADISLAV
发明人： RONN LARS CHRISTIAN B , BOCK ELISABETH , HOLM ARNE , OLSEN MARIANNE , OSTERGAARD SOREN , JENSEN PETER H , POULSEN FLEMMING M , SOROKA VLADISLAV , RALETS IGOR , BEREZIN VLADIMIR
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08 , C07K14/435 , C07K7/06 , A61K38/17
摘要： The invention provides novel compounds which are capable of stimulating the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to methods for treatment of normal, degenerated and damaged NCAM presenting cells.

5. 发明专利

CA2343975A1 NCAM BINDING COMPOUNDS 未知
公开(公告)号：CA2343975A1
公开(公告)日：2000-04-06
申请号：CA2343975
申请日：1999-09-23
申请人： HOLM ARNE , OLSEN MARIANNE , OSTERGAARD SOREN , RONN LARS CHRISTIAN , BEREZIN VLADIMIR , BOCK ELISABETH , RALETS IGOR , JENSEN PETER H , SOROKA VLADISLAV , POULSEN FLEMMING M
发明人： HOLM ARNE , OLSEN MARIANNE , OSTERGAARD SOREN , RONN LARS CHRISTIAN , BEREZIN VLADIMIR , BOCK ELISABETH , RALETS IGOR , JENSEN PETER H , SOROKA VLADISLAV , POULSEN FLEMMING M
IPC分类号： C12N15/09 , A61K38/00 , A61K38/39 , A61K39/395 , A61K45/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P15/08 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/18 , A61P25/28 , A61P43/00 , C07K7/08 , C07K14/705 , C07K14/78 , C07K16/42 , C07K16/46 , C12P21/08
摘要： The invention provides novel compounds which are capable to stimulate the proliferation or/and the outgrowth from cells presenting the neural cell adhesion molecule (NCAM). Additionally, the invention relates to pharmaceutical compositions, medicaments and methods for treatment of normal , degenerated and damaged NCAM presenting cells.

6. 发明申请

WO2005121168A3 HEPARIN BINDING PEPTIDE 审中-公开
公开(公告)号：WO2005121168A3
公开(公告)日：2006-03-16
申请号：PCT/DK2005000382
申请日：2005-06-10
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K14/705 , A61K38/17 , A61K39/395 , A61P25/28 , C07K7/00 , C07K16/28
CPC分类号： C07K14/70503
摘要： The invention relates to new peptide fragments capable of stimulating neurite outgrowth, stimulating of cell survival, stimulating neural plasticity associated with memory and learning, and modulating cell motility. The biological activity of the peptide fragments is associated with their capability of binding and activating a neurotrophin receptor of the Trk family. The peptide fragments of the invention comprise an amino acid motif which is essential for binding and activating a neurotrophin receptor of the Trk family. The invention also concerns pharmaceutical compositions comprising the compounds and uses thereof for prevention and/or treatment of conditions and/or diseases, wherein neurotrophing, Tkr receptors and/or NCAM play an important role, and wherein stimulating of neurite outgrowth, cell survival, neural plasticity associated with memory and learning, and/or modulating cell motility is beneficial for treatment.
摘要翻译：本发明涉及能够刺激神经突生长，刺激细胞存活，刺激与记忆和学习相关的神经可塑性以及调节细胞运动性的新肽片段。肽片段的生物活性与其结合并激活Trk家族的神经营养因子受体的能力相关。本发明的肽片段包含对于结合并激活Trk家族的神经营养因子受体必需的氨基酸基序。本发明还涉及包含该化合物的药物组合物及其用于预防和/或治疗病症和/或疾病的用途，其中神经刺激素，Tkr受体和/或NCAM起重要作用，并且其中刺激神经突生长，细胞存活，神经元与记忆和学习相关的可塑性和/或调节细胞运动性对治疗是有益的。

7. 发明申请

WO2005123759A8 FGFR BINDING PEPTIDES 审中-公开
标题翻译： FGFR结合肽
公开(公告)号：WO2005123759A8
公开(公告)日：2006-03-09
申请号：PCT/DK2005000400
申请日：2005-06-17
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR
发明人： BOCK ELISABETH , BEREZIN VLADIMIR
IPC分类号： C07K7/00 , C07K14/705 , A61K38/17 , A61P25/28 , C07K16/28
CPC分类号： C07K14/70503
摘要： The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
摘要翻译：本发明涉及能够直接结合成纤维细胞生长因子受体（FGFR）并激活所述受体的新肽化合物。本发明的化合物包含衍生自NCAM的纤连蛋白III型模块1（F3，1）的神经细胞粘附分子（NCAM）的肽片段。本发明的肽序列能够刺激学习和记忆和/或神经突生长和/或神经细胞存活。根据本发明的包含其的肽序列及其化合物可有利地用于治疗和/或预防其中FGFR和/或NCAM在病理学和/或疾病恢复中起作用的不同病理状况。因此，包含本发明的肽序列和化合物的药物组合物也在保护范围内。

8. 发明申请

WO2004056865A3 METHOD OF MODULATION OF INTERACTION BETWEEN RECEPTOR AND LIGAND 审中-公开
标题翻译：受体和配体之间相互作用的调节方法
公开(公告)号：WO2004056865A3
公开(公告)日：2005-02-24
申请号：PCT/DK0300901
申请日：2003-12-18
申请人： ENKAM PHARMACEUTICALS AS , BEREZIN VLADIMIR , ALBRECHTSEN MORTEN , BOCK ELISABETH
发明人： BEREZIN VLADIMIR , ALBRECHTSEN MORTEN , BOCK ELISABETH
IPC分类号： A61K38/00 , C07K7/06 , C07K7/08 , C07K16/22 , G01N33/566 , G01N33/74 , C07K7/00
CPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K16/22 , G01N33/566 , G01N33/74 , G01N2333/50
摘要： The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the receptor ligand and discloses a series of amino acid sequences, which are part of the structure of said binding site and/or involved in the interaction between the receptor and the ligand. Moreover, the present invention features methods for molecular design and screening of a candidate compound capable of modulating the interaction between the functional cell-surface receptor and receptor ligand through the described binding site, and provides a screening assay for identification of such a compound. The invention further describes an antibody capable of binding to the above binding site and/or to an epitope comprising an amino acid sequence essential for executing the receptor ligand interaction through said binding site. The invention also concerns a variety of uses of the disclosed methods, peptide sequences and antibodies. The invention in preferred embodiments concerns the binding site of the fibroblast growth factor receptor (FGFR) on FGFR ligands, compounds capable of modulating the receptor ligand interaction through said binding site, and antibody capable of recognition of said binding site.
摘要翻译：本发明涉及调节至少两种蛋白质之间的相互作用的方法，其中两种蛋白质中的至少一种是功能性细胞表面受体，而另一种蛋白质是受体配体。本发明的特征在于所述功能性细胞表面受体在受体配体上的结合位点，并公开了一系列氨基酸序列，其是所述结合位点结构的一部分和/或参与受体和配体之间的相互作用。此外，本发明的特征在于分子设计和筛选能够通过所述结合位点调节功能性细胞表面受体和受体配体之间的相互作用的候选化合物的方法，并提供了鉴定这种化合物的筛选试验。本发明还描述了能够结合上述结合位点和/或包含通过所述结合位点执行受体配体相互作用所必需的氨基酸序列的表位的抗体。本发明还涉及所公开的方法，肽序列和抗体的各种用途。本发明在优选实施方案中涉及成纤维细胞生长因子受体（FGFR）对FGFR配体的结合位点，能够通过所述结合位点调节受体配体相互作用的化合物和能够识别所述结合位点的抗体。

9. 发明申请

WO03016351B1 N - CAM RELATED COMPOUNDS MODULATING CELL GROTH 审中-公开
标题翻译： N - CAM相关化合物调节细胞培养
公开(公告)号：WO03016351B1
公开(公告)日：2004-05-06
申请号：PCT/DK0200541
申请日：2002-08-19
申请人： ENKAM PHARMACEUTICALS AS , KISELYOV VLADISLAV V , SKLADCHIKOVA GALINA , BEREZIN VLADIMIR , BOCK ELISABETH
发明人： KISELYOV VLADISLAV V , SKLADCHIKOVA GALINA , BEREZIN VLADIMIR , BOCK ELISABETH
IPC分类号： A61K38/00 , A61P1/18 , A61P3/10 , A61P9/10 , A61P13/12 , A61P17/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/24 , A61P25/28 , A61P35/00 , C07K7/06 , C07K7/08 , C07K14/705 , C07K14/78 , A61K38/04 , A61K38/17 , C07K7/00
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth Immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3, 1) module, and/or the second Fibronectin III (Fn3, 2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with a Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.
摘要翻译：本发明涉及包含第三免疫球蛋白（Ig3）模块和/或第四免疫球蛋白（Ig4）模块和/或第五免疫球蛋白（Ig5）模块和/或第一纤连蛋白III（Fn3,1）和/或能够与成纤维细胞生长因子（FGF）受体和/或腺苷-3-磷酸结合蛋白相互作用的片段或变体的神经细胞粘附分子（NCAM）的第二纤连蛋白III（Fn3,2）模块，三磷酸（ATP）和/或L1，并且由此所述化合物能够诱导分化，调节增殖，刺激再生，神经元可塑性和/或细胞存活。此外，本发明涉及包含所述化合物的药物组合物，制备药物组合物的方法以及所述化合物的用途。

10. 发明申请

WO2007110079A3 TARGETED DELIVERY OF FGFR LIGANDS INTO THE BRAIN 审中-公开
标题翻译：将FGFR配体定向送入脑
公开(公告)号：WO2007110079A3
公开(公告)日：2008-03-20
申请号：PCT/DK2007000152
申请日：2007-03-28
申请人： ENKAM PHARMACEUTICALS AS , BOCK ELISABETH , BEREZIN VLADIMIR , KISELYOV VLADISLAV V
发明人： BOCK ELISABETH , BEREZIN VLADIMIR , KISELYOV VLADISLAV V
IPC分类号： C07K14/825
CPC分类号： C07K14/825
摘要： The present invention relates to a compound consisting of metallothionein (MT) and a peptide sequence, wherein said peptide sequence and metallotionein are bound to each other via a non-covalent bond. A peptide sequence comprised by the compound is a biologically active short peptide sequence which comprises at most 25 amino acid residues. The peptide sequence is capable of binding to and modulating activity of a functional cell receptor, in particular fibroblast growth factor receptor (FGFR). The invention relates to pharmaceutical compositions comprising such compound or such peptide sequence and use of the compound, peptide sequence and pharmaceutical composition for treatment of conditions and diseases where modulating activity of FGFR is beneficial for treatment. In preferred embodiments the use is for treatment of conditions and diseases of the brain including conditions requiring stimulating brain cell proliferation, differentiation and/or survival, stimulating neural plasticity associated with learning and memory, modulating adhesion and motility of cells, in particular cancer cells. The compound of the invention is capable of penetrating the blood brain barrier (BBB).
摘要翻译：本发明涉及由金属硫蛋白（MT）和肽序列组成的化合物，其中所述肽序列和金属蛋白酶通过非共价键彼此结合。由化合物组成的肽序列是包含至多25个氨基酸残基的生物活性短肽序列。肽序列能够结合并调节功能性细胞受体，特别是成纤维细胞生长因子受体（FGFR）的活性。本发明涉及包含这种化合物或这种肽序列的药物组合物，以及该化合物，肽序列和药物组合物用于治疗调节FGFR活性对治疗有利的病症和疾病的用途。在优选的实施方案中，用于治疗脑的病症和疾病包括需要刺激脑细胞增殖，分化和/或存活的条件，刺激与学习和记忆相关的神经可塑性，调节细胞特别是癌细胞的粘附和运动性。本发明的化合物能够穿透血脑屏障（BBB）。

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