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1. 发明公开

EP0357137A2 New silylating agent for the preparation of chromatographic supports 失效
标题翻译： Silylierungsmittel zur Herstellung von色谱仪Trägern。
公开(公告)号：EP0357137A2
公开(公告)日：1990-03-07
申请号：EP89202171.8
申请日：1989-08-28
申请人： ENIRICERCHE S.p.A. , SCLAVO S.p.A.
发明人： Cardinali, Franco , Longobardi, Maria Grazia , Viscomi, Giuseppe Claudio , Ziggiotti, Alessandra
IPC分类号： C07F7/18 , B01J20/32
CPC分类号： C07F7/1896 , B01J20/103 , B01J20/28004 , B01J20/286 , B01J20/3071 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J2220/54 , B01J2220/58
摘要： A new mono-silylating agent of general formula (I)
(R₁,R₂,R₃)Si-NH-CO-O-Si(R₁,R₂,R₃) (I)
is described as well as its use in the preparation of chromatographic supports based on silica with functional groups covalently bonded thereto, the so-called "bonded stationary phases".
The new compounds are easy and safe to prepare from the corresponding mono-halosilanes with ammonium carbamate, and their use as silylating agents leads to stationary phases with a higher degree of surface coating than that attainable with the corresponding chlorosilanes.
摘要翻译：描述了通式（I）（R1，R2，R3）Si-NH-CO-O-Si（R1，R2，R3）（Ⅰ）的新单甲硅烷基化剂及其在色谱法制备中的应用基于与其共价键合的官能团的二氧化硅的载体，即所谓的“键合固定相”。新化合物由相应的单卤硅烷与氨基甲酸铵制备容易和安全，并且它们作为甲硅烷基化剂的用途导致具有比相应的氯硅烷可获得的更高程度的表面涂层的固定相。

2. 发明公开

EP0357137A3 New silylating agent for the preparation of chromatographic supports 失效
标题翻译：用于制备色谱支持剂的新硅胶剂
公开(公告)号：EP0357137A3
公开(公告)日：1991-01-16
申请号：EP89202171.8
申请日：1989-08-28
申请人： ENIRICERCHE S.p.A. , SCLAVO S.p.A.
发明人： Cardinali, Franco , Longobardi, Maria Grazia , Viscomi, Giuseppe Claudio , Ziggiotti, Alessandra
IPC分类号： C07F7/18 , B01J20/32
CPC分类号： C07F7/1896 , B01J20/103 , B01J20/28004 , B01J20/286 , B01J20/3071 , B01J20/3078 , B01J20/3085 , B01J20/3092 , B01J20/3204 , B01J20/3246 , B01J2220/54 , B01J2220/58
摘要： A new mono-silylating agent of general formula (I)
(R₁,R₂,R₃)Si-NH-CO-O-Si(R₁,R₂,R₃) (I)
is described as well as its use in the preparation of chromatographic supports based on silica with functional groups covalently bonded thereto, the so-called "bonded stationary phases". The new compounds are easy and safe to prepare from the corresponding mono-halosilanes with ammonium carbamate, and their use as silylating agents leads to stationary phases with a higher degree of surface coating than that attainable with the corresponding chlorosilanes.

3. 发明授权

EP0416416B1 Method for purifying low molecular weight compounds of peptide or pseudo-peptide structure 失效
标题翻译：一种用于在具有低分子量和肽或肽样结构纯化化合物过程。
公开(公告)号：EP0416416B1
公开(公告)日：1993-12-01
申请号：EP90116366.7
申请日：1990-08-27
申请人： SCLAVO S.p.A.
发明人： Viscomi, Giuseppe Claudio , Cardinali, Franco , Longobardi, Maria Grazia
IPC分类号： C07K1/14 , C07K5/02
CPC分类号： C07K1/18 , B01D15/422 , C07K5/0212 , G01N30/02

4. 发明公开

EP0416416A1 Method for purifying low molecular weight compounds of peptide or pseudo-peptide structure 失效
标题翻译：一种用于在具有低分子量和肽或肽样结构纯化化合物过程。
公开(公告)号：EP0416416A1
公开(公告)日：1991-03-13
申请号：EP90116366.7
申请日：1990-08-27
申请人： SCLAVO S.p.A.
发明人： Viscomi, Giuseppe Claudio , Cardinali, Franco , Longobardi, Maria Grazia
IPC分类号： C07K1/14 , C07K5/02
CPC分类号： C07K1/18 , B01D15/422 , C07K5/0212 , G01N30/02
摘要： This invention firstly provides a method for purifying particular compounds of peptide or pseudo-peptide structure in which the number of protonable basic functions is greater than the number of acid functions and which have a molecular weight of less than 1000 daltons, by ion exchange displacement chromatography. In the method of the present invention the stationary phase used is a cationic exchange resin or a cross-linked polymer matrix activated with acid groups; the transporter solvent used is water if the compound to be purified already possesses at least one net positive charge, or aqueous dilute solutions of inorganic or strong organic acids which protonate the basic groups of the peptide or pseudo-peptide to be separated without modifying the structure of the peptide compound, such as acetic acid, trifluoroacetic acid, formic acid, hydrochloric acid or sulphuric acid; the displacer compound used is a triethylenetetraammonium salt.
摘要翻译：本发明首先提供了一种用于纯化的肽或拟肽结构的具体化合物，其中的质子能够基本功能数比的酸官能团的数量更大，并且其中具有小于1,000道尔顿的分子量，通过离子交换置换色谱，在本发明的方法中使用的固定相为阳离子交换树脂或与酸基团活化的交联的聚合物基体; 所使用的转运溶剂是水，如果要被已经纯化化合物具有至少一个净正电荷，或wässrige稀的哪质子化肽或类肽的碱性基团，而无需修改结构被分离的无机或强有机酸溶液所述肽化合物，颜色：如乙酸，三氟乙酸，甲酸，盐酸或硫酸; 所使用的排代剂化合物为triethylenetetraammonium盐。

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