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1. 发明专利

FR2893252B1 未知
公开(公告)号：FR2893252B1
公开(公告)日：2008-02-15
申请号：FR0511672
申请日：2005-11-17
申请人： ENGELHARD LYON SA , YSL BEAUTE
发明人： REYMERMIER CORINNE , GUEZENNEC ANNE , GUESNET JOELLE , PERRIER ERIC
IPC分类号： A61K8/97 , A61Q19/08
摘要： The invention relates to plant extracts for stimulating the synthesis of hyaluronan synthase, particularly the synthesis of hyaluronan synthase 2 (HAS2). Specific aims of the invention are to increase firmness and/or elasticity and/or tissue moisturization, and/or increase the skin barrier effect, and/or increase tissue resilience, and/or modulate angiogenesis, or the neocreation of blood capillaries, and/or improve healing, and/or cell proliferation, migration or differentiation, and/or skin atrophy, and/or intended to combat the effects of ageing on the skin, and in particular to combat the loss of firmness of the skin observed in the course of ageing, and/or atrophied scars.

2. 发明专利

FR2893252A1 EXTRAITS VEGETAUX STIMULANT HAS2 未知
公开(公告)号：FR2893252A1
公开(公告)日：2007-05-18
申请号：FR0511672
申请日：2005-11-17
申请人： ENGELHARD LYON SA , YSL BEAUTE
发明人： REYMERMIER CORINNE , GUEZENNEC ANNE , GUESNET JOELLE , PERRIER ERIC
IPC分类号： A61K8/97 , A61Q19/08
摘要： L'invention concerne des extraits végétaux stimulant la synthèse de Hyaluronane Synthase, et en particulier la synthèse de Hyaluronane Synthase 2 (HAS2). L'invention concerne en particulier l'utilisation d'une quantité efficace d'au moins un extrait d'un végétal choisi parmi Guarana (Paullinia cupana), Millepertuis (Hypericum hircinum), Bambou (Bambusa vulgaris), Haricot mungo (Phaseolus aureus), Groseille (Ribes uva-crispa L.), Petit houx (Ruscus aculeatus), fêve (Vicia faba equina), Pois (Pisum sativum), Lupin (lupinus angustifolius), Ephedra (Ephedra sinica), Tanaisie (Tanacetum vulgare), Galanga (Alpinia galanga), Mûrier blanc (Morus alba), Brazzéine (Pentadiplandra brazzeana), et un mélange quelconque de ceux-ci.L'invention a pour but en particulier d'augmenter la fermeté, et/ou l'élasticité, et/ou l'hydratation des tissus, et/ou augmenter l'effet barrière cutanée, et/ou augmenter la résilience des tissus, et/ou moduler l'angiogenèse, ou la néo-création de capillaires sanguins, et/ou améliorer la cicatrisation, et/ou la prolifération, la migration, ou la différenciation cellulaire, et/ou l'atrophie cutanée, et/ou destinée à lutter contre les effets de vieillissement sur la peau, et en particulier contre la perte de fermeté cutanée observée au cours du vieillissement, et/ou les cicatrices atrophiées.

3. 发明专利

JP2004067660A TYPE 2 OR TYPE 3 HUMAN β-DEFENSIN-STIMULATING ACTIVE COMPONENT, AND COSMETIC AND MEDICINAL COMPOSITION CONTAINING THE SAME 有权
公开(公告)号：JP2004067660A
公开(公告)日：2004-03-04
申请号：JP2003006735
申请日：2003-01-15
申请人： Coletica , Ysl Beaute , コレティカColetica , ワイエスエル・ボーテYsl Beaute
发明人： PERRIER ERIC , GUEZENNEC ANNE , PERNET INGRID , REYMERNIER CORINNE , GUESNET JOELLE
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/365 , A61K8/44 , A61K8/64 , A61K8/67 , A61K8/96 , A61K8/97 , A61K31/07 , A61K31/19 , A61K31/198 , A61K31/223 , A61K33/06 , A61K36/00 , A61K36/18 , A61K36/28 , A61K36/42 , A61K36/53 , A61K38/00 , A61K38/02 , A61K38/16 , A61K38/34 , A61K39/00 , A61K45/00 , A61P17/00 , A61P17/04 , A61P31/04 , A61P31/10 , A61P43/00 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C12N5/08 , C12Q1/02 , C12Q1/25 , C12Q1/68 , G01N33/50 , A61K7/00 , A61K7/02 , A61K7/06 , A61K7/075 , A61K7/48 , A61K35/78
CPC分类号： A61K8/97 , A61K8/36 , A61K8/365 , A61K8/44 , A61K8/64 , A61K8/671 , A61K31/19 , A61K31/223 , A61K33/06 , A61K36/00 , A61K36/185 , A61K36/21 , A61K36/28 , A61K36/36 , A61K36/42 , A61K36/49 , A61K36/88 , A61K36/889 , A61K38/34 , A61K2800/70 , A61K2800/75 , A61Q1/02 , A61Q1/12 , A61Q5/006 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , G01N33/5008 , G01N33/5023 , G01N33/5044 , G01N33/5088 , G01N2500/10 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide an active component capable of stimulating the direct or indirect expression of type 2 and/or type 3 human β-defensin without inducing inflammation, irritation or hypersensitive reaction. SOLUTION: The increase of the amount of β-defensin in human skin prevents the pathogenic specific species (Staphylococcus aureus) from invading excessively into an ecosystem of a body, and contributes for protecting the skin and keeping it to be healthy. The active component is selected from the roots of mugwort, horseweed, bark of a red-berried elder, etc., or their extract, α-MSH, one of its constituting peptides and substance resembling to the peptides. The active components can be used as a cosmetic composition containing the same by 0.01-10 wt. %. Also, the active components can be used as medicinally permissible excipients. As the method for screening the active components without causing inflammation, a skin bio-test method using epithelial cells such as keratinocytes, cornecytes, etc., is cited. COPYRIGHT: (C)2004,JPO

4. 发明专利

JP2008019264A Active ingredient stimulating type 2 or type 3 human beta-defensin and cosmetic and pharmaceutical compositions containing such active ingredient 有权
标题翻译：活性成分刺激型2型或3型人类抗坏血酸和包含这种活性成分的化妆品和药物组合物
公开(公告)号：JP2008019264A
公开(公告)日：2008-01-31
申请号：JP2007208376
申请日：2007-08-09
申请人： Engelhard Lyon , Ysl Beaute , エンゲルハード・リヨン , ワイエスエル・ボーテYsl Beaute
发明人： PERRIER ERIC , GUEZENNEC ANNE , PERNET INGRID , REYMERNIER CORINNE , GUESNET JOELLE
IPC分类号： A61K8/30 , A61K31/19 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/365 , A61K8/44 , A61K8/64 , A61K8/67 , A61K8/96 , A61K8/97 , A61K31/07 , A61K31/198 , A61K31/223 , A61K33/06 , A61K36/00 , A61K36/18 , A61K36/28 , A61K36/42 , A61K36/53 , A61K38/00 , A61K38/02 , A61K38/16 , A61K38/34 , A61K39/00 , A61K45/00 , A61P17/00 , A61P17/04 , A61P31/04 , A61P31/10 , A61P43/00 , A61Q1/00 , A61Q1/02 , A61Q1/12 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C12N5/08 , C12N15/09 , C12Q1/02 , C12Q1/25 , C12Q1/68 , G01N33/50
CPC分类号： A61K8/97 , A61K8/36 , A61K8/365 , A61K8/44 , A61K8/64 , A61K8/671 , A61K31/19 , A61K31/223 , A61K33/06 , A61K36/00 , A61K36/185 , A61K36/21 , A61K36/28 , A61K36/36 , A61K36/42 , A61K36/49 , A61K36/88 , A61K36/889 , A61K38/34 , A61K2800/70 , A61K2800/75 , A61Q1/02 , A61Q1/12 , A61Q5/006 , A61Q5/02 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/06 , A61Q19/08 , G01N33/5008 , G01N33/5023 , G01N33/5044 , G01N33/5088 , G01N2500/10 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To provide an active ingredient capable of stimulating direct or indirect expression of type 2 and/or type 3 human beta-defensins.
SOLUTION: The active ingredient capable of stimulating direct or indirect expression of type 2 and/or type 3 human beta-defensins without causing any inflammatory, irritation or hypersensitive reaction is chosen from (i) an extract chosen from the group consisting of a quinoa extract, a boldo extract and a mixture of the quinoa and boldo extracts, (ii) jasmonic acid and (iii) mixtures thereof. A cosmetic or pharmaceutical composition containing the active ingredient at a concentration ranging from 0.001 wt.% to 20 wt.% exerts a bactericidal or antifungal property. A screening method for the selection of such active ingredient is also provided.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供能够刺激直接或间接表达2型和/或3型人β-防御素的活性成分。解决方案：能够刺激直接或间接表达2型和/或3型人β-防御素而不引起任何炎症，刺激或过敏反应的活性成分选自（i）选自以下的提取物：藜提取物，粗提物和藜麦酸和粗提物的混合物，（ii）茉莉酸和（iii）其混合物。含有0.001重量％至20重量％浓度的活性成分的化妆品或药物组合物发挥杀菌或抗真菌性能。还提供了选择这种活性成分的筛选方法。版权所有（C）2008，JPO＆INPIT

5. 发明专利

JP2006225392A CROSS-LINKED POLYMER OF CARBOHYDRATE 审中-公开
公开(公告)号：JP2006225392A
公开(公告)日：2006-08-31
申请号：JP2006041154
申请日：2006-02-17
申请人： ENGELHARD LYON SA
发明人： PERRIER ERIC , ABDUL-MALAK NABIL , SAGET JULIE
IPC分类号： C07H3/04 , A61K8/31 , A61K8/73 , A61K8/85 , A61Q19/00 , C07H3/06 , C08B37/00
摘要： PROBLEM TO BE SOLVED: To produce an active ingredient which is based on various proteins or peptides, does not have the problem of allergy facing on the employment of such the substances, and has a tightening effect, and furthermore to produce a cross-linked polymer of a carbohydrate. SOLUTION: This cross-linked polymer uses at least one carbohydrate having at least one primary alcohol functional group. This polymer can be used for producing compositions intended to be coated on the skins to obtain effects for tightening and/or arranging the skins. COPYRIGHT: (C)2006,JPO&NCIPI

6. 发明专利

JP2007137884A Plant extract for stimulating hyaluronan synthase 2 (has2) 有权
标题翻译：植物提取物刺激HYALURONON SYNTHASE 2（HAS2）
公开(公告)号：JP2007137884A
公开(公告)日：2007-06-07
申请号：JP2006311979
申请日：2006-11-17
申请人： Engelhard Lyon Sa , Yves Saint Laurent Beaute , イブサンローラン・ボーテ , エンゲルハード・リヨン・ソシエテ・アノニム
发明人： REYMERMIER CORINNE , GUEZENNEC ANNE , GUESNET JOELLE , PERRIER ERIC
IPC分类号： A61K8/97 , A61K8/06 , A61K36/18 , A61K36/28 , A61K36/48 , A61K36/60 , A61K36/896 , A61P9/00 , A61P17/00 , A61P17/02 , A61P43/00 , A61Q1/14 , A61Q5/02 , A61Q19/00
CPC分类号： A61K36/185 , A61K36/17 , A61K36/28 , A61K36/38 , A61K36/48 , A61K36/605 , A61K36/77 , A61K36/896 , A61K36/899 , A61K2300/00
摘要： PROBLEM TO BE SOLVED: To increase firmness, elasticity, tissue moisturization, and/or increase the skin barrier effect, increase tissue resilience, control modulate angiogenesis, or the neocreation of blood capillaries, and/or improve healing, cell proliferation, migration or differentiation, skin atrophy, and/or to combat the effects of ageing on the skin, in particular loss of firmness of the skin observed in the course of ageing or atrophied scars.
SOLUTION: The invention relates to plant extracts for stimulating the synthesis of hyaluronan synthase, in particular hyaluronan synthase 2 (HAS2).
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了增加坚固性，弹性，组织保湿和/或增加皮肤屏障效应，增加组织弹性，控制调节血管生成或毛细血管新生，和/或改善愈合，细胞增殖，迁移或分化，皮肤萎缩和/或抵抗老化对皮肤的影响，特别是在老化或萎缩性瘢痕过程中观察到的皮肤硬度的丧失。解决方案：本发明涉及用于刺激透明质酸合酶，特别是透明质酸合酶2（HAS2）的合成的植物提取物。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006290886A Cosmetic depigmentation care method comprising applying at least one auron 审中-公开
标题翻译：化妆品护理方法，包括至少一个AURON应用
公开(公告)号：JP2006290886A
公开(公告)日：2006-10-26
申请号：JP2006094625
申请日：2006-03-30
申请人： Engelhard Lyon Sa , エンゲルハード・リヨン・ソシエテ・アノニム
发明人： PERRIER ERIC , OKOMBI SABRINA , RIVAL DELPHINE , BOUMENDJEL AHCENE , MARIOTTE ANNE-MARIE
IPC分类号： A61K8/49 , A61K8/97 , A61Q19/02
CPC分类号： C07D405/06 , C07D209/36 , C07D307/83 , C07D333/64 , C07D409/06
摘要： PROBLEM TO BE SOLVED: To provide a preparation having a bleaching action and/or a melamine production-inhibiting action.
SOLUTION: At least one auron, a natural or synthetic derivative of auron whose independent phenyl ring may be substituted with a pyrrole, imidazole, triazole, pyridine, furan or thiophene type heterocycle, or an auron analog is disclosed as a cosmetic substance or an active substance for producing one of a cosmetic composition or a pharmaceutical composition, especially a dermatologic composition, having a melamine production-inhibiting action or a depigmentation or an anti-tyrosinase activity.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供具有漂白作用和/或三聚氰胺生产抑制作用的制剂。解决方案：作为化妆品物质，公开了至少一种天然或合成的衍生物，其独立的苯环可被吡咯，咪唑，三唑，吡啶，呋喃或噻吩型杂环取代，或用于生产具有三聚氰胺生产抑制作用或脱色素或抗酪氨酸酶活性的化妆品组合物或药物组合物，特别是皮肤病学组合物之一的活性物质。版权所有（C）2007，JPO＆INPIT

8. 发明专利

JP2007131622A Derivatives of para-coumaric acid, namely, para-hydroxycinnamic acid and their use in cosmetic or dermatological composition 有权
标题翻译：氨基酸，氨基酸，对羟基苯甲酸的衍生物及其在化妆或皮肤组成中的应用
公开(公告)号：JP2007131622A
公开(公告)日：2007-05-31
申请号：JP2006301831
申请日：2006-11-07
申请人： Engelhard Lyon Sa , Univ Joseph Fourier-Grenoble 1 , エンゲルハード・リヨン・ソシエテ・アノニム , ユニベルシテ・ジヨセフ・フーリエ−グルノーブル1
发明人： OKOMBI SABRINA , RIVAL DELPHINE , BOUMENDJEL AHCENE , MARIOTTE ANNE-MARIE , PERRIER ERIC
IPC分类号： A61K31/165 , A61K8/37 , A61K8/42 , A61K8/55 , A61K31/222 , A61K31/661 , A61P17/00 , A61P17/18 , A61P29/00 , A61P39/06 , A61Q19/00 , A61Q19/02 , C07F9/09
CPC分类号： A61K8/55 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/463 , A61K2800/782 , A61Q1/06 , A61Q1/10 , A61Q5/02 , A61Q17/00 , A61Q19/00 , A61Q19/02 , A61Q19/10
摘要： PROBLEM TO BE SOLVED: To obtain a bleaching agent having high activity and a composition having excellent bleaching activity and to provide a beauty care method and/or a pharmaceutical treatment method using the bleaching agent and a use of the bleaching agent so as to provide antiradical and/or anti-inflammatory activity. SOLUTION: The para-coumaric acid derivative represented by general formula (I) (Z is oxygen or an -NH- group; X and Y are each the same and a CH group or a CH 2 group) is used in a cosmetic or a dermatological composition. COPYRIGHT: (C)2007,JPO&INPIT

9. 发明申请

WO2007031871A2 SUPPORT DEVICE FOR CELLS CULTURE 审中-公开
标题翻译：支持细胞培养的装置
公开(公告)号：WO2007031871A2
公开(公告)日：2007-03-22
申请号：PCT/IB2006002916
申请日：2006-01-26
申请人： ENGELHARD LYON SA
发明人： PERRIER ERIC , DAMOUR ODILE , ANDRE VALERIE
CPC分类号： C12M25/04 , C12M23/12 , C12M23/20 , C12M23/46 , C12M25/14 , C12M37/00 , C12M41/48
摘要： The invention relates to a cell culture device. This cell culture device (100), intended for receiving cells with their culture medium, is characterised in that it contains at least one cell-supporting layer of porous material, this layer being obtained by dehydration of an aqueous gel which is poured directly either into said well bottom (110-111), or into the bottom of a cradle or insert (150) of a size which is adapted for being insertable into the volume of the well. The invention enables a culture to be made which can be automated.
摘要翻译：本发明涉及一种细胞培养装置。该细胞培养装置（100）旨在用它们的培养基接收细胞，其特征在于它含有至少一个多孔材料的细胞支持层，该层是通过将含水凝胶脱水获得的，该凝胶直接倒入所述井底（110-111）或进入适于可插入井的容积的尺寸的支架或插入件（150）的底部中。本发明使得能够实现可以自动化的培养。

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