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1. 发明申请

WO2008103722A3 MITRAL VALVE SYSTEM 审中-公开
标题翻译：麻醉阀系统
公开(公告)号：WO2008103722A3
公开(公告)日：2008-10-23
申请号：PCT/US2008054410
申请日：2008-02-20
申请人： ENDOVALVE INC , UNIV PENNSYLVANIA , LAMPHERE DAVID G , NGUYEN TUAN ANH , HERRMANN HOWARD C , TOMBA TODD C , GORMAN ROBERT C , GORMAN JOSEPH H III
发明人： LAMPHERE DAVID G , NGUYEN TUAN ANH , HERRMANN HOWARD C , TOMBA TODD C , GORMAN ROBERT C , GORMAN JOSEPH H III
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0075 , A61F2230/008
摘要： Valve prostheses for secure, aligned placement to a heart annulus, placed with transcatheter techniques Includes resilient ring, plural leaflet membranes mounted with respect to the ring, plural positioning elements movably mounted with respect to the ring Each positioning element defines proximal, intermediate, distal tissue engaging regions configured and dimensioned to engage separate corresponding areas of anatomical structure, including first, second, third elongate tissue-piercing elements The proximal, distal intermediate tissue-engaging regions configured and dimensioned to engage separate corresponding areas of tissue of anatomical structure to stabilize position of the valve with respect to anatomical structure, simultaneously engaging corresponding areas of tissue, one of the elongate tissue-piercing elements is pointed opposite the direction of blood flow, another is pointed along the direction Includes skirt mounted with respect to the ring, seals periphery of valve against reverse flow of blood.
摘要翻译：用于通过经导管技术放置的心脏环的安全的，对齐的安置的瓣膜假体包括弹性环，相对于环安装的多个传单膜，相对于环可移动地安装的多个定位元件每个定位元件限定近端，中间，远端组织构造和尺寸的接合区域与解剖结构的分开的对应区域相结合，包括第一，第二，第三细长组织穿刺元件。近端，远端中间组织接合区域被构造和尺寸设计成与解剖结构的组织的分开的相应区域接合以稳定位置相对于解剖结构，同时接合组织的相应区域，细长组织刺穿元件中的一个尖锐地相对于血流方向指向，另一个沿着该方向指向包括相对于环安装的裙部，密封周边的阀门再次 t反向流血。

2. 发明申请

WO2008103497A3 VALVE PROSTHESIS SYSTEMS AND METHODS 审中-公开
标题翻译：阀门预测系统和方法
公开(公告)号：WO2008103497A3
公开(公告)日：2009-12-30
申请号：PCT/US2008050096
申请日：2008-01-03
申请人： ENDOVALVE INC , UNIV PENNSYLVANIA , LAMPHERE DAVID G , NGUYEN TUAN ANH , HERRMANN HOWARD C
发明人： LAMPHERE DAVID G , NGUYEN TUAN ANH , HERRMANN HOWARD C
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position In which each of the first and second tissue engaging regions is outwardly directed for engaging tissue.
摘要翻译：公开了适于相对于心脏环的安全和对准放置的阀门假体。瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和第二组织接合区域与第一组织接合区域间隔开。定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内，其中第一和第二组织接合区域中的每一个向外指向用于接合组织。

3. 发明申请

WO2008103498A3 SYSTEMS AND METHODS FOR PLACEMENT OF VALVE PHOSTHESIS SYSTEM 审中-公开
标题翻译：阀门阀体系统的设置与方法
公开(公告)号：WO2008103498A3
公开(公告)日：2008-10-16
申请号：PCT/US2008050113
申请日：2008-01-03
申请人： ENDOVALVE INC , UNIV PENNSYLVANIA , ABESAMES GREGORIO RAMON M , ANTOCCI JOSEPH D , LAMPHERE DAVID G , CASTRO SALVATORE , HERRMANN HOWARD C
发明人： ANTOCCI JOSEPH D , LAMPHERE DAVID G , CASTRO SALVATORE , HERRMANN HOWARD C
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439
摘要： Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulablß by an operator to remotely rotate the positioning elements relative to the flexible ring A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ.
摘要翻译：提供了用于放置这种瓣膜假体的瓣膜假体系统和方法/系统，其促进有效，可靠和最小侵入性递送方式。瓣膜假体包括弹性环，相对于弹性环安装的多个小叶膜，以及多个相对于柔性环可移动地安装的定位元件。递送系统包括终止于瓣膜假体处的第一细长元件，并且由操作者操纵以相对于柔性环远程旋转定位元件。第二细长元件终止于瓣膜假体并且可由操作者操纵以将阀门假体向下远远地推进到解剖环形空间中。可以操纵第二细长元件以将瓣膜假体远程地前进到解剖学环空中，以呈现用于支持原位置植入瓣膜功能的位置。

4. 发明申请

WO2005086926A3 DEVICE FOR FACILITATING CARDIOPLEGIA DELIVERY IN PATIENTS WITH AORTIC INSUFFICIENCY 审中-公开
标题翻译：促进患有动脉粥样硬化患者的心脏病的手段
公开(公告)号：WO2005086926A3
公开(公告)日：2005-11-24
申请号：PCT/US2005008000
申请日：2005-03-10
申请人： UNIV PENNSYLVANIA , HERRMANN HOWARD C , WOO Y JOSEPH
发明人： HERRMANN HOWARD C , WOO Y JOSEPH
IPC分类号： A61B17/00 , A61B17/12 , A61M25/00 , A61M31/00
CPC分类号： A61B17/12022 , A61B17/1204 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B2017/00243 , A61B2017/1205 , A61M1/3659 , A61M1/3664 , A61M25/0084
摘要： A method and device that addresses the problem of an incompetent aortic valve by using a simple cardioplegia catheter that can deliver cardioplegia solution to the coronary arteries through the usual aortic cannulation site even in the presence of aortic valve incompetence. The device includes a cardioplegia cannula (32) with an additional lumen containing a nitinol wire (34) inside it that allows advancement of a folded nitinol umbrella (36) with a non-porous membrane or a compressed nitinol ring that covers the aortic valve when opened. During installation, after puncture of the aorta by the coaxial needle and removal of the coaxial needle but before installation of the cardioplegia solution through the central lumen of the catheter, the nitinol umbrella (in folded position) or nitinol ring (in compressed position) is advanced through the second lumen into the aorta just above the aortic valve. The nitinol umbrella is unfolded using the nitinol wire to expose the inverted umbrella configuration with attached membrane and is then advanced as a unit with the cardioplegia catheter until the nitinol umbrella covers the aortic valve at its deployed position.
摘要翻译：一种通过使用简单的心麻痹导管来解决无能的主动脉瓣的问题的方法和装置，即使在存在主动脉瓣不能力的情况下，也可以通过通常的主动脉插管部位将心麻痹液提供给冠状动脉。该装置包括心麻痹套管（32），其具有在其内部含有镍钛诺导线（34）的附加内腔，其允许利用覆盖主动脉瓣的无孔膜或压缩的镍钛诺环使折叠的镍钛诺（36）推进，打开。在安装过程中，在通过同轴针穿刺主动脉并取出同轴针之后，但是在通过导管的中央腔安装心麻痹液之前，尼诺诺伞（折叠位置）或镍钛诺环（压缩位置）是通过第二管腔进入主动脉瓣正上方的主动脉。镍钛诺伞使用镍钛诺丝展开，暴露具有附着膜的倒置伞形结构，然后以心麻痹导管作为一个单元前进，直到镍钛诺伞在其展开位置覆盖主动脉瓣。

5. 发明申请

WO2005009285A3 PERCUTANEOUS HEART VALVE 审中-公开
标题翻译： PERCUTANEOUS心脏瓣膜
公开(公告)号：WO2005009285A3
公开(公告)日：2005-05-06
申请号：PCT/US2004023211
申请日：2004-07-20
申请人： UNIV PENNSYLVANIA , HERRMANN HOWARD C , MANKAME NILESH , ANANTHASURESH SURESH G K
发明人： HERRMANN HOWARD C , MANKAME NILESH , ANANTHASURESH SURESH G K
IPC分类号： A61F20060101 , A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , Y10S623/904
摘要： A percutaneously inserted bistable heart valve prosthesis (10) is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve (10) has an annular ring (12), a body member (14) having a plurality of legs (16), each leg (16) connecting at one end to the annular ring (12), claws (18) that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws (18) in the second position, and leaflet membranes connected to the annular ring (12), the body member (14) and/or the legs (16), the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve (10) is designed such that upon removal of the external force the claws (18) elastically revert to the first position so as to grip the heart tissue positioned within the claws (18), thereby holding the heart valve (10) in place.. The heart valve (10) may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.
摘要翻译：经皮插入的双稳态心脏瓣膜假体（10）折叠在导管内，用于经心脏输送到患者的心脏以进行植入。心脏瓣膜（10）具有环形环（12），具有多个腿部（16）的主体构件（14），每个腿部（16）在一端连接到环形环（12），爪（18）其可通过施加外力从第一位置调节到第二位置，以便允许周围心脏组织进入第二位置的爪（18），以及连接到环形环（12）的小叶膜，身体构件（14）和/或腿部（16），所述小叶膜具有用于阻止血液流过其中的第一位置和用于允许血液流过其中的第二位置。心脏瓣膜（10）被设计成使得在去除外力时，爪（18）弹性回复到第一位置，以便夹紧位于爪（18）内的心脏组织，从而保持心脏瓣膜（10）心脏瓣膜（10）可以用作二尖瓣，主动脉瓣，肺动脉瓣或三尖瓣的假体，通过使环形圈适应于相应的二尖瓣，主动脉，肺或三尖瓣开口的心脏。

6. 发明申请

WO2005009285A2 PERCUTANEOUS HEART VALVE 审中-公开
标题翻译： PERCUTANEOUS心脏瓣膜
公开(公告)号：WO2005009285A2
公开(公告)日：2005-02-03
申请号：PCT/US2004023211
申请日：2004-07-20
申请人： UNIV PENNSYLVANIA , HERRMANN HOWARD C , MANKAME NILESH , ANANTHASURESH SURESH G K
发明人： HERRMANN HOWARD C , MANKAME NILESH , ANANTHASURESH SURESH G K
IPC分类号： A61F20060101 , A61F2/24 , A61F
CPC分类号： A61F2/2412 , A61F2/243 , Y10S623/904
摘要： A percutaneously inserted bistable heart valve prosthesis is folded inside a catheter for transseptal delivery to the patient's heart for implantation. The heart valve has an annular ring, a body member having a plurality of legs, each leg connecting at one end to the annular ring, claws that are adjustable from a first position to a second position by application of external force so as to allow ingress of surrounding heart tissue into the claws in the second position, and leaflet membranes connected to the annular ring, the body member and/or the legs, the leaflet membranes having a first position for blocking blood flow therethrough and a second position for allowing blood flow therethrough. The heart valve is designed such that upon removal of the external force the claws elastically revert to the first position so as to grip the heart tissue positioned within the claws, thereby holding the heart valve in place. The body member and claws may be integrated into a one-piece design. The heart valve may be used as a prosthesis for the mitral valve, aortic valve, pulmonary valve, or tricuspid valve by adapting the annular ring to fit in a respective mitral, aortic, pulmonary, or tricuspid valve opening of the heart.
摘要翻译：经皮插入的双稳态心脏瓣膜假体折叠在导管内，用于经口输送到患者的心脏用于植入。心脏瓣膜具有环形环，主体部件具有多个腿部，每个腿部在一端连接到环形环上，爪部通过施加外力从第一位置到第二位置可调节以允许进入周围的心脏组织进入第二位置的爪，以及连接到环形环，身体构件和/或腿的小叶膜，小叶膜具有用于阻止血液流过的第一位置和用于允许血液流动的第二位置穿过。心脏瓣膜被设计成使得在去除外力时，爪弹性地恢复到第一位置，以便夹住位于爪内的心脏组织，从而将心脏瓣膜保持在适当的位置。主体构件和爪可以集成成一体式设计。心脏瓣膜可用作二尖瓣，主动脉瓣，肺动脉瓣或三尖瓣的假体，通过使环形圈适应于心脏的相应二尖瓣，主动脉，肺或三尖瓣开口。

7. 发明专利

AU2008218700A1 Mitral valve system 未知
公开(公告)号：AU2008218700A1
公开(公告)日：2008-08-28
申请号：AU2008218700
申请日：2008-02-20
申请人： ENDOVALVE INC , UNIV PENNSYLVANIA
发明人： TOMBA TODD C , HERRMANN HOWARD C , NGUYEN TUAN ANH , GORMAN ROBERT C , LAMPHERE DAVID G , GORMAN JOSEPH H III
IPC分类号： A61F2/24
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via transcatheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.

8. 发明专利

CA2678970C VALVE PROSTHESIS SYSTEMS AND METHODS 未知
公开(公告)号：CA2678970C
公开(公告)日：2016-05-24
申请号：CA2678970
申请日：2008-01-03
申请人： ENDOVALVE INC , UNIV PENNSYLVANIA
发明人： LAMPHERE DAVID G , NGUYEN TUAN ANH , HERRMANN HOWARD C
IPC分类号： A61F2/24
摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.

9. 发明公开

EP2114305A4 VALVE PROSTHESIS SYSTEMS AND METHODS 审中-公开
标题翻译：皮瓣移植的系统和方法
公开(公告)号：EP2114305A4
公开(公告)日：2013-05-15
申请号：EP08713452
申请日：2008-01-03
申请人： ENDOVALVE INC , UNIV PENNSYLVANIA
发明人： LAMPHERE DAVID G , NGUYEN TUAN ANH , HERRMANN HOWARD C
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/243 , A61F2/2436 , A61F2/2439

10. 发明专利

CA2678970A1 VALVE PROSTHESIS SYSTEMS AND METHODS 未知
公开(公告)号：CA2678970A1
公开(公告)日：2008-08-28
申请号：CA2678970
申请日：2008-01-03
申请人： UNIV PENNSYLVANIA , ENDOVALVE INC
发明人： LAMPHERE DAVID G , NGUYEN TUAN ANH , HERRMANN HOWARD C
IPC分类号： A61F2/24
摘要： Valve prostheses are disclosed that are adapted for secure and aligned pl acement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positi oned/repositioned until proper alignment and positioning is achieved. The va lve prosthesis may include a resilient ring, a plurality of leaflet membrane s mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the pos itioning elements defining a first tissue engaging region and a second tissu e engaging region spaced from the first tissue engaging region. The position ing elements are adapted to substantially completely invert by rotating rela tive to the resilient ring between a first position in which each of the fir st and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is o utwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.

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