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1. 发明申请

WO2006124047A2 PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT 审中-公开
标题翻译：包含递送剂的微量元素或纳米颗粒的药物制剂
公开(公告)号：WO2006124047A2
公开(公告)日：2006-11-23
申请号：PCT/US2005028991
申请日：2005-08-15
申请人： EMISPHERE TECH INC , MAJURU SHINGAI , LIU PUCHUN , DINH STEVE , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHILL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
发明人： MAJURU SHINGAI , LIU PUCHUN , DINH STEVE , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHILL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
IPC分类号： A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and /or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米颗粒。本发明还涉及药物制剂和固体剂型，包括活性剂的控释固体剂型和递送剂

2. 发明申请

WO2006124047A9 PHARMACEUTICAL FORMULATIONS CONTAINING MICROPARTICLES OR NANOPARTICLES OF A DELIVERY AGENT 审中-公开
标题翻译：含有微粒或递送剂纳米颗粒的药物制剂
公开(公告)号：WO2006124047A9
公开(公告)日：2007-06-21
申请号：PCT/US2005028991
申请日：2005-08-15
申请人： EMISPHERE TECH INC , MAJURU SHINGAI , LIU PUCHUN , DINH STEVEN , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHIL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
发明人： MAJURU SHINGAI , LIU PUCHUN , DINH STEVEN , LIAO JUN , LEE JONGBIN , ARBIT EHUD , DHOOT NIKHIL , LEVCHIK HALINA , HARRIS JAMILA , WANG NAI FANG , KLEIN GEORGE F
IPC分类号： A61K9/14
CPC分类号： A61K47/12 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2027 , A61K9/2077 , A61K9/2081 , A61K9/2846 , A61K9/4858 , A61K38/28
摘要： This invention relates to microparticles and/or nanoparticles containing a delivery agent and /or an active agent. This invention also relates to pharmaceutical formulations and solid dosage forms, including controlled release solid dosage forms of active agent and a delivery agent
摘要翻译：本发明涉及含有递送剂和/或活性剂的微粒和/或纳米粒子。本发明还涉及药物制剂和固体剂型，包括控释固体剂型的活性剂和递送剂

3. 发明申请

WO2007121318A3 FORMULATIONS FOR DELIVERING INSULIN 审中-公开
标题翻译：交付胰岛素的配方
公开(公告)号：WO2007121318A3
公开(公告)日：2008-07-10
申请号：PCT/US2007066560
申请日：2007-04-12
申请人： EMISPHERE TECH INC , LEVCHIK HALINA , OYEWUMI MOSES O , MAJURU SHINGAI , BAY WILLIAM ELLIOTT , LIAO JUN , LIU PUCHUN , DINH STEVEN , DHOOT NIKHIL
发明人： LEVCHIK HALINA , OYEWUMI MOSES O , MAJURU SHINGAI , BAY WILLIAM ELLIOTT , LIAO JUN , LIU PUCHUN , DINH STEVEN , DHOOT NIKHIL
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： A61K9/2013 , A61K9/06 , A61K9/145 , A61K9/2009 , A61K9/2027 , A61K9/2063 , A61K9/2077 , A61K9/2095 , A61K38/28
摘要： Oral insulin formulations and processes for preparing oral insulin formulations are provided.
摘要翻译：提供口服胰岛素制剂和制备口服胰岛素制剂的方法。

4. 发明申请

WO2005107462A3 CRYSTALLINE POLYMORPHIC FORMS OF MONOSODIUM N-[8-(2-HYDROXYBENZOYL)AMINO]CAPRYLATE 审中-公开
标题翻译： N- [8-（2-羟基苯甲酰基）氨基]癸酸单甲基酯的多晶型多晶型
公开(公告)号：WO2005107462A3
公开(公告)日：2006-05-04
申请号：PCT/US2005016126
申请日：2005-05-06
申请人： EMISPHERE TECH INC , LEVCHIK HALINA , MAJURU SHINGAI , SINGH BRAHMA , HARRIS JAMILA
发明人： LEVCHIK HALINA , MAJURU SHINGAI , SINGH BRAHMA , HARRIS JAMILA
IPC分类号： A61K31/609 , A01N37/44 , C07C235/46 , C07C235/60
CPC分类号： A61K31/197 , A61J3/02 , A61K9/2095 , A61K31/198 , A61K45/06 , A61K2300/00 , C07C235/60
摘要： The present invention relates to crystalline polymorphic forms of monosodium N-[8-(2-hydroxybenzoyl)amino] caprylate ("SNAC"), including two hydrates, a methanol solvate, and an ethanol solvate, of SNAC. More specifically, the present invention provide six polymorphic forms of SNAC (hereafter referred to as Forms I-VI). The present invention also provides an amorphous form of SNAC.
摘要翻译：本发明涉及SNAC的包括两种水合物，甲醇溶剂化物和乙醇溶剂合物的N- [8-（2-羟基苯甲酰基）氨基]辛酸单钠（“SNAC”）的结晶多晶形式。更具体地说，本发明提供了六种多晶型的SNAC（以下称为形式I-VI）。本发明还提供了无定形形式的SNAC。

5. 发明申请

WO2006084164A9 GASTRIC RETENTION AND CONTROLLED RELEASE DELIVERY SYSTEM 审中-公开
标题翻译：气体保持和控制释放系统
公开(公告)号：WO2006084164A9
公开(公告)日：2007-03-01
申请号：PCT/US2006003899
申请日：2006-02-01
申请人： EMISPHERE TECH INC , LIAO JUN , LIU PUCHUN , DINH STEVEN , SINGH BRAHMA , MAJURU SHINGAI , BHARGAVA PRATEEK N , DHOOT NIKHIL
发明人： LIAO JUN , LIU PUCHUN , DINH STEVEN , SINGH BRAHMA , MAJURU SHINGAI , BHARGAVA PRATEEK N , DHOOT NIKHIL
IPC分类号： A61K9/20 , A61K9/16
CPC分类号： A61K9/0065
摘要： The present invention provice a device (fig. 3) for providing communication through power lines (fig. 2) comprised of multiple conductors by transmitting the data signals through a plurality of the conductors. One embodiment of the present invention comprises a transmit circuit communicatively coupled to a first conductor for applying the first voltage representing the data to the first energized conductor; the transmit circuit communicatively coupled to a second conductor for applying the second voltage representing the data to the second energized conductor; wherein the second voltage signal is opposite in polarity of the first voltage.
摘要翻译：本发明提供了一种用于通过通过多个导体发送数据信号来通过由多个导体构成的电力线（图2）来提供通信的装置（图3）。本发明的一个实施例包括通信地耦合到第一导体的发射电路，用于将表示数据的第一电压施加到第一带电导体; 所述发射电路通信地耦合到第二导体，用于将表示所述数据的所述第二电压施加到所述第二激励导体; 其中所述第二电压信号与所述第一电压的极性相反。

6. 发明申请

WO2006084164A8 GASTRIC RETENTION AND CONTROLLED RELEASE DELIVERY SYSTEM 审中-公开
标题翻译：气体保持和控制释放系统
公开(公告)号：WO2006084164A8
公开(公告)日：2007-10-18
申请号：PCT/US2006003899
申请日：2006-02-01
申请人： EMISPHERE TECH INC , LIAO JUN , LIU PUCHUN , DINH STEVEN , SINGH BRAHMA , MAJURU SHINGAI , BHARGAVA PRATEEK N
发明人： LIAO JUN , LIU PUCHUN , DINH STEVEN , SINGH BRAHMA , MAJURU SHINGAI , BHARGAVA PRATEEK N
IPC分类号： A61K9/20 , A61K9/16
CPC分类号： A61K9/0065
摘要： The present invention relates to gastric retention delivery systems and controlled release compositions containing a pharmaceutically acceptable active agent and a delivery agent.
摘要翻译：本发明涉及含有药学上可接受的活性剂和递送剂的胃滞留递送系统和控释组合物。

7. 发明申请

WO2006084164A2 GASTRIC RETENTION AND CONTROLLED RELEASE DELIVERY SYSTEM 审中-公开
标题翻译：气体保持和控制释放系统
公开(公告)号：WO2006084164A2
公开(公告)日：2006-08-10
申请号：PCT/US2006003899
申请日：2006-02-01
申请人： EMISPHERE TECH INC , LIAO JUN , LIU PUCHUN , DINH STEVEN , SINGH BRAHMA , MAJURU SHINGAI , BHARGAVA PRATEEK N
发明人： LIAO JUN , LIU PUCHUN , DINH STEVEN , SINGH BRAHMA , MAJURU SHINGAI , BHARGAVA PRATEEK N
IPC分类号： A61K9/56
CPC分类号： A61K9/0065
摘要： The present invention relates to gastric retention delivery systems and controlled release compositions containing a pharmaceutically acceptable active agent and a delivery agent.
摘要翻译：本发明涉及含有药学上可接受的活性剂和递送剂的胃滞留递送系统和控释组合物。

8. 发明申请

WO2004080401A2 ORAL INSULIN THERAPIES AND PROTOCOL 审中-公开
标题翻译：口服胰岛素治疗和协议
公开(公告)号：WO2004080401A2
公开(公告)日：2004-09-23
申请号：PCT/US2004006943
申请日：2004-03-05
申请人： EMISPHERE TECH INC , ARBIT EHUD , GOLDBERG MICHAEL , MAJURU SHINGAI
发明人： ARBIT EHUD , GOLDBERG MICHAEL , MAJURU SHINGAI
IPC分类号： A61K20060101 , A61K6/00 , A61K9/20 , A61K31/00 , A61K38/28 , A61K45/06 , A61K47/16 , A61P3/10 , A61K
CPC分类号： A61K9/2009 , A61K9/2013 , A61K38/28 , A61K45/06
摘要： Methods for treating impaired glucose tolerance and early and late stage diabetes in mammals, for prophylactically sparing beta-cell function, aiding in preventing beta-cell death, preventing the onset of overt diabetes in a mammal with type 2 diabetes, treating the current level of glycemic control dysfunction of a mammal with impaired glucose tolerance or diabetes, comprising orally administering insulin and a delivery agent that facilitates insulin absorption from the gastrointestinal tract at the time of or shortly before mealtime, e.g., within about 10 minutes prior to ingestion of a meal, on a chronic basis. The methods also comprise, in addition to administering a rapid-acting insulin to provide a first insulin peak, administering a slow acting insulin to provide a second insulin peak occurring at a later time but of a longer duration. These methods achieve improved glycemic control without the risks of hypoglycemia, hyperinsulinemia and weight gain and the need for frequent blood glucose monitoring that are normally associated with insulin therapy.
摘要翻译：用于治疗哺乳动物葡萄糖耐量异常和早期和晚期糖尿病的方法，用于预防性节省β-细胞功能，有助于预防β-细胞死亡，预防2型糖尿病哺乳动物的明显糖尿病发作，治疗目前的水平具有葡萄糖耐量降低或糖尿病的哺乳动物的血糖控制功能障碍，包括在摄食之前或之后约10分钟内口服胰岛素和促进胰岛素从胃肠道吸收的输送剂，长期的。除了施用快速作用的胰岛素以提供第一胰岛素峰之外，所述方法还包括施用缓慢作用的胰岛素以提供在稍后时间但持续时间更长的时间发生的第二胰岛素峰。这些方法可以改善血糖控制，没有低血糖，高胰岛素血症和体重增加的风险，以及通常与胰岛素治疗相关的频繁血糖监测的需要。

9. 发明申请

WO2005107773A8 SOLID DOSAGE FORM OF WETTED HEPARIN 审中-公开
标题翻译：湿的肝素的固体剂量形式
公开(公告)号：WO2005107773A8
公开(公告)日：2006-12-21
申请号：PCT/US2005016012
申请日：2005-05-06
申请人： EMISPHERE TECH INC , MAJURU SHINGAI , SINGH BRAHMA , DHOOT NIKHIL
发明人： MAJURU SHINGAI , SINGH BRAHMA , DHOOT NIKHIL
IPC分类号： A61K31/727
CPC分类号： A61K9/4866 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K31/727
摘要： The present invention relates to a solid pharmaceutical composition (such as a solid dosage form) comprising a delivery agent and wetted heparin. The inclusion of wetted heparin rather than un-wetted heparin in the solid pharmaceutical composition results in increased delivery of the heparin. Without being bound by any particular theory, applicants believe that because the polymer chain of the wetted heparin is already in an "open" form, while un-wetted heparin is not, less of the wetted heparin is broken down in the gastrointestinal tract and is more readily absorbed in the stomach.
摘要翻译：本发明涉及包含递送剂和湿肝素的固体药物组合物（例如固体剂型）。在固体药物组合物中包含润湿的肝素而不是未润湿的肝素导致肝素的递送增加。不受任何特定理论的约束，申请人认为，由于润湿的肝素的聚合物链已经处于“开放”形式，而未润湿的肝素不是，所以较少的润湿的肝素在胃肠道中分解并且更容易吸收在胃里。

10. 发明申请

WO2007035718A3 CRYSTALLINE FORMS OF THE DI-SODIUM SALT OF N-(5-CHLOROSALICYLOYL)-8-AMINOCAPRYLIC ACID 审中-公开
标题翻译： N-（5-氯乙酰氧基）-8-氨基丙酸的二钠盐的晶体形式
公开(公告)号：WO2007035718A3
公开(公告)日：2009-06-18
申请号：PCT/US2006036455
申请日：2006-09-18
申请人： EMISPHERE TECH INC , DHOOT NIKHIL , BAY WILLIAM ELLIOT , DINH STEVEN , MAJURU SHINGAI , CORVINO JOANNE P , O'TOOLE DORIS C
发明人： DHOOT NIKHIL , BAY WILLIAM ELLIOT , DINH STEVEN , MAJURU SHINGAI , CORVINO JOANNE P , O'TOOLE DORIS C
IPC分类号： C07C309/00
CPC分类号： A61K47/18 , C07B2200/13 , C07C231/24 , C07C235/52 , C07C235/60
摘要： The present invention relates to crystalline polymorphic forms of the di- sodium salt of N-(5-chlorosalicyloyl)-8-aminocaprylic acid, pharmaceutical compositions containing the same, methods of preparing the same, and methods for facilitating the delivery of active agents with the same.
摘要翻译：本发明涉及N-（5-氯水杨酰基）-8-氨基辛酸的二钠盐的结晶多晶型物，含有它们的药物组合物，其制备方法和促进活性剂递送方法，一样。

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