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1. 发明申请

WO2008084464A1 A SYSTEM FOR PROVIDING CARDIOVASCULAR INFORMATION 审中-公开
标题翻译：一种用于提供心脏血管信息的系统
公开(公告)号：WO2008084464A1
公开(公告)日：2008-07-17
申请号：PCT/IE2008/000003
申请日：2008-01-09
申请人： EMERGENT MEDICAL INNOVATIONS PATENTS LIMITED , BROWN, David , NORDIN, David , O'RIORDAN, Andrew, John
发明人： BROWN, David , NORDIN, David , O'RIORDAN, Andrew, John
IPC分类号： A61B5/0285 , A61B7/02 , A61H31/00
CPC分类号： A61B5/0285 , A61B7/04
摘要： A system (1) analyses blood flow pulsations in a patient. It has two main components, a sensor head (2) and a monitor (100). The sensor head (2) attaches to the patient and communicates with the monitor over a wireless link (27/30). The sensor head (2). comprises an array of ten acoustic transducers (21, 22) and within the head (2), the transducers (21) are linked with a signal processing unit (25), in turn linked with a control unit (26), in turn connected to the wireless communications interface (27). There is a battery power supply (28). The sensor head (2) comprises an adhesive, sound-insulating, flexible sleeve or pad (20). Because there is an array of transducers there is at least two per location on the artery, and the head may be placed at an approximate location. Because acoustic energy is detected, and there is temporal, spatial, and spectral analysis very comprehensive information can be deduced. The information is particularly beneficial for analysis of CPR and providing immediate feedback.
摘要翻译：系统（1）分析患者的血流脉动。它有两个主要部件，一个传感头（2）和一个监视器（100）。传感器头（2）连接到患者并通过无线链路与监视器通信（27/30）。传感头（2）。包括十个声换能器（21,22）的阵列，并且在头部（2）内，换能器（21）与信号处理单元（25）链接，信号处理单元（25）又与控制单元（26）连接，然后连接到无线通信接口（27）。有一个电池电源（28）。传感器头（2）包括粘合剂，隔音，柔性套筒或垫（20）。因为有一组传感器，所以在动脉上每个位置至少有两个，头部可以放置在大致位置。因为检测到声能，并且存在时间，空间和光谱分析，可以推导出非常全面的信息。该信息对于CPR的分析和提供即时反馈特别有利。

2. 发明申请

WO2012158840A1 PATIENT MONITORING AND SURVEILLANCE TAG 审中-公开
标题翻译：患者监护和监护标签
公开(公告)号：WO2012158840A1
公开(公告)日：2012-11-22
申请号：PCT/US2012/038208
申请日：2012-05-16
申请人： LIFEFLOW TECHNOLOGIES, INC. , BROWN, David , NORDIN, David , TERAN, Manuel
发明人： BROWN, David , NORDIN, David , TERAN, Manuel
IPC分类号： G08B1/08
CPC分类号： A61B5/002
摘要： Provided herein are methods, devices and systems for the remote monitoring and/or surveillance of a patient's location, position, movement, vital signs, biopotentials, or a combination thereof using transmission of stepped-frequency radar signals, detecting reflections of the transmitted signals and processing the frequency and phase shifts.
摘要翻译：本文提供的方法，装置和系统用于使用阶梯式频率雷达信号的传输，检测所发送的信号的反射和远程监视和/或监视患者的位置，位置，运动，生命体征，生物电位或其组合，处理频率和相移。

3. 发明申请

WO2011146517A3 PATIENT MONITORING AND SURVEILLANCE SYSTEM, METHODS, AND DEVICES 审中-公开
公开(公告)号：WO2011146517A3
公开(公告)日：2011-11-24
申请号：PCT/US2011/036857
申请日：2011-05-17
申请人： LIFEFLOW TECHNOLOGIES, INC. , BROWN, David , NORDIN, David , TERAN, Manuel
发明人： BROWN, David , NORDIN, David , TERAN, Manuel
IPC分类号： A61B5/02 , A61B5/0402 , A61B5/0476 , A61B5/145 , H04B7/24 , H04W88/02 , G06Q50/00
摘要： Provided herein are methods, devices and systems for the remote monitoring and/or surveillance of a patient's location, position, movement, vital signs, biopotentials, or a combination thereof using transmission of stepped-frequency radar signals, detecting reflections of the transmitted signals and processing the frequency and phase shifts.

4. 发明公开

EP4351615A2 MULTIPLEXED TP53 AND PAN-RAS MRNA CANCER VACCINES 审中-实审转让
公开(公告)号：EP4351615A2
公开(公告)日：2024-04-17
申请号：EP22821167.8
申请日：2022-06-10
申请人： Rnaimmune, Inc. , Shen, Dong , Brown, David
发明人： SHEN, Dong , BROWN, David
IPC分类号： A61K38/00 , A61K9/127 , B82Y5/00 , C07K14/47
CPC分类号： C07K14/82 , C07K14/4746 , A61K31/7105

5. 发明公开

EP0233258A1 ELECTROMYOGRAPHIC REPETITIVE STRAIN INJURY MONITOR 失效
标题翻译：肌电图监测，防止外伤导致的重复工作。
公开(公告)号：EP0233258A1
公开(公告)日：1987-08-26
申请号：EP86905148.0
申请日：1986-08-18
申请人： BROWN, David
发明人： BROWN, David
IPC分类号： A61B5
CPC分类号： A61B5/0488
摘要： Un dispositif de surveillance permettant de détecter la tension des muscles, laquelle pourrait entraîner une lésion par efforts répétitifs, comporte des détecteurs (11) d'électromyographie (EMG) produisant un signal EMG, des circuits de traitement du signal (13, 14, 15, 16, 17, 18, 26, 28) pour dériver un signal ou des signaux représentatifs des conditions d'effort indésirables, et un générateur de signaux acoustiques (30, 31, 35, 36) qui produit un signal pour indiquer la présence de conditions d'effort indésirables. L'unité de traitement de signaux comprend un filtre passe-bande (13) pour limiter la bande du signal EMG redresseur (15) et un filtre passe-bas (16) pour produire un signal d'enveloppe, et un circuit de recherche du niveau minimum du signal comportant des amplificateurs (17 et 18), un condensateur (25), des diodes (23 et (24) et des résistances (19, 21 et 24). Le circuit de recherche de niveau minimum du signal produit un signal de niveau minimum qui suit le signal d'enveloppe, avec une constante de temps brève tandis que le signal de niveau minimum est supérieur au signal d'enveloppe, et avec une constante de temps longue lorsque le signal de niveau minimum est inférieur au signal d'enveloppe. Le générateur de signaux acoustiques produit un signal d'alarme acoustique lorsque le signal de niveau minimum excède un niveau de seuil préréglé.

6. 发明申请

WO2015066324A1 SINGLE LINE PASSIVE OPTICAL NETWORK CONVERTER MODULE 审中-公开
标题翻译：单线被动光网络转换器模块
公开(公告)号：WO2015066324A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063151
申请日：2014-10-30
申请人： TYCO ELECTRONICS UK LTD , TYCO ELECTRONICS CORPORATION , TYCO ELECTRONICS RAYCHEM BVBA , BROWN, David , MATHER, David , SHADDOCK, Robert, Neil , WEEKS, William, Atley , FRANCKX, Joris , ERREYGERS, Jan Jozef Julia Maria
发明人： BROWN, David , MATHER, David , SHADDOCK, Robert, Neil , WEEKS, William, Atley , FRANCKX, Joris , ERREYGERS, Jan Jozef Julia Maria
IPC分类号： H04B10/25
CPC分类号： H04B10/802 , G02B6/3897 , G02B6/4201 , G02B6/4269 , G02B6/43 , H04B10/272 , H04B10/808 , H04Q11/0067
摘要： A single line converter module comprises a housing; an environmentally hardened fiber optic connector located in the housing and configured to be optically coupled to a service terminal for receiving downstream optical frames; a single electrical connector located in the housing and coupled over a metallic medium to a network terminal providing a service to respective customer premise equipment (CPE); and an optical-to-electrical (O/E) converter located in the housing and configured to convert the downstream optical frames to an electrical signal for transmission over the metallic medium to the network terminal.
摘要翻译：单线转换器模块包括壳体; 位于壳体中的环境硬化的光纤连接器，其被配置为光耦合到服务终端以接收下游光学帧; 位于壳体中的单个电连接器并且通过金属介质耦合到网络终端，以向相应的客户驻地设备（CPE）提供服务; 以及位于壳体中并被配置为将下游光学帧转换为电信号以在金属介质上传输到网络终端的光学到电气（O / E）转换器。

7. 发明申请

WO2012129181A1 METHOD AND SYSTEM FOR DYNAMICALLY TAGGING METRICS DATA 审中-公开
标题翻译：用于动态标注量度数据的方法和系统
公开(公告)号：WO2012129181A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/029701
申请日：2012-03-19
申请人： AMAZON TECHNOLOGIES, INC. , THEIMER, Marvin, M. , BRANDWINE, Eric, J. , BROWN, David , BROOKER, Marc, J. , FULLER, Erik, J.
发明人： THEIMER, Marvin, M. , BRANDWINE, Eric, J. , BROWN, David , BROOKER, Marc, J. , FULLER, Erik, J.
IPC分类号： G06F11/34 , G06F9/40
CPC分类号： G06F8/77 , G06F11/3409 , G06F11/3476 , G06F2201/815
摘要： Systems and methods are described for dynamically tagging metrics data by a provider of computing resources. A requesting user or application can request the provider of computing resources to tag the metrics based on configurations and/or settings specified by the requesting user or application. The tagged metrics data can then be processed by a processing user or application at a later time.
摘要翻译：描述了由计算资源的供应商动态地标记度量数据的系统和方法。请求用户或应用程序可以根据由请求用户或应用程序指定的配置和/或设置请求计算资源的提供者来标记度量。随后可以由处理用户或应用程序处理标记的量度数据。

8. 发明申请

WO2012106586A1 SYNTHETIC MIMICS OF MIR-124 审中-公开
标题翻译： MIR-124的合成纤维
公开(公告)号：WO2012106586A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023748
申请日：2012-02-03
申请人： MIRNA THERAPEUTICS, INC. , KELNAR, Kevin , BROWN, David
发明人： KELNAR, Kevin , BROWN, David
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/713 , A61K45/06 , C12N2310/141 , C12N2310/317 , C12N2310/321 , C12N2310/3521
摘要： Embodiments concern methods and compositions involving miR-124 mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-124 sequence and a complementary passenger strand.
摘要翻译：实施方案涉及涉及miR-124模拟物的方法和组合物。在一些实施方案中，存在具有经修饰的核苷酸的双链RNA分子，其具有具有miR-124序列和补体乘客链的活性链。

9. 发明申请

WO2010033878A3 SOLUTE CONCENTRATION MEASUREMENT DEVICE AND RELATED METHODS 审中-公开
公开(公告)号：WO2010033878A3
公开(公告)日：2010-03-25
申请号：PCT/US2009/057591
申请日：2009-09-18
申请人： BROWN, David
发明人： BROWN, David
IPC分类号： A61B5/145 , A61B5/157
摘要： A solute concentration measurement device is disclosed. The device may comprise a filter membrane, an exchange chamber, a sensing chamber, a separator, and a sensor. The device may be configured to be placed in fluid communication with a sample solution containing a solute and a solvent. The filter membrane may provide selective fluid communication between the solution and the exchange chamber. The separator may separate the exchange chamber from the sensing chamber and cause a change in a condition of the sensing chamber corresponding to a change of a condition of the exchange chamber. The sensor may sense the condition pertaining to the sensing chamber and calculate the concentration of the sample solution corresponding to this change.

10. 发明申请

WO2008121877A3 CFTR INHIBITOR COMPOUNDS AND USES THEREOF 审中-公开
公开(公告)号：WO2008121877A3
公开(公告)日：2008-10-09
申请号：PCT/US2008/058752
申请日：2008-03-28
申请人： INSTITUTE FOR ONEWORLD HEALTH , RUSSELL, Michael Geoffrey Neil , VATER, Huw David , MACRITCHIE, Jacqueline Anne , DOYLE, Kevin James , BROWN, David , PEACH, Joanne
发明人： RUSSELL, Michael Geoffrey Neil , VATER, Huw David , MACRITCHIE, Jacqueline Anne , DOYLE, Kevin James , BROWN, David , PEACH, Joanne
IPC分类号： C07C251/86 , C07C311/00 , C07C317/44 , C07C323/60 , C07D231/06 , C07D231/14 , C07D237/04 , A61K31/415 , A61K31/495 , A61P9/06 , A61P1/12
摘要： The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-6 or encompassed by formulas I-VI) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

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