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1. 发明公开

KR20180019753A 잔류물의 재순환을 이용한 싱글 패스 접선 유동 여과 시스템 및 접선 유동 여과 시스템 审中-公开
标题翻译：单通切向流过滤系统和回流再循环的切向流过滤系统
公开(公告)号：KR20180019753A
公开(公告)日：2018-02-26
申请号：KR20187004189
申请日：2015-08-28
申请人： EMD MILLIPORE CORP
发明人： STEEN JONATHAN , KOZLOV MIKHAIL , LUTZ HERBERT , PARRELLA JOSEPH , GOODRICH ELIZABETH M , RAGHUNATH BALA
IPC分类号： B01D61/14 , B01D29/52 , B01D29/60 , B01D29/90 , B01D63/08
CPC分类号： B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/082 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2315/10 , B01D2315/16 , B01D2319/022
摘要： 액체공급물을싱글패스접선유동여과(SPTFF) 시스템으로통과시키는단계와, 개별용기에서시스템으로부터잔류물및 투과물을회수하는단계를포함하는, 액체공급물을여과하는방법이기재된다. 또한, 액체공급물을접선유동여과(TFF) 시스템을통과시키는단계와, TFF 시스템을통한재순환없이개별용기내에서시스템으로부터투과물및 잔류물의일부분을회수하는단계와, TFF 시스템을통하여적어도한 번잔류물중 나머지를재순환시키는단계를포함하는액체공급물을여과하는방법이기재된다. 본발명의방법은디버터플레이트를필요로하지않고공급물및 잔류물의유로를직렬화하기위해매니폴드세그먼트를포함하는 SPTFF 또는 TFF 시스템을사용하여수행될수 있다.
摘要翻译：描述了一种过滤液体进料的方法，包括使液体进料通过单程切向流动过滤（SPTFF）系统并且将渗余物和渗透物从系统中分离出来的容器中回收。还描述了一种过滤液体进料的方法，其包括使液体进料通过切向流动过滤（TFF）系统，从系统中回收渗透物和一部分滞留物在分开的容器中，而没有再循环通过TFF系统，并将剩余物通过TFF系统保留至少一次。本发明的方法可以使用SPTFF或TFF系统来执行，该系统包括歧管段，以串行化进料和滞留物的流动路径而不需要转向板。

2. 发明公开

KR20180018851A 잔류물의 재순환에 의한 싱글 패스 접선 유동 여과 시스템 및 접선 유동 여과 시스템을 사용하여 액체를 여과하는 공정 审中-公开
标题翻译：使用单通道切向流过滤系统和带有再循环再循环的切向流过滤系统过滤液体的过程
公开(公告)号：KR20180018851A
公开(公告)日：2018-02-21
申请号：KR20187004190
申请日：2015-08-28
申请人： EMD MILLIPORE CORP
发明人： STEEN JONATHAN , KOZLOV MIKHAIL , LUTZ HERBERT , PARRELLA JOSEPH , GOODRICH ELIZABETH M , RAGHUNATH BALA
IPC分类号： B01D61/14 , B01D29/52 , B01D29/60 , B01D29/90 , B01D63/04 , B01D63/12
CPC分类号： B01D29/908 , B01D29/52 , B01D29/603 , B01D61/142 , B01D61/145 , B01D61/147 , B01D63/04 , B01D63/12 , B01D2313/105 , B01D2313/125 , B01D2313/21 , B01D2313/44 , B01D2315/10
摘要： 액체공급물을여과하는방법이개시된다. 일형태에서, 방법은액체공급물을싱글패스접선유동여과(SPTFF) 시스템을통과시키는단계와, SPTFF 시스템을통한재순환없이개별용기에서시스템으로부터잔류물및 투과물을회수하는단계를포함한다. 다른형태에서, 액체공급물을여과하는방법은, 액체공급물을접선유동여과(TFF) 시스템을통과시키는단계와, TFF 시스템을통한재순환없이개별용기내에서시스템으로부터투과물및 잔류물의일부분을회수하는단계와, TFF 시스템을통하여적어도한 번잔류물중 나머지를재순환시키는단계를포함한다. 방법은디버터플레이트를필요로하지않고공급물및 잔류물의유로를직렬화하기위해매니폴드세그먼트를포함하는 SPTFF 또는 TFF 시스템을사용하여수행될수 있다.
摘要翻译：公开了过滤液体进料的方法。在一个版本中，该方法包括使液体进料通过单程切向流动过滤（SPTFF）系统，并且将回收物和渗透物从系统回收到分开的容器中，而不通过SPTFF系统再循环。在另一个版本中，过滤液体进料的方法包括使液体进料通过切向流过滤（TFF）系统，从系统中回收渗透物和一部分滞留物在分开的容器中，而没有再循环通过TFF系统，并且再循环剩余物通过TFF系统至少一次。该方法可以使用SPTFF或TFF系统进行，该系统包括多个歧管段，以串行化进料和滞留物的流动路径而不需要转向板。

3. 发明申请

WO2015195452A4 SINGLE-PASS FILTRATION SYSTEMS AND PROCESSES 审中-公开
标题翻译：单通滤波系统和过程
公开(公告)号：WO2015195452A4
公开(公告)日：2016-03-31
申请号：PCT/US2015035250
申请日：2015-06-11
申请人： EMD MILLIPORE CORP
发明人： LUTZ HERBERT , PARRELLA JOSEPH , RAGHUNATH BALA
IPC分类号： B01D61/14 , B01D61/18 , B01D63/08 , B01D65/02 , C07K1/34
CPC分类号： B01D61/145 , B01D61/142 , B01D61/18 , B01D63/082 , B01D65/02 , B01D2313/18 , B01D2315/10 , B01D2319/022 , B01D2319/04 , B01D2321/04 , B01D2321/06 , B01D2321/164 , C07K1/34 , Y10T29/49828
摘要： The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
摘要翻译：本发明在各种实施例中提供了混合单通道切向流过滤组件，一次性单通道切向流过滤组件，可扩展单通道切向流过滤组件和可适应的模块化单通道切向流过滤组件。在其它实施方案中，本发明涉及在单程切向流过滤组件中从过滤膜的表面回收蛋白质并用于清洗切向流过滤组件的方法。在另外的实施例中，本发明提供了增加单通切向流过滤组件的处理能力的方法。

4. 发明申请

WO2015195452A3 SINGLE-PASS FILTRATION SYSTEMS AND PROCESSES 审中-公开
标题翻译：单通过滤系统和过程
公开(公告)号：WO2015195452A3
公开(公告)日：2016-02-11
申请号：PCT/US2015035250
申请日：2015-06-11
申请人： EMD MILLIPORE CORP
发明人： LUTZ HERBERT , PARRELLA JOSEPH , RAGHUNATH BALA
IPC分类号： B01D61/14 , B01D61/18 , B01D63/08 , B01D65/02 , C07K1/34
CPC分类号： B01D61/145 , B01D61/142 , B01D61/18 , B01D63/082 , B01D65/02 , B01D2313/18 , B01D2315/10 , B01D2319/022 , B01D2319/04 , B01D2321/04 , B01D2321/06 , B01D2321/164 , C07K1/34 , Y10T29/49828
摘要： The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.
摘要翻译：在各种实施例中，本发明提供了混合单程切向流过滤组件，一次性单程切向流过滤组件，可缩放单程切向流过滤组件和适应性模块化单程切向流过滤组件。在其它实施方案中，本发明涉及在单程切向流过滤组件中从过滤膜表面回收蛋白质和清洁切向流过滤组件的方法。在另外的实施例中，本发明提供了增加单程切向流过滤组件的处理能力的方法。

5. 发明专利

SG11201508665QA Processes For Filtering Liquids Using Single Pass Tangential Flow Filtration Systems AndTangential Flow Filtration Systems With Recirculation of Retentate 未知
公开(公告)号：SG11201508665QA
公开(公告)日：2016-03-30
申请号：SG11201508665Q
申请日：2015-08-28
申请人： EMD MILLIPORE CORP
发明人： STEEN JONATHAN , KOZLOV MIKHAIL , LUTZ HERBERT , PARRELLA JOSEPH , GOODRICH ELIZABETH M , RAGHUNATH BALA
IPC分类号： B01D63/04 , B01D61/14 , B01D63/12
摘要： Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

6. 发明专利

ES2926043T3 Sistemas de filtración de flujo tangencial de paso único y sistemas de filtración de flujo tangencial con recirculación de retenido 未知
公开(公告)号：ES2926043T3
公开(公告)日：2022-10-21
申请号：ES15760041
申请日：2015-08-28
申请人： EMD MILLIPORE CORP
发明人： STEEN JONATHAN , KOZLOV MIKHAIL , LUTZ HERBERT , PARRELLA JOSEPH , GOODRICH ELIZABETH , RAGHUNATH BALA
IPC分类号： B01D61/14 , B01D63/08
摘要： Se describe un método para filtrar una alimentación líquida, que comprende pasar una alimentación líquida a través de un sistema de filtración de flujo tangencial de un solo paso (SPTFF) y recuperar el retenido y el permeado del sistema en contenedores separados. También se describe un método para filtrar una alimentación líquida que comprende pasar una alimentación líquida a través de un sistema de filtración de flujo tangencial (TFF), recuperar el permeado y una parte del retenido del sistema en recipientes separados sin recirculación a través del sistema TFF y recircular el resto. del retenido a través del sistema TFF al menos una vez. Los métodos de la invención se pueden realizar utilizando un sistema SPTFF o TFF que comprende múltiples segmentos para serializar la ruta de flujo de la alimentación y el retenido sin necesidad de placas desviadoras. (Traducción automática con Google Translate, sin valor legal)

7. 发明专利

SG10202006102UA Processes For Filtering Liquids Using Single Pass Tangential Flow Filtration Systems AndTangential Flow Filtration Systems With Recirculation of Retentate 未知
公开(公告)号：SG10202006102UA
公开(公告)日：2020-07-29
申请号：SG10202006102U
申请日：2015-08-28
申请人： EMD MILLIPORE CORP
发明人： STEEN JONATHAN , KOZLOV MIKHAIL , LUTZ HERBERT , PARRELLA JOSEPH , GOODRICH ELIZABETH , RAGHUNATH BALA
摘要： Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

8. 发明专利

ES2811108T3 Sistemas y procesos de filtración de un solo 未知
公开(公告)号：ES2811108T3
公开(公告)日：2021-03-10
申请号：ES15172144
申请日：2015-06-15
申请人： EMD MILLIPORE CORP
发明人： LUTZ HERBERT , PARRELLA JOSEPH , RAGHUNATH BALA
IPC分类号： B01D61/14 , B01D61/18 , B01D63/08 , B01D65/02 , C07K1/34
摘要： Un conjunto de filtración de flujo tangencial de un solo paso (SPTFF), que comprende: una pluralidad de unidades de procesamiento (1, 2, 3) que 5 están conectadas fluidamente, en el que cada unidad de procesamiento comprende un portacasetes que contiene al menos un casete de TFF, y en el que las unidades de procesamiento en el conjunto están configuradas para el procesamiento en paralelo y/o en serie; un primer canal (4) conectado a una entrada de alimentación (5) que se extiende a través de la pluralidad de unidades de procesamiento; un segundo canal (6) conectado a una salida de retenido (7) que se extiende a través de la pluralidad de unidades de procesamiento; un canal de permeado (8) que se extiende a través de la pluralidad de unidades de procesamiento; y una o más válvulas (9, 10), en el que cada válvula está ubicada en el primer canal o en el segundo canal entre dos unidades de procesamiento adyacentes, y en el que las válvulas alternan entre el primer canal y el segundo canal para pares consecutivos de unidades de procesamiento adyacentes; en el que la pluralidad de unidades de procesamiento están conectadas fluidamente en paralelo cuando la una o más válvulas están abiertas, o en serie cuando la una o más válvulas están cerradas; y en el que la una o más válvulas están integradas en los portacasetes.

9. 发明专利

SG10201901555UA Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate 未知
公开(公告)号：SG10201901555UA
公开(公告)日：2019-03-28
申请号：SG10201901555U
申请日：2015-08-28
申请人： EMD MILLIPORE CORP
发明人： STEEN JONATHAN , KOZLOV MIKHAIL , LUTZ HERBERT , PARRELLA JOSEPH , GOODRICH ELIZABETH , RAGHUNATH BALA
摘要： OF THE DISCLOSURE A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates. Figure 1

10. 发明专利

SG11201508664VA Single Pass Tangential Flow Filtration Systems and Tangential Flow Filtration Systems withRecirculation of Retentate 未知
公开(公告)号：SG11201508664VA
公开(公告)日：2016-03-30
申请号：SG11201508664V
申请日：2015-08-28
申请人： EMD MILLIPORE CORP
发明人： STEEN JONATHAN , KOZLOV MIKHAIL , LUTZ HERBERT , PARRELLA JOSEPH , GOODRICH ELIZABETH M , RAGHUNATH BALA
IPC分类号： B01D61/14 , B01D63/08
摘要： A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.

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