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1. 发明申请

WO2007124337A8 BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 审中-公开
公开(公告)号：WO2007124337A8
公开(公告)日：2007-11-01
申请号：PCT/US2007/066921
申请日：2007-04-19
申请人： ELI LILLY AND COMPANY , AICHER, Thomas, Daniel , CHEN, Zhaogen , HINKLIN, Ronald, Jay , HITE, Gary, Alan , KRASUTSKY, Alexei, Pavlovych , LI, Renhua , MCCOWAN, Jefferson, Ray , SAEED, Ashraf , SNYDER, Nancy, June , TOTH, James, Lee , WALLACE, Owen, Brendan , WINNEROSKI, JUNIOR, Leonard, Larry , XU, Yanping , YORK, Jeremy, Schulenburg
发明人： AICHER, Thomas, Daniel , CHEN, Zhaogen , HINKLIN, Ronald, Jay , HITE, Gary, Alan , KRASUTSKY, Alexei, Pavlovych , LI, Renhua , MCCOWAN, Jefferson, Ray , SAEED, Ashraf , SNYDER, Nancy, June , TOTH, James, Lee , WALLACE, Owen, Brendan , WINNEROSKI, JUNIOR, Leonard, Larry , XU, Yanping , YORK, Jeremy, Schulenburg
IPC分类号： C07D207/12 , C07D401/10 , C07D401/12 , C07D403/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/08 , C07D491/10 , C07D498/04 , A61P3/10 , A61K31/4015
摘要： The present invention discloses novel compounds of Formula I: possessing 11 ß-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 ß -HSD type 1 activity.

2. 发明申请

WO2007124254A3 CYCLOHEXYLPYRAZOLE-LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 审中-公开
公开(公告)号：WO2007124254A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/066069
申请日：2007-04-05
申请人： ELI LILLY AND COMPANY , AICHER, Thomas, Daniel , ANZEVENO, Peter, Biagio , LI, Renhua , KRASUTSKY, Alexei, Pavlovych , MABRY, Thomas, Edward , SAEED, Ashraf , SNYDER, Nancy, June , STEPHENSON, Gregory, Alan , TIAN, Hongqi , WALLACE, Owen, Brendan , WINNEROSKI, Leonard, Larry, Junior , XU, Yanping
发明人： AICHER, Thomas, Daniel , ANZEVENO, Peter, Biagio , LI, Renhua , KRASUTSKY, Alexei, Pavlovych , MABRY, Thomas, Edward , SAEED, Ashraf , SNYDER, Nancy, June , STEPHENSON, Gregory, Alan , TIAN, Hongqi , WALLACE, Owen, Brendan , WINNEROSKI, Leonard, Larry, Junior , XU, Yanping
IPC分类号： C07D403/04 , A61K31/416 , A61P3/10 , A61P9/10
摘要： The present invention discloses novel compounds of Formula (I): having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula (I), as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.

3. 发明申请

WO2006068992A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 审中-公开
标题翻译：作为11-羟基脱氢酶脱氢酶抑制剂的环丙基乳糖衍生物
公开(公告)号：WO2006068992A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/045907
申请日：2005-12-16
申请人： ELI LILLY AND COMPANY , AICHER, Thomas, Daniel , CHICARELLI, Mark, Joseph , GAUTHIER, Cassandra, A. , HINKLIN, Ronald, Jay , TIAN, Hongqi , WALLACE, Owen, Brendan , KRASUTSKY, Alexei, Pavlovych , ALLEN, John, Gordon
发明人： AICHER, Thomas, Daniel , CHICARELLI, Mark, Joseph , GAUTHIER, Cassandra, A. , HINKLIN, Ronald, Jay , TIAN, Hongqi , WALLACE, Owen, Brendan , KRASUTSKY, Alexei, Pavlovych , ALLEN, John, Gordon
IPC分类号： A61K31/4015 , C07D207/27 , C07D211/76 , C07D401/12 , A61K31/4025 , A61K31/4412 , A61P3/04
CPC分类号： C07D207/26 , C07D207/267 , C07D207/27 , C07D401/10
摘要： The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention compositions containing these compounds for the treatment of metabolic syndrome, diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula I wherein G 1 is methylene or ethylene; L is-(C 1 -C 4 )alkylene-, -S-, -CH(OH)-, or -O-; R 0 is Formula II or Formula III and the other substituents are as defined in the claims.
摘要翻译：本发明提供可用作11-β羟基类固醇脱氢酶1的有效和选择性抑制剂的式I化合物。本发明还提供了一种药物组合物，其包含式I化合物或其药学上可接受的盐载体，稀释剂或赋形剂。此外，含有这些化合物用于治疗代谢综合征，糖尿病，高血糖症，肥胖症，高血压，高脂血症，与高血糖症有关的其它症状以及相关疾病的本发明组合物。式I其中G 1是亚甲基或亚乙基; L是 - （C 1 -C 4 -C 4）亚烷基 - ， - S - ， - CH（OH） - 或-O-; R 0是式II或式III，其它取代基如权利要求中所定义。

4. 发明申请

WO2006068991A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 审中-公开
标题翻译：作为11-羟基脱氢酶脱氢酶1的抑制剂的环丙基乳糖衍生物
公开(公告)号：WO2006068991A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/045906
申请日：2005-12-16
申请人： ELI LILLY AND COMPANY , AICHER, Thomas, Daniel , CHICARELLI, Mark, Joseph , HINKLIN, Ronald, Jay , TIAN, Hongqi , WALLACE, Owen, Brendan
发明人： AICHER, Thomas, Daniel , CHICARELLI, Mark, Joseph , HINKLIN, Ronald, Jay , TIAN, Hongqi , WALLACE, Owen, Brendan
IPC分类号： A61K31/4015 , C07D207/27 , C07D211/76 , C07D401/06 , C07D403/06 , C07D495/04 , A61K31/4025 , A61K31/4412 , A61P3/04
CPC分类号： C07D207/26 , C07D405/06 , C07D409/06 , C07D409/14 , C07D495/04
摘要： The present invention provides compounds of formula I that are useful as potent and selective inhibitors of 11-beta hydroxysteroid dehydrogenase 1. The present invention further provides a pharmaceutical composition which comprises a compound of Formula I, or a pharmaceutical salt thereof, and a pharmaceutically acceptable carrier, diluent, or excipient. In addition, the present invention provides compositions comprising compounds of formula I for the treatment of metabolic syndrome, diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, other symptoms associated with hyperglycemia, and related disorders. Formula (I) wherein, R 0 is (II), or (III) G 1 is methylene or ethylene; L is a divalent linking group selected from -(C 1 -C 4 ) alkylene-, -S-, -CH(OH)-, or -O-; A is methylene, -S-, -O-, or -NH-; and the other substituents are as defined in the claims.
摘要翻译：本发明提供了可用作11-β羟基类固醇脱氢酶1的有效和选择性抑制剂的式I化合物。本发明还提供一种药物组合物，其包含式I化合物或其药学上可接受的盐载体，稀释剂或赋形剂。此外，本发明提供包含式I化合物用于治疗代谢综合征，糖尿病，高血糖症，肥胖，高血压，高脂血症，与高血糖症相关的其它症状以及相关疾病的组合物。式（I）其中R 0为（II）或（III）G 1为亚甲基或亚乙基; L是选自 - （C 1 -C 4 -C 4）亚烷基 - ， - S - ， - CH（OH） - 或-O-的二价连接基团。 A是亚甲基，-S-，-O-或-NH-; 而其它取代基如权利要求中所定义。

5. 发明申请

WO2004014895A1 PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES 审中-公开
标题翻译：哌嗪取代的ARYL BENZODIAZEPINES
公开(公告)号：WO2004014895A1
公开(公告)日：2004-02-19
申请号：PCT/IB2003/003583
申请日：2003-07-28
申请人： ELI LILLY AND COMPANY , AICHER, Thomas, Daniel , CHEN, Zhaogen , LE HUEROU, Yvan , MARTIN, Fionna, Mitchell , PINEIRO-NUNEZ, Marta, Maria , ROCCO, Vincent, Patrick , RULEY, Kevin, Michael , SCHAUS, John, Mehnert , SPINAZZE, Patrick, Gianpietro , TUPPER, David, Edward
发明人： AICHER, Thomas, Daniel , CHEN, Zhaogen , LE HUEROU, Yvan , MARTIN, Fionna, Mitchell , PINEIRO-NUNEZ, Marta, Maria , ROCCO, Vincent, Patrick , RULEY, Kevin, Michael , SCHAUS, John, Mehnert , SPINAZZE, Patrick, Gianpietro , TUPPER, David, Edward
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , C07D495/04 , C07D513/04
摘要： Described herein are compounds of formula (I) wherein: is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, S, and O; Alk is (C 1-4 ) alkylene or hydroxy substituted (C 1-4 ) alkylene; X is oxygen or sulfur; R 1 is hydrogen, (C 1-6 ) fluoroalkyl, (C 3-6 ) cycloalkyl, or (C 1-4 ) alkyl, wherein the (C 1-4 ) alkyl is unsubstituted or substituted with hydroxy, methoxy, ethoxy, OCH 2 CH 2 OH, or -CN; R 2 is H, halogen, (C 1-6 ) fluoroalkyl, (C 1-6 ) cycloalkyl, OR 4 , SR 4 , N0 2 , CN, COR 4 , C(O)OR 4 , CONR 5 R 6 , NR 5 R 6 , S0 2 NR 5 R 6 , NR 5 COR 4 , NR 5 SO 2 R 4 , optionally substituted aromatic, or (C 1-6 ) alkyl, wherein (C 1-6 ) alkyl is unsubstituted or substituted with a hydroxy group; R 3 is hydrogen, (C 1-6 ) fluoroalkyl, (C 2-6 ) alkenyl, Ar, (C 1-4 )alkyl-Ar, or (C 1-4 ) alkyl wherein (C 1-4 ) alkyl is unsubsituted or substituted with a phenyl; R 4 is hydrogen, (C 1-6 alkyl, (C 1-6 ) fluoroalkyl, or optionally substituted aromatic; R 5 and R 6 are independently hydrogen, (C 1-6 ) alkyl, or optionally substituted aromatic, R 7 is hydrogen, (C 1-6 ) alkyl, (C 1-6 ) fluoroalkyl, or optionally substituted aromatic; R 8 and R 9 are independently hydrogen, (C 1-6 ) alkyl, or optionally substituted aromatic; Ar is optionally substituted phenyl, napthyl, monocyclic heteroaromatic or bicyclic heteroaromatic; Z 1 and Z 2 are independently selected from hydrogen, halogen, (C 1-6 ) alkyl, (C 1-6 ) fluoroalkyl, OR 7 , SR 7 , NO 2 , CN, COR 7 , CONR 8 R 9 , NR 8 R 9 , and optionally substituted aromatic; and all salts, solvates, optical and geometric isomers, and crystalline forms thereof. Also, described are the use of the compounds of formula (I) as antagonists of the dopamine D2 receptor and as agents for the treament of psychosis and bipolar disorders, and pharmaceutical formulations of the compounds of formula (I).
摘要翻译：本文描述的是式（I）的化合物，其中：是任选苯并稠合的五元或六元芳族环，其具有独立地选自N，S和O的0至3个杂原子; Alk是（C1-4）亚烷基或羟基取代的（C1-4）亚烷基; X是氧或硫; R 1是氢，（C 1-6）氟烷基，（C 3-6）环烷基或（C 1-4）烷基，其中（C 1-4）烷基是未取代的或被羟基，甲氧基，乙氧基，OCH 2 CH 2 OH，或-CN; R 2是H，卤素，（C 1-6）氟烷基，（C 1-6）环烷基，OR 4，SR 4，NO 2，CN，COR 4，C（O），CONR 5 R 6，NR 5 R 6，SO 2 NR 5 R 6，NR 5 COR 4，NR 5 SO 2 R 4，任选取代的芳族，或（C 1-6）烷基，其中（C 1-6）烷基未被取代或被羟基取代; R 3是氢，（C 1-6）氟代烷基，（C 2-6）烯基，Ar，（C 1-4）烷基-Ar或（C 1-4）烷基，其中（C 1-4）烷基是未取代或取代的与苯基; R 4是氢，（C 1-6烷基，（C 1-6）氟代烷基或任选取代的芳族; R 5和R 6独立地是氢，（C 1-6）烷基或任选取代的芳族， R 7是氢，（C 1-6）烷基，（C 1-6）氟代烷基或任选取代的芳族; R 8和R 9独立地是氢，（C 1-6）烷基或任选取代的芳族 ; Ar是任选取代的苯基，萘基，单环杂芳族或双环杂芳族; Z 1和Z 2独立地选自氢，卤素，（C 1-6）烷基，（C 1-6）氟代烷基，OR 7，，SR 7，NO 2，CN，COR 7，CONR 8 R 9，NR 8 R 9和任选取代的芳族;以及所有盐，溶剂合物，光学和几何异构体和结晶形式，还描述了式（I）化合物作为多巴胺D2受体的拮抗剂和精神病和双相性精神障碍的药物的用途，以及式（I ）。

6. 发明申请

WO2003082877A1 PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS 审中-公开
标题翻译：哌嗪取代的ARYL苯并嗪及其作为多巴胺受体拮抗剂用于治疗心理疾病
公开(公告)号：WO2003082877A1
公开(公告)日：2003-10-09
申请号：PCT/US2003/006708
申请日：2003-03-17
申请人： ELI LILLY AND COMPANY , AICHER, Thomas, Daniel , CHEN, Zhaogen , CHEN, Ying , FAUL, Margaret, Mary , KRUSHINSKI, Joseph, Herman, Jr. , LE HUEROU, Yvan , PINEIRO-NUNEZ, Marta, Maria , ROCCO, Vincent, Patrick , RULEY, Kevin, Michael , SCHAUS, John, Mehnert , THOMPSON, Dennis, Charles , TUPPER, David, Edward
发明人： AICHER, Thomas, Daniel , CHEN, Zhaogen , CHEN, Ying , FAUL, Margaret, Mary , KRUSHINSKI, Joseph, Herman, Jr. , LE HUEROU, Yvan , PINEIRO-NUNEZ, Marta, Maria , ROCCO, Vincent, Patrick , RULEY, Kevin, Michael , SCHAUS, John, Mehnert , THOMPSON, Dennis, Charles , TUPPER, David, Edward
IPC分类号： C07D495/04
CPC分类号： C07D487/04 , C07D243/38 , C07D495/04 , C07D513/04
摘要： Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; Alk is (C 1-4 ) alkylene optionally substituted with OH, methoxy, ethoxy, or F; Ar is optionally substituted phenyl, naphthyl, monocyclic heteroaromatic, or bicyclic heteroaromatic; R 1 is hydrogen or (C 1-4 ) alkyl optionally substituted with OH, OR 3 , or OCH 2 CH 2 OH, wherein R 3 is (C 1-2 ) alkyl; R 2 is H, (C 1-6 ) alkyl, halogen, fluorinated (C 1-6 ) alkyl, OR 4 , SR 4 , NO 2 , CN, COR 4 , CONR 5 R 6 , SO 2 NR 5 R 6 , NR 5 R 6 , NR 5 COR 4 , NR 5 SO 2 R 4 , or optionally substituted phenyl,wherein R 4 is hydrogen, (C 1-6 ) alkyl, fluorinated (C 1-6 ) alkyl, benzyl, or optionally substituted phenyl, R 5 and R 6 are independently hydrogen, (C 1-6 ) alkyl, or optionally substituted phenyl; Z is one or two substituents independently selected from hydrogen, halogen, (C 1-6 ) alkyl, fluorinated (C 1-6 ) alkyl, OR 7 , SR 7 , NO 2 , CN, COR 7 , CONR 8 R 9 , SO 2 NR 8 R 9 , NR 8 SO 2 R 7 , NR 8 R 9 , or optionally substituted phenyl, wherein R 7 is hydrogen, (C 1-6 ) alkyl, fluorinated (C 1-6 ) alkyl, benzyl, or optionally substituted phenyl, R 8 and R 9 are independently hydrogen, (C 1-6 ) alkyl, or optionally substituted phenyl; and salts, solvates, and crystal forms thereof. Also described are the use of the compounds of formula (I) as antagonists of the dopamine D 2 receptor and as agents for the treatment of psychosis and bipolar disorders, and pharmaceutical formulations of the compounds of formula (I). Also described are compounds useful as intermediates for the synthesis of the compounds of formula (I).
摘要翻译：本文描述的是式（I）的抗颤动化合物，其中A是任选苯并稠合的五元或六元芳族环，其具有独立地选自N，O和S的0至3个杂原子; Alk是任选被OH，甲氧基，乙氧基或F取代的（C 1-4）亚烷基; Ar是任选取代的苯基，萘基，单环杂芳族或双环杂芳族; R 1是氢或任选被OH，OR 3或OCH 2 CH 2 OH取代的（C 1-4）烷基，其中R 3是（C 1-2）烷基; R 2是H，（C 1-6）烷基，卤素，氟化（C 1-6）烷基，OR 4，SR 4，NO 2，CN，COR 4，CONR 5 ，SO 2 NR 5 R 6，NR 5 R 6，NR 5 COR 4，NR 5 SO 2 R 4或任选取代的苯基，其中R 4是氢，（C 1-6）烷基，氟化（C 1-6）烷基，苄基或任选取代的苯基，R 5和R 6独立地是氢，（C 1-6）烷基或任选取代的苯基; Z是一个或两个独立地选自氢，卤素，（C 1-6）烷基，氟化（C 1-6）烷基，OR 7，SR 7，NO 2，CN，COR 7，CONR 8中的取代基 R 9，SO 2 NR 8 R 9，NR 8 SO 2 R 7，NR 8 R 9或任选取代的苯基，其中R 7是氢，（C 1-6））烷基，氟化（C 1-6）烷基，苄基或任选取代的苯基，R 8和R 9独立地是氢，（C 1-6）烷基或任选取代的苯基; 及其盐，溶剂合物和晶体形式。还描述了式（I）化合物作为多巴胺D2受体的拮抗剂和用于治疗精神病和双相性障碍的药物以及式（I）化合物的药物制剂的用途。还描述了可用作合成式（I）化合物的中间体的化合物。

7. 发明公开

EP1986645A1 GLUCOKINASE ACTIVATORS 有权
标题翻译：葡糖激酶活化剂
公开(公告)号：EP1986645A1
公开(公告)日：2008-11-05
申请号：EP07716991.0
申请日：2007-01-24
申请人： Array Biopharma, Inc. , Aicher, Thomas Daniel , BOYD, Steven Armen , Chicarelli, Mark Joseph , Condroski, Kevin Ronald , Hinklin, Ronald Jay , Singh, Ajay , Turner, Timothy Mark , Rustam, Ferdinand Garrey
发明人： AICHER, Thomas, Daniel , BOYD, Steven, Armen , CHICARELLI, Mark, Joseph , CONDROSKI, Kevin, Ronald , HINKLIN, Ronald, J. , SINGH, Ajay , TURNER, Timothy, Mark , RUSTAM, Ferdinand, Garrey
IPC分类号： A61K31/427 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , A61P3/10 , A61K31/428
CPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase. (Formula I) wherein R2, L, Z, Y, G and R1 are as defined in the claims.
摘要翻译：提供可用于治疗和/或预防由葡萄糖激酶活性水平不足（例如糖尿病）介导的疾病的式I化合物。还提供治疗或预防葡萄糖激酶活性降低或可通过激活葡萄糖激酶进行治疗的疾病和病症的方法。（式I）其中R2，L，Z，Y，G和R1如权利要求中所定义。

8. 发明申请

WO2008118718A2 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译： 2-氨基吡啶类似物作为GLUCOKINASE激活剂
公开(公告)号：WO2008118718A2
公开(公告)日：2008-10-02
申请号：PCT/US2008/057543
申请日：2008-03-19
申请人： ARRAY BIOPHARMA INC. , AICHER, Thomas, Daniel , BOYD, Steven, Armen , CHICARELLI, Mark, Joseph , CONDROSKI, Kevin, Ronald , HINKLIN, Ronald, Jay , SINGH, Ajay
发明人： AICHER, Thomas, Daniel , BOYD, Steven, Armen , CHICARELLI, Mark, Joseph , CONDROSKI, Kevin, Ronald , HINKLIN, Ronald, Jay , SINGH, Ajay
IPC分类号： C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , A61P3/10 , A61K31/427 , A61K31/4427
CPC分类号： C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04
摘要： Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译：提供了可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病的化合物。还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。

9. 发明申请

WO2007117381A2 GLUCOKINASE ACTIVATORS 审中-公开
公开(公告)号：WO2007117381A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/007444
申请日：2007-03-23
申请人： ARRAY BIOPHARMA INC. , AICHER, Thomas, Daniel , BOYD, Steven, Armen , CHICARELLI, Mark, Joseph , CONDROSKI, Kevin, Ronald , HINKLIN, Ronald, Jay , SINGH, Ajay
发明人： AICHER, Thomas, Daniel , BOYD, Steven, Armen , CHICARELLI, Mark, Joseph , CONDROSKI, Kevin, Ronald , HINKLIN, Ronald, Jay , SINGH, Ajay
CPC分类号： C07D417/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译：提供了可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病的化合物。还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。

10. 发明申请

WO2006057860A1 POTENTIATORS OF GLUTAMATE RECEPTORS 审中-公开
标题翻译：谷氨酸受体的潜力
公开(公告)号：WO2006057860A1
公开(公告)日：2006-06-01
申请号：PCT/US2005/041367
申请日：2005-11-15
申请人： ELI LILLY AND COMPANY , AICHER, Thomas, Daniel , BENESH, Dana, Rae , BLANCO-PILLADO, Maria-jesus , CORTEZ, Guillermo, S. , GROENDYKE, Todd, Michael , KHILEVICH, Albert , KNOBELSDORF, James, Allen , MARMSATER, Fredrik, Pehr , SCHKERYANTZ, Jeffrey, Michael , TANG, Tony, Pisal
发明人： AICHER, Thomas, Daniel , BENESH, Dana, Rae , BLANCO-PILLADO, Maria-jesus , CORTEZ, Guillermo, S. , GROENDYKE, Todd, Michael , KHILEVICH, Albert , KNOBELSDORF, James, Allen , MARMSATER, Fredrik, Pehr , SCHKERYANTZ, Jeffrey, Michael , TANG, Tony, Pisal
IPC分类号： C07D401/04 , C07D257/04 , C07D213/79 , C07D213/70 , A61K31/4427 , A61P25/00 , A61P37/08
CPC分类号： C07C229/60 , C07C317/44 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/70 , C07D213/79 , C07D213/80 , C07D213/84 , C07D213/85 , C07D257/04 , C07D401/04 , C07D401/12
摘要： The present invention provides compounds of formula (I); pharmaceutical compositions thereof, and methods of using the same, processes or preparing the same, and intermediates thereof.
摘要翻译：本发明提供式（I）化合物; 其药物组合物及其使用方法，方法或制备方法及其中间体。

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