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1. 发明申请

WO2011163559A1 IMPLANTABLE OPHTHALMIC DEVICES WITH CIRCULARLY ASYMMETRIC OPTIC AND METHODS 审中-公开
标题翻译：具有圆形非对称光学和方法的可植入眼科装置
公开(公告)号：WO2011163559A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/041764
申请日：2011-06-24
申请人： ELENZA, INC. , BLUM, Ronald D. , GUPTA, Amitava , SAUVET, Julien , FEHR, Jean-Noel , SCHNELL, Urban
发明人： BLUM, Ronald D. , GUPTA, Amitava , SAUVET, Julien , FEHR, Jean-Noel , SCHNELL, Urban
IPC分类号： A61F2/16
CPC分类号： A61F2/1624 , A61F2/1637
摘要： Astigmatism is an optical aberration that displaces the eye's vertical focal plane with respect to its horizontal focal plane. This displacement in focal planes, which may be caused by an irregularly shaped cornea and/or crystalline lens, causes images to appear blurry. Astigmatism can be corrected by implanting an optic, such as section of a spherical lens, whose projection onto a plane perpendicular to the optical axis is noncircular (e.g., rectangular or elliptical). Because the optic is noncircular, it provides more optical power along one axis than along another axis. As a result, it introduces an astigmatism that can be used to offset or compensate the eye's corneal and/or lenticular astigmatism when aligned properly with respect to the principal meridians of the cornea and/or crystalline lens.
摘要翻译：散光是相对于其水平焦平面移动眼睛的垂直焦平面的光学像差。可能由不规则形状的角膜和/或晶状体引起的焦平面中的位移导致图像看起来模糊。可以通过植入诸如球面透镜的部分的光学元件校正散光，其中投影在垂直于光轴的平面上是非圆形的（例如，矩形或椭圆形）。因为光学元件是非圆形的，所以它沿着一个轴提供比另一个轴更多的光学功率。结果，当相对于角膜和/或晶状体的主经脉正确对准时，其引入散光，其可用于抵消或补偿眼睛的角膜和/或透镜散光。

2. 发明申请

WO2012018583A1 HERMETICALLY SEALED IMPLANTABLE OPHTHALMIC DEVICES AND METHODS OF MAKING SAME 审中-公开
标题翻译：密封的可植入的眼部器械及其制造方法
公开(公告)号：WO2012018583A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/045188
申请日：2011-07-25
申请人： ELENZA, INC. , BLUM, Ronald, D. , GUPTA, Amitava , FEHR, Jean-Noel , ROULET, Jean-Christophe , SCHNELL, Urban , DOLL, Walter , MICHAELY, Roland
发明人： BLUM, Ronald, D. , GUPTA, Amitava , FEHR, Jean-Noel , ROULET, Jean-Christophe , SCHNELL, Urban , DOLL, Walter , MICHAELY, Roland
IPC分类号： G02C7/02
CPC分类号： A61F2/1624 , A61F2/14 , A61F2/1613 , A61F2002/482 , A61F2240/001 , A61F2250/0069 , G02F1/1341 , H01L23/15 , H01L23/5389 , H05K3/301 , H05K3/36 , Y10T29/49126
摘要： Many modern implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically sealed within cavities formed by bonding together two or more glass wafers. Bonding the glass wafers together with laser fusion bonding, pressure bonding, or anodic bonding creates a seal that leaks at a rate of less than about 5x10 -12 Pa m 3 s -1 when subjected to a helium leak test. Hermetically sealed feedthroughs formed of conductive material running through channels in the wafers provide electrical connections to components inside the sealed cavities. In some cases, the conductive material has a coefficient of thermal expansion (CTE) that is roughly equal to (e.g., within 10% of) the CTE of the glass wafers to minimize leakage due to thermally induced expansion and contraction of the conductive material and the glass wafer.
摘要翻译：许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件，例如电活性细胞。在本文公开的可植入眼科装置中，将电子部件气密地密封在通过将两个或更多个玻璃晶片结合在一起形成的腔内。通过激光熔接，压接或阳极接合将玻璃晶片结合在一起形成密封，当进行氦气泄漏测试时，密封件以小于约5×10-12 Pa m3 s-1的速率泄漏。由导电材料形成的密封馈通通过晶片中的通道提供电连接到密封空腔内的组件。在一些情况下，导电材料的热膨胀系数（CTE）大致等于玻璃晶片的CTE的（例如，在10％以内），以最小化由于导致导电材料的热诱导的膨胀和收缩引起的泄漏，玻璃晶片。

3. 发明公开

EP3091939A1 ELECTRO-OPTICAL MONOFOCAL INTRAOCULAR LENS 审中-公开
标题翻译： ELEKTROOPTISCHE MONOFOKALE INTRAOKULARLINSE
公开(公告)号：EP3091939A1
公开(公告)日：2016-11-16
申请号：EP15735493.7
申请日：2015-01-07
申请人： Elenza, Inc. , Gupta, Amitava , Mazzocchi, Rudy , Trip, Roel , Schnell, Urban , Fehr, Jean-Noel
发明人： GUPTA, Amitava , MAZZOCCHI, Rudy , TRIP, Roel , SCHNELL, Urban , FEHR, Jean-Noel
IPC分类号： A61F2/16
CPC分类号： A61F2/1624 , A61B5/0059 , A61F2/1627 , A61F2/1659 , A61F2002/1696 , A61F2250/0001 , A61F2250/0002
摘要： Described herein is an implantable intraocular lens that can automatically adjust its optical power based on the eye's natural response for accommodation of targets at varying distances. The implantable intraocular lens includes a physiological sensor for detecting a physiological response of an eye associated with an ocular accommodation, and an electro-optical element configured to adjust optical power based on the detected physiological response of the eye.

4. 发明申请

WO2016141349A1 WIRELESS POWER BASE UNIT AND A SYSTEM AND METHOD FOR BODY-WORN REPEATER CHARGING OF WEARABLE ELECTRONIC DEVICES 审中-公开
标题翻译：无线电力基站和用于身体电子装置的身体重复充电的系统和方法
公开(公告)号：WO2016141349A1
公开(公告)日：2016-09-09
申请号：PCT/US2016/021038
申请日：2016-03-04
申请人： POGOTEC, INC. , BLUM, Ronald D. , KOKONASKI, William , GUPTA, Amitava , RICHMAN, Scott , SCHNELL, Urban , BAUER, Stefan , FEHR, Jean-Noel , ZIEGLER, Alan Read Jr. , CLOMPUS, Richard , PINAZZA, Massimo , LONGA, Claudio Dalla , DANNHARDT, Walter
发明人： BLUM, Ronald D. , KOKONASKI, William , GUPTA, Amitava , RICHMAN, Scott , SCHNELL, Urban , BAUER, Stefan , FEHR, Jean-Noel , ZIEGLER, Alan Read Jr. , CLOMPUS, Richard , PINAZZA, Massimo , LONGA, Claudio Dalla , DANNHARDT, Walter
IPC分类号： H04B5/00
CPC分类号： H02J50/12 , H02J7/0042 , H02J50/50 , H02J50/80 , H02J50/90
摘要： Base units, systems and methods for wireless energy transfer are described. A wireless energy transfer system according to some examples includes a transmitter of wireless energy located within a communication device, such as a mobile phone, or attached to the communication device and a distance separated receiver located within an electronic wearable device other than the communication device, wherein the receiver is configured to receive wireless energy from the transmitter and convert the wireless energy into electrical power, which may be used to power the electronic wearable device.
摘要翻译：描述了用于无线能量传输的基本单元，系统和方法。根据一些示例的无线能量传输系统包括位于通信设备（例如移动电话）内或附接到通信设备的无线能量的发射机，以及位于除通信设备之外的电子可佩戴设备内的距离分离的接收机，其中所述接收器被配置为从所述发射器接收无线能量，并将所述无线能量转换成电功率，所述电力可用于为所述电子可穿戴设备供电。

5. 发明申请

WO2012037019A1 METHOD AND APPARATUS FOR DETECTING ACCOMMODATION 审中-公开
标题翻译：检测住房的方法和装置
公开(公告)号：WO2012037019A1
公开(公告)日：2012-03-22
申请号：PCT/US2011/051198
申请日：2011-09-12
申请人： FEHR, Jean-Noel , SCHNELL, Urban , DOLL, Walter , MICHAELY, Roland , ROULET, Jean-Christophe , GUPTA, Amitava , BLUM, Ronald D. , MAZZOCCHI, Rudy
发明人： FEHR, Jean-Noel , SCHNELL, Urban , DOLL, Walter , MICHAELY, Roland , ROULET, Jean-Christophe , GUPTA, Amitava , BLUM, Ronald D. , MAZZOCCHI, Rudy
IPC分类号： A61B3/11
CPC分类号： A61B3/11 , A61B3/09 , A61B3/112 , A61F2/1624 , A61F2250/0002 , G02C7/083
摘要： A sensor system includes at least two sensors for distinguishing accommodative stimuli from changes in ambient lights levels and task-induced changes in the pupil diameter. When implanted, the first sensor is disposed completely within the pupil; even when fully constricted, the pupil does not occlude the first sensor, allowing the sensor to make precise measurements of ambient luminous flux levels. The pupil occludes part of the second sensor's active area(s) as the pupil dilates and constricts. As a result, the second sensor measures both ambient luminous flux and pupil diameter. A processor estimates the pupil diameter and determines whether it's changing in response to accommodative stimuli or other factors by comparing to predetermined values. The sensor system sends a signal to an optical component, which in turn can respond by changing optical power to focus for near vision upon detection of accommodative stimuli.
摘要翻译：传感器系统包括至少两个传感器，用于区分调节刺激与环境光照水平的变化以及瞳孔直径的任务引起的变化。当植入时，第一传感器完全设置在瞳孔内; 即使完全收缩，瞳孔也不会堵塞第一个传感器，从而允许传感器对环境光通量水平进行精确测量。当瞳孔扩大和收缩时，瞳孔封闭第二传感器的有效区域的一部分。结果，第二传感器测量环境光通量和瞳孔直径。处理器估计瞳孔直径并且通过与预定值进行比较来确定其是否响应于调节刺激或其他因素而改变。传感器系统将信号发送到光学部件，光学部件又可以通过改变光焦度进行响应，以便在检测到适应刺激时进行近视。

6. 发明申请

WO2013059656A2 METHODS AND APPARATUS FOR DETECTING ACCOMMODATIVE TRIGGERS 审中-公开
标题翻译：检测住宿触发器的方法和装置
公开(公告)号：WO2013059656A2
公开(公告)日：2013-04-25
申请号：PCT/US2012/061115
申请日：2012-10-19
申请人： ELENZA, INC. , GUPTA, Amitava , FEHR, Jean-Noel , MICHAELY, Roland , MONTICONE, Pier Paolo , MUEHLEMANN, Thomas , MORRIS, Michael , SCHNELL, Urban
发明人： GUPTA, Amitava , FEHR, Jean-Noel , MICHAELY, Roland , MONTICONE, Pier Paolo , MUEHLEMANN, Thomas , MORRIS, Michael , SCHNELL, Urban
IPC分类号： A61F2/14
CPC分类号： A61B3/09 , A61B3/16 , A61F2/1624 , A61F9/0017 , A61F9/00781
摘要： An intraocular implant includes a sensor that, when implanted the eye, detects a physiological change (e.g., change in pupil diameter) associated with an accommodative trigger and emits a signal representing the detected change. A processor coupled to the implant senses and interprets the signal based on one or more thresholds representing the patient's pupillary response to changes in object distance and/or ambient light level. If the processor determines that the signal represents an accommodative trigger, it actuates an electro-active optical element, such as a pixelated liquid-crystal cell, to change the eye's effective optical power and/or depth of field.
摘要翻译：眼内植入物包括当植入眼睛时检测与调节性触发相关联的生理变化（例如，瞳孔直径的变化）并且发出表示检测到的变化的信号的传感器。耦合到植入物的处理器基于表示患者对物体距离和/或环境光水平的变化的瞳孔响应的一个或多个阈值来感测和解释信号。如果处理器确定信号表示调节触发器，则其致动诸如像素化液晶单元之类的电活性光学元件，以改变眼睛的有效光功率和/或景深。

7. 发明申请

WO2015105881A1 ELECTRO-OPTICAL MONOFOCAL INTRAOCULAR LENS 审中-公开
标题翻译：电光单眼镜片
公开(公告)号：WO2015105881A1
公开(公告)日：2015-07-16
申请号：PCT/US2015/010489
申请日：2015-01-07
申请人： ELENZA, INC. , GUPTA, Amitava , MAZZOCCHI, Rudy , TRIP, Roel , SCHNELL, Urban , FEHR, Jean-Noel
发明人： GUPTA, Amitava , MAZZOCCHI, Rudy , TRIP, Roel , SCHNELL, Urban , FEHR, Jean-Noel
IPC分类号： A61F2/16
CPC分类号： A61F2/1624 , A61B5/0059 , A61F2/1627 , A61F2/1659 , A61F2002/1696 , A61F2250/0001 , A61F2250/0002
摘要： Described herein is an implantable intraocular lens that can automatically adjust its optical power based on the eye's natural response for accommodation of targets at varying distances. The implantable intraocular lens includes a physiological sensor for detecting a physiological response of an eye associated with an ocular accommodation, and an electro-optical element configured to adjust optical power based on the detected physiological response of the eye.
摘要翻译：这里描述的是可植入的眼内透镜，其可以基于眼睛的自然响应自动调节其光焦度，以适应不同距离的目标。可植入人工晶状体包括用于检测与眼部调节相关联的眼睛的生理反应的生理传感器，以及被配置为基于检测到的眼睛的生理反应来调节光焦度的电光元件。

8. 发明申请

WO2011008846A1 FOLDING DESIGNS FOR INTRAOCULAR LENSES 审中-公开
标题翻译：折叠设计用于内窥镜
公开(公告)号：WO2011008846A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/041958
申请日：2010-07-14
申请人： OCULAR OPTICS, INC. , SCHNELL, Urban , FEHR, Jean-Noel , SAURER, Alain , GUPTA, Amitava
发明人： SCHNELL, Urban , FEHR, Jean-Noel , SAURER, Alain , GUPTA, Amitava
IPC分类号： A61F2/16
CPC分类号： A61F2/16 , A61F2002/169053
摘要： Folding patterns for intraocular lens are provided In a first embodiment, an intraocular lens is disclosed comprising a body comprising one or more fold lines such that the body can assume a folded configuration and an unfolded configuration, and an electroactive component contained in or on the body, wherein at least one dimension of the folded configuration is less than about 7 mm
摘要翻译：提供眼内透镜的折叠图案在第一实施例中，公开了一种眼内透镜，其包括主体，其包括一个或多个折叠线，使得本体可以呈现折叠构型和展开构型，以及容纳在身体中或身体上的电活性成分，其中所述折叠构型的至少一个尺寸小于约7mm

9. 发明申请

WO2011163080A1 OPHTHALMIC DEVICES AND METHODS WITH APPLICATION SPECIFIC INTEGRATED CIRCUITS 审中-公开
标题翻译：具有应用特定集成电路的光学器件和方法
公开(公告)号：WO2011163080A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/040896
申请日：2011-06-17
申请人： ELENZA, INC. , FEHR, Jean-Noel , DOLL, Walter , SCHNELL, Urban
发明人： FEHR, Jean-Noel , DOLL, Walter , SCHNELL, Urban
IPC分类号： A61B18/00
CPC分类号： A61F2/1624 , A61F2/1627 , A61F2210/0076 , A61F2250/0001 , A61F2250/0002
摘要： Ophthalmic devices with dynamic electro-active elements offer variable optical power and/or depth of field that restore lost accommodation in individuals suffering from presbyopia or aphakia. An illustrative device senses physiological processes indicative of the accommodative response and actuates a dynamic electro-active element to provide the desired change in optical power and/or depth of field. The illustrative device includes two application-specific integrated circuits (ASICs) for processing the accommodative response and actuating the electro-active element: a high-voltage ASIC that steps up a low voltage from a power supply to a higher voltage suitable for actuating the electro-active element, and another ASIC that operates at low voltage (and therefore consumes little power) and controls the operating state of the high-voltage ASIC. Because each ASIC operates at the lowest possible voltage, the illustrative ophthalmic device dissipates less power than other ophthalmic devices.
摘要翻译：具有动态电活性元件的眼科装置提供可变光学功率和/或景深，以恢复患有老花眼或无晶状体的个体的失调。说明性装置感测指示调节响应的生理过程，并且启动动态电活性元件以提供光功率和/或景深的期望变化。说明性装置包括用于处理调节响应并致动电活动元件的两个特定应用集成电路（ASIC）：将电压从低电压升高到适合于致动电极的较高电压的高电压ASIC - 活性元件和另一个以低电压工作（因此消耗很少功率）并且控制高电压ASIC的工作状态的ASIC。因为每个ASIC以尽可能低的电压工作，因此说明性的眼科装置比其他眼科装置消耗的功率更小。

10. 发明申请

WO2012033752A1 INSTALLATION AND SEALING OF A BATTERY ON A THIN GLASS WAFER TO SUPPLY POWER TO AN INTRAOCULAR IMPLANT 审中-公开
标题翻译：一个电池在一个薄的玻璃上的电源的安装和密封，以供应到一个室内植被
公开(公告)号：WO2012033752A1
公开(公告)日：2012-03-15
申请号：PCT/US2011/050533
申请日：2011-09-06
申请人： ELENZA, INC. , FEHR, Jean-Noel , SAURER, Alain , SCHLAPPI, Andreas
发明人： FEHR, Jean-Noel , SAURER, Alain , SCHLAPPI, Andreas
IPC分类号： C01D7/37
CPC分类号： A61F2/14 , A61F2/1624 , A61F2250/0069 , H01M2/1022 , Y10T29/49117
摘要： Many modem implantable ophthalmic devices include electronic components, such as electro-active cells, that can leak harmful substances into the eye and/or surrounding tissue. In the implantable ophthalmic devices disclosed herein, electronic components are hermetically sealed to facilitate mechanically connecting components of an implantable ophthalmic device. Furthermore, the device includes at least one battery with a surface comprising electrical contact portions, a housing for the at least one battery, a first wafer bonded to the housing such that the housing and the first wafer form a hermetically sealed surface around the battery, and an electronic circuit electrically connected to the electrical contact portions of the battery.
摘要翻译：许多现代可植入眼科装置包括可将有害物质渗入眼睛和/或周围组织的电子部件，例如电活性细胞。在本文公开的可植入眼科装置中，电子部件被气密地密封以便于可植入眼科装置的机械连接部件。此外，该装置包括具有包括电接触部分的表面的至少一个电池，用于至少一个电池的壳体，结合到壳体的第一晶片，使得壳体和第一晶片形成围绕电池的密封表面，以及电连接到电池的电接触部分的电子电路。

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