专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007089862A3 ALPHA-SYNUCLEIN KINASE 审中-公开
标题翻译： ALPHA-SYNUCLEIN激酶
公开(公告)号：WO2007089862A3
公开(公告)日：2008-12-04
申请号：PCT/US2007002685
申请日：2007-01-30
申请人： ELAN PHARM INC , CHILCOTE TAMIE J , BANDUCCI KELLY , FRIGON NORMAND L JR , BASI GURIQBAL S , ANDERSON JOHN P , GOLDSTEIN JASON , GRIWOLD-PRENNER IRENE , CHEREAU DAVID
发明人： CHILCOTE TAMIE J , BANDUCCI KELLY , FRIGON NORMAND L JR , BASI GURIQBAL S , ANDERSON JOHN P , GOLDSTEIN JASON , GRIWOLD-PRENNER IRENE , CHEREAU DAVID
IPC分类号： A61K39/00 , A61P43/00 , C12N15/113 , C12P21/04 , C12Q1/00 , C12Q1/20 , C12Q1/68
CPC分类号： C12Q1/6883 , C12N15/1137 , C12N15/86 , C12N2310/11 , C12N2310/14 , C12N2740/15043 , C12Q1/485 , C12Q2600/136 , C12Q2600/158 , C12Y207/11016 , C12Y207/11021 , G01N2500/04 , G01N2800/28
摘要： The invention provides agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 and GRK6 kinases.
摘要翻译：本发明提供了用于治疗与患者脑中的路易体疾病（LBD）相关的疾病的药剂和方法。优选的试剂包括PLK2和GRK6激酶的抑制剂。

2. 发明申请

WO2009103010A3 ALPHA-SYNUCLEIN KINASE 审中-公开
标题翻译： ALPHA-SYNUCLEIN激酶
公开(公告)号：WO2009103010A3
公开(公告)日：2009-11-05
申请号：PCT/US2009034135
申请日：2009-02-13
申请人： ELAN PHARM INC , ANDERSON JOHN P , BANDUCCI KELLY , BASI GURIQBAL S , CHEREAU DAVID , CHILCOTE TAMIE J , FRIGNON NORMAND L JR , GOLDSTEIN JASON , GRISWOLD-PRENNER IRENE
发明人： ANDERSON JOHN P , BANDUCCI KELLY , BASI GURIQBAL S , CHEREAU DAVID , CHILCOTE TAMIE J , FRIGNON NORMAND L JR , GOLDSTEIN JASON , GRISWOLD-PRENNER IRENE
IPC分类号： C12Q1/48 , C12Q1/68
CPC分类号： C12Q1/485 , C12N15/1137 , C12N2310/14 , G01N2500/04 , G01N2800/2835
摘要： Agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient are provided. Preferred agents include inhibitors of PLK2 kinase.
摘要翻译：提供了用于治疗患者脑中与路易体病（LBD）相关的疾病的药剂和方法。优选的药剂包括PLK2激酶的抑制剂。

3. 发明申请

WO2007092861A3 INHIBITORS SPECIFIC OF PRESENILIN-1 AND THEIR USES 审中-公开
标题翻译： PRESENILIN-1的特异性抑制剂及其用途
公开(公告)号：WO2007092861A3
公开(公告)日：2008-03-20
申请号：PCT/US2007061714
申请日：2007-02-06
申请人： ELAN PHARM INC , ZHAO BYRON B , YU MEI , BASI GURIQBAL S
发明人： ZHAO BYRON B , YU MEI , BASI GURIQBAL S
IPC分类号： C07K14/47 , A61K31/00 , A61K39/395 , A61P25/28 , C07K16/00 , C12Q1/00
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/4711
摘要： The invention provides methods for determining whether an agent piefeientially inhibits Presenilin-1-compiised ?-secretase relative to Presenilin-2-comprised ?-secretase. The invention also piovides agents that pieferentially inhibit Presenilin-1-comprised y- secietase lelative to Presenilin-2-comprised ?-sectetase, pharmaceutical compositions compiising such compounds, and methods of heating Alzheimer's disease using such compounds. The invention also discloses that the N-terminal domain of presenilis 1 and -2 determines the difference in the production of Aß by PS1-comprised and PS2-comprised gamma secretases. This finding identified the structuial determinant for the observed difference in the production of Aß by PS1-comprised and PS2-comprised gamma secretases. Such structural deteiminant was not identified before This invention also provides a method foi deteimining whether an agent specifically binds the N terminus of PS1 The invention further provides for methods of treatment of Alzheimer's Disease by administration of an effective dose of an agent which specifically binds PSl, thereby inhibiting PS1 activity.
摘要翻译：本发明提供了用于确定试剂是否相对于早老素-2-包含的γ-分泌酶有效抑制早老素-1-合成的γ-分泌酶的方法。本发明还提供了将早老素-1-包含的β-半胱氨酸酶切割酶抑制成早老素-2-包含α-丝氨酸酶的药剂，以及使用这些化合物加热阿尔茨海默氏病的方法。本发明还公开了前提物1和-2的N末端结构域决定了由包含PS1和含PS2的γ分泌酶产生的Aβ的差异。该发现确定了由PS1包含的和包含PS2的γ分泌酶产生Aβ的观察差异的结构决定因素。本发明还提供了一种方法，用于确定药物是否特异性结合PS1的N末端。本发明还通过施用有效剂量的特异性结合PS1的药剂来提供治疗阿尔茨海默氏病的方法，从而抑制PS1活性。

4. 发明申请

WO2007092861A9 PREFERENTIAL INHIBITION OF PRESENILIN-1 审中-公开
标题翻译： PRESENILIN-1的优选抑制作用
公开(公告)号：WO2007092861A9
公开(公告)日：2007-10-11
申请号：PCT/US2007061714
申请日：2007-02-06
申请人： ELAN PHARM INC , ZHAO BYRON B , YU MEI , BASI GURIQBAL S
发明人： ZHAO BYRON B , YU MEI , BASI GURIQBAL S
CPC分类号： G01N33/5008 , A61K38/00 , C07K14/4711
摘要： The invention provides methods for determining whether an agent piefeientially inhibits Presenilin-1-compiised ?-secretase relative to Presenilin-2-comprised ?-secretase. The invention also piovides agents that pieferentially inhibit Presenilin-1-comprised y- secietase lelative to Presenilin-2-comprised ?-sectetase, pharmaceutical compositions compiising such compounds, and methods of heating Alzheimer's disease using such compounds. The invention also discloses that the N-terminal domain of presenilis 1 and -2 determines the difference in the production of Aß by PS1-comprised and PS2-comprised gamma secretases. This finding identified the structuial determinant for the observed difference in the production of Aß by PS1-comprised and PS2-comprised gamma secretases. Such structural deteiminant was not identified before This invention also provides a method foi deteimining whether an agent specifically binds the N terminus of PS1 The invention further provides for methods of treatment of Alzheimer's Disease by administration of an effective dose of an agent which specifically binds PSl , thereby inhibiting PS1 activity
摘要翻译：本发明提供了用于确定试剂是否相对于早老素-2-包含的γ-分泌酶有效抑制早老素-1-组成的γ-分泌酶的方法。本发明还提供了将早老素-1-包含的β-半胱氨酸酶切割酶抑制成早老素-2-包含α-丝氨酸酶的药剂，以及使用这些化合物加热阿尔茨海默氏病的方法。本发明还公开了前提物1和-2的N末端结构域决定了由包含PS1和含PS2的γ分泌酶产生的Aβ的差异。该发现确定了由PS1包含的和包含PS2的γ分泌酶产生Aβ的观察差异的结构决定因素。本发明还提供了一种方法，用于确定药物是否特异性结合PS1的N末端。本发明还通过施用有效剂量的特异性结合PS1的药剂来提供治疗阿尔茨海默氏病的方法，从而抑制PS1活性

5. 发明公开

EP1989330A4 ALPHA-SYNUCLEIN KINASE 审中-公开
标题翻译： ALPHA-SYNUKLEIN - 激酶
公开(公告)号：EP1989330A4
公开(公告)日：2009-10-21
申请号：EP07762749
申请日：2007-01-30
申请人： ELAN PHARM INC
发明人： CHILCOTE TAMIE J , BANDUCCI KELLY , FRIGON NORMAND L JR , BASI GURIQBAL S , ANDERSON JOHN P , GOLDSTEIN JASON , GRIWOLD-PRENNER IRENE , CHEREAU DAVID
IPC分类号： A61K39/00 , A61P43/00 , C12N15/113 , C12P21/04 , C12Q1/00 , C12Q1/20 , C12Q1/68
CPC分类号： C12Q1/6883 , C12N15/1137 , C12N15/86 , C12N2310/11 , C12N2310/14 , C12N2740/15043 , C12Q1/485 , C12Q2600/136 , C12Q2600/158 , C12Y207/11016 , C12Y207/11021 , G01N2500/04 , G01N2800/28

6. 发明专利

CA2641555A1 INHIBITORS SPECIFIC OF PRESENILIN-1 AND THEIR USES 未知
公开(公告)号：CA2641555A1
公开(公告)日：2007-08-16
申请号：CA2641555
申请日：2007-02-06
申请人： ELAN PHARM INC
发明人： ZHAO BYRON B , BASI GURIQBAL S , YU MEI
IPC分类号： C07K14/47 , A61K31/00 , A61K39/395 , A61P25/28 , C07K16/00 , C12Q1/00
摘要： The invention provides methods for determining whether an agent preferentially inhibits Presenilin-1-comprised gamma-secretase relative to Presenilin-2-comprised gamma-secretase. The invention also provides agents that preferentially inhibit Presenilin-1-comprised gamma-secretase relative to Presenilin-2-comprised gamma-secretase, pharmaceutical compositions comprising such compounds, and methods of treating Alzheimer's disease using such compounds. The invention also discloses that the N-terminal domain of presenilin-1 and -2 determines the difference in the production of Abeta by PS1-comprised and PS2-comprised gamma secretases. This finding identified the structural determinant for the observed difference in the production of Abeta by PS1-comprised and PS2-comprised gamma secretases. Such structural determinant was not identified before. This invention also provides a method for determining whether an agent specifically binds the N terminus of PS1. The invention further provides for methods of treatment of Alzheimer's Disease by administration of an effective dose of an agent which specifically binds PS1, thereby inhibiting PS1 activity.

7. 发明专利

CA2641219A1 ALPHA-SYNUCLEIN KINASE 未知
公开(公告)号：CA2641219A1
公开(公告)日：2007-08-09
申请号：CA2641219
申请日：2007-01-30
申请人： ELAN PHARM INC
发明人： ANDERSON JOHN P , CHILCOTE TAMIE J , BASI GURIQBAL S , CHEREAU DAVID , BANDUCCI KELLY , GRISWOLD-PRENNER IRENE , GOLDSTEIN JASON , FRIGON NORMAND L JR
IPC分类号： C12Q1/68 , C12N15/113
摘要： The invention provides agents and methods for treatment of diseases associat ed with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 and GRK6 kinases.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式