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1. 发明申请

WO2015184145A1 USE OF ERIBULIN AND POLY (ADP RIBOSE) POLYMERASE (PARP) INHIBITORS AS COMBINATION THERAPY FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：使用ERIBULIN和POLY（ADP RIBOSE）聚合酶（PARP）抑制剂作为治疗癌症的组合疗法
公开(公告)号：WO2015184145A1
公开(公告)日：2015-12-03
申请号：PCT/US2015/032990
申请日：2015-05-28
申请人： EISAI R&D MANAGEMENT CO., LTD. , COX, David , KREMER, Alton , MCGONIGLE, Sharon , WU, Jiayi
发明人： COX, David , KREMER, Alton , MCGONIGLE, Sharon , WU, Jiayi
IPC分类号： A01N43/58
CPC分类号： A61K31/357 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The invention features methods for treating cancer in a patient in need thereof by administering eribulin, in combination with one or more PARP inhibitors, and, optionally, a platinum-based antineoplastic drug, and kits therefor. The invention is based in part on the observation that combinations of eribulin mesylate, a PARP 10 inhibitor (e.g., E7449), and, optionally, a platinum-based antineoplastic drug (e.g., carboplatin), show improved (e.g., synergistic) antitumor effects. Therefore, the present invention features methods of preventing and treating cancer (e.g., homologous recombination (HR)-deficient cancer; see below) by the use of combinations of eribulin (e.g., eribulin mesylate) and one or more PARP inhibitors (e.g., E7449 or a pharmaceutically acceptable salt thereof (e.g., the tartrate salt), optionally in combination with a 15 platinum-based antineoplastic drug (e.g., carboplatin).
摘要翻译：本发明的特征在于在有需要的患者中治疗癌症的方法，其通过与一种或多种PARP抑制剂和任选的基于铂的抗肿瘤药物组合施用eribulin及其试剂盒。本发明部分基于以下观察结果：甲磺酸艾美林，PARP 10抑制剂（例如E7449）和任选的基于铂的抗肿瘤药物（例如卡铂）的组合显示出改善的（例如协同）抗肿瘤效果。因此，本发明的特征在于通过使用eribulin（例如，甲磺酸eribulin）和一种或多种PARP抑制剂（例如E7449）的组合来预防和治疗癌症（例如，同源重组（HR）缺陷性癌症;参见下文）或其药学上可接受的盐（例如，酒石酸盐），任选地与15种基于铂的抗肿瘤药物（例如卡铂）组合。

2. 发明授权

EP3148336B1 ERIBULIN AND POLY (ADP RIBOSE) POLYMERASE (PARP) INHIBITORS AS COMBINATION THERAPY FOR THE TREATMENT OF CANCER 有权
公开(公告)号：EP3148336B1
公开(公告)日：2019-10-02
申请号：EP15799685.1
申请日：2015-05-28
申请人： Eisai R&D Management Co., Ltd.
发明人： COX, David , KREMER, Alton , MCGONIGLE, Sharon , WU, Jiayi
IPC分类号： A61K31/357 , A61K31/519 , A61K31/555 , A01N43/58 , A61K45/06 , A61P35/00

3. 发明公开

EP3148336A1 USE OF ERIBULIN AND POLY (ADP RIBOSE) POLYMERASE (PARP) INHIBITORS AS COMBINATION THERAPY FOR THE TREATMENT OF CANCER 有权
标题翻译： ERIBULIN-和聚（ADP-核糖）聚合酶（PARP）抑制剂的作为组合疗法用于癌症治疗中的用途
公开(公告)号：EP3148336A1
公开(公告)日：2017-04-05
申请号：EP15799685.1
申请日：2015-05-28
申请人： Eisai R&D Management Co., Ltd.
发明人： COX, David , KREMER, Alton , MCGONIGLE, Sharon , WU, Jiayi
IPC分类号： A01N43/58
CPC分类号： A61K31/357 , A61K31/519 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： The invention features methods for treating cancer in a patient in need thereof by administering eribulin, in combination with one or more PARP inhibitors, and, optionally, a platinum-based antineoplastic drug, and kits therefor. The invention is based in part on the observation that combinations of eribulin mesylate, a PARP inhibitor (e.g., E7449), and, optionally, a platinum-based antineo-plastic drug (e.g., carboplatin), show improved (e.g., synergistic) antitumor effects. Therefore, the present invention features methods of preventing and treating cancer (e.g., homologous recombination (HR)-deficient cancer by the use of combinations of eribulin (e.g., eribulin mesylate) and one or more PARP inhibitors (e.g., E7449 or a pharmaceutically acceptable salt thereof (e.g., the tartrate salt), optionally in combination with a platinum-based antineoplastic drug (e.g., carboplatin).
摘要翻译：本发明的特征为在有需要的患者中治疗癌症的方法，其通过施用组合布林与一种或多种PARP抑制剂，和任选地，基于铂的抗肿瘤药物，和试剂盒为此。本发明是基于在所述观察部做日布林甲磺酸盐，PARP抑制剂（例如，E7449）的组合，和任选地，基于铂的antineo塑料药物（例如，卡铂）的抗肿瘤，表现出改进的（例如，协同）效果。因此，本发明的特征在于预防和治疗癌症（例如，同源重组（HR）缺陷癌症通过使用艾日布林的组合（例如，艾日布林甲磺酸盐）和一种或多种PARP抑制剂的方法（例如，E7449或药学上可接受的的盐（例如，酒石酸盐），任选与基于铂的抗肿瘤药物（例如，卡铂）组合。

4. 发明申请

WO2015040485A1 WHEEL BARROW WITH IMPROVED STRUCTURE FOR LOADING AND UNLOADING 审中-公开
标题翻译：具有改进的装载和卸载结构的车轮轨道
公开(公告)号：WO2015040485A1
公开(公告)日：2015-03-26
申请号：PCT/IB2014/002134
申请日：2014-09-17
申请人： COX, David
发明人： COX, David
IPC分类号： B62B1/18
CPC分类号： B62B1/24 , B62B1/20 , B62B5/0485 , B62B5/067
摘要： The invention disclosed relates to an improved structure for a wheel barrow to provide efficient loading and unloading. The additional method of loading that separates it from existing designs is the ability to load the wheel barrow tub at ground level and then raise the tub to the standard position while maintaining the base of the tub largely horizontal. The movement of the tub is made possible by a parallel linkage to the frame consisting of two arms on each side of the tub. Through geometrical constraints, the arms keep the tub substantially horizontal throughout the entire movement. The ability to remove or rotate the back panel of the tub allows the tub to be loaded at ground level without having to raise the load over the sides of the tub.
摘要翻译：所公开的发明涉及一种改进的轮式推土机结构，以提供有效的装载和卸载。将其与现有设计分开的附加加载方法是将手推车盆装载在地面水平上的能力，然后将浴缸升高到标准位置，同时将浴缸的底部保持在很大程度上水平。通过与由桶的每一侧上的两个臂构成的框架的平行连接，可以实现桶的移动。通过几何约束，臂在整个运动中保持桶基本上水平。移除或旋转洗手盆的后面板的能力允许桶被装载在地面水平，而不必提高桶的两侧的负荷。

5. 发明申请

WO2013022978A2 HAPTIC DIRECTIONAL FEEDBACK HANDLES FOR LOCATION DEVICES 审中-公开
标题翻译：定位设备的方向性反馈手柄
公开(公告)号：WO2013022978A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/050004
申请日：2012-08-08
申请人： OLSSON, Mark , NEWBY, Garrett , WARREN, Alexander , COX, David
发明人： OLSSON, Mark , NEWBY, Garrett , WARREN, Alexander , COX, David
IPC分类号： G01V3/12
CPC分类号： G08B6/00 , G01V3/081 , G01V3/12 , G01V3/165
摘要： Locating devices and systems providing haptic tactile feedback are disclosed. In one embodiment, a locator includes a haptic handle configured to provide directional signals through an operator's sense of touch to aid in locating and tracing a buried conductor or other object such as a pipe or cable.
摘要翻译：公开了提供触觉触觉反馈的定位设备和系统。在一个实施例中，定位器包括触觉手柄，该触觉手柄被配置成通过操作者的触觉提供定向信号以帮助定位和追踪掩埋导体或其他物体，例如管道或电缆。

6. 发明申请

WO2007064776A2 MARKERS FOR BREAST CANCER 审中-公开
标题翻译：乳腺癌标志物
公开(公告)号：WO2007064776A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/045812
申请日：2006-11-29
申请人： PERLEGEN SCIENCES, INC. , UNIVERSITY OF CAMBRIDGE , COX, David , BALLINGER, Dennis , PONDER, Bruce , EASTON, Doug
发明人： COX, David , BALLINGER, Dennis , PONDER, Bruce , EASTON, Doug
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/16
摘要： Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.
摘要翻译：提供多态性与乳腺癌的相关性。提供诊断，预后和治疗乳腺癌的方法。提供用于乳腺癌诊断，预后和治疗的系统和试剂盒。还描述了确定乳腺癌调节剂的方法。

7. 发明申请

WO2008149061A3 INTERNAL COMBUSTION ENGINES 审中-公开
公开(公告)号：WO2008149061A3
公开(公告)日：2008-12-11
申请号：PCT/GB2008/001798
申请日：2008-05-28
申请人： COX POWERTRAIN LTD , COX, David
发明人： COX, David
IPC分类号： F01B1/08 , F01B7/04 , F01B9/02 , F02B75/24 , F02B75/28 , F02B25/08 , F16H21/36 , F02B75/02 , F02B75/18 , F02F1/22 , F01B7/10 , F02F3/00
摘要： The invention provides a 2-stroke internal combustion engine comprising two opposed cylinders, each cylinder housing two opposed pistons and having at least one exhaust port and at least one intake port, and a crankshaft having asymmetrically arranged journals and scotch-yoke mechanisms for driving the journals from the pistons. The pistons in each cylinder operate to open its exhaust port or ports before its intake port or ports and to close its exhaust port or ports before its intake port or ports.

8. 发明申请

WO2007084108A2 BODY ARMOR 审中-公开
标题翻译：身体护具
公开(公告)号：WO2007084108A2
公开(公告)日：2007-07-26
申请号：PCT/US2005/046912
申请日：2005-12-23
申请人： VAN WINKLE, Christopher , COX, David
发明人： VAN WINKLE, Christopher , COX, David
IPC分类号： A41D13/00
CPC分类号： F41H1/02
摘要： A body armor accessory adds protection to unguarded areas of conventional body armor. The removable accessory comprises an axillary panel having a coverage area and is made of material that impedes the penetration of a foreign object. The accessory can be worn on either the left or right side of the wearer. The coverage area to the deltoid and flank areas of the wearer provided by the axillary panel is greater than that provided by the vest without the panel. A deltoid panel provides added protection to the deltoid area of the wearer.
摘要翻译：身体护甲附件为常规护甲的无保护区域增添保护。可移除附件包括具有覆盖区域的腋窝面板，并且由妨碍异物渗透的材料制成。附件可以穿在佩戴者的左侧或右侧。由腋窝板提供的穿戴者的三角肌和侧腹区域的覆盖区域大于没有面板的背心提供的覆盖区域。三角形面板为佩戴者的三角肌区域提供了额外的保护。

9. 发明申请

WO2006063332A2 MARKERS FOR METABOLIC SYNDROME OBESITY AND INSULIN RESISTANCE 审中-公开
标题翻译：代谢综合征和胰岛素抵抗的标记
公开(公告)号：WO2006063332A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044876
申请日：2005-12-09
申请人： PERLEGEN SCIENCES, INC. , COX, David , BALLINGER, Dennis , HOCKETT, Richard , KIRKWOOD, Sandra
发明人： COX, David , BALLINGER, Dennis , HOCKETT, Richard , KIRKWOOD, Sandra
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： Correlations between polymorphisms and metabolic syndrome, obesity, treatment-emergent weight gain and insulin resistance are provided. Methods of diagnosing and treating metabolic syndrome, obesity, treatment-emergent weight gain and insulin resistance are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, obesity, treatment-emergent weight gain and insulin resistance are provided.
摘要翻译：提供多态性与代谢综合征之间的相关性，肥胖症，治疗突发性体重增加和胰岛素抵抗。提供诊断和治疗代谢综合征，肥胖症，治疗突发性体重增加和胰岛素抵抗的方法。提供了用于诊断和治疗代谢综合征，肥胖症，治疗突发性体重增加和胰岛素抵抗的系统和试剂盒。

10. 发明申请

WO2005009225A2 TISSUE ADHESIVE SEALANT 审中-公开
标题翻译：组织胶粘剂
公开(公告)号：WO2005009225A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/023920
申请日：2004-07-23
申请人： COVALENT MEDICAL, INC. , LOWINGER, Johan , LOWINGER, Bruno , DELUSTRO, Frank , COX, David , BROWDIE, David, A.
发明人： LOWINGER, Johan , LOWINGER, Bruno , DELUSTRO, Frank , COX, David , BROWDIE, David, A.
IPC分类号： A61B
CPC分类号： A61L24/102 , A61L24/108
摘要： A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
摘要翻译：组织粘合剂密封剂包括溶液中的可交联蛋白质，当与包含醛和氨基酸的交联剂溶液组合时，所述交联剂溶液含有与醛交联反应的物质以形成密封。密封剂非常适合单独粘合组织或与贴片组合。醛和含氨基酸的物质之间的比例在醛部分上为20:1和1:1之间：氨基酸或肽亚单位摩尔。当蛋白质和交联剂以15:1至1:1的摩尔比存在时，形成特别强的密封。

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