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1. 发明申请

WO2003011223A2 IMMUNOMODULATORY COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫调节化合物及其使用方法
公开(公告)号：WO2003011223A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024258
申请日：2002-07-31
申请人： EISAI CO., LTD. , HAWKINS, Lynn, D. , ISHIZAKA, Sally, T. , LEWIS, Michael , MCGUINNESS, Pamela , ROSE, Jeffrey
发明人： HAWKINS, Lynn, D. , ISHIZAKA, Sally, T. , LEWIS, Michael , MCGUINNESS, Pamela , ROSE, Jeffrey
IPC分类号： A61K
CPC分类号： C07F9/10 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/65515
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.
摘要翻译：本发明涉及当与抗原（例如细菌和病毒疾病疫苗）共施用时起免疫佐剂作用的新型化合物，涉及新型佐剂制剂，其包含至少一种佐剂化合物本发明涉及包含抗原和至少一种本发明佐剂化合物的新型免疫刺激组合物，以及通过共同给予本发明化合物与动物所针对的抗原来免疫动物的方法被免疫。

2. 发明申请

WO2007011709A2 MANUALLY-ASSISTED AUTOMATED INDEXING OF IMAGES USING FACIAL RECOGNITION 审中-公开
标题翻译：手动自动识别使用人脸识别的图像索引
公开(公告)号：WO2007011709A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/027323
申请日：2006-07-12
申请人： YOUFINDER INTELLECTUAL PROPERTY LICENSING LIMITED LIABILITY COMPANY , GOLDBERG, David, A. , GRAY, Robert , ANGELL, Joe , ROSE, Jeffrey
发明人： GOLDBERG, David, A. , GRAY, Robert , ANGELL, Joe , ROSE, Jeffrey
IPC分类号： G06T7/20
CPC分类号： G06K9/033 , G06K9/00295
摘要： The present method relates to the manual assistance for the automated indexing of a collection of images using facial recognition. In a first automated indexing step, automated indexing of faces within a collection of images is performed, creating sets of faces each of which comprises faces that are determined by the automated process to be representative of the same person. In a second splitting step, sets are displayed to an operator, who determines whether there are false-positive associations within a set. If false-positive associations are found, the faces representing different people are manually split into different sets. In this way, there will be no false-positive associations within the collection of images. In a third merging step, sets that have some degree of similarity are presented to the operator, who determines whether the two sets comprise representations of the same person. If so, the two sets are manually merged, thereby eliminating false-negative errors. In this way, all of the faces in the image collection can be completely and accurately indexed.
摘要翻译：本方法涉及使用面部识别的图像集合的自动索引的手动辅助。在第一自动索引步骤中，执行图像集合内的面部的自动索引，创建一组面部，每个面部包括由自动化过程确定为代表相同人物的面部。在第二分割步骤中，集合被显示给运算符，运算符确定集合内是否存在假阳性关联。如果发现假阳性关联，则表示不同人员的面部手动分割成不同的集合。这样，图像集合中就不会有虚假的关联。在第三合并步骤中，将具有一定程度的相似性的集合呈现给运营商，运营商确定两组是否包括同一人的表示。如果是这样，这两套手动合并，从而消除假阴性错误。以这种方式，图像集合中的所有面都可以被完全和准确的编入索引。

3. 发明公开

EP1307466A2 IMMUNOLOGICAL ADJUVANT COMPOUNDS 有权
标题翻译：免疫佐剂CONNECTIONS
公开(公告)号：EP1307466A2
公开(公告)日：2003-05-07
申请号：EP01963334.6
申请日：2001-07-27
申请人： Eisai Co., Ltd.
发明人： HAWKINS, Lynn, D. , ISHIZAKA, Sally, T. , LEWIS, Michael , McGUINESS, Pamela , ROSE, Jeffrey
IPC分类号： C07F9/09 , A61K39/39 , A61P37/04 , C07F9/113
CPC分类号： C07F9/091 , A61K39/39 , A61K2039/55572 , C07F9/113
摘要： The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.

4. 发明公开

EP1147117A1 IMMUNOLOGICAL ADJUVANT COMPOUNDS 有权
标题翻译： CONNECTIONS免疫佐剂
公开(公告)号：EP1147117A1
公开(公告)日：2001-10-24
申请号：EP00907124.2
申请日：2000-02-01
申请人： Eisai Co., Ltd.
发明人： HAWKINS, Lynn, D. , ISHIZAKA, Sally, T. , LEWIS, Michael , MCGUINESS, Pamela , NAULT, Anneliese , ROSE, Jeffrey , ROSSIGNOL, Daniel, P.
IPC分类号： C07F9/10 , A61K39/39 , A61P37/04 , C07F9/09 , C07F9/655
CPC分类号： C07F9/65515 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/10
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.

5. 发明授权

EP1307466B1 IMMUNOLOGICAL ADJUVANT COMPOUNDS 有权
标题翻译：免疫佐剂CONNECTIONS
公开(公告)号：EP1307466B1
公开(公告)日：2005-11-16
申请号：EP01963334.6
申请日：2001-07-27
申请人： Eisai Co., Ltd.
发明人： HAWKINS, Lynn, D. , ISHIZAKA, Sally, T. , LEWIS, Michael , McGUINESS, Pamela , ROSE, Jeffrey
IPC分类号： C07F9/09 , A61K39/39 , A61P37/04 , C07F9/113
CPC分类号： C07F9/091 , A61K39/39 , A61K2039/55572 , C07F9/113
摘要： The present invention provides novel compounds that function as immunological adjuvants when co-administered with antigens, including, antigens used as vaccines for any disease or condition amenable to vaccination. The invention also provides adjuvant formulations comprising the novel compounds of the invention and methods for immunizing humans and non-human animals.

6. 发明授权

EP1147117B1 IMMUNOLOGICAL ADJUVANT COMPOUNDS 有权
标题翻译： CONNECTIONS免疫佐剂
公开(公告)号：EP1147117B1
公开(公告)日：2004-06-16
申请号：EP00907124.2
申请日：2000-02-01
申请人： Eisai Co., Ltd.
发明人： HAWKINS, Lynn, D. , ISHIZAKA, Sally, T. , LEWIS, Michael , MCGUINESS, Pamela , NAULT, Anneliese , ROSE, Jeffrey , ROSSIGNOL, Daniel, P.
IPC分类号： C07F9/10 , A61K39/39 , A61P37/04 , C07F9/09 , C07F9/655
CPC分类号： C07F9/65515 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/10
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.

7. 发明公开

EP1420825A2 IMMUNOMODULATORY COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫调节化合物及其用途
公开(公告)号：EP1420825A2
公开(公告)日：2004-05-26
申请号：EP02768378.8
申请日：2002-07-31
申请人： Eisai Co., Ltd.
发明人： HAWKINS, Lynn, D. , ISHIZAKA, Sally, T. , LEWIS, Michael , MCGUINNESS, Pamela , ROSE, Jeffrey
IPC分类号： A61K45/00 , A61K39/295 , A61K39/00 , C07C261/00
CPC分类号： C07F9/10 , A61K39/39 , A61K2039/55511 , A61K2039/55555 , C07F9/091 , C07F9/65515
摘要： The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of the invention, to novel immunostimulatory compositions which comprise an antigen and at least one of the adjuvant compounds of the invention, and to methods for the immunization of an animal by co-administration of a compound of the invention with an antigen against which the animal is to be immunized.

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