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1. 发明申请

WO9942087A3 CONTROLLED RELEASE POTASSIUM CHLORIDE PELLET BASED PHARMACEUTICAL COMPOSITIONS HAVING A HIGH ACTIVE INGREDIENT CONTENT 审中-公开
标题翻译：基于控制释放氯化钾颗粒的具有高活性成分含量的药物组合物
公开(公告)号：WO9942087A3
公开(公告)日：1999-11-25
申请号：PCT/HU9900013
申请日：1999-02-19
申请人： EGYT GYOGYSZERVEGYESZETI GYAR , NAGY TIBOR , PATAKI KAROLY , GUENTHER GABOR , FEKETE PAL , FARAGO GABOR , LADY BLANKA
发明人： NAGY TIBOR , PATAKI KAROLY , GUENTHER GABOR , FEKETE PAL , FARAGO GABOR , LADY BLANKA
IPC分类号： A61K9/20 , A61K9/50 , A61K9/52 , A61K33/08 , A61K33/14 , A61K9/16 , A61K9/26 , A61K9/48
CPC分类号： A61K33/08 , A61K9/2081 , A61K9/5026 , A61K9/5084
摘要： The invention relates to controlled release multi-dosage pharmaceutical composition in solid oral form, preferably in the form of tablets or hard gelatine capsules and having a potassium chloride content of 500-1000 mg per dosage unit characterized by a content of at least 70 % by weight of potassium chloride, in the form of coated or partially uncoated pellets. The tablets or hard gelatine capsules according to the present invention are comprising pellets which contain at least 70 % by weight of potassium chloride, 10-25 % by weight of microcrystalline cellulose, 0.1-0.5 % by weight of an anti-adhesion agent and 0.1-5.0 % by weight of a hydrophobizing agent; a coating layer applied onto said pellets comprising 3-10 % by weight of an ethyl acrylate/methyl methacrylate copolymer and/or an ammonium methacrylate copolymer, a hydrophobizing agent, talc and optionally a dye; and optionally potassium chloride particles and further auxiliary agents applied onto said layer.
摘要翻译：本发明涉及固体口服形式的控释多剂量药物组合物，优选片剂或硬明胶胶囊的形式，并且每个剂量单位的氯化钾含量为500-1000mg，其含量至少为70％重量的氯化钾，呈涂层或部分未涂覆的颗粒的形式。根据本发明的片剂或硬明胶胶囊包含含有至少70重量％氯化钾，10-25重量％微晶纤维素，0.1-0.5重量％抗粘连剂和0.1重量％ -5.0重量％的疏水化剂; 涂覆在所述颗粒上的涂层，其包含3-10重量％的丙烯酸乙酯/甲基丙烯酸甲酯共聚物和/或甲基丙烯酸铵共聚物，疏水化剂，滑石和任选的染料; 和任选的氯化钾颗粒和另外的助剂施加在所述层上。

2. 发明申请

WO2005002553A3 FLUCONAZOLE CAPSULES WITH IMPROVED RELEASE 审中-公开
标题翻译：具有改善释放的氟康唑胶囊
公开(公告)号：WO2005002553A3
公开(公告)日：2005-03-24
申请号：PCT/HU2004000071
申请日：2004-06-30
申请人： EGYT GYOGYSZERVEGYESZETI GYAR , FEKETE PAL , VIRGULA JUDIT , FURDYGA EVA , LEVENTISZNE HUSZAR MAGDOLNA , KLEBOVICH IMRE , BALOGHNE NEMES KATALIN
发明人： FEKETE PAL , VIRGULA JUDIT , FURDYGA EVA , LEVENTISZNE HUSZAR MAGDOLNA , KLEBOVICH IMRE , BALOGHNE NEMES KATALIN
IPC分类号： A61K9/48 , A61K9/50 , A61K31/4196 , A61K9/16
CPC分类号： A61K31/4196 , A61K9/4858 , A61K9/4866 , A61K9/5015
摘要： The object of the invention is to provide fluconazole containing capsules with improved active ingredient release. The in vitro dissolution as well as in vivo absorption of the fluconazole capsules according to the invention is faster and more consistent than those of commercial compositions containing fluconazole. The invention is based on the fact that granulation of fluconazole particles with an agent capable to provide hydrophilic surface, e.g. lactose, to said particles results in fast an consistent release of the active ingredient. In this way, capsules according to the invention are suitable to provide enhanced absorption of said active ingredient.
摘要翻译：本发明的目的是提供具有改善的活性成分释放的含氟康唑的胶囊。根据本发明的氟康唑胶囊的体外溶出以及体内吸收比含有氟康唑的商业组合物更快且更一致。本发明是基于以下事实：氟康唑颗粒与能够提供亲水表面的试剂例如乳糖对所述颗粒导致活性成分的快速释放。以这种方式，根据本发明的胶囊适合于提供所述活性成分的增强的吸收。

3. 发明申请

WO2005051348A3 ENTERIC-COATED TABLETS OF PANTOPRAZOLE 审中-公开
标题翻译：潘多卡因的包装薄片
公开(公告)号：WO2005051348A3
公开(公告)日：2006-04-27
申请号：PCT/HU2004000111
申请日：2004-11-24
申请人： EGYT GYOGYSZERVEGYESZETI GYAR , FEKETE PAL , SZLAVYNE SZELL ZSUZSA , BURESNE PAPP CECILIA , FURDYGA EVA
发明人： FEKETE PAL , SZLAVYNE SZELL ZSUZSA , BURESNE PAPP CECILIA , FURDYGA EVA
IPC分类号： A61K9/20 , A61K9/28 , A61K9/50 , A61K31/44
CPC分类号： A61K9/2886 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/5078
摘要： The invention relates to enteric-coated tablets containing pantoprazole as active ingredient and a process for the preparation thereof. The tablets according to the invention comprise a.) a core consisting of 20-50% by weight (related to the weight of the tablet core) of the active ingredient, spray-dried or granulated mannitol having an average particle size between 100 µm and 500 µm, an alkalizing agent, a disintegrant and a lubricant conventionally applied in the pharmaceutical industry; b.) a water-soluble separating film coating; c.) an enterosolvent film coating insoluble in gastric juices; and d.) an optional water-soluble protecting film coating, and show increased stability during storage.
摘要翻译：本发明涉及含泮托拉唑作为活性成分的肠溶片剂及其制备方法。根据本发明的片剂包含a。）由活性成分的20-50重量％（与片芯的重量相关），喷雾干燥的或颗粒状的甘露醇组成的核心，其平均粒径在100μm和 500μm，碱性化剂，崩解剂和常规用于制药工业的润滑剂; b。）水溶性分离膜涂层; c。）不溶于胃液的肠溶胶膜; 和d。）任选的水溶性保护膜涂层，并且在储存期间显示出增加的稳定性。

4. 发明专利

JPH07277957A NEW DIFFUSION-PERMEATION CONTROLLING DRUG-RELEASABLE PHARMACEUTICAL COMPOSITION AND ITS PREPARATION 失效
公开(公告)号：JPH07277957A
公开(公告)日：1995-10-24
申请号：JP30673794
申请日：1994-12-09
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： FEKETE PAL , KIRALYNE IGNACZ MARIA , SIPOS GABOR , DRABANT SANDOR , BARCZAY ERZSEBET , JAMBOR ISTVANNE , UJFALUSSY GYOERGY , GORA LASZLONE , KLEBOVICZ IMRE , KISS ANDRASNE , KRISZTIAN MARIA , MANDI ATTILA
IPC分类号： A61K9/36 , A61J3/10 , A61K9/00 , A61K9/22 , A61K9/32 , A61K47/34
摘要： PURPOSE: To obtain a diffusion-osmotic controlled drug-release pharmaceutical composition by coating a core layer, containing an active agent, with a specific coating material, making a bore on the coated layer to release the active agent. CONSTITUTION: This composition contains one-layer tablet core including a therapeutically active agent and a hydrophilic polymer (for example; hydroxypropylmethylcellulose), coated with 3-25 mg/cm amount of ammoniummethylmethacrylate copolymer. If desired, a two-layer tablet core including active agent and hydrophilic polymer in the first layer thereof and a hydrophilic polymer in the second layer thereof is prepared. The composition contains at least one bore on the part of coated layer in contact with the core or core layer containing the active agent and, if desired, contains one or more bore(s) in the part thereof in contact with the second layer containing the hydrophilic polymer. The active agent is released with aqueous dispersion of the polymer or the solution by the extruding pressure, partly through the wall of the coated layer, or the bore made on the coated layer.

5. 发明专利

FR2559389A1 PROCEDE POUR LA PREPARATION DE COMPOSITIONS PHARMACEUTIQUES A LIBERATION SOUTENUE, AYANT UNE FORTE TENEUR EN INGREDIENT ACTIF 未知
公开(公告)号：FR2559389A1
公开(公告)日：1985-08-16
申请号：FR8402050
申请日：1984-02-10
申请人： EGYT GYOGYSZERVEGYESZETI GYAR , EGYT GYOGYSZERVEGYESZETI GYAR
发明人： TOTH ZOLTAN , FEKETE PAL , PAL FEKETE TIBOR KOVACS DENES BEZZEGH ILONA BOR NEE BAUMGARTNER ZOLTAN TOTH KATALIN ZUKOVICS NEE SUM , KOVACS TIBOR , BEZZEGH DENES , BOR ILONA , BAUMGARTNER NEE , ZUKOVICS KATALIN , SUMEG NEE , TAMAS EVA
IPC分类号： A61K9/20 , A61K9/22 , A61K9/00 , A61K9/50 , A61K9/52
摘要： LA PRESENTE INVENTION EST RELATIVE A UN PROCEDE POUR LA PREPARATION DE COMPOSITIONS PHARMACEUTIQUES A LIBERATION SOUTENUE, AYANT UNE FORTE TENEUR EN INGREDIENT ACTIF. LE PROCEDE SE CARACTERISE EN CE QU'IL COMPREND L'ENDUCTION DE PARTICULES D'INGREDIENTS ACTIFS AVEC UN POLYMERE INSOLUBLE DANS L'EAU, PUIS LE MELANGE DE CRISTAUX ENDUITS AVEC UN AGENT DE DESAGREGATION CAPABLE DE GONFLER EN MILIEU AQUEUX ET LA COMPRESSION DU MELANGE EN COMPRIMES. APPLICATION: INDUSTRIE PHARMACEUTIQUE.

6. 发明专利

UA83094C2 未知
公开(公告)号：UA83094C2
公开(公告)日：2008-06-10
申请号：UAA200607053
申请日：2004-11-24
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： FEKETE PAL , FEIKUS SYLVIA , SLAVINE SELL ZHUZHA
IPC分类号： A61K31/343 , A61K9/20 , A61K47/26 , A61K47/38 , A61P25/24

7. 发明专利

EA009695B1 ГРАНУЛЫ, СОДЕРЖАЩИЕ ГИДРОХЛОРИД ВЕНЛАФАКСИНА 未知
公开(公告)号：EA009695B1
公开(公告)日：2008-02-28
申请号：EA200600675
申请日：2004-10-08
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： FEKETE PAL , KORBELY TIBOR , BPZSO AGNES , MORICZ ESZTER
IPC分类号： A61K31/137 , A61K9/16 , A61K47/02 , A61K47/38
摘要： Изобретениеотноситсяк гранулам, содержащимгидрохлоридвенлафаксина, испособуихприготовления. Гранулыв соответствиис изобретениемимеютформу, близкуюк сферической, ивключаютфармацевтическиактивныйгидрохлоридвенлафаксинав количестве, максимум, 80 мас.%, крометого, от 10 до 60 мас.% хлориданатрияи/илихлоридакалия, от 10 до 60 мас.% микрокристаллическойцеллюлозыи возможнодругихфармацевтическиприемлемыхэксципиентови/илидобавок, способствующихгрануляции. Указанныегранулыособенноподходятдляпокрытияслоем, обеспечивающимконтролируемоевысвобождениеактивногоингредиента.

8. 发明专利

EA009681B1 ТАБЛЕТКА ДЕРАМЦИКЛАНФУМАРАТА И СПОСОБ ЕЁ ПРИГОТОВЛЕНИЯ 未知
公开(公告)号：EA009681B1
公开(公告)日：2008-02-28
申请号：EA200501883
申请日：2004-06-03
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： FEKETE PAL , MAROSHELYI LASZLONE , ZSIGMOND ZSOLT , GORA LASZLONE , LEVENTISZNE HUSZAR MAGDOLNA , JAMBOR ISTVANNE , TARI JOZSEF
IPC分类号： A61K31/13 , A61K9/20 , A61K31/135 , A61P25/22 , C07C217/12
摘要： Изобретениеотноситсяк таблеткам, содержащимдерамцикланфумаратформулы (I), содержащим (относительнообщеймассы) болеечем 50 мас.% дерамцикланфумарата, 5-20 мас.% связующеговещества, 5-20 мас.% микрокристаллическойцеллюлозы, имеющейсреднийразмерчастицменьше 30 мкм, 1-10 мас.% разрыхлителя, 0,5-4 мас.% смазывающеговещества, 0,5-4 мас.% антиадгезионноговеществаи 0-30 мас.% наполнителя. Дерамцикланфумаратявляетсяизвестныманксиолитическимактивнымкомпонентом. Такжеизобретениеотноситсяк способуприготовленияуказанныхтаблеток, включающемугрануляциюдерамцикланфумаратас микрокристаллическойцеллюлозой, имеющейсреднийразмерчастицменьше 30 мкм, суспендированнойв растворесвязующеговещества; гомогенизациюполученныхгранулс разрыхлителем, смазывающимвеществом, антиадгезионнымвеществоми наполнителеми послеэтогопрессованиеполученнойсмесив таблетки, причемдолииспользуемыхв способевеществтакие, какуказанновышедлясоответствующихингредиентовтаблетки.

9. 发明专利

DE60213464D1 未知
公开(公告)号：DE60213464D1
公开(公告)日：2006-09-07
申请号：DE60213464
申请日：2002-12-17
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： FEKETE PAL , KIRALYNE IGNACZ MARIA , TOEMPE PETER , GORA LASZLONE , SZENTGROTI PALNE , LEVENTISZNE HUSZAR MAGDOLNA , THUROCZI PALNE , LONKAINE MAGYAR OLGA
IPC分类号： A61K31/4422 , A61K9/20

10. 发明专利

DE60212464D1 未知
公开(公告)号：DE60212464D1
公开(公告)日：2006-07-27
申请号：DE60212464
申请日：2002-04-29
申请人： EGYT GYOGYSZERVEGYESZETI GYAR
发明人： FEKETE PAL , KIRALYNE IGNACZ MARIA , SZLAVYNE SZELL ZSUZSA , GORA LASZLONE , PALFI ZOLTANNE , JAMBOR ISTVANNE
IPC分类号： A61K9/16 , A61K9/20
摘要： The invention refers to a process for the preparation of tablets that can be well compressed and have good mechanical strength from pharmaceutically active ingredient(s) having unfavourable tabletting properties. In the process of the invention a granulating liquid is used which is a suspension of 5-30% of microcrystalline cellulose-90% of which have a particle size that is lower than 50 Sg(m)m, and the amount of the microcrystalline cellulose refers to the final tablet mass in water and/or ethanol and/or isopropanol, and said suspension may contain also a part of the ingredients of the granules in dissolved form.

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