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1. 发明申请

WO2007089431A1 SYSTEM, APPARATUS, AND METHOD FOR FASTENING TISSUE 审中-公开
标题翻译：系统，装置和用于紧固组织的方法
公开(公告)号：WO2007089431A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/001273
申请日：2007-01-19
申请人： EDWARDS LIFESCIENCES CORPORATION , TIEU, Tai , BENJAMIN, Joshua , ZARBATANY, David
发明人： TIEU, Tai , BENJAMIN, Joshua , ZARBATANY, David
IPC分类号： A61B17/04 , A61B17/00
CPC分类号： A61B17/0487 , A61B17/0467 , A61B17/0469 , A61B2017/00243 , A61B2017/00575 , A61B2017/00867 , A61B2017/0451 , A61B2017/0454 , A61B2017/0464 , A61B2017/0488 , A61B2017/0496 , Y10T24/3916
摘要： A clip (20) for securing suture includes a generally tubular body (44), with one or more tabs (54) cut from the wall of the generally tubular body. The tab in an open configuration has the tabs in general alignment with the wall, and the tab in a closed configuration has the tabs bent or otherwise positioned to extend into and at least partially obstruct the inner lumen (48). The tab may be formed as a generally horse-shoe shaped cut out, and may include a generally elliptical portion having a width and length. The tab may have a width generally the same size as the diameter of the inner lumen. The clip can be formed from memory material such as nitinol, and the clip may be biased toward its closed configuration.
摘要翻译：用于固定缝合线的夹子（20）包括大致管状的本体（44），其中一个或多个突片（54）从大体管状体的壁切割。处于打开构型的突片具有与壁大致对准的突出部，并且处于闭合构造的突片具有弯曲或以其他方式定位成伸出并至少部分地阻碍内腔（48）的突舌。突片可以形成为大致为马鞋形切口，并且可以包括具有宽度和长度的大致椭圆形部分。突片的宽度通常与内腔直径相同。夹子可以由诸如镍钛诺的记忆材料形成，并且夹子可以朝向其闭合构型偏置。

2. 发明申请

WO2004082523A3 MITRAL VALVE REPAIR SYSTEM 审中-公开
公开(公告)号：WO2004082523A3
公开(公告)日：2004-09-30
申请号：PCT/US2004/007383
申请日：2004-03-11
申请人： EDWARDS LIFESCIENCES CORPORATION , ZARBATANY, David , TIEU, Tai , PUNG, Ponaka , VIDELL, Joseph , PERRY, Kenneth, E. , KRUMME, John , BUCHBINDER, Maurice
发明人： ZARBATANY, David , TIEU, Tai , PUNG, Ponaka , VIDELL, Joseph , PERRY, Kenneth, E. , KRUMME, John , BUCHBINDER, Maurice
IPC分类号： A61B17/068
摘要： A mitral valve repair system comprises a guide catheter having a proximal end, a distal end, and at least one internal lumen formed therein, a therapy catheter capable of applying a suture to the tissue, and a fastener catheter capable of attaching a fastener to the suture. The therapy catheter and the fastener catheter are capable of traversing the internal lumen of the guide catheter. The mitral valve is repaired by advancing the catheter through the guide catheter, stabilizing a first leaflet with the therapy catheter, deploying a first suture into the stabilized first leaflet, disengaging the first leaflet from the therapy catheter while leaving the first suture attached thereto, stabilizing a second leaflet with the therapy catheter, deploying a second suture into the second leaflet, disengaging the second leaflet from the therapy catheter while leaving the second suture attached thereto, and joining the first and second leaflets by reducing the distance between the first and second sutures.

3. 发明申请

WO2007005579A1 SYSTEM, APPARATUS, AND METHOD FOR REPAIRING SEPTAL DEFECTS 审中-公开
标题翻译：系统，装置和修复缺陷缺陷的方法
公开(公告)号：WO2007005579A1
公开(公告)日：2007-01-11
申请号：PCT/US2006/025531
申请日：2006-06-28
申请人： EDWARDS LIFESCIENCES CORPORATION , ZARBATANY, David , TIEU, Tai
发明人： ZARBATANY, David , TIEU, Tai
IPC分类号： A61M1/00 , A61B17/00 , A61B17/04
CPC分类号： A61B17/0482 , A61B17/0057 , A61B17/0467 , A61B17/0487 , A61B2017/00243 , A61B2017/00575 , A61B2017/0445 , A61B2017/0451 , A61B2017/0464 , A61B2017/0472 , A61B2017/0488 , A61B2017/0496 , A61B2017/306
摘要： An apparatus and method for repairing septal defects includes advancing a catheter to the site of the defect, grasping opposing edges of the defect, passing one or more suture lines through the opposing edges, and tightening the suture lines. The catheter can include one or more vacuum ports, with the vacuum ports being sized and configured to grasp opposing edges of the defect when vacuum is applied thereto. The vacuum ports may be positioned longitudinally distant from each other along the catheter, and may also be on different sides of the catheter. The vacuum ports may have vacuum applied via independent control. The catheter can also include suture deploying structure that prevents the suture line from becoming entangled in the catheter.
摘要翻译：用于修复间隔缺损的装置和方法包括将导管推进到缺损部位，抓住缺损的相对边缘，使一条或多条缝合线穿过相对边缘，并收紧缝合线。导管可以包括一个或多个真空端口，其中真空端口的尺寸和构造被设计成当向其施加真空时抓住缺陷的相对边缘。真空端口可以沿着导管相对于彼此纵向定位，并且也可以在导管的不同侧面上。真空端口可以通过独立控制来施加真空。导管还可以包括防止缝合线缠结在导管中的缝线展开结构。

4. 发明申请

WO2005082288A1 METHODS AND DEVICES FOR ENDOVASCULAR MITRAL VALVE CORRECTION FROM THE LEFT CORONARY SINUS 审中-公开
标题翻译：来自左冠状动脉内膜血管内膜修复的方法和装置
公开(公告)号：WO2005082288A1
公开(公告)日：2005-09-09
申请号：PCT/US2004/027692
申请日：2004-08-25
申请人： EDWARDS LIFESCIENCES CORPORATION , ZARBATANY, David , SCHRECK, Stefan
发明人： ZARBATANY, David , SCHRECK, Stefan
IPC分类号： A61F2/24
CPC分类号： A61F2/2451 , A61M25/1011 , A61M2025/1013
摘要： Apparatuses and methods for reshaping a mitral valve annulus to correct for mitral regur gitation. The apparatuses include one or more balloons in a balloon assembly that are delivered in a deflated state and inflated within the left coronary sinus adjacent mitral annulus. The balloon or balloon assembly may be linear and have one or both en ds more flexible than a mid section, or may be curvilinear. A single balloon having differently constructed end sections may be used. Alternatively, a balloon assembly may include two concentrically arranged balloons with an inner, shorter balloon and an outer, longer balloon. The outer balloon defines the ends of the balloon assembly and is inflated to a lesser pressure than the inner balloon so as to result in the flexible ends. Two or more balloons in series may be mounted on a catheter with gaps therebetween to permit relative flexing or bending. The inflation fluid may be saline or other biocompatible inflation fluid, or may be a fluid that can be subsequently hardened by curing or cross -linking. In either case, a one -way valve is typically utiliz ed to prevent deflation of the balloon once implanted, and structure for decoupling the delivery catheter from the balloon or balloon assembly may be included.
摘要翻译：用于重塑二尖瓣环以纠正二尖瓣反复的装置和方法。这些装置包括气囊组件中的一个或多个气囊，其以放气状态递送并在邻近二尖瓣环的左冠状窦内膨胀。球囊或球囊组件可以是线性的，并且具有比中间部分更柔性的一个或两个，或者可以是曲线的。可以使用具有不同构造的端部的单个气囊。或者，球囊组件可以包括两个同心布置的气球，其具有内部，较短气囊和外部较长气囊。外球囊限定球囊组件的端部并且被充气到比内球囊更小的压力，从而导致柔性端部。串联的两个或更多个气囊可以安装在具有间隙的导管上，以允许相对的弯曲或弯曲。充气流体可以是盐水或其他生物相容的充气流体，或者可以是可以随后通过固化或交联而硬化的流体。在任一种情况下，通常使用单向阀来防止一旦植入后气囊的放气，并且可以包括用于将输送导管与球囊或球囊组件分离的结构。

5. 发明公开

EP1718249A1 METHODS AND DEVICES FOR ENDOVASCULAR MITRAL VALVE CORRECTION FROM THE LEFT CORONARY SINUS 有权
标题翻译：血管内MITRALKLAPPENKORREKTUR设备免受左冠状动脉窦
公开(公告)号：EP1718249A1
公开(公告)日：2006-11-08
申请号：EP04782223.4
申请日：2004-08-25
申请人： Edwards Lifesciences Corporation , Zarbatany, David , Schreck, Stefan
发明人： ZARBATANY, David , SCHRECK, Stefan
IPC分类号： A61F2/24 , A61M25/10
CPC分类号： A61F2/2451 , A61M25/1011 , A61M2025/1013
摘要： Apparatuses and methods for reshaping a mitral valve annulus to correct for mitral regur gitation. The apparatuses include one or more balloons in a balloon assembly that are delivered in a deflated state and inflated within the left coronary sinus adjacent mitral annulus. The balloon or balloon assembly may be linear and have one or both en ds more flexible than a mid section, or may be curvilinear. A single balloon having differently constructed end sections may be used. Alternatively, a balloon assembly may include two concentrically arranged balloons with an inner, shorter balloon and an outer, longer balloon. The outer balloon defines the ends of the balloon assembly and is inflated to a lesser pressure than the inner balloon so as to result in the flexible ends. Two or more balloons in series may be mounted on a catheter with gaps therebetween to permit relative flexing or bending. The inflation fluid may be saline or other biocompatible inflation fluid, or may be a fluid that can be subsequently hardened by curing or cross -linking. In either case, a one -way valve is typically utiliz ed to prevent deflation of the balloon once implanted, and structure for decoupling the delivery catheter from the balloon or balloon assembly may be included.

6. 发明申请

WO2012057912A1 CRYO-ABLATION DEVICE WITH DEPLOYABLE INJECTION TUBE 审中-公开
标题翻译：具有可注射管的CRYO-ABLATION DEVICE
公开(公告)号：WO2012057912A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/049701
申请日：2011-08-30
申请人： MEDTRONIC ABLATION FRONTIERS LLC , ASCONEGUY, Alexander J. , ZARBATANY, David
发明人： ASCONEGUY, Alexander J. , ZARBATANY, David
IPC分类号： A61B18/02 , A61M25/10
CPC分类号： A61B18/02 , A61B2017/00243 , A61B2017/00867 , A61B2018/0022 , A61B2018/00357 , A61B2018/0212 , A61B2018/1861 , A61M25/104 , A61M2025/0004 , A61M2025/0175
摘要： A medical system is provided, including a catheter body having a proximal portion and a distal portion; a shaft slidably disposed within a portion of the catheter body, the shaft defining a distal tip; a fluid injection tube coupled to the distal portion of the catheter body and the distal tip of the shaft, the fluid injection tube being transitionable from a first geometric configuration to a second geometric configuration; a membrane coupled to the shaft and enclosing at least a portion of the fluid injection tube therein; and a coolant source in fluid communication with the fluid injection tube. The first geometric configuration may be substantially linear, the second geometric configuration may be substantially helical, and the membrane may be tensioned across at least a portion of the fluid injection tube in the second geometric configuration.
摘要翻译：提供了一种医疗系统，包括具有近端部分和远端部分的导管主体; 可滑动地设置在所述导管主体的一部分内的轴，所述轴限定远端; 流体注入管，其耦合到所述导管主体的远端部分和所述轴的远侧末端，所述流体注入管可从第一几何构型转换到第二几何构型; 膜，其联接到所述轴并且包围所述流体注入管的至少一部分; 以及与流体注入管流体连通的冷却剂源。第一几何构型可以是基本上线性的，第二几何构型可以是基本上螺旋的，并且膜可以在第二几何构型中跨过流体注入管的至少一部分张紧。

7. 发明授权

EP1718249B1 DEVICES FOR ENDOVASCULAR MITRAL VALVE CORRECTION FROM THE LEFT CORONARY SINUS 有权
标题翻译：血管内MITRALKLAPPENKORREKTUR设备免受左冠状动脉窦
公开(公告)号：EP1718249B1
公开(公告)日：2011-04-27
申请号：EP04782223.4
申请日：2004-08-25
申请人： Edwards Lifesciences Corporation
发明人： ZARBATANY, David , SCHRECK, Stefan
IPC分类号： A61F2/24 , A61M25/10
CPC分类号： A61F2/2451 , A61M25/1011 , A61M2025/1013
摘要： Apparatuses and methods for reshaping a mitral valve annulus to correct for mitral regur gitation. The apparatuses include one or more balloons in a balloon assembly that are delivered in a deflated state and inflated within the left coronary sinus adjacent mitral annulus. The balloon or balloon assembly may be linear and have one or both en ds more flexible than a mid section, or may be curvilinear. A single balloon having differently constructed end sections may be used. Alternatively, a balloon assembly may include two concentrically arranged balloons with an inner, shorter balloon and an outer, longer balloon. The outer balloon defines the ends of the balloon assembly and is inflated to a lesser pressure than the inner balloon so as to result in the flexible ends. Two or more balloons in series may be mounted on a catheter with gaps therebetween to permit relative flexing or bending. The inflation fluid may be saline or other biocompatible inflation fluid, or may be a fluid that can be subsequently hardened by curing or cross -linking. In either case, a one -way valve is typically utiliz ed to prevent deflation of the balloon once implanted, and structure for decoupling the delivery catheter from the balloon or balloon assembly may be included.

8. 发明申请

WO2012109297A2 ATRIAL APPENDAGE OCCLUSION AND ARRHYTHMIA TREATMENT 审中-公开
标题翻译：心房附壁堵塞和心律失常治疗
公开(公告)号：WO2012109297A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024231
申请日：2012-02-08
申请人： ATRIAL INNOVATIONS, INC. , ZARBATANY, David , WERNETH, Randell, L.
发明人： ZARBATANY, David , WERNETH, Randell, L.
IPC分类号： A61F2/24 , A61F2/82 , A61P9/06
CPC分类号： A61N1/3756 , A61B17/0057 , A61B2017/00243 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615
摘要： Atrial appendage occlusion devices and arrhythmia treatment.
摘要翻译：心脏附件闭塞装置和心律失常治疗。

9. 发明申请

WO2012151048A2 COMPLIANT SLEEVES COUPLED WITH WIRE STRUCTURES FOR CRYOABLATION 审中-公开
标题翻译：合适的纱线与结扎线结合使用
公开(公告)号：WO2012151048A2
公开(公告)日：2012-11-08
申请号：PCT/US2012/033927
申请日：2012-04-17
申请人： MEDTRONIC CRYOCATH LP , MIHALIK, Teresa Ann , ZARBATANY, David , PATEL, Kaushik A. , ASCONEGUY, Alexander J. , LAY, Sitha , ROBISON, Karmi
发明人： MIHALIK, Teresa Ann , ZARBATANY, David , PATEL, Kaushik A. , ASCONEGUY, Alexander J. , LAY, Sitha , ROBISON, Karmi
IPC分类号： A61F7/12 , A61M25/10
CPC分类号： A61B18/02 , A61B18/1492 , A61B2017/00867 , A61B2018/0022 , A61B2018/00267 , A61B2018/00839 , A61B2018/00875 , A61B2018/00892 , A61B2018/0212 , A61B2090/065 , A61M25/1002 , A61M25/104 , A61M2025/1084
摘要： A medical system, including a catheter body, a mesh coupled to the catheter body; an expandable element enclosing the mesh, the expandable element made from a compliant natural rubber emulsion, such as Yulex® HA; and a cryogenic coolant source in fluid communication with the expandable element.
摘要翻译：医疗系统，包括导管主体，联接到导管主体的网; 包围网的可膨胀元件，由柔顺天然橡胶乳液（例如Yulex HA）制成的可膨胀元件; 以及与可膨胀元件流体连通的低温冷却剂源。

10. 发明申请

WO2007111972A2 ACTIVATION DEVICE FOR DYNAMIC RING MANIPULATION 审中-公开
标题翻译：用于动态环控制的激活装置
公开(公告)号：WO2007111972A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/007194
申请日：2007-03-23
申请人： MICARDIA CORPORATION , SHAOLIAN, Samuel , TRAN, Jason , MOADDEB, Shahram , BUCHBINDER, Maurice , ZARBATANY, David
发明人： SHAOLIAN, Samuel , TRAN, Jason , MOADDEB, Shahram , BUCHBINDER, Maurice , ZARBATANY, David
IPC分类号： A61F2/24 , A61B18/18
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2250/0001
摘要： An activation device for applying energy to an implanted annuloplasty ring is described. In some embodiments, the activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween. In some embodiments, the activation device further includes an inner elongate member having a inner elongate member distal end and a inner elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one energy-transfer element coupled to the adjustable spline.
摘要翻译：描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。在一些实施例中，激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔。在一些实施例中，激活装置还包括具有内部细长构件远端和内部细长构件近端的内部细长构件和其间的内腔，其中内部细长构件可滑动地插入穿过外部细长构件的内腔。在一些实施例中，激活装置还包括具有花键近端和花键远端的至少一个可调节花键，花键远端连接到内部管状构件远端，花键近端连接到外部管状构件远端，其中，当内部细长构件驻留在外部细长构件的内腔中时，可调节花键构造成随着内部管状构件远端朝向外部管状构件远端被拉近而弯曲。在一些实施例中，激活装置还包括耦合到可调节花键的至少一个能量传递元件。

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