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1. 发明申请

WO2019139643A1 NATIVE VALVE REPAIR DEVICES AND PROCEDURES 审中-公开
公开(公告)号：WO2019139643A1
公开(公告)日：2019-07-18
申请号：PCT/US2018/045985
申请日：2018-08-09
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： METCHIK, Asher, L. , TYLER, Gregory, Scott, II , WINSTON, Matthew, T. , DELGADO, Sergio , FRESCHAUF, Lauren, R. , DIXON, Eric, Robert , SIEGEL, Alexander, J.
IPC分类号： A61F2/24 , A61B17/34
CPC分类号： A61F2/246 , A61F2/2466 , A61F2220/0016 , A61F2220/0025 , A61F2230/0013 , A61F2230/0045
摘要： A system for implanting a repair device onto a native valve of a natural heart to repair the native valve of a patient during a non-open-heart procedure. The system includes a base assembly having a plurality of pivoting links, a pair of paddles attached to the base assembly, a pair of gripping members attached to the base assembly, and at least one coaptation or spacer element disposed between the pair of gripping members. Movement of the pivoting links of the base assembly causes the paddles to move between an open position and a closed position. The paddles and the gripping members are configured to attach to valve leaflets of the patient. The coaptation or spacer element is configured to fill at least a portion of a gap between the valve leaflets of the patient.

2. 发明申请

WO2016183485A1 HEART VALVE SEALING DEVICES AND DELIVERY DEVICES THEREFOR 审中-公开
标题翻译：心瓣密封装置及其输送装置
公开(公告)号：WO2016183485A1
公开(公告)日：2016-11-17
申请号：PCT/US2016/032462
申请日：2016-05-13
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： CHAU, Mark , TAYLOR, David, M. , SIEGEL, Alexander, J. , OLSON, Christopher, J. , DELGADO, Sergio , COOPER, Alexander, H. , FRESCHAUF, Lauren, R. , METCHIK, Asher, L. , WINSTON, Matthew, T. , HERNANDEZ, Cristobal, R. , KARAPETIAN, Emil , KHUU, Bao , DIXON, Eric
IPC分类号： A61F2/24
CPC分类号： A61F2/246 , A61F2/2454 , A61F2/2463 , A61F2/2466 , A61F2220/0016 , A61F2310/00023
摘要： In one representative embodiment, an implantable prosthetic device comprises a spacer body portion configured to be disposed between native leaflets of a heart, and an anchor portion configured to secure the native leaflets against the spacer body portion, wherein the prosthetic device is movable between a compressed configuration, in which the spacer body portion is radially compressed and is axially spaced relative to the anchor portion, and an expanded configuration, in which the spacer body portion expands radially outwardly relative to the compressed configuration and overlaps at least a portion of the anchor portion.
摘要翻译：在一个代表性的实施例中，可植入假体装置包括被配置为设置在心脏的天然传播单元之间的间隔体本体部分和被配置为将天然传单固定在间隔体主体部分上的锚定部分，其中假体装置可在压缩配置，其中间隔件主体部分被径向压缩并且相对于锚固部分轴向间隔开，并且膨胀构型，其中间隔件主体部分相对于压缩构造径向向外扩张并与锚定部分的至少一部分重叠。

3. 发明申请

WO2019060261A1 MULTI-DIRECTION STEERABLE HANDLES FOR STEERING CATHETERS 审中-公开
公开(公告)号：WO2019060261A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/051419
申请日：2018-09-18
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： KHUU, Bao , WINSTON, Matthew, T. , METCHIK, Asher, L. , DIXON, Eric, Robert
IPC分类号： A61B1/005 , A61B1/00 , A61M25/01
摘要： Disclosed herein are steerable-catheter control handles and catheter assemblies that include pull wires and direction and magnitude controls on the handle operable such that adjustment of the direction and magnitude controls adjusts a direction and degree of catheter flex, thereby to steer the catheter as an operator directs.

4. 发明申请

WO2017165229A1 CAM CONTROLLED MULTI-DIRECTION STEERABLE HANDLES 审中-公开
标题翻译： CAM控制多向可控手柄
公开(公告)号：WO2017165229A1
公开(公告)日：2017-09-28
申请号：PCT/US2017/023034
申请日：2017-03-17
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： KHUU, Bao , WINSTON, Matthew, T. , METCHIK, Asher, L. , DIXON, Eric, Robert
IPC分类号： A61M25/01
摘要： Disclosed herein are catheter control handles that include various cam-based mechanisms for controlling the circumferential angle and radial magnitude of flexion of an attached catheter. Control handles can comprise a housing defining a longitudinal axis extending in distal and proximal directions, a cam member that is movable axially relative to the housing and also movable rotationally about the longitudinal axis relative to the housing, at least one follower engaged with the cam member such that the at least one follower moves relative to the handle in response to the movement of the cam member, and pull wires that are coupled to the at least one follower and that extend distally out of the handle and into a steerable catheter. The at least one follower can comprise plural axial sliders, a gimbal mechanism, a ball and socket mechanism, or other mechanisms.
摘要翻译：本文公开了导管控制手柄，其包括用于控制附接导管的圆周角度和径向幅度的各种基于凸轮的机构。控制手柄可包括限定沿远侧和近侧方向延伸的纵向轴线的壳体，可相对于壳体轴向移动并且还可相对于壳体围绕纵向轴线旋转运动的凸轮构件，至少一个从动件与凸轮构件接合使得所述至少一个从动件响应于所述凸轮构件的移动而相对于所述手柄移动，以及牵拉线，所述牵拉线联接到所述至少一个从动件并且向远侧延伸出所述手柄并进入可操纵导管。所述至少一个从动件可以包括多个轴向滑动件，万向节机构，球窝机构或其他机构。

5. 发明申请

WO2012174383A2 HEART VALVE PROSTHESIS ANCHORING DEVICES AND METHODS 审中-公开
标题翻译：心脏瓣膜锚固装置和方法
公开(公告)号：WO2012174383A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042676
申请日：2012-06-15
申请人： EDWARDS LIFESCIENCES CORPORATION , KARAPETIAN, Emil , OKOS, Chris, J. , WINSTON, Matthew, T.
发明人： KARAPETIAN, Emil , OKOS, Chris, J. , WINSTON, Matthew, T.
CPC分类号： A61F2/2409 , A61F2/2448 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2250/0063
摘要： Apparatus and methods for securing heart valve repair or replacement prostheses in or near the heart. The apparatus and methods are particularly well suited for traditional surgery or minimally invasive surgery. The invention secures a heart valve repair or replacement prosthesis in place while lowering surgical exposure. The invention improves the ease of implantation because it reduces the number of surgical knots a clinician would normally tie in the limited space in and around the heart.
摘要翻译：用于在心脏内部或附近确保心脏瓣膜修复或更换假体的装置和方法。该装置和方法特别适用于传统手术或微创手术。本发明在降低手术暴露的同时确保心脏瓣膜修复或更换假体就位。本发明改善了植入的便利性，因为它减少了临床医生通常将心脏内和周围的有限空间结合的手术结的数量。

6. 发明申请

WO2019199421A1 MITRAL VALVE SPACER DEVICE 审中-公开
公开(公告)号：WO2019199421A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/023250
申请日：2019-03-20
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： FRANKLIN, Michael, D. , WINSTON, Matthew, T. , FRESCHAUF, Lauren, R. , DIXON, Eric, Robert , KOWN, Yoon, Hee
IPC分类号： A61F2/24
摘要： An implantable prosthetic spacer device can include an inflatable spacer having a plurality of inflatable members and a frame, the frame comprising one or more anchors and one or more clasps. The inflatable spacer can be configured to be disposed between native leaflets of a heart. The implantable prosthetic spacer can be disposed in a symmetrical or an asymmetrical configuration. The inflatable spacers can be inflatable between an uninflated and an inflated configuration.

7. 发明申请

WO2018209021A1 MITRAL VALVE SPACER DEVICE 审中-公开
公开(公告)号：WO2018209021A1
公开(公告)日：2018-11-15
申请号：PCT/US2018/031959
申请日：2018-05-10
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： MARR, Devin, H. , DELGADO, Sergio , DIXON, Eric, Robert , TAYLOR, David, M. , METCHIK, Asher, L. , WINSTON, Matthew, T. , STEARNS, Grant, Matthew , SOK, Sam , NGUYEN, Tam, Van , KWON, Rhayoung , WU, Victoria, Cheng-tan , WHITE, Amanda, Kristine, Anderson
IPC分类号： A61F2/24 , A61L27/06 , A61L27/50 , A61B17/34
摘要： An implantable prosthetic device can include a spacer member, a plurality of anchors, and a plurality of clasps. The spacer member can be configured to be disposed between native leaflets of a heart. The anchors can be coupled to the spacer member and configured to secure the native leaflets against the spacer member. The clasps can be coupled to a respective anchor and configured to secure the native leaflets to the anchors. The clasps can be independently movable between an open configuration and a closed configuration.

8. 发明申请

WO2018085812A1 APPARATUS FOR THE INTRODUCTION AND MANIPULATION OF MULTIPLE TELESCOPING CATHETERS 审中-公开
标题翻译：用于引导和操纵多根伸长导管的装置
公开(公告)号：WO2018085812A1
公开(公告)日：2018-05-11
申请号：PCT/US2017/060336
申请日：2017-11-07
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： WINSTON, Matthew, T. , OLSON, Christopher, J. , METCHIK, Asher, L. , TRAN, Tri, D. , SIEGEL, Alexander, J.
IPC分类号： A61M25/01 , A61M25/00 , A61F2/24
摘要： A delivery apparatus includes a steerable shaft having a proximal portion, a distal portion, and a pull-wire conduit that extends through the proximal and distal portions. A pull wire extends through the conduit and has a distal portion that is fixed to the shaft. An adjustment mechanism is connected to the proximal end portion of the pull wire and configured to increase and decrease tension in the pull wire to adjust the curvature of the shaft. The distal portion of the shaft has a steerable portion including one or more layers. A compression-resistance portion is incorporated into a layer of the steerable portion, and extends angularly along a portion of a cross-section of the layer. The layer of the steerable portion into which the compression-resistance portion is incorporated has a first hardness, and the compression-resistance portion has a second hardness that is greater than the first hardness.
摘要翻译：输送设备包括可操纵轴，该可操纵轴具有近侧部分，远侧部分和延伸穿过近侧部分和远侧部分的拉线导管。拉线延伸穿过导管并具有固定到轴上的远侧部分。调节机构连接到拉线的近端部分，并被配置成增加和减小拉线中的张力以调节轴的曲率。轴的远侧部分具有包括一个或多个层的可转向部分。抗压部分被结合到可转向部分的层中，并且沿着层的横截面的一部分成角度地延伸。其中引入抗压部分的可转向部分的层具有第一硬度，并且抗压部分具有大于第一硬度的第二硬度。

9. 发明申请

WO2019199421A8 MITRAL VALVE SPACER DEVICE 审中-公开
公开(公告)号：WO2019199421A8
公开(公告)日：2019-10-17
申请号：PCT/US2019/023250
申请日：2019-03-20
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： FRANKLIN, Michael, D. , WINSTON, Matthew, T. , FRESCHAUF, Lauren, R. , DIXON, Eric, Robert , KWON, Yoon, Hee
IPC分类号： A61F2/24
摘要： An implantable prosthetic spacer device can include an inflatable spacer having a plurality of inflatable members and a frame, the frame comprising one or more anchors and one or more clasps. The inflatable spacer can be configured to be disposed between native leaflets of a heart. The implantable prosthetic spacer can be disposed in a symmetrical or an asymmetrical configuration. The inflatable spacers can be inflatable between an uninflated and an inflated configuration.

10. 发明申请

WO2018200985A1 MEDICAL DEVICE STABILIZING APPARATUS AND METHOD OF USE 审中-公开
公开(公告)号：WO2018200985A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029843
申请日：2018-04-27
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： TYLER, Gregory, Scott, II , TUASON, Arnold, Cruz , TAYLOR, David, M. , WINSTON, Matthew, T. , SIEGEL, Alexander, J. , GANGENESS, Grant, Jason
IPC分类号： A61B50/26 , A61B50/15 , A61B17/00 , A61F2/24 , A61M25/01
摘要： The present disclosure provides a stabilizing unit for a medical device. The stabilizing unit includes a retaining arm having a surface configured to abut a surface of the medical device. The stabilizing unit also includes a stabilizing fork having a slot configured to receive the medical device. A biasing member is in contact with the stabilizing fork and is configured to urge the slot of the stabilizing fork towards the retaining arm. When the medical device is placed in the slot of the stabilizing fork, the basing member urges the stabilizing fork against an adjacent surface of the medical device, and an opposing surface of the medical device against the retaining arm.

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