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1. 发明申请

WO2011097355A3 DEVICES AND METHODS FOR TREATING A HEART 审中-公开
标题翻译：用于治疗心脏的装置和方法
公开(公告)号：WO2011097355A3
公开(公告)日：2011-12-15
申请号：PCT/US2011023568
申请日：2011-02-03
申请人： EDWARDS LIFESCIENCES CORP , BOBO DONALD E , BASH ASSAF , CAMPBELL LOUIS A , CURTIS ALISON S , CHEUNG TAK , MIGLIAZZA JOHN F
发明人： BOBO DONALD E , BASH ASSAF , CAMPBELL LOUIS A , CURTIS ALISON S , CHEUNG TAK , MIGLIAZZA JOHN F
IPC分类号： A61B17/12 , A61B5/02 , A61B5/107 , A61F2/24
CPC分类号： A61F2/2445 , A61B5/1076 , A61B6/503 , A61F2/2457 , A61F2/2487 , A61F2220/0008 , A61F2250/0004 , A61F2250/0007 , A61F2250/0012
摘要： Devices and related methods of use are provided for improving heart function. In one embodiment of the present disclosure, a device includes a ring-like structure configured to be secured to a heart valve; at least one elongate member extending from the ring-like structure, wherein an end of the elongate member is configured to be secured to heart geometry other than a heart valve; and an adjustment mechanism for simultaneously altering a dimension of the ring-like structure and a length of the elongate member.
摘要翻译：提供了设备和相关的使用方法来改善心脏功能。在本公开的一个实施例中，装置包括构造成固定到心脏瓣膜的环状结构; 从所述环形结构延伸的至少一个细长构件，其中所述细长构件的端部构造成固定到心脏瓣膜以外的心脏几何形状; 以及用于同时改变环状结构的尺寸和细长构件的长度的调节机构。

2. 发明申请

WO2012012761A8 RETAINING MECHANISMS FOR PROSTHETIC VALVES 审中-公开
标题翻译：保留机构的前置阀
公开(公告)号：WO2012012761A8
公开(公告)日：2013-04-04
申请号：PCT/US2011045072
申请日：2011-07-22
申请人： EDWARDS LIFESCIENCES CORP , OLSON CHRISTOPHER , RABITO GLEN T , ARMER DUSTIN P , MA MINH , MARR DEVIN , HUANG MARK , OKABE HIROSHI , STEWART KEVIN , CURTIS ALISON S , CORSO PHILIP P JR
发明人： OLSON CHRISTOPHER , RABITO GLEN T , ARMER DUSTIN P , MA MINH , MARR DEVIN , HUANG MARK , OKABE HIROSHI , STEWART KEVIN , CURTIS ALISON S , CORSO PHILIP P JR
IPC分类号： A61F2/24 , A61B17/00 , A61F2/82 , A61M25/088
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076 , A61F2250/006
摘要： Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support- structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.
摘要翻译：这里公开了用于将假性心脏瓣膜递送到缺陷阀的方法，装置和系统的代表性实施例。在一个实施例中，例如，支撑结构和可扩张的假体瓣膜通过使用递送系统的患者的主动脉弓前进。支撑结构被输送到主动脉瓣（限定支撑结构内部的支撑结构）的流出侧的表面上或邻近的位置。可膨胀假体瓣膜被输送到主动脉瓣并进入支撑结构内部。可扩张假体心脏瓣膜膨胀，而可扩张假体心脏瓣膜处于支撑结构内部，而支撑结构处于主动脉瓣的流出侧表面上或邻近主动脉瓣的流出侧的位置，从而导致一个或多个本机主动脉瓣的小叶被摩擦地固定在支撑结构和扩张的假体心脏瓣膜之间。

3. 发明申请

WO2012074993A2 REDUCED DEHISCENCE ANNULOPLASTY RING 审中-公开
标题翻译：减少死亡环节
公开(公告)号：WO2012074993A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062374
申请日：2011-11-29
申请人： EDWARDS LIFESCIENCES CORP , BRUNNETT WILLIAM C , CURTIS ALISON S
发明人： BRUNNETT WILLIAM C , CURTIS ALISON S
IPC分类号： A61F2/24 , A61L27/06
CPC分类号： A61F2/2445 , A61F2/2442 , A61F2/2448 , A61F2210/0076 , A61F2220/0008 , A61F2230/0004 , A61F2230/0008 , A61F2230/0013 , A61F2250/0019 , A61F2250/0036
摘要： A prosthetic remodeling annuloplasty ring for use in tricuspid or mitral valve repairs to provide support after annuloplasty surgery. The annuloplasty ring includes a relatively rigid core extending around an axis that is discontinuous to define two free ends. A suture-permeable interface surrounding the core includes floppy regions adjacent both free ends of the core. Sutures are used to attach the annuloplasty ring to the annulus, including at least one suture through each of the floppy regions to secure the free ends of the ring and minimize the risk of ring dehiscence, or pull through of the sutures through the annulus tissue. The floppy regions may project from each free end into the gap toward each other, be radially enlarged such as paddle-like extensions, or may comprise outwardly lateral extensions at the free ends of the core. The interface may include an elastomeric sleeve and a fabric covering, wherein the floppy regions may be formed by molded portions of the sleeve with the fabric covering, or just the fabric covering.
摘要翻译：假体重塑瓣环成形术环用于三尖瓣或二尖瓣修复术以在瓣环成形术后提供支撑。瓣环成形术环包括围绕轴线延伸的相对刚性的芯，该轴不连续以限定两个自由端。包围芯的缝合线可渗透界面包括与芯的两个自由端相邻的软盘区。使用缝合线将瓣环成形术环附接到瓣环上，包括穿过每个软盘区域的至少一根缝合线以固定环的自由端并且使环裂开或穿过缝合线穿过瓣环组织的风险最小化。松软区域可以从每个自由端向彼此朝向彼此突出，径向扩大如桨状延伸部分，或者可以在核心的自由端处包括向外的横向延伸部分。该界面可以包括弹性体套筒和织物覆盖物，其中软质区域可以由具有织物覆盖物的套筒的模制部分形成，或者仅由织物覆盖物形成。

4. 发明申请

WO2012012761A3 RETAINING MECHANISMS FOR PROSTHETIC VALVES 审中-公开
标题翻译：人造血管保留机制
公开(公告)号：WO2012012761A3
公开(公告)日：2012-08-09
申请号：PCT/US2011045072
申请日：2011-07-22
申请人： EDWARDS LIFESCIENCES CORP , OLSON CHRISTOPHER , RABITO GLEN T , ARMER DUSTIN P , MA MINH , MARR DEVIN , HUANG MARK , OKABE HIROSHI , STEWART KEVIN , CURTIS ALISON S , CORSO PHILIP P
发明人： OLSON CHRISTOPHER , RABITO GLEN T , ARMER DUSTIN P , MA MINH , MARR DEVIN , HUANG MARK , OKABE HIROSHI , STEWART KEVIN , CURTIS ALISON S , CORSO PHILIP P
IPC分类号： A61F2/24 , A61B17/00 , A61F2/82 , A61F2/84 , A61M25/088
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0075 , A61F2230/0054 , A61F2230/0076 , A61F2250/006
摘要： Disclosed herein are representative embodiments of methods, apparatus, and systems used to deliver a prosthetic heart valve to a deficient valve. In one embodiment, for instance, a support structure and an expandable prosthetic valve are advanced through the aortic arch of a patient using a delivery system. The support structure is delivered to a position on or adjacent to the surface of the outflow side of the aortic valve (the support structure defining a support- structure interior). The expandable prosthetic valve is delivered into the aortic valve and into the support-structure interior. The expandable prosthetic heart valve is expanded while the expandable prosthetic heart valve is in the support-structure interior and while the support structure is at the position on or adjacent to the surface of the outflow side of the aortic valve, thereby causing one or more native leaflets of the aortic valve to be frictionally secured between the support structure and the expanded prosthetic heart valve.
摘要翻译：本文公开了用于将假体心脏瓣膜递送至不足瓣膜的方法，设备和系统的代表性实施例。在一个实施例中，例如，使用输送系统使支撑结构和可扩张假体瓣膜前进通过患者的主动脉弓。支撑结构被递送到主动脉瓣的流出侧的表面上或附近的位置（支撑结构限定支撑结构内部）。可扩张假体瓣膜被输送到主动脉瓣并进入支撑结构内部。当可扩张假体心脏瓣膜处于支撑结构内部时并且当支撑结构位于主动脉瓣膜流出侧表面上或附近的位置时，可扩张人造心脏瓣膜被扩张，从而导致一个或多个原生主动脉瓣的小叶被摩擦地固定在支撑结构和膨胀的人工心脏瓣膜之间。

5. 发明申请

WO2011091222A8 TRICUSPID RING 审中-公开
标题翻译： TRICUSPID戒指
公开(公告)号：WO2011091222A8
公开(公告)日：2012-04-19
申请号：PCT/US2011021996
申请日：2011-01-21
申请人： EDWARDS LIFESCIENCES CORP , BRUNNETT WILLIAM C , CURTIS ALISON S
发明人： BRUNNETT WILLIAM C , CURTIS ALISON S
IPC分类号： A61F2/24 , A61L27/04 , A61L27/06 , A61L27/34
CPC分类号： A61F2/2445 , A61F2210/0076 , A61F2230/0013 , A61F2230/0095 , A61F2250/0029 , B32B1/00 , B32B3/04 , B32B3/18 , B32B5/024 , B32B15/04 , B32B15/08 , B32B15/09 , B32B15/18 , B32B27/12 , B32B27/283 , B32B27/286 , B32B27/288 , B32B27/322 , B32B27/36 , B32B27/365 , B32B2250/44 , B32B2262/02 , B32B2262/0276 , B32B2307/546 , B32B2535/00
摘要： A prosthetic tricuspid remodeling annuloplasty ring having two free ends can be configured to be stiff in the XY plane and relatively flexible along the Z axis. A tricuspid ring can be provided with a substantially elliptical shape in the XY plane, and a saddle shape in the Z direction. Disclosed tricuspid rings can include an inner core, an elastomeric interface, and an outer fabric covering. In some embodiments, the inner core can include a plurality of stacked layers of different materials. In some embodiments, the inner core can be formed of a single material and sized specifically to create a tricuspid ring that has a greater stiffness in the XY plane than along the Z axis.
摘要翻译：具有两个自由端的假体三尖瓣重塑瓣环成形术环可以构造成在XY平面中刚性并且沿着Z轴具有相对柔性。三角形环可以在XY平面中具有基本上椭圆形的形状，并且在Z方向上具有鞍形。公开的三尖瓣环可以包括内芯，弹性体界面和外部织物覆盖物。在一些实施例中，内芯可以包括多个不同材料的堆叠层。在一些实施例中，内芯可以由单一材料形成并且特别地尺寸以形成在XY平面中具有比沿Z轴更大刚度的三尖瓣环。

6. 发明申请

WO2011087834A2 BIMODAL TRICUSPID ANNULOPLASTY RING 审中-公开
公开(公告)号：WO2011087834A2
公开(公告)日：2011-07-21
申请号：PCT/US2010061752
申请日：2010-12-22
申请人： EDWARDS LIFESCIENCES CORP , CARPENTIER ALAIN , CURTIS ALISON S
发明人： CARPENTIER ALAIN , CURTIS ALISON S
CPC分类号： A61F2/2445
摘要： A prosthetic remodeling tricuspid annuloplasty ring having two free ends can be configured to more accurately mimic native valve anatomy (e.g., shape) and movement during the cardiac cycle. A tricuspid ring can be provided with a substantially elliptical shape in the X-Y plane, and a bimodal saddle shape in the Z direction. The tricuspid ring can be configured to contract and expand during each cardiac cycle such that the area of the orifice and/or the diameter of the ring decrease with each contraction. Further, the elevation or non-planarity of the bimodal saddle shape can increase with each contraction. Movement of the tricuspid ring can vary in each different segment of the tricuspid ring. Tricuspid annuloplasty rings can be provided in a set, with changing ratios of diameter, changing out-of-plane static amplitudes, and changing amounts of dynamic movement in each different size of tricuspid ring.
摘要翻译：具有两个自由端的假体重塑三尖瓣瓣膜成形术环可以被配置成更准确地模拟心脏周期期间的自然瓣膜解剖结构（例如，形状）和运动。三角环可以在X-Y平面中设置为大致椭圆形，并且在Z方向上设置双峰鞍形。三尖瓣环可以配置成在每个心动周期期间收缩和扩张，使得孔口的面积和/或环的直径随着每次收缩而减小。此外，双峰鞍形的仰角或非平面度可随着每次收缩而增加。三尖瓣环的运动可以在三尖瓣环的每个不同区段中变化。三尖瓣瓣环成形术环可以在一组中提供，具有改变的直径比率，改变平面外静态振幅以及在每个不同尺寸的三尖瓣环中改变的动态运动量。

7. 发明专利

CA2785509A1 BIMODAL TRICUSPID ANNULOPLASTY RING 未知
公开(公告)号：CA2785509A1
公开(公告)日：2011-07-21
申请号：CA2785509
申请日：2010-12-22
申请人： EDWARDS LIFESCIENCES CORP
发明人： CARPENTIER ALAIN , CURTIS ALISON S
IPC分类号： A61F2/24
摘要： A prosthetic remodeling tricuspid annuloplasty ring having two free ends can be configured to more accurately mimic native valve anatomy (e.g., shape) and movement during the cardiac cycle. A tricuspid ring can be provided with a substantially elliptical shape in the X-Y plane, and a bimodal saddle shape in the Z direction. The tricuspid ring can be configured to contract and expand during each cardiac cycle such that the area of the orifice and/or the diameter of the ring decrease with each contraction. Further, the elevation or non-planarity of the bimodal saddle shape can increase with each contraction. Movement of the tricuspid ring can vary in each different segment of the tricuspid ring. Tricuspid annuloplasty rings can be provided in a set, with changing ratios of diameter, changing out-of-plane static amplitudes, and changing amounts of dynamic movement in each different size of tricuspid ring.

8. 发明专利

CA2787650A1 TRICUSPID RING 未知
公开(公告)号：CA2787650A1
公开(公告)日：2011-07-28
申请号：CA2787650
申请日：2011-01-21
申请人： EDWARDS LIFESCIENCES CORP
发明人： BRUNNETT WILLIAM C , CURTIS ALISON S
IPC分类号： A61F2/24 , A61L27/04 , A61L27/06 , A61L27/34
摘要： A prosthetic tricuspid remodeling annuloplasty ring having two free ends can be configured to be stiff in the XY plane and relatively flexible along the Z axis. A tricuspid ring can be provided with a substantially elliptical shape in the XY plane, and a saddle shape in the Z direction. Disclosed tricuspid rings can include an inner core, an elastomeric interface, and an outer fabric covering. In some embodiments, the inner core can include a plurality of stacked layers of different materials. In some embodiments, the inner core can be formed of a single material and sized specifically to create a tricuspid ring that has a greater stiffness in the XY plane than along the Z axis.

9. 发明专利

CA2818819A1 REDUCED DEHISCENCE ANNULOPLASTY RING 未知
公开(公告)号：CA2818819A1
公开(公告)日：2012-06-07
申请号：CA2818819
申请日：2011-11-29
申请人： EDWARDS LIFESCIENCES CORP
发明人： BRUNNETT WILLIAM C , CURTIS ALISON S
IPC分类号： A61F2/24 , A61L27/06
摘要： A prosthetic remodeling annuloplasty ring for use in tricuspid or mitral valve repairs to provide support after annuloplasty surgery. The annuloplasty ring includes a relatively rigid core extending around an axis that is discontinuous to define two free ends. A suture-permeable interface surrounding the core includes floppy regions adjacent both free ends of the core. Sutures are used to attach the annuloplasty ring to the annulus, including at least one suture through each of the floppy regions to secure the free ends of the ring and minimize the risk of ring dehiscence, or pull through of the sutures through the annulus tissue. The floppy regions may project from each free end into the gap toward each other, be radially enlarged such as paddle-like extensions, or may comprise outwardly lateral extensions at the free ends of the core. The interface may include an elastomeric sleeve and a fabric covering, wherein the floppy regions may be formed by molded portions of the sleeve with the fabric covering, or just the fabric covering.

10. 发明专利

CA2818819C REDUCED DEHISCENCE ANNULOPLASTY RING 未知
公开(公告)号：CA2818819C
公开(公告)日：2017-01-17
申请号：CA2818819
申请日：2011-11-29
申请人： EDWARDS LIFESCIENCES CORP
发明人： BRUNNETT WILLIAM C , CURTIS ALISON S
IPC分类号： A61F2/24 , A61L27/06
摘要： A prosthetic remodeling annuloplasty ring for use in tricuspid or mitral valve repairs to provide support after annuloplasty surgery. The annuloplasty ring includes a relatively rigid core extending around an axis that is discontinuous to define two free ends. A suture-permeable interface surrounding the core includes floppy regions adjacent both free ends of the core. Sutures are used to attach the annuloplasty ring to the annulus, including at least one suture through each of the floppy regions to secure the free ends of the ring and minimize the risk of ring dehiscence, or pull through of the sutures through the annulus tissue. The floppy regions may project from each free end into the gap toward each other, be radially enlarged such as paddle-like extensions, or may comprise outwardly lateral extensions at the free ends of the core. The interface may include an elastomeric sleeve and a fabric covering, wherein the floppy regions may be formed by molded portions of the sleeve with the fabric covering, or just the fabric covering.

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