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1. 发明申请

WO2023076200A1 LOW TEMPERATURE PROCESSES FOR RECYCLING POLY(ETHYLENE TEREPHTHALATE) 审中-公开
公开(公告)号：WO2023076200A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/047637
申请日：2022-10-25
申请人： EASTMAN CHEMICAL COMPANY
发明人： BOAZ, Neil, Warren , STAPLETON, Jennifer, Lloyd
IPC分类号： C07C67/03 , C07C69/82
摘要： Processes are provided for the conversion of diglycol terephthalates to a dialkyl terephthalate, specifically bis(hydroxyalkyl) terephthalate to dimethyl terephthalate at low temperatures. The process involves initial catalyzed transesterification of bis(hydroxyalkyl) terephthalate with methanol at a first temperature of between 0°C and 70°C for an initial time followed by a second stage of the reaction at or below 30°C. In particular, the process is tolerant of significant amounts of glycol and water, so the precursor bis(hydroxyalkyl) terephthalate does not necessarily need to be highly pure or dry. Filtration of the reaction mixture allows recovery of high yields of dimethyl terephthalate of sufficiently high purity such that further purification is often not required in order to be repurposed for the manufacture of polyesters.

2. 发明申请

WO2010039174A1 ESTERS OF 4,5-DISUBSTITUTED-OXY-2-METHYL-3,6-DIOXO-CYCLOHEXA-1,4-DIENYL ALKYL ACIDS AND PREPARATION THEREOF 审中-公开
标题翻译： 4,5-二氧杂-2-甲基-3,6-二氧代环己基-1,4-二烯基酸的酯及其制备
公开(公告)号：WO2010039174A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/005183
申请日：2009-09-17
申请人： EASTMAN CHEMICAL COMPANY
发明人： WEMPE, Michael, Fitzpatrick , DENG, Liu , CLENDENNEN, Stephanie Kay , BOAZ, Neil, Warren
IPC分类号： C07C67/08 , C07C69/608 , C07C69/95 , A61K31/23 , A61P17/00
CPC分类号： A61K31/22 , A61K31/23 , C07C67/08 , C07C69/95 , C07C2601/16
摘要： Esters of 4,5-disubstituted-oxy-2-rnethyl-3,6-dioxo-cyclohexa-1,4-dienyl alkyl acids were prepared chemically and/or enzymatically. Depending upon the ester, improved melanocyte cytotoxicity was achieved. Improved cytotoxicity characteristics are consistent with ester analogs being more physiologically compatible and less irritating to skin than their corresponding acids.
摘要翻译：化学和/或酶促制备4,5-二取代 - 氧基-2-甲基-3,6-二氧代环己烷-1,4-二烯基烷基酯的酯。取决于酯，实现了改善的黑素细胞细胞毒性。改进的细胞毒性特征与酯类似物与其相应的酸相比更具生理学相容性并且对皮肤刺激性较低。

3. 发明申请

WO2003082885A1 PHOSPHINOMETALLOCENYLAMIDES AS NOVEL LIGANDS FOR ASYMMETRIC CATALYSIS 审中-公开
标题翻译：作为不对称催化的新型配体的磷杂环戊烯酰胺
公开(公告)号：WO2003082885A1
公开(公告)日：2003-10-09
申请号：PCT/US2003/009003
申请日：2003-03-24
申请人： EASTMAN CHEMICAL COMPANY
发明人： BOAZ, Neil, Warren
IPC分类号： C07F17/00
CPC分类号： B01J31/2404 , B01J31/2226 , B01J31/2252 , B01J31/2295 , B01J2231/4205 , B01J2531/40 , B01J2531/50 , B01J2531/60 , B01J2531/70 , B01J2531/80 , B01J2531/821 , B01J2531/824 , B01J2531/825 , B01J2531/842 , C07F17/00 , C07F17/02
摘要： Disclosed are novel phosphinometallocenylamides that are useful as ligands for asymmetric catalysis. The novel ligands, which are readily modifiable, contain both a phosphine and an amide functionality linked by a metallocene backbone. In addition, the novel compounds are phosphine-amides derived from a phosphine amine, rather than a phosphine-carboxylic acid. Further, described herein are both processes to make the novel ligands as well as processes that employ such ligands in a catalytically active composition comprising one or more phosphinometallocenylamide compounds in complex association with one or more Group VIb or Group VIII metals to provide chiral products. Further, we describe exemplary catalyst complexes incorporating the novel ligands.
摘要翻译：公开了可用作不对称催化配体的新型次膦基金属烯基酰胺。容易修饰的新配体含有通过茂金属主链连接的膦和酰胺官能团。此外，新化合物是衍生自膦胺的膦酰胺，而不是膦 - 羧酸。此外，本文描述的是制备新型配体的方法以及在包含一种或多种次金属茂金属酰胺化合物的催化活性组合物中使用这种配体的方法，其与一种或多种VIb族或VIII族金属络合以提供手性产物。此外，我们描述了掺入新配体的示例性催化剂配合物。

4. 发明申请

WO2016209629A1 REDUCTIVE PREPARATION OF TERTIARY DIMETHYLAMINES FROM NITRILES 审中-公开
标题翻译：从硝酸盐还原二甲胺的制备
公开(公告)号：WO2016209629A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/036600
申请日：2016-06-09
申请人： EASTMAN CHEMICAL COMPANY
发明人： BOAZ, Neil, Warren
IPC分类号： C07C209/48 , C07C213/02 , C07C211/27 , C07C215/08
CPC分类号： C07C209/48 , C07C213/02 , C07C211/27 , C07C211/08 , C07C215/08 , C07C211/09
摘要： This disclosure describes a low temperature process for the preparation of dimethyl amines from nitriles via reductive amination. In some embodiments, the process proceeds under mild conditions with aqeuous dimethylamine and show an unexpected rate acceleration by the inclusion of an acid addition salt of the dimethylamine.
摘要翻译：本公开描述了通过还原胺化由腈制备二甲基胺的低温方法。在一些实施方案中，该方法在温和的条件下用饱和的二甲胺进行，并且通过加入二甲胺的酸加成盐显示意想不到的速率加速。

5. 发明申请

WO2009099524A1 ESTERS OF LONG-CHAIN ALCOHOLS AND THEIR USE TO TREAT THE SKIN 审中-公开
标题翻译：长链酒精及其用于治疗皮肤的食物
公开(公告)号：WO2009099524A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/000404
申请日：2009-01-22
申请人： EASTMAN CHEMICAL COMPANY
发明人： CLENDENNEN, Stephanie, Kay , BOAZ, Neil, Warren
IPC分类号： A61K8/37 , A61Q19/08 , A61Q19/00
CPC分类号： A61Q19/08 , A61K8/37 , A61K2800/75 , A61Q17/00 , A61Q19/004 , A61Q19/005 , A61Q19/02
摘要： Disclosed is a composition and methods of treating a skin condition. The ester includes an ester and a dermatologically acceptable carrier. The ester is represented by general formula (I).
摘要翻译：公开了治疗皮肤状况的组合物和方法。酯包括酯和皮肤病学上可接受的载体。该酯由通式（I）表示。

6. 发明申请

WO2015065780A1 HYDROXYTYROSOL DERIVATIVES THEIR METHOD OF PREPARATION AND USE IN PERSONAL CARE 审中-公开
标题翻译：羟基恶唑衍生物他们的个人护理准备和使用方法
公开(公告)号：WO2015065780A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/061679
申请日：2014-10-22
申请人： EASTMAN CHEMICAL COMPANY
发明人： BOAZ, Neil, Warren , MALESKI, Robert, Joseph
IPC分类号： C07C67/29 , C07C69/28 , C07C69/30 , C07C69/96 , A61Q19/00
CPC分类号： C07C69/96 , A61K8/37 , A61Q19/00 , A61Q19/08 , C07C67/293 , C07C67/31 , C07C68/02 , C07C69/28 , C07C69/732 , C07C69/738 , C07C69/30
摘要： Hydroxytyrosol derivative compositions containing a compound of Formula 2, methods for their manufacture, and their use in personal care products are disclosed. Lipophilic hydroxytyrosol carbonate ester compound can be made by oxidizing a substituted hydroxybenzaldehyde compound with an oxidizing agent such as hydrogen peroxide under mild conditions. The process involves enzymatic esterification of 4-(2-hydroxyethyl)phenol to form the corresponding ester, the introduction of a formyl group ortho to the phenolic hydroxyl group of the ester to form a lipophilic formyltyrosol ester; oxidation of the lipophilic formyltyrosol ester with a peroxide compound to form a lipophilic hydroxytyrosol ester compound; and reaction of lipophilic hydroxytyrosol ester compound with carbonic acid ester derivatives to form a lipophilic hydroxytyrosol carbonic ester compound. These compounds are useful is a wide variety of personal care compositions as anti-aging compounds that are stable against oxidation.
摘要翻译：公开了含有式2化合物的羟基酪醇衍生物组合物，其制备方法及其在个人护理产品中的用途。亲油性羟基酪氨酸酯化合物可以通过在温和条件下用氧化剂如过氧化氢氧化取代的羟基苯甲醛化合物来制备。该方法包括将4-（2-羟基乙基）苯酚酶促酯化形成相应的酯，在酯的酚羟基的邻位引入甲酰基，形成亲脂甲酰酪醇酯; 用过氧化物氧化亲脂性甲酰酪酯以形成亲脂性羟基酪醇酯化合物; 和亲脂性羟基酪氨酸酯化合物与碳酸酯衍生物的反应形成亲脂性羟基酪醇碳酸酯化合物。这些化合物可用作各种各样的个人护理组合物作为抗氧化稳定的抗衰老化合物。

7. 发明申请

WO2012015790A1 ESTERS OF O-SUBSTITUTED HYDROXY CARBOXYLIC ACIDS AND PREPARATIONS THEREOF 审中-公开
标题翻译： O-取代羟基羧酸的酯及其制备方法
公开(公告)号：WO2012015790A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045303
申请日：2011-07-26
申请人： EASTMAN CHEMICAL COMPANY
发明人： DENG, Liu , BOAZ, Neil, Warren
IPC分类号： C07C69/734 , C07C403/12 , C07C403/20 , A61K8/67 , A61Q19/08 , C12P7/62 , C07D309/40
CPC分类号： A61K8/671 , A61Q19/00 , A61Q19/002 , A61Q19/02 , A61Q19/08 , C07C67/03 , C07C67/10 , C07C67/11 , C07C69/734 , C07C403/12 , C07C403/20 , C07C2601/16 , C07D213/80 , C07D213/803 , C07D309/38 , C07D309/40 , C12P7/62 , C07C69/63
摘要： Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R 1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C 1 -C 22 alkyl, substituted and unsubstituted C 3 -C 8 cycloalkyl, substituted and unsubstituted C 6 -C 20 carbocyclic aryl, and substituted and unsubstituted C 4 -C 20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1 -6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.
摘要翻译：提供O-取代的羟基羧酸的酯，其具有式1或2或两者或式2或其两者：其中R和R 1独立地选自取代和未取代的，支链和直链的，饱和的，不饱和的和多不饱和C1-C22烷基，取代和未取代的C3-C8环烷基，取代和未取代的C6-C20碳环芳基和取代和未取代的C4-C20杂环; 其中所述杂原子选自硫，氮和氧; 并且其中n为1-6。还提供了生产O-取代羟基羧酸酯的方法。

8. 发明申请

WO2004108651A1 SUPPORTED METAL-PHOSPHINE-AMINOPHOSPHINE CATALYSTS 审中-公开
标题翻译：支持的金属 - 磷酰胺 - 氨基磷酸酯催化剂
公开(公告)号：WO2004108651A1
公开(公告)日：2004-12-16
申请号：PCT/US2004/017935
申请日：2004-06-07
申请人： EASTMAN CHEMICAL COMPANY , SETON HALL UNIVERSITY
发明人： AUGUSTINE, Robert, Leo , TANIELYAN, Setrak, Kavork , REYES, Clementine , BOAZ, Neil, Warren
IPC分类号： C07C67/303
CPC分类号： B01J31/1616 , B01J21/04 , B01J21/18 , B01J31/0212 , B01J31/165 , B01J31/2295 , B01J31/2409 , B01J31/34 , B01J37/0207 , B01J37/0209 , B01J2231/645 , B01J2531/0205 , B01J2531/80 , B01J2531/822 , B01J2531/842 , C07B2200/07 , C07C67/303 , Y02P20/588 , C07C69/34
摘要： The present invention is a re-usable and stable supported catalyst comprising a support, an anchoring agent, and a metal complex of a substantially enantiomerically pure phosphine-aminophosphine ligand. The resulting catalyst is useful for asymmetric catalytic reactions, such as asymmetric hydrogenation reactions. Also included are methods for preparing the supported catalyst and its use for asymmetric reactions.
摘要翻译：本发明是一种可重复使用且稳定的载体催化剂，其包括基本上对映体纯的膦 - 氨基膦配体的载体，锚固剂和金属络合物。所得催化剂可用于不对称催化反应，例如不对称氢化反应。还包括制备负载型催化剂的方法及其用于不对称反应的方法。

9. 发明申请

WO2019160705A1 ENZYMATIC PROCESS FOR PRODUCING INTERMEDIATES USEFUL AS ESTERQUAT PRECURSORS 审中-公开
公开(公告)号：WO2019160705A1
公开(公告)日：2019-08-22
申请号：PCT/US2019/016571
申请日：2019-02-05
申请人： EASTMAN CHEMICAL COMPANY
发明人： BOAZ, Neil, Warren , LLOYD, Jennifer, Michelle
IPC分类号： C12P13/00 , C11D1/62 , C11D3/30
摘要： The invention provides a process for the preparation of a modified triethanolamine/fatty acid ester composition ratio by treatment of a conventional tnethanolamine fatty acid ester composition with a hydrolytic enzyme. Also provided are novel mixtures of tnethanolamine and mono-, di-, and tri-esters of fatty acids which are useful in the preparation of cationic surfactants useful in fabric softening applications. In one aspect, the method increases the triester fraction without significantly affecting the amount of mono-ester and unesterified species, which in turn adds to the flexibility in the formulation of the corresponding fabric softening compositions.

10. 发明申请

WO2018081221A1 ENZYMATIC PREPARATION OF PROPAMOCARB 审中-公开
标题翻译： PROPAMOCARB的酶法制备
公开(公告)号：WO2018081221A1
公开(公告)日：2018-05-03
申请号：PCT/US2017/058217
申请日：2017-10-25
申请人： EASTMAN CHEMICAL COMPANY
发明人： CLENDENNEN, Stephanie, Kay , BOAZ, Neil, Warren , RABASSE, Jean-Michel
IPC分类号： C12P13/00 , C12P13/02
摘要： A process for preparing Propamocarb is presented. The preparation of Propamocarb (propyl 3-(dimethylamino)propylcarbamate) from 3- dimethylaminopropylamine and dipropyl carbonate is performed using an enzyme catalyst. In certain embodiments, the catalyst is a lipase enzyme, immobilized on a solid support. Advantages of the process include the avoidance of the use of chloroformate or vinyl carbonate.
摘要翻译：介绍了一种制备Propamocarb的方法。由3-二甲基氨基丙胺和碳酸二丙酯制备Propamocarb（丙基3-（二甲基氨基）丙基氨基甲酸酯）使用酶催化剂进行。在某些实施方案中，催化剂是固定在固体支持物上的脂肪酶。该过程的优点包括避免使用氯甲酸酯或碳酸乙烯酯。

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