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1. 发明申请

WO2012016055A1 IMPROVED CRYOGENIC SPECIMEN HOLDER 审中-公开
标题翻译：改进的低温样品架
公开(公告)号：WO2012016055A1
公开(公告)日：2012-02-02
申请号：PCT/US2011/045741
申请日：2011-07-28
申请人： E.A. FISCHIONE INSTRUMENTS, INC. , STABACINSKIENE, Halina , GRONSKY, Jeffrey, J. , THOMAS, Christine, M. , DESHMUKH, Pushkarraj, V. , ROBINS, Alan, C. , FISCHIONE, Paul, E.
发明人： STABACINSKIENE, Halina , GRONSKY, Jeffrey, J. , THOMAS, Christine, M. , DESHMUKH, Pushkarraj, V. , ROBINS, Alan, C. , FISCHIONE, Paul, E.
IPC分类号： H01J37/20
CPC分类号： G01N23/20033 , H01J37/20 , H01J37/26 , H01J2237/2001 , H01J2237/20207 , H01J2237/204
摘要： An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and the amount of liquid nitrogen present in the vessel. The Dewar neck design reduces the entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations.
摘要翻译：用于成像和分析的改进的低温试样保持器便于在具有大视场的非常高的倾斜角下进行成像。可伸缩的样品架头在运输过程中保护样品。优化的杜瓦设计相对于保持器的轴线定位成固定的倾斜角度，提供连续冷却样品的手段，而不管存在于容器中的高倾斜角和液氮量。杜瓦瓶颈设计减少了氮气气泡的夹带，其形状可以防止液氮在高倾角下溢出。样品架具有可收缩的尖端，其将样品完全包封在样品保持体内部的屏蔽环境内。冷却和样品转移机制减少了热漂移和振动的有害影响。

2. 发明公开

EP2599102A1 IMPROVED CRYOGENIC SPECIMEN HOLDER 审中-公开
标题翻译：改进的低温样品架
公开(公告)号：EP2599102A1
公开(公告)日：2013-06-05
申请号：EP11813190.3
申请日：2011-07-28
申请人： E.A. Fischione Instruments, Inc.
发明人： STABACINSKIENE, Halina , GRONSKY, Jeffrey, J. , THOMAS, Christine, M. , DESHMUKH, Pushkarraj, V. , ROBINS, Alan, C. , FISCHIONE, Paul, E.
IPC分类号： H01J37/20
CPC分类号： G01N23/20033 , H01J37/20 , H01J37/26 , H01J2237/2001 , H01J2237/20207 , H01J2237/204
摘要： An improved cryogenic specimen holder for imaging and analysis facilitates imaging at very high tilt angles with a large field of view. A retractable specimen holder tip protects the specimen during transport. An optimized Dewar design is positioned at a fixed, tilted angle with respect to the axis of the holder, providing a means of continuously cooling the specimen irrespective of the high tilt angle and the amount of liquid nitrogen present in the vessel. The Dewar neck design reduces the entrapment of nitrogen gas bubbles and its shape prevents the spilling of liquid nitrogen at high tilt angles. The specimen holder has a retractable tip that completely encapsulates the specimen within a shielded environment internal to the specimen holder body. The cooling and specimen transfer mechanisms reduce thermal drift and the detrimental effects of vibrations.

3. 发明申请

WO2003054577A1 METHOD FOR LOCALIZING A TARGET IN AN OBJECT 审中-公开
标题翻译：在目标中定位目标的方法
公开(公告)号：WO2003054577A1
公开(公告)日：2003-07-03
申请号：PCT/IB2002/005625
申请日：2002-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , COHEN, Julius, S. , THOMAS, Christine, M.
发明人： COHEN, Julius, S. , THOMAS, Christine, M.
IPC分类号： G01S5/16
CPC分类号： A61B6/12 , A61B6/4028 , G01S5/166
摘要： A method for localising a target 2 (f.i. a tumour) in an object 4 (f.i. human tissue) by means of scanning the object with a fan shaped X-ray beam 6. In known methods the X-ray beam is scanned twice over the object. In the first scan a shadow image of the object 4 and the target 2 in it is projected on an X-ray detector 10. In the second scan the position and the orientation of the X-ray beam 6 differs from the position and orientation of it in the first scan. Also during the second scan a shadow image of the object and the target is projected on the X-ray detector, in such a way that the positions of the target on the detector are mutually different. In this way the height of the target above the detector surface 10 may be calculated from the distance between the two shadow images of the target if both positions of the X-ray beam as well as both orientations are known. According to the invention it is proposed to translate and simultaneously rotate the X-ray beam 6 during the scan, the translatory and rotational movements being connected in such a way that the shadow image 12 of the target 2 is kept on the surface 10 of the detector during the scan. In this way it is possible to measure the translation d of that image during the scan, from which translation in combination with the translation D and the rotation during the scan the height of the target 2 above the detector surface 10 may be calculated. In this way only one scan is needed.
摘要翻译：通过用扇形X射线束6扫描物体来定位物体4（fi人体组织）中的靶2（成像肿瘤）的方法。在已知方法中，X射线束被扫描两次目的。在第一扫描中，物体4和其中的目标2的阴影图像投影在X射线检测器10上。在第二次扫描中，X射线束6的位置和取向与它在第一次扫描。此外，在第二扫描期间，物体和目标的阴影图像被投影在X射线检测器上，使得目标在探测器上的位置相互不同。以这种方式，如果X射线束的两个位置以及两个方向都是已知的，则可以从目标的两个阴影图像之间的距离来计算目标在检测器表面10上方的高度。根据本发明，提出了在扫描期间平移和同时旋转X射线束6，平移和旋转运动以这样的方式连接，使得目标2的阴影图像12保持在检测器在扫描期间。以这种方式，可以在扫描期间测量该图像的平移d，其中可以计算与平移D结合的平移和扫描期间的旋转，可以计算检测器表面10上方的目标2的高度。这样只需要一次扫描。

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