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1. 发明申请

WO2003066668A2 PEPTIDE DEFORMYLASE 审中-公开
标题翻译：肽变态酶
公开(公告)号：WO2003066668A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/005865
申请日：2003-02-06
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , BUTLER, Karlene, H. , FALCO, Saverio, Carl , GUTTERIDGE, Steven , HARVELL, Leslie, T.
发明人： BUTLER, Karlene, H. , FALCO, Saverio, Carl , GUTTERIDGE, Steven , HARVELL, Leslie, T.
IPC分类号： C07K
CPC分类号： C12N9/80
摘要： This invention relates to an isolated nucleic acid fragment encoding a metalloprotease, more specifically peptide deformylase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of peptide deformylase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of peptide deformylase in a transformed host cell.
摘要翻译：本发明涉及编码金属蛋白酶的分离的核酸片段，更具体地涉及肽变性酶。本发明还涉及在正义或反义方向上构建编码全部或部分肽变性酶的重组DNA构建体，其中重组DNA构建体的表达导致转化的宿主细胞中肽形成酶的水平的变化。

2. 发明申请

WO2003066668A3 PEPTIDE DEFORMYLASE 审中-公开
公开(公告)号：WO2003066668A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/005865
申请日：2003-02-06
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , BUTLER, Karlene, H. , FALCO, Saverio, Carl , GUTTERIDGE, Steven , HARVELL, Leslie, T.
发明人： BUTLER, Karlene, H. , FALCO, Saverio, Carl , GUTTERIDGE, Steven , HARVELL, Leslie, T.
IPC分类号： A01H1/00
摘要： This invention relates to an isolated nucleic acid fragment encoding a metalloprotease, more specifically peptide deformylase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of peptide deformylase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of peptide deformylase in a transformed host cell.

3. 发明申请

WO2013009971A1 DETECTION AND SCREENING METHOD AND MATERIALS USEFUL IN PERFORMANCE THEREOF 审中-公开
标题翻译：检测和筛选方法和材料在其性能方面有用
公开(公告)号：WO2013009971A1
公开(公告)日：2013-01-17
申请号：PCT/US2012/046437
申请日：2012-07-12
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , ANDREASSI II, John, Lawrence , GUTTERIDGE, Steven , PEMBER, Stephen, Ogden , SWEIGARD, James, A.
发明人： ANDREASSI II, John, Lawrence , GUTTERIDGE, Steven , PEMBER, Stephen, Ogden , SWEIGARD, James, A.
IPC分类号： G01N33/50 , G01N33/53 , C07K14/37
CPC分类号： C07K14/37 , C07K2319/20 , C12Q1/18
摘要： This invention relates to polynucleotides, polypeptides, and methods of using them to screen compounds for anti- Oomycetes activity and to to detect resistance developed to such compounds and detecting compounds capable of overcoming such resistance.
摘要翻译：本发明涉及多核苷酸，多肽和使用它们筛选化合物用于抗卵菌纲活性的方法，以及检测对这些化合物产生的耐药性和检测能够克服这种抗性的化合物。

4. 发明申请

WO2009124225A1 MULTIZYMES 审中-公开
公开(公告)号：WO2009124225A1
公开(公告)日：2009-10-08
申请号：PCT/US2009/039373
申请日：2009-04-03
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , PIONEER HI-BRED INTERNATIONAL, INC. , DAMUDE, Howard, Glenn , GUTTERIDGE, Steven , KINNEY, Anthony, J. , LASSNER, Michael, W. , SIEHL, Daniel, L.
发明人： DAMUDE, Howard, Glenn , GUTTERIDGE, Steven , KINNEY, Anthony, J. , LASSNER, Michael, W. , SIEHL, Daniel, L.
IPC分类号： C12N15/62 , C12N9/00
CPC分类号： C12N9/1085 , C07K2319/00 , C12N9/00 , C12N9/0004 , C12N9/0036 , C12N9/0071 , C12N9/0093 , C12N9/1029 , C12N9/16
摘要： Multizymes (i.e., single polypeptides having at least two independent and separable enzymatic activities) are disclosed for a variety of applications beyond the synthesis of long chain polyunsaturated fatty acids.
摘要翻译：公开了多长时间（即具有至少两个独立且可分离的酶活性的单一多肽）用于多链多不饱和脂肪酸合成之外的各种应用。

5. 发明申请

WO2012031061A2 FUNGICIDAL PYRAZOLES AND THEIR MIXTURES 审中-公开
标题翻译：杀真菌剂及其混合物
公开(公告)号：WO2012031061A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050124
申请日：2011-09-01
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , LONG, Jeffrey, Keith , GREGORY, Vann , GUTTERIDGE, Steven , TAGGI, Andrew, Edmund , BEREZNAK, James, Francis
发明人： LONG, Jeffrey, Keith , GREGORY, Vann , GUTTERIDGE, Steven , TAGGI, Andrew, Edmund , BEREZNAK, James, Francis
IPC分类号： A01N43/48
CPC分类号： A01N43/56 , A01N37/34 , A01N37/44 , A01N43/12 , A01N43/26 , A01N43/30 , A01N43/40 , A01N43/42 , A01N43/48 , A01N43/50 , A01N43/54 , A01N43/653 , A01N43/78 , A01N43/80 , A01N43/84 , A01N43/90 , A01N47/08 , A01N47/12 , A01N47/28 , A01N59/20 , C07D231/20 , C07D231/38 , A01N37/38 , A01N37/46 , A01N43/36 , A01N45/02 , A01N47/04 , A01N47/14 , A01N47/24 , A01N47/34 , A01N47/38
摘要： Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula (1), N -oxides, and salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in the disclosure; and (b) at least one additional fungicidal compound. Also disclosed is a method for controlling plant diseases caused by fungal plant pathogens comprising applying to the plant or portion thereof, or to the plant seed, a fungicidally effective amount of a compound of Formula (1), an N -oxide, or salt thereof (e.g., as a component in the aforesaid composition). Also disclosed is a composition comprising: (a) at least one compound selected from the compounds of Formula (1) described above, N -oxides, and salts thereof; and at least one invertebrate pest control compound or agent.
摘要翻译：公开了一种杀真菌组合物，其包含（a）至少一种选自式（1）的化合物，N-氧化物及其盐的化合物，其中R 1，R 2，R 3，R 4，R 5和R 6如本公开中所定义; 和（b）至少一种另外的杀真菌化合物。还公开了一种用于控制由真菌植物病原体引起的植物病害的方法，包括向植物或其部分或植物种子施用杀真菌有效量的式（1），N-氧化物或其盐的化合物（例如，作为上述组合物中的组分）。还公开了一种组合物，其包含：（a）至少一种选自上述式（1）的化合物，N-氧化物及其盐的化合物; 和至少一种无脊椎害虫防治化合物或药剂。

6. 发明申请

WO2004027042A2 ISOLATION AND USE OF RYANODINE RECEPTORS 审中-公开
标题翻译： RYANODINE受体的分离和应用
公开(公告)号：WO2004027042A2
公开(公告)日：2004-04-01
申请号：PCT/US2003/029834
申请日：2003-09-23
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , CASPAR, Timothy , CORDOVA, Daniel , GUTTERIDGE, Steven , RAUH, James, J. , SMITH, Rejane, M. , WU, Lihong , TAO, Yong
发明人： CASPAR, Timothy , CORDOVA, Daniel , GUTTERIDGE, Steven , RAUH, James, J. , SMITH, Rejane, M. , WU, Lihong , TAO, Yong
IPC分类号： C12N
CPC分类号： C07K14/43563 , C07K14/705
摘要： The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial cells. Expression in insect cells shows that the recombinant protein folds into a functional calcium release channel. The genes and their corresponding polypeptides have a number of uses including, but not limited to, the isolation of other pest ryanodine receptors, the development of screens to identify insecticidally active compounds, use of fragments of genes as pesticides, fragments of protein for antibody production, fragments of protein for determination of the structure of insecticide binding sites, and identification of insecticides that disrupt the calcium balance in cells through other messengers that interact with the receptor calcium release mechanism. Methods are outlined for overcoming toxic effects of expressing recombinant proteins in host cells.
摘要翻译：编码兰尼碱受体同系物的基因已经从多种昆虫科目表征，所述昆虫科包括鳞翅目烟夜蛾（Heliothis virescens），同翅目绿桃蚜（Myzus persicae），玉米植物漏斗（Peregrinus maidis），棉瓜蚜（Aphis gossypii）和果蝇（果蝇（果蝇））。已经在细菌细胞中分离，克隆和扩增全长基因。在昆虫细胞中的表达显示重组蛋白折叠成功能性钙释放通道。这些基因及其相应的多肽具有许多用途，包括但不限于分离其它害虫兰尼碱受体，开发鉴定杀虫活性化合物的筛选，使用基因片段作为农药，用于抗体产生的蛋白质片段，用于测定杀虫剂结合位点结构的蛋白质片段，以及通过与受体钙释放机制相互作用的其他信使破坏细胞中钙平衡的杀虫剂的鉴定。概述了克服在宿主细胞中表达重组蛋白的毒性作用的方法。

7. 发明申请

WO2003015501A1 3-DEOXY-D-MANNO-OCTULOSONIC ACID 8-PHOSPHATE SYNTHASES 审中-公开
标题翻译： 3-去氧-D-壬烷 - 十八烷酸8-磷酸酯合成
公开(公告)号：WO2003015501A1
公开(公告)日：2003-02-27
申请号：PCT/US2002/026294
申请日：2002-08-16
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , ALLEN, Stephen, M. , FLINT, Dennis , GUTTERIDGE, Steven , FALCO, Saverio, Carl
发明人： ALLEN, Stephen, M. , FLINT, Dennis , GUTTERIDGE, Steven , FALCO, Saverio, Carl
IPC分类号： A01H3/00
CPC分类号： C12N9/88 , C12Y205/01055
摘要： An isolated nucleic acid fragment encoding a KDO 8-P synthase. A recombinant DNA construct encoding all or a portion of the KDO 8-P synthase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the KDO 8-P synthase in a transformed host cell. The isolated nucleic acid fragments encoding a KDO 8-P synthase are useful in herbicide, fungicide, bactericide, and pesticide discovery and design.
摘要翻译：编码KDO 8-P合酶的分离的核酸片段。在正义或反义方向上编码全部或部分KDO 8-P合酶的重组DNA构建体，其中重组DNA构建体的表达导致转化的宿主细胞中KDO 8-P合酶水平的变化。编码KDO 8-P合酶的分离的核酸片段可用于除草剂，杀真菌剂，杀菌剂和农药的发现和设计。

8. 发明申请

WO2013188291A2 METHODS AND COMPOSITIONS INVOLVING ALS VARIANTS WITH NATIVE SUBSTRATE PREFERENCE 审中-公开
标题翻译：涉及具有原始基底偏好的ALS变量的方法和组合
公开(公告)号：WO2013188291A2
公开(公告)日：2013-12-19
申请号：PCT/US2013/044969
申请日：2013-06-10
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , PIONEER HI-BRED INTERNATIONAL, INC.
发明人： ALBERT, Henrik , ANDREASSI II, John, Lawrence , BERTAIN, Sean , CASTLE, Linda, A. , GUTTERIDGE, Steven , SIEHL, Daniel, L. , WALTER, Kay
IPC分类号： C12N15/82 , C07K14/415
CPC分类号： C12N15/8274 , C07K14/415 , C12N15/8278
摘要： Compositions and methods comprising polynucleotides and polypeptides having ALS activity and tolerance to at least one ALS inhibitor are provided. In specific embodiments, the sequence has an increased preference for 2-ketobutyrate, when compared to an appropriate control, such as for example, HRA, and/or a preference for 2-ketobutyrate similar to a native ALS. Further provided are nucleic acid constructs, plants, plant cells, explants, seeds and grain having the ALS inhibitor tolerant sequences. Various methods of employing the ALS inhibitor tolerant sequences are provided. Such methods include methods for producing an ALS inhibitor tolerant plant, plant cell, explant or seed and methods of controlling weeds in a field containing a crop employing the plants and/or seeds disclosed herein.
摘要翻译：提供了包含具有ALS活性和对至少一种ALS抑制剂的耐受性的多核苷酸和多肽的组合物和方法。在具体实施方案中，当与适当的对照（例如HRA）和/或与天然ALS相似的2-酮丁酸酯的偏好相比时，该序列对2-酮丁酸酯的偏好优先。还提供了具有ALS抑制剂耐受序列的核酸构建体，植物，植物细胞，外植体，种子和谷物。提供了使用ALS抑制剂耐受序列的各种方法。这样的方法包括用于产生ALS抑制剂耐受植物，植物细胞，外植体或种子的方法以及在含有本文公开的植物和/或种子的作物的田地中控制杂草的方法。

9. 发明申请

WO2017075559A1 DIHYDROOROTATE DEHYDROGENASE INHIBITOR COMPOSITIONS EFFECTIVE AS HERBICIDES 审中-公开
标题翻译：二氢脱氧核糖酸脱氢酶抑制剂组合物有效地作为除草剂
公开(公告)号：WO2017075559A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/059620
申请日：2016-10-30
申请人： E. I. DU PONT DE NEMOURS AND COMPANY
发明人： GUTTERIDGE, Steven , KANG, Il-Ho , ANDREASSI II, John Lawrence
IPC分类号： G01N33/50 , C12N9/04
CPC分类号： C12Q1/32 , C12N9/0006 , G01N2333/90206
摘要： This invention relates to the production of herbicidal compounds and compositions comprising the same which inhibit dihydroorotate dehydrogenase.
摘要翻译：本发明涉及除草剂化合物的制备以及包含其抑制二氢乳清酸脱氢酶的组合物的组合物。

10. 发明申请

WO2014004064A1 FUNGICIDAL HETEROCYCLIC CARBOXAMIDES 审中-公开
标题翻译：杀真菌剂
公开(公告)号：WO2014004064A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/044951
申请日：2013-06-10
申请人： E. I. DU PONT DE NEMOURS AND COMPANY
发明人： BEREZNAK, James, Francis , GUTTERIDGE, Steven , TAGGI, Andrew, Edmund , REDDY, Ravisekhara, P. , CAMPBELL, Matthew, James , KAR, Moumita , DESAEGER, Johan, A., J.
IPC分类号： C07D403/12 , C07D405/14 , C07D403/14 , C07D405/12 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14 , A01N43/78 , C07D411/14
CPC分类号： C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D411/14 , C07D417/12 , C07D417/14
摘要： Disclosed are compounds of Formula 1, including all stereoisomers, N -oxides, and salts thereof, wherein L is C(R 12a )R 12b -C(R 13a )R 13b -, wherein the carbon atom bonded to R 12a and R 12b is also bonded to the carboxamide nitrogen atom in Formula 1; or 1,2-phenylene optionally substituted with up to 4 substituents independently selected from halogen and C 1 -C 2 alkyl; and A, Z, R 1 , R 2 , n, G and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are methods for controlling a phytophagous nematode comprising contacting the nematode or its environment with a nematocidally effective amount of a compound of Formula 1 wherein L is -C(R 12a )R 12b -C(R 13a )R 13b- ; and A, Z, R 1 , R 2 , n, G and Q are as defined in the disclosure.
摘要翻译：公开了式1的化合物，包括所有的立体异构体，N-氧化物及其盐，其中L是C（R12a）R12b-C（R13a）R13b-，其中与R12a和R12b键合的碳原子也与羧酰胺键合式1中的氮原子; 或任选被至多4个独立地选自卤素和C 1 -C 2烷基的取代基取代的1,2-亚苯基; 并且A，Z，R 1，R 2，n，G和Q如本公开所定义。还公开了含有式1化合物的组合物和用于控制由真菌病原体引起的植物病害的方法，包括施用有效量的本发明化合物或组合物。还公开了控制植物性线虫的方法，包括使线虫或其环境与杀线虫有效量的式1化合物（其中L是-C（R12a）R12b-C（R13a）R13b-; 并且A，Z，R 1，R 2，n，G和Q如本公开所定义。

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