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1. 发明授权

US5547846A Immunogenic regions on the E7 protein of human papillomavirus type 16 失效
标题翻译：人类乳头瘤病毒16型E7蛋白上的免疫原性区域
公开(公告)号：US5547846A
公开(公告)日：1996-08-20
申请号：US292169
申请日：1994-08-16
申请人： Dusan Bartsch , Lutz Gissmann , Martin Muller
发明人： Dusan Bartsch , Lutz Gissmann , Martin Muller
IPC分类号： G01N33/569 , A61K39/00 , A61K39/12 , A61K39/395 , A61K39/42 , C07K4/02 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/025 , C07K16/00 , C07K16/08 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/19 , G01N33/577 , C12Q1/00 , C07K7/02 , G01N33/53
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/20022
摘要： The invention describes two immunogenic regions of the E7 protein of human papillomavirus type 16 (HPV 16), one immunoreactive region being located downstream from nucleotide 595 and the other being located downstream from nucleotide 667 of the HPV 16 genome.
摘要翻译：本发明描述了人乳头状瘤病毒16型（HPV16）的E7蛋白的两个免疫原性区域，一个免疫反应区位于核苷酸595的下游，另一个位于HPV16基因组的核苷酸667的下游。

2. 发明授权

US06551821B1 Brain cyclic nucleotide gated ion channel and uses thereof 失效
标题翻译：脑环核苷酸门控离子通道及其用途
公开(公告)号：US06551821B1
公开(公告)日：2003-04-22
申请号：US08997685
申请日：1997-12-23
申请人： Eric R. Kandel , Bina Santoro , Dusan Bartsch , Steven Siegelbaum , Gareth Tibbs , Seth Grant
发明人： Eric R. Kandel , Bina Santoro , Dusan Bartsch , Steven Siegelbaum , Gareth Tibbs , Seth Grant
IPC分类号： C07H2104
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C12Q1/6883 , C12Q2600/158
摘要： The present invention provides an isolated nucleic acid molecule encoding a brain cyclic nucleotide gated ion channel (BCNG) protein. An isolated BCNG protein is also provided as is a composition comprising a BCNG encoding nucleic acid or protein or a portion thereof. The present invention also provides a method of identifying an ion channel subunit related protein encoding nucleic acid molecule in a sample. The invention further provides a method for evaluating the ability of a compound to modulate an ion channel associated neurological, cardia, or renal condition. The invention also provides a method for evaluating the ability of a compound to interact with a BCNG-related ion channel subunit protein. Additionally, the present invention provides a method for identifying a compound capable of modulating the activity of a BCNG-related protein. The present invention additionally provides a method of treating a cardiac, renal or neurological condition. Finally, the present invention provides an antibody which specifically reacts with BCNG protein.
摘要翻译：本发明提供了编码脑环核苷酸门控离子通道（BCNG）蛋白质的分离的核酸分子。还提供分离的BCNG蛋白质，其包含BCNG编码核酸或蛋白质或其部分的组合物。本发明还提供了一种鉴定样品中离子通道亚基相关蛋白编码核酸分子的方法。本发明还提供了一种评估化合物调节离子通道相关神经，贲门或肾脏状况的能力的方法。本发明还提供了一种评估化合物与BCNG相关离子通道亚基蛋白相互作用的能力的方法。此外，本发明提供了鉴定能够调节BCNG相关蛋白的活性的化合物的方法。本发明另外提供了治疗心脏，肾脏或神经病症的方法。最后，本发明提供了与BCNG蛋白特异性反应的抗体。

3. 发明授权

US07015190B1 Method for enhancing long-term memory in a subject and uses thereof 失效
标题翻译：用于增强受试者的长期记忆的方法及其用途
公开(公告)号：US07015190B1
公开(公告)日：2006-03-21
申请号：US08656811
申请日：1996-06-03
申请人： Dusan Bartsch , Eric R. Kandel , Mirella Ghirardi
发明人： Dusan Bartsch , Eric R. Kandel , Mirella Ghirardi
IPC分类号： A61K38/00 , A61K48/00
CPC分类号： C07K16/18 , A01K2217/05 , A61K38/00 , C07K14/4702
摘要： The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.
摘要翻译：本发明提供了一种增强受试者的长期记忆的方法，其中cAMP反应基因表达受到cAMP反应元件结合蛋白-2与蛋白或与cAMP相关的DNA的结合的抑制，响应基因表达或两者，其包括向所述受试者施用能够以有效干扰所述蛋白质或DNA结合的量干扰所述结合的化合物，从而消除所述受试者中cAMP反应性基因表达并增强该科目的长期记忆。

4. 发明授权

US06703485B2 Brain and heart cyclic nucleotide gated ion channel compounds and uses thereof 失效
标题翻译：脑和心脏环核苷酸门控离子通道化合物及其用途
公开(公告)号：US06703485B2
公开(公告)日：2004-03-09
申请号：US09086436
申请日：1998-05-28
申请人： Eric R. Kandel , Bina Santoro , Dusan Bartsch , Steven Siegelbaum , Gareth Tibbs , Seth Grant
发明人： Eric R. Kandel , Bina Santoro , Dusan Bartsch , Steven Siegelbaum , Gareth Tibbs , Seth Grant
IPC分类号： C07K100
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C12Q1/6883 , C12Q2600/158
摘要： The present invention provides an isolated nucleic acid encoding a BCNG protein or a portion thereof or BCNG-related protein or a portion thereof. The present invention further provides a method for identifying a nucleic acid in a sample which encodes a BCNG protein or a BCNG-related protein. The present invention also provides a method for testing whether a compound affects the expression of a BCNG protein or a BCNG-related protein. In addition, the present invention further provides a method for identifying a compound capable of interacting with a BCNG protein or a BCNG-related protein. Also, the present invention provides a method for identifing a compound capable of modulating BCNG protein or BCNG-related protein activity. Further, the present invention also provides a method of treating a condition in a subject which comprises administering to the subject an amount of the provided compound, effective to treat the condition.
摘要翻译：本发明提供编码BCNG蛋白或其部分或BCNG相关蛋白或其部分的分离的核酸。本发明还提供了用于鉴定编码BCNG蛋白或BCNG相关蛋白的样品中核酸的方法。本发明还提供了一种用于测试化合物是否影响BCNG蛋白或BCNG相关蛋白的表达的方法。此外，本发明还提供了鉴定能够与BCNG蛋白质或BCNG相关蛋白质相互作用的化合物的方法。此外，本发明提供了鉴定能够调节BCNG蛋白或BCNG相关蛋白活性的化合物的方法。此外，本发明还提供了一种治疗受试者的病症的方法，其包括向所述受试者施用有效治疗所述病症的量的所述化合物。

5. 发明申请

US20060088535A1 Method for enhancing long-term memory in a subject and uses thereof 审中-公开
公开(公告)号：US20060088535A1
公开(公告)日：2006-04-27
申请号：US11301602
申请日：2005-12-13
申请人： Dusan Bartsch , Eric Kandel , Mirella Ghirardi
发明人： Dusan Bartsch , Eric Kandel , Mirella Ghirardi
IPC分类号： A61K39/395 , A61K31/52 , A61K48/00
CPC分类号： C07K16/18 , A01K2217/05 , A61K38/00 , C07K14/4702
摘要： The present invention provides for a method to enhance long-term memory in a subject whose cAMP-responsive gene expression is repressed due to binding of a cAMP-response-element-binding-protein-2 to a protein or a DNA associated with cAMP-responsive gene expression, or both, which comprises administering to the subject a compound capable of interfering with such binding in an amount effective to interfere with binding of the protein or the DNA so as to thereby derepress cAMP-responsive gene expression in the subject and enhance the subject's long-term memory.

6. 发明申请

US20050003477A1 Pacemaker ion channel proteins and uses thereof 审中-公开
标题翻译：起搏器离子通道蛋白及其用途
公开(公告)号：US20050003477A1
公开(公告)日：2005-01-06
申请号：US10384107
申请日：2003-03-06
申请人： Eric Kandel , Bina Santoro , Dusan Bartsch , Steven Siegelbaum , Gareth Tibbs , Seth Grant
发明人： Eric Kandel , Bina Santoro , Dusan Bartsch , Steven Siegelbaum , Gareth Tibbs , Seth Grant
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , C12N5/02 , C12Q1/68 , C07H21/04 , C12N15/74 , C12N15/85
CPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C12Q1/6883 , C12Q2600/158
摘要： The present invention provides an isolated nucleic acid molecule encoding a brain cyclic nucleotide gated ion channel (BCNG) protein. An isolated BCNG protein is also provided as is a composition comprising a BCNG encoding nucleic acid or protein or a portion thereof. The present invention also provides a method of identifying an ion channel subunit related protein encoding nucleic acid molecule in a sample. The invention further provides a method for evaluating the ability of a compound to modulate an ion channel associated neurological, cardia, or renal condition. The invention also provides a method for evaluating the ability of a compound to interact with a BCNG-related ion channel subunit protein. Additionally, the present invention provides a method for identifying a compound capable of modulating the activity of a BCNG-related protein. The present invention additionally provides a method of treating a cardiac, renal or neurological condition. Finally, the present invention provides an antibody which specifically reacts with BCNG protein.
摘要翻译：本发明提供了编码脑环核苷酸门控离子通道（BCNG）蛋白质的分离的核酸分子。还提供分离的BCNG蛋白质，其包含BCNG编码核酸或蛋白质或其部分的组合物。本发明还提供了一种鉴定样品中离子通道亚基相关蛋白编码核酸分子的方法。本发明还提供了一种评估化合物调节离子通道相关神经，贲门或肾脏状况的能力的方法。本发明还提供了一种评估化合物与BCNG相关离子通道亚基蛋白相互作用的能力的方法。此外，本发明提供了鉴定能够调节BCNG相关蛋白的活性的化合物的方法。本发明另外提供了治疗心脏，肾脏或神经病症的方法。最后，本发明提供了与BCNG蛋白特异性反应的抗体。

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