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1. 发明授权

US07291154B2 Shape memory polymer actuator and catheter 有权
标题翻译：形状记忆聚合物致动器和导管
公开(公告)号：US07291154B2
公开(公告)日：2007-11-06
申请号：US10713622
申请日：2003-11-13
申请人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
发明人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
IPC分类号： A61F11/00
CPC分类号： A61B17/32075 , A61B17/22031 , A61B17/221 , A61B17/320725 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/22034 , A61B2017/320064 , A61M25/0158 , A61M2025/0064
摘要： An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.
摘要翻译：提供用于作用在容器中的材料的致动器系统。该系统包括可操作地连接到光纤的光纤和形状记忆聚合物材料。形状记忆聚合物材料适于从用于移动通过所述容器的第一形状移动到其可以作用在所述材料上的第二形状。

2. 发明授权

US06740094B2 Shape memory polymer actuator and catheter 有权
公开(公告)号：US06740094B2
公开(公告)日：2004-05-25
申请号：US09761023
申请日：2001-01-16
申请人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
发明人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Dennis L. Matthews , Derek E. Decker , Charles A. Jungreis
IPC分类号： A61F1100
CPC分类号： A61B17/32075 , A61B17/22031 , A61B17/221 , A61B17/320725 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/22034 , A61B2017/320064 , A61M25/0158 , A61M2025/0064
摘要： An actuator system is provided for acting upon a material in a vessel. The system includes an optical fiber and a shape memory polymer material operatively connected to the optical fiber. The shape memory polymer material is adapted to move from a first shape for moving through said vessel to a second shape where it can act upon said material.

3. 发明授权

US6102917A Shape memory polymer (SMP) gripper with a release sensing system 失效
标题翻译：形状记忆聚合物（SMP）夹具与释放感应系统
公开(公告)号：US6102917A
公开(公告)日：2000-08-15
申请号：US116019
申请日：1998-07-15
申请人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Luiz Da Silva
发明人： Duncan J. Maitland , Abraham P. Lee , Daniel L. Schumann , Luiz Da Silva
IPC分类号： B25J7/00 , A61B17/00 , A61B17/12 , A61B17/28 , A61B19/00 , B81B7/02 , A61F11/00
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00022 , A61B2017/00398 , A61B2017/00867 , A61B2017/00871 , A61B2017/1205 , A61B2017/12072
摘要： A system for releasing a target material, such as an embolic coil from an SMP located at the end of a catheter utilizing an optical arrangement for releasing the material. The system includes a laser, laser driver, display panel, photodetector, fiber optics coupler, fiber optics and connectors, a catheter, and an SMP-based gripper, and includes a release sensing and feedback arrangement. The SMP-based gripper is heated via laser light through an optic fiber causing the gripper to release a target material (e.g., embolic coil for therapeutic treatment of aneurysms). Various embodiments are provided for coupling the laser light into the SMP, which includes specific positioning of the coils, removal of the fiber cladding adjacent the coil, a metal coating on the SMP, doping the SMP with a gradient absorbing dye, tapering the fiber optic end, coating the SMP with low refractive index material, and locating an insert between the fiber optic and the coil.
摘要翻译：一种用于从位于导管端部的SMP释放目标材料（例如栓塞线圈）的系统，其利用用于释放材料的光学装置。该系统包括激光，激光驱动器，显示面板，光电检测器，光纤耦合器，光纤和连接器，导管和基于SMP的夹持器，并且包括释放感测和反馈装置。基于SMP的夹持器通过光纤通过光纤被加热，使得夹具释放靶材料（例如用于治疗动脉瘤的栓塞线圈）。提供了用于将激光耦合到SMP中的各种实施例，其包括线圈的特定定位，邻近线圈的光纤包层的移除，SMP上的金属涂层，用梯度吸收染料掺杂SMP，使光纤以低折射率材料涂覆SMP，并将插入物定位在光纤和线圈之间。

4. 发明授权

US6059815A Microfabricated therapeutic actuators and release mechanisms therefor 失效
标题翻译：微型治疗执行器及其释放机制
公开(公告)号：US6059815A
公开(公告)日：2000-05-09
申请号：US67824
申请日：1998-04-28
申请人： Abraham P. Lee , Joseph P. Fitch , Daniel L. Schumann , Luiz Da Silva , William J. Benett , Peter A. Krulevitch
发明人： Abraham P. Lee , Joseph P. Fitch , Daniel L. Schumann , Luiz Da Silva , William J. Benett , Peter A. Krulevitch
IPC分类号： A61B17/00 , A61B17/12 , A61M25/16 , A61B17/28
CPC分类号： A61B17/1214 , A61B17/12022 , A61B2017/00867 , A61B2017/00871 , A61B2017/12068 , A61B2017/12077
摘要： Microfabricated therapeutic actuators are fabricated using a shape memory polymer (SMP), a polyurethane-based material that undergoes a phase transformation at a specified temperature (Tg). At a temperature above temperature Tg material is soft and can be easily reshaped into another configuration. As the temperature is lowered below temperature Tg the new shape is fixed and locked in as long as the material stays below temperature Tg. Upon reheating the material to a temperature above Tg, the material will return to its original shape. By the use of such SMP material, SMP microtubing can be used as a retaining/release actuator for the delivery of material, such as embolic coils, for example, through catheters into aneurysms, for example. The microtubing can be manufactured in various sizes and the phase change temperature Tg is determinate for an intended temperature target and intended use. The SMP microtubing can be positioned around or within an end of a deposit material. Various heating arrangements can be utilized with the SMP release mechanism, and the SMP microtubing can include a metallic coating for enhanced light absorption.
摘要翻译：使用形状记忆聚合物（SMP），在特定温度（Tg）下经历相变的基于聚氨酯的材料制造微制剂治疗致动器。在高于温度的温度下，Tg材料是柔软的并且可以容易地重塑成另一种构型。当温度降低到温度Tg以下时，只要材料保持低于温度Tg，新形状就会被固定和锁定。将材料重新加热至高于Tg的温度时，材料将恢复到原来的形状。通过使用这种SMP材料，SMP微管可用作用于例如通过导管穿入动脉瘤等物质输送的保持/释放致动器。微管可以以各种尺寸制造，相变温度Tg对于预期的温度目标和预期用途是确定的。 SMP微管可以定位在沉积材料的周围或内部。 SMP释放机构可以使用各种加热装置，并且SMP微管可以包括用于增强光吸收的金属涂层。

5. 发明授权

US06240630B1 Apparatus for loading shape memory gripper mechanisms 失效
标题翻译：装载形状记忆夹持机构的装置
公开(公告)号：US06240630B1
公开(公告)日：2001-06-05
申请号：US08984624
申请日：1997-12-03
申请人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
发明人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
IPC分类号： B21D3904
CPC分类号： A61B17/221 , A61B17/1219 , A61B2017/00345 , A61B2017/00867 , A61B2017/00871 , A61B2017/1205 , A61B2017/12068 , A61B2017/12072 , Y10T29/49865 , Y10T29/49929 , Y10T29/53439 , Y10T29/53987
摘要： A method and apparatus for loading deposit material, such as an embolic coil, into a shape memory polymer (SMP) gripping/release mechanism. The apparatus enables the application of uniform pressure to secure a grip by the SMP mechanism on the deposit material via differential pressure between, for example, vacuum within the SMP mechanism and hydrostatic water pressure on the exterior of the SMP mechanism. The SMP tubing material of the mechanism is heated to above the glass transformation temperature (Tg) while reshaping, and subsequently cooled to below Tg to freeze the shape. The heating and/or cooling may, for example, be provided by the same water applied for pressurization or the heating can be applied by optical fibers packaged to the SMP mechanism for directing a laser beam, for example, thereunto. At a point of use, the deposit material is released from the SMP mechanism by reheating the SMP material to above the temperature Tg whereby it returns to its initial shape. The reheating of the SM material may be carried out by injecting heated fluid (water) through an associated catheter or by optical fibers and an associated beam of laser light, for example.
摘要翻译：一种用于将诸如栓塞线圈的沉积材料装载到形状记忆聚合物（SMP）夹持/释放机构中的方法和装置。该装置能够通过例如SMP机构中的真空和SMP机构的外部上的静水压力之间的压差来施加均匀的压力，以通过SMP机构来确保在沉积材料上的握持。将机构的SMP管材料加热至高于玻璃化转变温度（Tg），同时重塑，随后冷却至Tg以下以冻结形状。加热和/或冷却可以例如由施加加压的相同的水提供，或者可以通过包封在SMP机构中的光纤施加加热，以引导例如激光束。在使用时，通过将SMP材料再加热到高于Tg的温度Tg，沉积材料从SMP机制释放，由此其恢复到初始形状。 SM材料的再加热可以通过例如通过相关联的导管或通过光纤和相关的激光束注入加热的流体（水）来进行。

6. 发明授权

US06370757B1 Method for loading shape memory polymer gripper mechanisms 有权
公开(公告)号：US06370757B1
公开(公告)日：2002-04-16
申请号：US09568615
申请日：2000-05-10
申请人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
发明人： Abraham P. Lee , William J. Benett , Daniel L. Schumann , Peter A. Krulevitch , Joseph P. Fitch
IPC分类号： B23P1102
摘要： A method and apparatus for loading deposit material, such as an embolic coil, into a shape memory polymer (SMP) gripping/release mechanism. The apparatus enables the application of uniform pressure to secure a grip by the SMP mechanism on the deposit material via differential pressure between, for example, vacuum within the SMP mechanism and hydrostatic water pressure on the exterior of the SMP mechanism. The SMP tubing material of the mechanism is heated to above the glass transformation temperature (Tg) while reshaping, and subsequently cooled to below Tg to freeze the shape. The heating and/or cooling may, for example, be provided by the same water applied for pressurization or the heating can be applied by optical fibers packaged to the SMP mechanism for directing a laser beam, for example, thereunto. At a point of use, the deposit material is released from the SMP mechanism by reheating the SMP material to above the temperature Tg whereby it returns to its initial shape. The reheating of the SMP material may be carried out by injecting heated fluid (water) through an associated catheter or by optical fibers and an associated beam of laser light, for example.

7. 发明授权

US06575965B1 Medical devices utilizing optical fibers for simultaneous power, communications and control 有权
标题翻译：利用光纤同时进行电力，通信和控制的医疗设备
公开(公告)号：US06575965B1
公开(公告)日：2003-06-10
申请号：US09713988
申请日：2000-11-16
申请人： Joseph P. Fitch , Dennis L. Matthews , Karla G. Hagans , Abraham P. Lee , Peter Krulevitch , William J. Benett , Robert E. Clough , Luiz B. DaSilva , Peter M. Celliers
发明人： Joseph P. Fitch , Dennis L. Matthews , Karla G. Hagans , Abraham P. Lee , Peter Krulevitch , William J. Benett , Robert E. Clough , Luiz B. DaSilva , Peter M. Celliers
IPC分类号： A61B1822
CPC分类号： A61B17/12022 , A61B5/0084 , A61B17/1214 , A61B17/29 , A61B2017/00292 , A61B2017/00345 , A61B2017/12072 , A61B2017/12077 , A61B2017/2926
摘要： A medical device is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a proximal end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a proximal end for external coupling of laser light energy. A laser-light-to-mechanical-power converter is connected to receive light from the distal end of the fiber optic cable and may include a photo-voltaic cell and an electromechanical motor or a heat-sensitive photo-thermal material. An electronic sensor is connected to receive electrical power from said distal end of the fiberoptic cable and is connected to provide signal information about a particular physical environment and communicated externally through the fiberoptic cable to the proximal end thereof. A mechanical sensor is attached to the distal end of the fiberoptic cable and connected to provide light signal information about a particular physical environment and communicated externally through the fiberoptic cable.
摘要翻译：医疗装置构造成具有导管的基本形式，其具有用于插入体内和在体内操作的远端，并且近端为使用者提供控制体内远端的操作。光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的光，并且可以包括光电池和机电马达或热敏光热材料。电子传感器被连接以从光纤电缆的所述远端接收电力，并且被连接以提供关于特定物理环境的信号信息，并且通过光纤电缆向外传播到其近端。机械传感器连接到光纤电缆的远端并被连接以提供关于特定物理环境的光信号信息，并通过光纤电缆在外部通信。

8. 发明授权

US5722989A Microminiaturized minimally invasive intravascular micro-mechanical systems powered and controlled via fiber-optic cable 失效
标题翻译：通过光纤电缆供电和控制的微小型微创血管内微机械系统
公开(公告)号：US5722989A
公开(公告)日：1998-03-03
申请号：US812142
申请日：1997-03-06
申请人： Joseph P. Fitch , Karla Hagans , Robert Clough , Dennis L. Matthews , Abraham P. Lee , Peter A. Krulevitch , William J. Benett , Luiz Da Silva , Peter M. Celliers
发明人： Joseph P. Fitch , Karla Hagans , Robert Clough , Dennis L. Matthews , Abraham P. Lee , Peter A. Krulevitch , William J. Benett , Luiz Da Silva , Peter M. Celliers
IPC分类号： B25J15/08 , A61B17/00 , A61B17/12 , A61B17/28 , A61B19/00 , B81B3/00
CPC分类号： A61B17/1214 , A61B17/12022 , A61B17/29 , A61B2017/00292 , A61B2017/00345 , A61B2017/00398 , A61B2017/1205 , A61B2017/12068 , A61B2017/12077 , A61B2017/12081 , A61B2017/2926
摘要： A micro-mechanical system for medical procedures is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a near end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a near end for external coupling of laser light energy. A microgripper is attached to the distal end of the catheter and providing for the gripping or releasing of an object within the body. A laser-light-to-mechanical-power converter is connected to receive laser light from the distal end of the fiberoptic cable and connected to mechanically actuate the microgripper.
摘要翻译：用于医疗程序的微机械系统以导管的基本形式构造，其具有用于插入身体内部和在身体内操作的远端，并且近端提供用户以控制身体内的远端的操纵。光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。微型抓爪附接到导管的远端，并提供用于在体内夹持或释放物体。连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的激光并连接到机械致动微型抓爪。

9. 发明授权

US09517465B2 Lateral cavity acoustic transducer based microfluidic switch 有权
标题翻译：基于侧腔声学换能器的微流体开关
公开(公告)号：US09517465B2
公开(公告)日：2016-12-13
申请号：US13613623
申请日：2012-09-13
申请人： Maulik V. Patel , Armando R. Tovar , Abraham P. Lee
发明人： Maulik V. Patel , Armando R. Tovar , Abraham P. Lee
IPC分类号： G01N15/14 , B01L3/00 , G01N15/00
CPC分类号： B01L3/502761 , B01L3/502738 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2400/0622 , G01N15/1484 , G01N2015/0053 , G01N2015/149 , Y10T436/2575
摘要： A microfluidic switching device that includes an upstream microfluidic channel configured to contain a liquid having particles therein and a plurality of outlet channels coupled to the upstream microfluidic channel at a junction. A dead-end side channel or LCAT is oriented generally perpendicular to the upstream microfluidic channel and coupled to the upstream microfluidic channel at the junction, the dead-end side channel having a gas contained therein. The device includes a transducer configured to apply an external source of acoustic energy. Actuation of the transducer effectuates symmetrical oscillation of a gas/liquid boundary at the junction. Preferably, the junction comprises a bifurcation with two outlets. Further, the LCAT has a leading edge and a trailing edge and wherein the trailing edge of the LCAT is substantially aligned with the bifurcation.
摘要翻译：一种微流体开关装置，其包括被配置为容纳其中具有颗粒的液体的上游微流体通道和在连接处耦合到上游微流体通道的多个出口通道。死端侧通道或LCAT通常垂直于上游微流体通道定向并且在接合处与上游微流体通道耦合，死端侧通道具有包含在其中的气体。该装置包括配置成施加外部声能源的换能器。传感器的作用会导致接头处气/液边界的对称振荡。优选地，连接点包括具有两个出口的分叉。此外，LCAT具有前缘和后缘，并且其中LCAT的后缘基本上与分叉对齐。

10. 发明授权

US5783130A Fabrication method for miniature plastic gripper 失效
标题翻译：微型塑料夹具的制作方法
公开(公告)号：US5783130A
公开(公告)日：1998-07-21
申请号：US753720
申请日：1996-11-27
申请人： William J. Benett , Peter A. Krulevitch , Abraham P. Lee , Milton A. Northrup , James A. Folta
发明人： William J. Benett , Peter A. Krulevitch , Abraham P. Lee , Milton A. Northrup , James A. Folta
IPC分类号： A61B17/00 , A61B17/12 , A61B17/28 , B29C37/02 , B28B7/14 , B29C33/40
CPC分类号： A61B17/29 , A61B2017/00292 , A61B2017/00345 , A61B2017/00526 , A61B2017/12081 , A61B2017/2926 , A61B2017/2932 , Y10T29/49826
摘要： A miniature plastic gripper actuated by inflation of a miniature balloon and method of fabricating same. The gripper is constructed of either heat-shrinkable or heat-expandable plastic tubing and is formed around a mandrel, then cut to form gripper prongs or jaws and the mandrel removed. The gripper is connected at one end with a catheter or tube having an actuating balloon at its tip, whereby the gripper is opened or dosed by inflation or deflation of the balloon. The gripper is designed to removably retain a member to which is connected a quantity or medicine, plugs, or micro-components. The miniature plastic gripper is inexpensive to fabricate and can be used for various applications, such as gripping, sorting, or placing of micron-scale particles for analysis.
摘要翻译：由微型气球膨胀致动的微型塑料夹具及其制造方法。夹具由热收缩或热膨胀塑料管构成，并围绕心轴形成，然后切割以形成夹爪或钳口，并移除心轴。夹具在一端与在其顶端具有致动气囊的导管或管连接，由此通过气囊的充气或放气来打开或放药夹具。夹具被设计成可移除地保持连接有数量或药物，插头或微组件的构件。微型塑料夹具制造成本低廉，可用于各种应用，例如夹紧，分选或放置微米级颗粒进行分析。

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