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    • 4. 发明专利
    • Process for producing coated particles
    • NZ755788A
    • 2022-05-27
    • NZ75578818
    • 2018-02-16
    • DSM IP ASSETS BV
    • FUNDA ELGERURBAN KAIACHKAR JIHANESCHWEIKERT LONIVIDONI OLIVIAZEDI ERNST
    • A61K9/16A61K9/50
    • The present patent application relates to coated particles. These coated particles show improved properties when used in compressed tablets. More specifically, the present application relates to a process for the production of coated particles having a core and a coating layer surrounding the core, wherein the process comprises the steps of: (a) forming cores of the coated particles by introducing into a top spraying device 40 wt-% 95 wt-%, based on the total weight of the coated particles, of a core material which consists of: (i) at least 20 wt-%, based on the total weight of the solid particles, of at least one fat soluble vitamin, (ii) at least one emulsifier, and (iii) at least one non-reducing sugar, (b) introducing into the top spraying device 5 wt-%-60 wt-%, based on the total weight of the coated particles, of a coating system which comprises at least one wax and/or at least one fat selected from the group consisting of carnauba wax, candelilla wax, sugarcane wax and hydrogenated palm oil, and (c) operating the top spraying device to spray a molten form of the coating system onto the cores to thereby form the coated particles each comprised of a core formed of the core material and a deformable coating layer having an irregular thickness and a plurality of vacuoles formed of the coating system surrounding the core, wherein the top spraying device is operated throughout steps (a) – (c) at an atomizing air pressure of I bar and an atomizing air temperature of 100 to 1200 C.