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1. 发明专利

JP2013255495A Composition comprising carnosic acid 12-methylether 有权
标题翻译：包含卡诺卡酸12-甲基酯的组合物
公开(公告)号：JP2013255495A
公开(公告)日：2013-12-26
申请号：JP2013134253
申请日：2013-06-26
申请人： Dsm Ip Assets Bv , ディーエスエムアイピーアセッツビー.ブイ.
发明人： RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH , WEHRLI CHRISTOF
IPC分类号： A23L1/30 , A61K31/192 , A61K36/00 , A61K36/53 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： PROBLEM TO BE SOLVED: To provide a novel composition comprising an effective amount of carnosic acid 12-methylether for the treatment, co-treatment, or prevention of inflammatory disorders.SOLUTION: There are disclosed a nutraceutical comprising carnosic acid 12-methylether in an amount in the range of 0.01 to 1,000 mg per dosage, and a nutraceutical for the treatment, co-treatment, or prevention of joint disorders, which is a food product, a foodstuff, a dietary supplement, a nutritional supplement, or a supplement composition for a food product or a foodstuff.
摘要翻译：要解决的问题：提供一种包含有效量的鼠尾草酸12-甲基醚的新型组合物，用于治疗，共同治疗或预防炎症性疾病。解决方案：公开了一种营养药物，其含有一定量的卡诺卡酸12-甲基醚在每剂量0.01至1,000mg的范围内，以及作为食品，食品，膳食补充剂，营养补充剂或补充剂组合物的治疗，共同治疗或预防关节疾病的营养药物食品或食品。

2. 发明专利

JP2013227328A Use of tricyclic diterpene and the derivative for treatment, co-treatment or prevention of inflammatory disorder and/or joint disorder 有权
标题翻译：三碘甲苯的使用及其用于治疗，共同治疗或预防炎症性疾病和/或并发症的衍生物
公开(公告)号：JP2013227328A
公开(公告)日：2013-11-07
申请号：JP2013134254
申请日：2013-06-26
申请人： Dsm Ip Assets Bv , ディーエスエムアイピーアセッツビー.ブイ.
发明人： RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH , WEHRLI CHRISTOF
IPC分类号： A61K31/045 , A23L1/30 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/37 , A61K8/49 , A61K8/97 , A61K31/047 , A61K31/122 , A61K31/19 , A61K31/215 , A61K31/365 , A61P17/00 , A61P17/18 , A61P19/02 , A61P29/00 , A61Q17/04 , A61Q19/00
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： PROBLEM TO BE SOLVED: To provide a nutraceutical or pharmaceutical for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders.SOLUTION: A use of at least one tricyclic diterpene of formula I and/or II, wherein the at least one tricyclic diterpene is comprised in a plant extract in an amount of at least 30 wt%.
摘要翻译：要解决的问题：提供用于治疗，共同治疗或预防炎症性疾病和/或关节病症的营养药物或药物。解决方案：使用至少一种式I和/或II的三环二萜，其中在至少一种三环二萜以至少30重量％的量包含在植物提取物中。

3. 发明专利

JP2013063974A Use of composition for purpose of manufacturing novel medicament for preventing and treating disorder connected to impaired neurotransmission 审中-公开
标题翻译：使用组合物用于制造新药物用于预防和治疗与受阻神经递质连接的疾病的用途
公开(公告)号：JP2013063974A
公开(公告)日：2013-04-11
申请号：JP2012223342
申请日：2012-10-05
申请人： Dsm Ip Assets Bv , ディーエスエムアイピーアセッツビー.ブイ.
发明人： DE SAIZIEU ANTOINE , FOWLER ANN , GORALCZYK REGINA , MUSSLER BERND , SCHUELER GOEDE
IPC分类号： A61K31/37 , A23K1/16 , A23K1/18 , A23L1/30 , A61P1/14 , A61P25/20 , A61P25/22 , A61P25/24
CPC分类号： A61K31/37 , A23L2/39 , A23L7/126 , A23L33/105 , A23V2002/00 , A23V2250/21 , A23V2200/322
摘要： PROBLEM TO BE SOLVED: To provide a medicament for the treatment and/or the prevention of disorders connected to impaired neurotransmission.SOLUTION: There are provided coumarin ethers expressed by formula I, preferably obliquin, and foods, pharmaceutical compositions and vegetable extracts each including such coumarin ether, and the use of them. In the formula, R is H, OH, or a predetermined substituent.
摘要翻译：待解决的问题：提供用于治疗和/或预防与神经传递受损有关的障碍的药物。提供由式I表示的香豆素醚，优选为棱晶，以及各自包含这种香豆素醚的食品，药物组合物和植物提取物以及它们的用途。式中，R为H，OH或预定的取代基。版权所有（C）2013，JPO＆INPIT

4. 发明专利

JP2012006923A Use of phthalide derivatives for the treatment and prevention of diabetes mellitus 有权
标题翻译：用于治疗和预防糖尿病的PHTHALIDE衍生物的使用
公开(公告)号：JP2012006923A
公开(公告)日：2012-01-12
申请号：JP2011131574
申请日：2011-06-13
申请人： Dsm Ip Assets Bv , ディーエスエムアイピーアセッツビー.ブイ.
发明人： WANG YING , DE SAIZIEU ANTOINE , SCHUELER GOEDE , D ORAZIO DANIEL , RAEDERSTORFF DANIEL , WOLFRAM SWEN , WEBER PETER , TEIXEIRA SANDRA
IPC分类号： A61K31/343 , A23K1/16 , A23L1/30 , A23L2/52 , A61K9/16 , A61K9/20 , A61K9/46 , A61K9/48 , A61P3/04 , A61P3/10 , C07D307/88 , C07D307/89
CPC分类号： A61K31/343
摘要： PROBLEM TO BE SOLVED: To provide a compound as an agent effective for the prevention or the treatment of diabetes mellitus in mammals.SOLUTION: The compound is selected from the group consisting of: (E)-senkyunolide E; senkyunolide C; senkyunolide B; 3-butyl-4, 5, 6, 7-tetrahydro-3, 6, 7-trihydroxy-1(3H)-isobenzofuranone; 3-butyl-1(3H)-isobenzofuranone; 3-butylphthalide; 3-butylidenephthalide; chuangxinol; ligustilidiol; senkyunolide F; 3-hydroxy-senkyunolide A; angeloylsenkyunolide F; senkyunolide M; 3-hydroxy-8-oxo-senkyunolide A; ligustilide; 6, 7-dihydro-(6S, 7R)-dihydroxyligustilide; 3a, 4-dihydro-3-(3-methylbutylidene)-1(3H)-isobenzofuranone; sedanolide; and cnidilide.
摘要翻译：要解决的问题：提供作为有效预防或治疗哺乳动物糖尿病的药剂的化合物。化合物选自：（E） - 顺式烯醇化物E; 松果苷C; 松果苷B; 3-丁基-4,5,6,7-四氢-3,6,7-三羟基-1（3H） - 异苯并呋喃酮; 3-丁基-1-（3H）异苯并呋喃酮; 3-丁基苯酞; 3-丁烯酜; chuangxinol; ligustilidiol; 松果苷F 3-羟基 - 松果烯内酯A; 芥子酰甘油醚F; 松果苷M; 3-羟基-8-氧代 - 松果烯内酯A; 藁本内酯; 6,7-二氢 - （6S，7R） - 二羟基司必西; 3a，4-二氢-3-（3-甲基亚丁基）-1（3H） - 异苯并呋喃酮; sedanolide; 和替尼迪。版权所有（C）2012，JPO＆INPIT

5. 发明申请

WO2007134867A2 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：WO2007134867A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007004627
申请日：2007-05-24
申请人： DSM IP ASSETS BV , D ORAZIO DANIEL , RAEDERSTORFF DANIEL , SCHUELER GOEDE , WANG-SCHMIDT YING , WERTZ KARIN , WOLFRAM SWEN
发明人： D ORAZIO DANIEL , RAEDERSTORFF DANIEL , SCHUELER GOEDE , WANG-SCHMIDT YING , WERTZ KARIN , WOLFRAM SWEN
IPC分类号： A61P21/00 , A23L1/30 , A61K31/12 , A61K31/166 , A61K31/352 , A61P1/00 , A61P9/00 , A61P9/10 , A61P19/02
CPC分类号： A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/12 , A61K31/166 , A61K31/352 , A23V2200/316 , A23V2200/328 , A23V2200/326 , A23V2200/318 , A23V2200/32
摘要： The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy,, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle : fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物的肌肉功能。其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病，类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如肠炎综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

6. 发明申请

WO2008017491A8 LIGUSTILIDE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM 审中-公开
标题翻译：用于治疗中枢神经系统疾病的LIGESTILIDE衍生物
公开(公告)号：WO2008017491A8
公开(公告)日：2009-05-07
申请号：PCT/EP2007007086
申请日：2007-08-10
申请人： DSM IP ASSETS BV , DE SAIZIEU ANTOINE , GORALCZYK REGINA , SCHUELER GOEDE
发明人： DE SAIZIEU ANTOINE , GORALCZYK REGINA , SCHUELER GOEDE
IPC分类号： A61K31/343 , A61P25/22 , A61P25/24
CPC分类号： A61K31/343
摘要： The present invention refers to compounds of the general formula (I) wherein R1 is hydrogen or hydroxy; R2 is butyl or butyryl if R1 is hydroxy, but R2 is butyl if R1 is hydrogen; or R1 and R2 taken together are 1-propylidene or 1-butylidene optionally substituted by hydroxy, methyl, or 3-(a,ß-dimethylacryloyloxy); the dotted line is an optional bond; X is an optionally substituted aliphatic C4- residue selected from the group consisting of X1, X2, X3, X4, and X5; wherein X is X2, X3 or X5 if the dotted line in formula (I) is absent; and X is Xl, X4 or X5 if the dotted line signifies a bond in formula (I) above; R3 and R4 are, independently from each other, hydrogen or hydroxy; and R5 is hydroxy or butyryl, for use in the treatment of disorders connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions containing such compounds, and their uses.
摘要翻译：本发明涉及通式（I）的化合物，其中R 1是氢或羟基; 如果R 1是羟基，则R 2是丁基或丁酰基，但如果R 1是氢，则R 2是丁基; 或R 1和R 2一起为1-羟基，甲基或3-（a，β-二甲基丙烯酰氧基）任意取代的1-亚丙基或1-亚丁基; 虚线是可选的键; X是选自X 1，X 2，X 3，X 4和X 5的任选取代的脂族C 4 - 残基; 其中如果式（I）中的虚线不存在，X是X 2，X 3或X 5; 如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R 3和R 4彼此独立地为氢或羟基; 和R5是羟基或丁酰基，用于治疗与受损的神经传递相关的疾病，以及含有这些化合物的饮食和药物组合物及其用途。

7. 发明申请

WO2006125651A2 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：WO2006125651A2
公开(公告)日：2006-11-30
申请号：PCT/EP2006005005
申请日：2006-05-24
申请人： DSM IP ASSETS BV , FOWLER ANN , RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH
发明人： FOWLER ANN , RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH
IPC分类号： A61K31/343 , A61P11/00 , A61P19/02 , A61P19/06 , A61P29/00
CPC分类号： A61K31/343
摘要： The present invention relates to the use of compounds of the formula (I) wherein the clotted line is an optional bond; R 1 is butyl or butyryl if R 2 is hydroxyl but is butyl if R 2 is hydrogen; or R 1 and R 2 taken together are 1-butylidene optionally substituted by hydroxyl, methyl, or 3- (a,ß-dimethylacrylyloxy)-pentylidenyl; X is a residue selected from the group consisting of X1 , X2, X3, X4, and X5; wherein X is X2, X3or X5 if the dotted line in formula (I) is absent ;and X is X1 , X4 or X5 if the dotted line signifies a bond in formula (I) above; R 3 is hydroxyl or butyryl; and n is 1 or 2, as agents for the prevention, control and treatment of conditions requiring modulation of inflammation in mammals. In another aspect, the present invention relates to the use of compounds of the formula (I) as active ingredients in the manufacture of medicaments/compositions for the prevention, control and treatment of conditions requiring modulation of inflammation. The compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the management of pain, fever and injuries, especially sport injuries. Moreover, the compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the maintenance and regeneration of articular cartilage.
摘要翻译：本发明涉及式（I）化合物的用途，其中凝血线是任选的键; 如果R 2是羟基，则R 1是丁基或丁酰基，如果R 2是氢，则是丁基; 或R 1和R 2一起是任选被羟基，甲基或3-（a，β-二甲基丙烯酰氧基） - 戊酰基取代的1-亚丁基; X是选自X1，X2，X3，X4和X5的残基; 其中，如果不存在式（I）中的虚线，X为X 2，X 3或X 5;如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R 3是羟基或丁酰基; 和n为1或2，作为预防，控制和治疗需要调节哺乳动物炎症的病症的药剂。另一方面，本发明涉及式（I）化合物作为活性成分在制备用于预防，控制和治疗需要调节炎症的病症的药物/组合物中的用途。如上定义的式（I）化合物也可用于治疗疼痛，发烧和损伤，特别是运动损伤（用于制造组合物）。此外，如上定义的式（I）化合物也可用于维持和再生关节软骨（用于制备组合物）。

8. 发明申请

WO2008061755A8 DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING CARNOSOL AND/OR ROSMANOL AND THEIR USES 审中-公开
标题翻译：含有卡罗糖醇和/或罗莫诺的膳食和药物组合物及其用途
公开(公告)号：WO2008061755A8
公开(公告)日：2009-07-30
申请号：PCT/EP2007010133
申请日：2007-11-22
申请人： DSM IP ASSETS BV , NESTEC SA , FOWLER ANN , GORALCZYK REGINA , KILPERT CLAUS , MOHAJERI HASAN , RAEDERSTORFF DANIEL , DE SAIZIEU ANTOINE , SCHUELER GOEDE , WANG-SCHMIDT YING , WEHRLI CHRISTOF
发明人： FOWLER ANN , GORALCZYK REGINA , KILPERT CLAUS , MOHAJERI HASAN , RAEDERSTORFF DANIEL , DE SAIZIEU ANTOINE , SCHUELER GOEDE , WANG-SCHMIDT YING , WEHRLI CHRISTOF
IPC分类号： A23L1/30 , A23K1/16 , A61K36/00
CPC分类号： A61K31/365 , A23K20/10 , A23K20/111 , A23L33/105 , A61K2300/00
摘要： The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途。

9. 发明申请

WO2008061720A3 USE OF TRICYCLIC DITERPENES AND THEIR DERIVATIVES FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS AND/OR JOINT DISORDERS 审中-公开
标题翻译：治疗，治疗或预防感染性疾病和/或联合疾病的三环磷酸酯及其衍生物的使用
公开(公告)号：WO2008061720A3
公开(公告)日：2008-10-23
申请号：PCT/EP2007010071
申请日：2007-11-21
申请人： DSM IP ASSETS BV , RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH , WEHRLI CHRISTOF
发明人： RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH , WEHRLI CHRISTOF
IPC分类号： A61K31/05 , A23K1/16 , A23K1/18 , A61K8/34 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/49 , A61K31/122 , A61K31/192 , A61K31/216 , A61K31/343 , A61P17/00 , A61P17/16 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention refers to the use of at least one tricyclic diterpenes for the manufacture of a nutraceutical or pharmaceutical for the treatment, co-treatment or prevention of inflammatory disorders and/ or joint disorders.
摘要翻译：本发明涉及至少一种三环二萜用于制备用于治疗，共同治疗或预防炎症性疾病和/或关节病症的营养药物或药物的用途。

10. 发明申请

WO2008061754A8 DIETARY OR PHARMACEUTICAL COMPOSITIONS CONTAINING TRICYCLIC DITERPENES AND DERIVATIVES THEREOF FOR THE TREATMENT OF DEPRESSION 审中-公开
标题翻译：含有三环二萜类及其衍生物的膳食或药物组合物，用于治疗抑郁症
公开(公告)号：WO2008061754A8
公开(公告)日：2008-07-24
申请号：PCT/EP2007010132
申请日：2007-11-22
申请人： DSM IP ASSETS BV , DE SAIZIEU ANTOINE , FOWLER ANN , GORALCZYK REGINA , KILPERT CLAUS , SCHUELER GOEDE , WEHRLI CHRISTOF
发明人： DE SAIZIEU ANTOINE , FOWLER ANN , GORALCZYK REGINA , KILPERT CLAUS , SCHUELER GOEDE , WEHRLI CHRISTOF
IPC分类号： A61K31/19 , A61K31/085 , A61K36/53 , A61K36/537 , A61P25/22 , A61P25/24 , A61P25/26
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/085 , A61K31/122 , A61K31/19 , A61K31/365 , A23V2200/322 , A23V2250/21
摘要： The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R 1 is hydrogen or C 1-6 -alkyl; R 2 is hydroxy, C 3-5 -acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C 1-6 -alkyl; R 3 and R 4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C 1-5 - acyloxy or C 1 -6 -alkoxy; R 5 is C 1-6 -alkyl, hydroxymethyl, carboxy or methoxycarbonyl; R 9 is hydrogen, hydroxymethyl, methoxy, oxo or C 1-5 -acyloxy; R 10 is hydrogen, or R 5 and R 9 taken together are -CH 2 -O- or -0-CH 2 -; or R 5 and R 10 taken together are -CO-O-, -O-CO-, -CH 2 -O- or -0-CH 2 -; R 6 is hydrogen, or R 5 and R 6 together form a bond; R 7 and R 8 independently from each other are C 1-6 -alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C 1-6 -alkoxycarbonyl with the proviso that at least one of R 7 and R 8 is C 1-6 -alkyl; R 11 and R 12 are both hydrogen or R 11 and R 12 together are oxo, with the further proviso for formula (I) that if R 2 is hydroxy R 1 is C 1-6 -alkyl, for use as medicaments for the treatment of a disorder connected to impaired neurotransmission, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及式（I）和（II）的三环二萜及其衍生物，其中R 1是氢或C 1-6烷基; R 2是羟基，C 3-5酰基氧基，羟甲基，1,3-二羟基丙基或C 1-6烷基; R 3和R 4彼此独立地为氢，羟基，羟甲基，C 1-5酰氧基或C 1-4亚烷基， 6 - 烷氧基; R 5是C 1-6烷基，羟甲基，羧基或甲氧羰基; R 9是氢，羟甲基，甲氧基，氧代或C 1-5酰氧基; R 10为氢或者R 5和R 9一起为-CH 2 -O-或 - 0-CH _{2 - ; 或R 5和R 10一起为-CO-O - ， - O-CO - ， - CH 2 -O-或 - 0-CH _{2 - ; R 6是氢，或者R 5和R 6一起形成键; R 7和R 8彼此独立地为C 1-6烷基，羧基，x-羟基-C 1 -C 4烷基（其中x 为1至6的整数）或C 1-6烷氧基羰基，条件是R 7和R 8中的至少一个为氢，是C 1-6烷基; R 11和R 12都是氢或者R 11和R 12一起是氧代，其他条件是对于式（I），如果R 2是羟基，R 1是C 1-6烷基，其用作药物用于治疗与神经传递受损相关的障碍，以及饮食和药物组合物及其用途。}}

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