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1. 发明授权

US08551481B2 Anti-cancer vaccine composition comprising an anti-CD223 antibody and kit comprising an anti-cancer vaccine and an anti-CD223 antibody 有权
标题翻译：包含抗-CD223抗体和包含抗癌疫苗和抗-CD223抗体的试剂盒的抗癌疫苗组合物
公开(公告)号：US08551481B2
公开(公告)日：2013-10-08
申请号：US12578887
申请日：2009-10-22
申请人： Drew M Pardoll , Ching-Tai Huang , Jonathan Powell , Charles Drake , Dario A Vignali , Creg J Workman
发明人： Drew M Pardoll , Ching-Tai Huang , Jonathan Powell , Charles Drake , Dario A Vignali , Creg J Workman
IPC分类号： A61K39/00 , A61K39/395 , A61K39/38 , C12P21/08
CPC分类号： C07K16/2803 , A01K67/0271 , A01K67/0276 , A01K2267/0381 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K2035/122 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , A61K2039/55516 , C07K14/70503 , C07K16/18 , C07K16/42 , C12N5/0636 , C12N2501/599 , C12N2510/00 , C12N2799/027
摘要： Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.
摘要翻译：调节性T细胞（Treg）限制自身免疫，但也可以减弱抗病原体和抗肿瘤免疫的程度。了解Treg功能的机制和体内Treg的治疗操作需要鉴定Treg选择性受体。分化为效应物/记忆或调节表型的抗原特异性CD4 + T细胞的基因表达阵列的比较分析揭示了TAG选择性表达LAG-3（CD223），一种结合MHC II类的CD4相关分子。 CD4 + T细胞上的LAG-3表达与细胞的体外抑制活性相关，LAG-3在CD4T细胞上的异位表达赋予T细胞抑制活性。 LAG-3的抗体在体外和体内均抑制抑制。 LAG-3标记调节性T细胞群体并有助于其抑制活性。

2. 发明申请

US20060240024A1 T cell regulation 审中-公开
标题翻译： T细胞调节
公开(公告)号：US20060240024A1
公开(公告)日：2006-10-26
申请号：US10547371
申请日：2004-03-01
申请人： Drew Pardoll , Ching-Tai Huang , Dario Vignali , Creg Workman , Jonathan Powell , Charles Drake
发明人： Drew Pardoll , Ching-Tai Huang , Dario Vignali , Creg Workman , Jonathan Powell , Charles Drake
IPC分类号： A61K39/395
CPC分类号： C07K16/2803 , A01K67/0271 , A01K67/0276 , A01K2267/0381 , A61K39/0011 , A61K39/3955 , A61K39/39558 , A61K2035/122 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , A61K2039/55516 , C07K14/70503 , C07K16/18 , C07K16/42 , C12N5/0636 , C12N2501/599 , C12N2510/00 , C12N2799/027
摘要： Regulatory T cells (Treg) limit autoimmunity but can also attenuate the magnitude of anti-pathogen and anti-tumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Treg in vivo requires identification of Treg selective receptors. A comparative analysis of gene expression arrays from antigen specific CD4+ T cells differentiating to either an effector/memory or a regulatory phenotype revealed Treg selective expression of LAG-3 (CD223), a CD4-related molecule that binds MHC class II. LAG-3 expression on CD4+ T cells correlates with the cells' in vitro suppressor activity, and ectopic expression of LAG-3 on CD4 T cells confers suppressor activity on the T cells. Antibodies to LAG-3 inhibit suppression both in vitro and in vivo. LAG-3 marks regulatory T cell populations and contributes to their suppressor activity.
摘要翻译：调节性T细胞（Treg）限制自身免疫，但也可以减弱抗病原体和抗肿瘤免疫的程度。了解Treg功能的机制和体内Treg的治疗操作需要鉴定Treg选择性受体。分化为效应物/记忆或调节表型的抗原特异性CD4 + T细胞的基因表达阵列的比较分析揭示了TAG选择性表达LAG-3（CD223），一种结合MHC II类的CD4相关分子。 CD4 + T细胞上的LAG-3表达与细胞的体外抑制活性相关，LAG-3在CD4T细胞上的异位表达赋予T细胞抑制活性。 LAG-3的抗体在体外和体内均抑制抑制。 LAG-3标记调节性T细胞群体并有助于其抑制活性。

3. 发明申请

US20050095414A1 Process belt and method of forming the same 审中-公开
标题翻译：工艺带及其成型方法
公开(公告)号：US20050095414A1
公开(公告)日：2005-05-05
申请号：US10498937
申请日：2002-12-20
申请人： Michael Maguire , John Schmitt , Charles Drake
发明人： Michael Maguire , John Schmitt , Charles Drake
IPC分类号： D03D15/00 , D03D15/02 , D21F1/00 , F16G3/02 , D04H1/00
CPC分类号： D03D15/00 , D03D1/0094 , D03D15/02 , D10B2101/12 , D10B2101/20 , D10B2401/041 , D21F1/0054 , F16G3/02 , Y10T428/249924
摘要： A process belt and method for manufacturing the same are provided. The belt includes at least one elongated resilient coupling filament operatively connected to a first end section of the belt and to a second end section of the belt such that the first end section, the second end section and a body portion of the belt are substantially continuous with one another. The belt is configured to operatively engage a board processing machine configured to process a board stock or other paper product.
摘要翻译：提供了一种加工带及其制造方法。所述带包括至少一个细长的弹性联接细丝，其可操作地连接到所述带的第一端部部分和所述带的第二端部部分，使得所述带的第一端部部分，所述第二端部部分和主体部分基本连续彼此之间。带被配置为可操作地接合被配置为处理板料或其它纸产品的板加工机。

4. 发明申请

US20060122052A1 Selective para-xylene production via methylation of toluene with methanol in the presence of modified HZSM-5 catalyst 有权
公开(公告)号：US20060122052A1
公开(公告)日：2006-06-08
申请号：US11334245
申请日：2006-01-18
申请人： An-hsiang Wu , Charles Drake
发明人： An-hsiang Wu , Charles Drake
IPC分类号： C07C15/00 , C07C2/68
CPC分类号： B01J29/40 , B01J2229/32 , B01J2229/36 , B01J2229/37 , C07C2/864 , Y02P20/52 , C07C15/08
摘要： We disclose a method for converting toluene to xylenes, comprising contacting toluene with methanol in the presence of a silica-bound HZSM-5 catalyst. As an example, in one embodiment the method can include: (i) first silylating HZSM-5, to form silylated HZSM-5; (ii) first calcining the silylated HZSM-5, to form calcined silylated HZSM-5; (iii) binding the calcined silylated HZSM-5 to silica, to form silica-bound calcined silylated HZSM-5; (iv) extruding the silica-bound calcined silylated HZSM-5, to form extruded silica-bound calcined silylated HZSM-5; (v) second calcining the extruded silica-bound calcined silylated HZSM-5, to form extruded silica-bound twice-calcined silylated HZSM-5; (vi) second silylating the extruded silica-bound twice-calcined silylated HZSM-5, to form extruded silica-bound twice-calcined twice-silylated HZSM-5; and (vii) third calcining the extruded silica-bound twice-calcined twice-silylated HZSM-5, to form the silica-bound HZSM-5 catalyst.

5. 发明申请

US20110195509A1 TREATMENT OF TH17-MEDIATED AUTOIMMUNE DISEASE VIA INHIBITION OF STAT 3 审中-公开
标题翻译：通过STAT3的抑制治疗TH17介导的自发性疾病
公开(公告)号：US20110195509A1
公开(公告)日：2011-08-11
申请号：US12677094
申请日：2008-09-05
申请人： Drew Pardoll , Charles Drake , Timothy Harris , Hua Yu
发明人： Drew Pardoll , Charles Drake , Timothy Harris , Hua Yu
IPC分类号： G01N33/68 , C07H21/02 , C07K16/18 , C07K16/24 , G01N33/48
CPC分类号： C07K16/2866 , A61K2039/507 , C07K16/244 , G01N33/564 , G01N33/6872 , G01N2800/12 , G01N2800/24 , G01N2800/26 , Y10T436/143333
摘要： Methods for treating autoimmune disease using one or more inhibitor of STAT3 are provided herein. Also disclosed are methods for diagnosing and monitoring autoimmune disease or the propensity to develop autoimmune disease in a subject. The present invention demonstrates that inhibition of STAT3 prevents development of autoimmune disease in vivo. Based on this finding, Stat3 inhibitors can be used to treat and/or diagnose autoimmune disease in a subject.
摘要翻译：本文提供了使用一种或多种STAT3抑制剂治疗自身免疫疾病的方法。还公开了用于诊断和监测自身免疫疾病或在受试者中发展自身免疫疾病的倾向的方法。本发明表明STAT3的抑制可预防体内自身免疫疾病的发展。基于这一发现，Stat3抑制剂可用于治疗和/或诊断受试者中的自身免疫性疾病。

6. 发明申请

US20070253265A1 Bitline leakage limiting with improved voltage regulation 失效
标题翻译：位线泄漏限制与改进的电压调节
公开(公告)号：US20070253265A1
公开(公告)日：2007-11-01
申请号：US11414364
申请日：2006-05-01
申请人： Christopher Miller , Charles Drake
发明人： Christopher Miller , Charles Drake
IPC分类号： G11C7/00 , G11C7/02
CPC分类号： G11C7/12 , G11C7/02
摘要： Circuit arrangements and methods are provided for regulating and maintaining voltage on bitlines of a semiconductor memory device. According to one embodiment, first and second regulation devices are connected to a charging circuit. At the beginning of a charging period, voltage on the bitlines is regulated with the second regulation device as the bitlines are initially charged to a voltage. After initially charging the bitlines to the voltage, voltage on the bitlines is regulated with the first regulation device that also limits current to the bitlines when there is a leakage anomaly associated with the bitlines. According to another embodiment, a charging circuit that is connected to sense nodes of a sense amplifier while the sense nodes are connected to the bitlines is activated so that the charging circuit assists in charging the bitlines at the beginning of a charging period. After the bitlines are initially charged at the beginning of the charging period, voltage on the bitlines is regulated with a first regulation device that regulates current to the bitlines and limits current to the bitlines when there is a leakage anomaly associated with the bitlines.
摘要翻译：提供电路布置和方法用于调节和维持半导体存储器件的位线上的电压。根据一个实施例，第一和第二调节装置连接到充电电路。在充电周期开始时，由于位线最初被充电到电压，所以利用第二调节装置调节位线上的电压。在最初将位线充电到电压之后，利用第一调节装置来调节位线上的电压，当与位线相关联的泄漏异常时也将电流限制到位线。根据另一个实施例，当感测节点连接到位线时连接到感测放大器的感测节点的充电电路被激活，使得充电电路在充电周期开始时协助对位线充电。在充电周期开始之后，位线最初充电之后，利用第一调节装置来调节位线上的电压，该第一调节装置在与位线相关联的泄漏异常时将电流调节到位线并限制位线的电流。

7. 发明授权

US07403439B2 Bitline leakage limiting with improved voltage regulation 失效
标题翻译：位线泄漏限制与改进的电压调节
公开(公告)号：US07403439B2
公开(公告)日：2008-07-22
申请号：US11414364
申请日：2006-05-01
申请人： Christopher Miller , Charles Drake
发明人： Christopher Miller , Charles Drake
IPC分类号： G11C7/00
CPC分类号： G11C7/12 , G11C7/02
摘要： Circuit arrangements and methods are provided for regulating and maintaining voltage on bitlines of a semiconductor memory device. According to one embodiment, first and second regulation devices are connected to a charging circuit. At the beginning of a charging period, voltage on the bitlines is regulated with the second regulation device as the bitlines are initially charged to a voltage. After initially charging the bitlines to the voltage, voltage on the bitlines is regulated with the first regulation device that also limits current to the bitlines when there is a leakage anomaly associated with the bitlines. According to another embodiment, a charging circuit that is connected to sense nodes of a sense amplifier while the sense nodes are connected to the bitlines is activated so that the charging circuit assists in charging the bitlines at the beginning of a charging period. After the bitlines are initially charged at the beginning of the charging period, voltage on the bitlines is regulated with a first regulation device that regulates current to the bitlines and limits current to the bitlines when there is a leakage anomaly associated with the bitlines.
摘要翻译：提供电路布置和方法用于调节和维持半导体存储器件的位线上的电压。根据一个实施例，第一和第二调节装置连接到充电电路。在充电周期开始时，由于位线最初被充电到电压，所以利用第二调节装置调节位线上的电压。在最初将位线充电到电压之后，利用第一调节装置来调节位线上的电压，当与位线相关联的泄漏异常时也将电流限制到位线。根据另一个实施例，当感测节点连接到位线时连接到感测放大器的感测节点的充电电路被激活，使得充电电路在充电周期开始时协助对位线充电。在充电周期开始之后，位线最初充电之后，利用第一调节装置来调节位线上的电压，该第一调节装置在与位线相关联的泄漏异常时将电流调节到位线并限制位线的电流。

8. 发明申请

US20090304711A1 Combinatorial Therapy of Cancer and Infectious Diseases with Anti-B7-H1 Antibodies 审中-公开
标题翻译：用抗B7-H1抗体组合治疗癌症和传染病
公开(公告)号：US20090304711A1
公开(公告)日：2009-12-10
申请号：US12441996
申请日：2007-09-20
申请人： Drew Pardoll , Lieping Chen , Charles Drake , Andrea Cox
发明人： Drew Pardoll , Lieping Chen , Charles Drake , Andrea Cox
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/2827 , A61K39/0011 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , C07K16/2818 , C07K2317/76 , A61K2300/00
摘要： Described are uses of an agent that reduces B7-H1 interaction with PD-1, and particularly monoclonal antibodies that bind to B7-H1 and interfere with B7-H1 interaction with PD-1 in combination with a vaccine to provide synergistic effects. The application provides methods of treatment and vaccination based on the combination of these compounds on T cell responses.
摘要翻译：描述了减少与PD-1的B7-H1相互作用的试剂的用途，特别是结合B7-H1并干扰与PD-1与疫苗组合以提供协同效应的B7-H1相互作用的单克隆抗体。该应用提供了基于这些化合物对T细胞应答的组合的治疗和疫苗接种的方法。

9. 发明申请

US20060128556A1 Selective para-xylene production via methylation of toluene with methanol in the presence of modified HZSM-5 catalyst 有权
公开(公告)号：US20060128556A1
公开(公告)日：2006-06-15
申请号：US11334703
申请日：2006-01-18
申请人： An-Hsiang Wu , Charles Drake
发明人： An-Hsiang Wu , Charles Drake
IPC分类号： C07C15/00 , C07C2/68 , B01J29/06
CPC分类号： B01J29/40 , B01J2229/32 , B01J2229/36 , B01J2229/37 , C07C2/864 , Y02P20/52 , C07C15/08
摘要： We disclose a method for converting toluene to xylenes, comprising contacting toluene with methanol in the presence of a silica-bound HZSM-5 catalyst. As an example, in one embodiment the method can include: (i) first silylating HZSM-5, to form silylated HZSM-5; (ii) first calcining the silylated HZSM-5, to form calcined silylated HZSM-5; (iii) binding the calcined silylated HZSM-5 to silica, to form silica-bound calcined silylated HZSM-5; (iv) extruding the silica-bound calcined silylated HZSM-5, to form extruded silica-bound calcined silylated HZSM-5; (v) second calcining the extruded silica-bound calcined silylated HZSM-5, to form extruded silica-bound twice-calcined silylated HZSM-5; (vi) second silylating the extruded silica-bound twice-calcined silylated HZSM-5, to form extruded silica-bound twice-calcined twice-silylated HZSM-5; and (vii) third calcining the extruded silica-bound twice-calcined twice-silylated HZSM-5, to form the silica-bound HZSM-5 catalyst.

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