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1. 发明授权

US07405299B2 Compounds as pharmaceutical agents 失效
标题翻译：化合物作为药剂
公开(公告)号：US07405299B2
公开(公告)日：2008-07-29
申请号：US10535381
申请日：2003-11-24
申请人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
发明人： Douglas Wade Beight , Timothy Paul Burkholder , Todd Vincent Decollo , Alexander Glenn Godfrey , Charles Raymond Heap , Chi-Hsin Richard King , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Yan Wang , Clive Gideon Diefenbacher , Thomas Albert Engler , Sushant Malhotra , Sreenivasa Reedy Mundla
IPC分类号： C07D241/36 , C07D217/00 , C07D401/00
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula: (Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译：本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。

2. 发明授权

US07087626B2 Pyrrole derivatives as pharmaceutical agents 有权
标题翻译：吡咯衍生物作为药剂
公开(公告)号：US07087626B2
公开(公告)日：2006-08-08
申请号：US10477111
申请日：2002-05-13
申请人： Douglas Wade Beight , Todd Vincent DeCollo , Alexander Glenn Godfrey , Theodore Goodson, Jr. , Hong-Yu Li , William Thomas McMillen , Shawn Christopher Miller , Jason Scott Sawyer , Edward C. R. Smith , Jonathan Michael Yingling
发明人： Douglas Wade Beight , Todd Vincent DeCollo , Alexander Glenn Godfrey , Theodore Goodson, Jr. , Hong-Yu Li , William Thomas McMillen , Shawn Christopher Miller , Jason Scott Sawyer , Edward C. R. Smith , Jonathan Michael Yingling
IPC分类号： A61K31/47 , C07D205/16 , C07D307/00 , C07D405/00
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S
摘要翻译：新型吡唑衍生物化合物及其作为药剂的用途，特别是其作为TGF-β信号转导抑制剂的用途。所公开的发明涉及结构（I）的化合物，其中（I）是四，五或六元饱和环，X是C，O或S

3. 发明申请

US20100130466A1 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS 失效
标题翻译：三唑基氨基嘧啶化合物
公开(公告)号：US20100130466A1
公开(公告)日：2010-05-27
申请号：US12596957
申请日：2008-05-07
申请人： Harold Burns Brooks , Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
发明人： Harold Burns Brooks , Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
IPC分类号： A61K31/506 , C07D409/14 , A61P35/00 , C07D413/14 , A61K31/5377
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
摘要翻译：本发明提供可用于治疗癌症的三唑基氨基嘧啶化合物。

4. 发明授权

US08063035B2 Triazolyl aminopyrimidine compounds 失效
标题翻译：三唑基氨基嘧啶化合物
公开(公告)号：US08063035B2
公开(公告)日：2011-11-22
申请号：US12598926
申请日：2008-05-07
申请人： Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
发明人： Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
IPC分类号： A61K31/381 , C07D333/16 , C07D409/14
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
摘要翻译：本发明提供可用于治疗癌症的三唑基氨基嘧啶化合物。

5. 发明授权

US08114872B2 Triazolyl aminopyrimidine compounds 失效
标题翻译：三唑基氨基嘧啶化合物
公开(公告)号：US08114872B2
公开(公告)日：2012-02-14
申请号：US12596957
申请日：2008-05-07
申请人： Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
发明人： Joyce Z. Crich , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang , James Robert Henry , Hong Hu , Sachin Govindlal Maniar
IPC分类号： C07D409/14 , A61K31/506
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.
摘要翻译：本发明提供可用于治疗癌症的三唑基氨基嘧啶化合物。

6. 发明申请

US20100087431A1 TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS 失效
公开(公告)号：US20100087431A1
公开(公告)日：2010-04-08
申请号：US12598926
申请日：2008-05-07
申请人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
发明人： Harold Burns Brooks , Joyce Z. Crich , James Robert Henry , Hong Hu , Delu Jiang , Hong-Yu Li , William Thomas McMillen , Jason Scott Sawyer , Melissa Kate Slater , Yan Wang
IPC分类号： A61K31/506 , C07D409/14 , C07D413/14 , A61K31/5377 , A61P35/00
CPC分类号： C07D409/14
摘要： The present invention provides triazolyl aminopyrimidine compounds useful in the treatment of cancer.

7. 发明授权

US07365066B2 Pyrazolopyridine derivatives as pharmaceutical agents 失效
标题翻译：吡唑并吡啶衍生物作为药剂
公开(公告)号：US07365066B2
公开(公告)日：2008-04-29
申请号：US10524577
申请日：2003-09-16
申请人： Douglas Wade Beight , Rosanne Bonjouklian , Junkai Liao , William Thomas McMillen , Brandon Lee Parkhurst , Jason Scott Sawyer , Jonathan Michael Yingling , Jeremy Schulenburg York
发明人： Douglas Wade Beight , Rosanne Bonjouklian , Junkai Liao , William Thomas McMillen , Brandon Lee Parkhurst , Jason Scott Sawyer , Jonathan Michael Yingling , Jeremy Schulenburg York
IPC分类号： A61K31/535 , A61K31/50 , A01N43/42 , C07D471/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Novel pyrazolopyridine derivative compounds are disclosed and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors useful in the treatment of cancer and other disease states influenced by TGF beta.
摘要翻译：公开了新的吡唑并吡啶衍生物化合物及其作为药剂的用途，特别是其用作TGF-β信号转导抑制剂的用途，其用于治疗受TGFβ影响的癌症和其它疾病状态。

8. 发明授权

US06797723B1 Heterocycle substituted diphenyl leukotriene antagonists 失效
公开(公告)号：US06797723B1
公开(公告)日：2004-09-28
申请号：US10111544
申请日：2002-04-24
申请人： Jason Scott Sawyer , Douglas Wade Beight , Edward C R Smith , William Thomas McMillen
发明人： Jason Scott Sawyer , Douglas Wade Beight , Edward C R Smith , William Thomas McMillen
IPC分类号： A61K31415
CPC分类号： C07D207/08 , C07D207/333 , C07D231/12 , C07D233/64 , C07D249/06 , C07D261/08 , C07D275/02 , C07D277/24 , C07D285/01 , C07D285/06 , C07D285/10 , C07D285/12 , C07D307/12 , C07D307/42 , C07D333/16
摘要： The invention relates to novel heterocycle substituted diphenyl leukotriene B4 (LTB4) antagonists, to compositions containing such compounds, and to methods of using such compounds for treatment of inflammatory diseases.

9. 发明授权

US07368445B2 Fused pyrazole derivatives as TGF-β signal transduction inhibitors for the treatment of fibrosis and neoplasms 失效
标题翻译：融合的吡唑衍生物作为TGF-β信号转导抑制剂用于治疗纤维化和肿瘤
公开(公告)号：US07368445B2
公开(公告)日：2008-05-06
申请号：US10597979
申请日：2005-02-16
申请人： Hong-Yu Li , William Thomas McMillen , Yan Wang
发明人： Hong-Yu Li , William Thomas McMillen , Yan Wang
IPC分类号： C07D487/04 , A61K31/517
CPC分类号： C07D413/14 , C07D401/14 , C07D487/04
摘要： The disclosed invention is directed to compounds of the formula: Formula (I) and methods of using these compounds.
摘要翻译：所公开的发明涉及下式的化合物：式（I）和使用这些化合物的方法。

10. 发明授权

US06809080B2 Macrolide antibiotics 失效
标题翻译：大环内酯抗生素
公开(公告)号：US06809080B2
公开(公告)日：2004-10-26
申请号：US09892081
申请日：2001-06-26
申请人： Takushi Kaneko , William Thomas McMillen
发明人： Takushi Kaneko , William Thomas McMillen
IPC分类号： A61K3170
CPC分类号： C07H17/08
摘要： This invention relates to compounds of the formula and to pharmaceutically acceptable salts, prodrugs, and solvates thereof wherein X, Y, R1, R2, R3, R4, and R6 are as defined herein. The compounds of formula I are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula I, methods of making the compounds, and to methods of treating bacterial and protozoal infections by administering the compounds.
摘要翻译：本发明涉及下式的化合物及其药学上可接受的盐，前药和溶剂化物，其中X，Y，R 1，R 2，R 3，R 4和R 6如本文定义。式I化合物是可用于治疗各种细菌和原生动物感染的抗细菌剂和抗原虫药，以及与这种感染有关的疾病。本发明还涉及含有式I化合物的药物组合物，制备化合物的方法，以及通过施用化合物治疗细菌和原生动物感染的方法。

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