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1. 发明授权

US07953486B2 Maximum pacing rate limiter implemented using the evoked response—T-wave interval 失效
标题翻译：使用诱发响应T波间隔实现最大起搏速率限制器
公开(公告)号：US07953486B2
公开(公告)日：2011-05-31
申请号：US11225712
申请日：2005-09-13
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

2. 发明授权

US06963778B2 Maximum pacing rate limiter implemented using the evoked response-T-wave interval 失效
标题翻译：使用诱发响应T波间隔实现最大起搏速率限制器
公开(公告)号：US06963778B2
公开(公告)日：2005-11-08
申请号：US10053223
申请日：2002-01-17
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio Spinelli
IPC分类号： A61N1/365 , A61N1/18
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

3. 发明授权

US08532771B2 Maximum pacing rate limiter system 失效
标题翻译：最大起搏速率限制系统
公开(公告)号：US08532771B2
公开(公告)日：2013-09-10
申请号：US13115825
申请日：2011-05-25
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

4. 发明申请

US20110230926A1 MAXIMUM PACING RATE LIMITER SYSTEM 失效
标题翻译：最大速率限制系统
公开(公告)号：US20110230926A1
公开(公告)日：2011-09-22
申请号：US13115825
申请日：2011-05-25
申请人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
发明人： Douglas R. Daum , Geng Zhang , Qingsheng Zhu , Gerrard M. Carlson , Julio C. Spinelli
IPC分类号： A61N1/365
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

5. 发明申请

US20060009812A1 Maximum pacing rate limiter implemented using the evoked response - T-wave interval 失效
标题翻译：使用诱发反应 - T波间隔实现最大起搏速率限制器
公开(公告)号：US20060009812A1
公开(公告)日：2006-01-12
申请号：US11225712
申请日：2005-09-13
申请人： Douglas Daum , Geng Zhang , Qingsheng Zhu , Gerrard Carlson , Julio Spinelli
发明人： Douglas Daum , Geng Zhang , Qingsheng Zhu , Gerrard Carlson , Julio Spinelli
IPC分类号： A61N1/37
CPC分类号： A61N1/365
摘要： A maximum pacing rate limiter for use in adaptive rate pacing in conjunction with a cardiac rhythm management system for a heart. The maximum pacing rate limiter may function to measure an interval, termed the ERT interval, between a paced ventricular evoked response and a T-wave. The maximum pacing rate limiter may further function to maintain the ERT interval at less than a certain percentage of the total cardiac cycle. In one disclosed embodiment, a maximum pacing rate limiter calculates an ERT rate based on the detected paced ventricular evoked response and the T-wave, and the pacing rate limiter module further communicates the minimum of the ERT rate and an adaptive-rate sensor indicated rate to a pacemaker.
摘要翻译：与心脏心律管理系统结合使用的适应性起搏速度的最大起搏速率限制器。最大起搏速率限制器可以用于测量在起搏心室诱发反应和T波之间的称为ERT间期的间隔。最大起搏速率限制器可进一步起作用以将ERT间期维持在小于总心律周期的一定百分比。在一个公开的实施例中，最大起搏速率限制器基于检测到的起搏心室诱发反应和T波计算ERT率，并且起搏速率限制器模块进一步传达最小ERT率和自适应速率传感器指示率到起搏器。

6. 发明授权

US07113825B2 Method and apparatus for detecting acoustic oscillations in cardiac rhythm 有权
公开(公告)号：US07113825B2
公开(公告)日：2006-09-26
申请号：US10138046
申请日：2002-05-03
申请人： Joseph M. Pastore , William C. Lincoln , Gerrard M. Carlson , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , William C. Lincoln , Gerrard M. Carlson , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/39 , A61B5/02
CPC分类号： A61N1/3925 , A61N1/3622 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by measuring the amplitudes of heart sounds during successive heart beats. Upon detection of acoustic alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

7. 发明授权

US08636669B2 Method and apparatus for monitoring of diastolic hemodynamics 有权
标题翻译：用于监测舒张血流动力学的方法和装置
公开(公告)号：US08636669B2
公开(公告)日：2014-01-28
申请号：US12985055
申请日：2011-01-05
申请人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

8. 发明授权

US07972275B2 Method and apparatus for monitoring of diastolic hemodynamics 有权
标题翻译：用于监测舒张血流动力学的方法和装置
公开(公告)号：US07972275B2
公开(公告)日：2011-07-05
申请号：US10334694
申请日：2002-12-30
申请人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
发明人： Krzysztof Z. Siejko , Qingsheng Zhu , Gerrard M. Carlson
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

9. 发明授权

US07062323B2 Maximum atrial tracking rate for cardiac rhythm management system 失效
标题翻译：心律管理系统最大心房跟踪率
公开(公告)号：US07062323B2
公开(公告)日：2006-06-13
申请号：US10040287
申请日：2001-10-19
申请人： Gerrard M. Carlson , Julio C. Spinelli , Qingsheng Zhu
发明人： Gerrard M. Carlson , Julio C. Spinelli , Qingsheng Zhu
IPC分类号： A61N1/18
CPC分类号： A61N1/36542 , A61N1/3622 , A61N1/36521
摘要： A cardiac rhythm management system includes an operational mode in which ventricular pacing pulses are delivered at a rate that tracks a sinoatrial rate up to an appropriate maximum atrial tracking rate (MATR) value determined by the system. In one example, the MATR value is based on a patient activity level and a hemodynamic maximum rate (HMR) determined from a QRS-to-S2 interval, where S2 is an accelerometer-generated fiducial correlative to aortic valve closure (AVC). In a further example, a correlation between the QRS-to-S2 interval and heart rate is established, and the MATR is based on the patient activity level and heart rate. In a further example, a lower rate threshold for providing antitachyarrhythmia therapy is modified based on the MATR. For example, when the MATR exceeds a default value of the antitachyarrhythmia therapy lower rate threshold, the threshold tracks the MATR. In another example, the MATR is based on an active time between a QRS complex and a heart impedance signal maximum slope during the same cardiac cycle.
摘要翻译：心律管理系统包括操作模式，其中心率起搏脉冲以跟踪窦房速率直到由系统确定的合适的最大心房跟踪率（MATR）值的速率递送。在一个示例中，MATR值基于患者活动水平和从QRS至S 2区间确定的血流动力学最大速率（HMR），其中S < 是与主动脉瓣闭合（AVC）相关的加速度计产生的基准。在另一个例子中，建立了QRS-S-SUB间隔和心率之间的相关性，并且MATR基于患者活动水平和心率。在另一个实例中，基于MATR修改用于提供抗心律不齐治疗的较低速率阈值。例如，当MATR超过抗心律不齐治疗较低速率阈值的默认值时，阈值跟踪MATR。在另一个例子中，MATR基于在相同心动周期期间QRS波形与心脏阻抗信号最大斜率之间的活动时间。

10. 发明授权

US06650940B1 Accelerometer-based heart sound detection for autocapture 有权
标题翻译：基于加速度计的心脏声音检测
公开(公告)号：US06650940B1
公开(公告)日：2003-11-18
申请号：US09496832
申请日：2000-02-02
申请人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
发明人： Qingsheng Zhu , Julio C. Spinelli , Gerrard M. Carlson
IPC分类号： A61N1365
CPC分类号： A61N1/36542 , A61N1/3712
摘要： An implantable cardiac rhythm management device capable of automatically detecting intrinsic and evoked response of a patient's heart. The device operates in an automatic capture verification mode, wherein a global accelerometer signal is utilized to identify heart sounds (S1 and S2) of the patient's heart. The presence or absence of one or more of the heart sounds S1 and S2 in the accelerometer signal indicates whether a stimulation pulse evokes a response by the patient's heart. The device may automatically adjust the stimulation output in accordance with a step down stimulation protocol, wherein the presence of a predetermined heart sound indicates capture. Also, the device may suspend the automatic capture verification sequence if the patient's physical activity level exceeds a predetermined threshold.
摘要翻译：一种能够自动检测患者心脏的内在和诱发反应的植入式心律管理装置。该装置以自动捕获验证模式工作，其中使用全局加速度计信号来识别患者心脏的心音（S1和S2）。加速度计信号中存在或不存在一个或多个心音S1和S2表示刺激脉冲是否引起患者心脏的反应。设备可以根据降压刺激协议自动调节刺激输出，其中预定心音的存在指示捕获。此外，如果患者的身体活动水平超过预定阈值，则设备可以暂停自动捕获验证序列。

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