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1. 发明申请

US20060132878A1 Method of scanning and light collection for a rare cell detector 有权
标题翻译：稀有细胞检测器的扫描和光采集方法
公开(公告)号：US20060132878A1
公开(公告)日：2006-06-22
申请号：US11017440
申请日：2004-12-20
申请人： Douglas Curry , Richard Bruce , Robert Krivacic
发明人： Douglas Curry , Richard Bruce , Robert Krivacic
IPC分类号： G02B26/08
CPC分类号： G01N21/6456 , G01N21/6428 , G01N2021/6484 , G01N2201/1085
摘要： An apparatus images a surface. An imager stage has a planar surface for supporting a sample. A fiber optic bundle has a first end of parallel first fiber ends that are arranged to define an input aperture for viewing the sample on the imager stage. A distal bundle end is arranged to define an output aperture disposed away from the imager stage. A scanning radiation source scans a radiation beam along a path that is perpendicular to the sample on the imager stage. The input aperture of the fiber optic bundle receives a light signal that is produced by the radiation source scan of the imager stage sample. The light signal is transmitted to the bundle output aperture. A photodetector detects the light signal at the distal bundle end, and a processor processes the detected light.
摘要翻译：装置对表面进行成像。成像器台具有用于支撑样品的平坦表面。光纤束具有平行的第一光纤端的第一端，其布置成限定用于观察成像器台上的样品的输入孔。远侧束端布置成限定远离成像器台布置的输出孔。扫描辐射源沿着与成像器台上的样品垂直的路径扫描辐射束。光纤束的输入孔径接收由成像器台样品的辐射源扫描产生的光信号。光信号被传输到束输出孔径。光电检测器检测远侧束端处的光信号，并且处理器处理检测到的光。

2. 发明申请

US20060132778A1 Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems 有权
标题翻译：多探头多激光荧光检测系统的多路复用扫描光源
公开(公告)号：US20060132778A1
公开(公告)日：2006-06-22
申请号：US11018759
申请日：2004-12-21
申请人： Douglas Curry , Richard Bruce
发明人： Douglas Curry , Richard Bruce
IPC分类号： G01N21/64 , G01J3/30
CPC分类号： G01N21/6456 , G01N15/1468 , G01N2201/1085
摘要： An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and parallel to the surface, and a second end defining an output aperture. A plurality of radiation beams linearly scan and interact in time-multiplexed alternating turns with the surface below the input aperture to produce a time-multiplexed light signal that is collected by the input aperture and transmitted by the light path to the output aperture. A photodetector arrangement detects the light signal at the output aperture. A processor processes the detected time-multiplexed light.
摘要翻译：装置对表面进行成像。成像器台沿第一方向线性平移表面。光路具有限定垂直于第一方向并平行于表面的输入孔的第一端，以及限定输出孔的第二端。多个辐射束在时间多路复用的交替匝中线性扫描并与输入孔下方的表面相互作用，以产生由输入孔收集并由光路传输到输出孔的时间复用光信号。光电检测器装置检测输出孔处的光信号。处理器处理检测到的时间复用光。

3. 发明申请

US20070166770A1 Novel immunocytostaining methods for enhanced dye ratio discrimination in rare event detection 有权
标题翻译：用于在罕见事件检测中增强染料比率鉴别的新型免疫细胞染色方法
公开(公告)号：US20070166770A1
公开(公告)日：2007-07-19
申请号：US11333731
申请日：2006-01-17
申请人： Huangpin Hsieh , Nicole Lazarus , Robert Krivacic , Douglas Curry , Richard Bruce
发明人： Huangpin Hsieh , Nicole Lazarus , Robert Krivacic , Douglas Curry , Richard Bruce
IPC分类号： G01N33/567
CPC分类号： G01N1/30 , G01N15/1468 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N33/56966 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit signals having spectral characteristics sufficient to permit filtering to differentiate and eliminate most false positives from true positives among acquired imaging events, in an imaging system employing a laser spot having a range of diameters from 1 to 20 μm or greater and which excites the fluorescence in a conventional or novel manner. These filtered events may be subsequently imaged and confirmed with another higher resolution device such as a fluorescent microscope in a short amount of time.
摘要翻译：提供了一种制备包含潜在感兴趣的细胞的样品并使用基于激光的系统的激光进行新颖的激发和发射采集以及数据使用的方法，包括使用获得的数据进行直接和基于比率的测量。所制备的样品被配置为发射具有足够的光谱特性的信号，以在使用具有1至20μm或更大直径范围的激光光斑的成像系统中进行滤光以区分并消除所获得的成像事件之间的真阳性的大多数假阳性并以常规或新颖的方式激发荧光。这些过滤的事件可以随后在较短的时间内用另一种较高分辨率的装置例如荧光显微镜进行成像和证实。

4. 发明申请

US20060078999A1 Apparatus and method for a nanocalorimeter for detecting chemical reactions 失效
标题翻译：用于检测化学反应的纳米光度计的装置和方法
公开(公告)号：US20060078999A1
公开(公告)日：2006-04-13
申请号：US11149632
申请日：2005-06-10
申请人： Alan Bell , Richard Bruce , Scott Elrod , Eric Peeters , Francisco Torres
发明人： Alan Bell , Richard Bruce , Scott Elrod , Eric Peeters , Francisco Torres
IPC分类号： G01K17/02
CPC分类号： B82Y15/00 , G01N25/4846 , G01N25/4866 , Y10S977/957 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A method for detecting chemical reactions uses a nanocalorimeter having a substrate including thermal isolation capability residing on the substrate, thermal equilibration regions residing within the thermal isolation capability, and thermal measurement capability residing within each of the thermal equilibration regions. The thermal measurement device is connected to detection electronics. The method includes depositing drops of potentially reactive chemical solutions within the thermal equilibration region. These potentially reactive solution drops are merged through the use of drop merging electrodes residing within the thermal isolation region. The thermal change occurring within the merged solution drops is then measured with the detection electronics.
摘要翻译：用于检测化学反应的方法使用具有包含驻留在基底上的热隔离能力的基底，驻留在热隔离能力内的热平衡区域和驻留在每个热平衡区域内的热测量能力的纳米尺度计。热测量设备连接到检测电子设备。该方法包括在热平衡区域内沉积潜在的反应性化学溶液的液滴。这些潜在的反应性溶液滴通过使用位于热隔离区域内的滴合并电极而合并。然后用检测电子元件测量在合并溶液中发生的热变化。

5. 发明授权

US5442467A Enhanced off-axis viewing performance and luminous efficiency of a liquid crystal display employing fiberoptic faceplate elements 失效
标题翻译：使用光纤面板元件的液晶显示器的增强的离轴观察性能和发光效率
公开(公告)号：US5442467A
公开(公告)日：1995-08-15
申请号：US215454
申请日：1994-03-21
申请人： Louis D. Silverstein , Thomas G. Fiske , Richard Bruce , Robert A. Sprague
发明人： Louis D. Silverstein , Thomas G. Fiske , Richard Bruce , Robert A. Sprague
IPC分类号： G02B6/00 , G02B6/08 , G02F1/1335 , G02F1/13357
CPC分类号： G02B6/08 , G02F1/133514 , G02F1/133524 , G02F1/133604 , Y10S385/901
摘要： A transmissive, backlit color twisted-nematic or super-twisted-nematic liquid crystal display employing a front fiber-optic faceplate as a front retaining element of a liquid crystal cell that increases viewing angle between the display and a viewer while minimizing or eliminating undesirable variations in luminance, contrast ratio and chromaticity is described. This novel configuration effectively decouples the liquid crystal cell and other optical elements behind the front fiber optic faceplate from the angular orientation of the viewer with respect to the display. The liquid crystal display described in this invention further provides a high quality color display, without viewing parallax, using a color selection filter mosaic outside of the liquid crystal cell. The display also increases luminous efficiency and improves color saturation by concentrating the transmission of available backlight illumination through the use of a rear fiber-optic faceplate and a second rear-mounted mosaic of color interference filters.
摘要翻译：使用前光纤面板作为液晶单元的前保持元件的透射式背光彩色扭曲向列或超扭曲向列型液晶显示器，其在最小化或消除不期望的变化的同时增加显示器和观看者之间的视角描述了亮度，对比度和色度。这种新颖的配置有效地将液晶单元和前光纤面板后面的其它光学元件与观看者相对于显示器的角度定向分离。在本发明中描述的液晶显示器还使用液晶单元外部的选色滤光片马赛克，提供了不观看视差的高质量彩色显示器。该显示器还通过使用后部光纤面板和第二个后置安装的彩色干涉滤光片马赛克集中可用背光照明的透射来提高发光效率并提高色彩饱和度。

6. 发明授权

US5196652A Wireless electrical connections of abutting tiled arrays 失效
标题翻译：无线电缆连接
公开(公告)号：US5196652A
公开(公告)日：1993-03-23
申请号：US633923
申请日：1990-12-26
申请人： James C. Mikkelsen, Jr. , William Meuli , Richard Bruce , Jackson Ho
发明人： James C. Mikkelsen, Jr. , William Meuli , Richard Bruce , Jackson Ho
IPC分类号： G09F9/00 , G09F9/35 , G09F9/40 , H01R4/02 , H01R4/04 , H01R12/52 , H05K1/11 , H05K1/14 , H05K3/32 , H05K3/34 , H05K3/36
CPC分类号： H05K1/142 , G09F9/35 , H01R12/52 , H05K3/3405 , H05K3/36 , H01R4/02 , H05K1/117 , H05K2201/09154 , H05K2203/049 , H05K3/321 , H05K3/328 , Y10T29/49149
摘要： A method for electrically connecting planar element substrates (12) to form an array (10) by forming conductive bridges (16) between metal pads (14) located on the surface of array elements (12). These bridges (16) are designed to transmit or receive visual, acoustical or other electromagnetic data and power. The conductive bridges (16) are formed to be nearly coplanar with the planar elements (12) and are made to connect the edges (14b) of pads (14) which are fused to the planar substrate (12). Metal wire (16a), solder (16b-c), a conductive polymer (16d), or a suspension of conductive particles in paste (16e) are used to bridge and electrically connect the pads (14) located on the array elements (12). The bridges (16) have a low profile, occupy a very small area and reduce the need for highly accurate alignment of adjacent substrates (12) within the tiled array (10) before electrical connections are formed. These low profile bridges (16) are especially advantageous in that they allow a protective plastic or similar cover sheet, or a liquid crystal laminate to be surface mounted on the composite array (10) without causing detrimental surface blemishes or ridges. The small area of the bridges (16) greatly reduces the non-transmitting area of the visual display. The bridges (16), being substantially narrower than the pads (14) which they connect, are more likely to connect the intended pads (14) and less likely to "short" pads (14) which are not in accurate alignment.

7. 发明申请

US20060123462A1 Systems and methods for protecting private information in a mobile environment 失效
标题翻译：在移动环境中保护私人信息的系统和方法
公开(公告)号：US20060123462A1
公开(公告)日：2006-06-08
申请号：US11004748
申请日：2004-12-02
申请人： Teresa Lunt , Daniel Greene , Philippe Golle , Richard Bruce , Jessica Staddon
发明人： Teresa Lunt , Daniel Greene , Philippe Golle , Richard Bruce , Jessica Staddon
IPC分类号： H04L9/00
CPC分类号： H04L63/0421 , H04L63/102
摘要： Techniques for protecting non-public information in a mobile environment are provided. A request for non-public information about users in a mobile environment is received. Privacy policies, non-public and optional public information about the users affected by the request are determined. An optional privacy impact indicator is determined based on how satisfying the request increases the current public information about the users. Crowds of users having similar attribute name/values are optionally determined. User and optional requestor privacy policies which associate threshold release criteria such minimum crowd size, minimum consideration with the non-public information are determined. A privacy agreement is reached for the disclosure of the requested non-public information based on the compatibility of the requester and user privacy policies. Privacy protecting transformations are optionally determined and applied to create crowds or groups associated with the requested attribute.
摘要翻译：提供了在移动环境中保护非公开信息的技术。接收到关于用户在移动环境中的非公开信息的请求。确定关于受请求影响的用户的隐私政策，非公开和可选的公开信息。可选的隐私影响指标是根据请求如何满足当前有关用户的公开信息来确定的。具有相似属性名称/值的用户群可以任选地确定。用户和可选择的请求者隐私策略，其将阈值释放标准与最小人群大小，最小考虑与非公开信息相关联。根据请求者和用户隐私政策的兼容性，达成了所要求的非公开信息披露的隐私协议。可选地确定并应用隐私保护转换以创建与所请求的属性相关联的人群或组。

8. 发明申请

US20060038120A1 Sample manipulator 有权
标题翻译：样品机械手
公开(公告)号：US20060038120A1
公开(公告)日：2006-02-23
申请号：US10921556
申请日：2004-08-19
申请人： Meng Lean , Francisco Torres , Huangpin Hsieh , Armin Volkel , Bryan Preas , Scott Elrod , John Fitch , Richard Bruce
发明人： Meng Lean , Francisco Torres , Huangpin Hsieh , Armin Volkel , Bryan Preas , Scott Elrod , John Fitch , Richard Bruce
IPC分类号： H01J49/00
CPC分类号： B03C1/253
摘要： A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.
摘要翻译：公开了一种使用静电行波选择性地移动沉积在其表面上的一个或多个样品的样品操纵器。样品操纵器使得操作者能够在沉积的样品上执行各种各样的处理。还公开了用于分离两个或更多个样品，聚焦样品并使试剂通过样品的策略，全部在样品操纵器的表面上进行。

9. 发明申请

US20050254552A1 Thermal sensing 有权
标题翻译：热传感
公开(公告)号：US20050254552A1
公开(公告)日：2005-11-17
申请号：US11167746
申请日：2005-06-27
申请人： Richard Bruce , Dirk De Bruyker , Francisco Torres , Michal Wolkin
发明人： Richard Bruce , Dirk De Bruyker , Francisco Torres , Michal Wolkin
IPC分类号： G01F1/68 , G01K1/00 , G01K7/30 , G01K17/00 , G01N25/20 , G01N25/48 , G01N27/00
CPC分类号： G01K7/30 , G01K17/00 , G01K17/006 , G01N25/482
摘要： In thermal sensing devices, such as for calorimetry, a support layer or central layer can have a thermometer element or other thermal sensor on one side and a thermally conductive structure or component on the other. The thermally conductive structure can conduct temperature or other thermal input signals laterally across the support layer or central layer. The temperature or signals can then be provided to the thermometer element, such as by thermal contact through the support layer. An electrically conducting, thermally isolating anti-coupling layer, such as of gold or chromium, can reduce capacitive coupling between the thermally conductive structure and the thermometer element or other thermal sensor.
摘要翻译：在诸如用于量热法的热感测装置中，支撑层或中心层可以在一侧具有温度计元件或其它热传感器，而在另一侧可以具有导热结构或部件。导热结构可以横跨支撑层或中心层横向传导温度或其他热输入信号。然后可以将温度或信号提供给温度计元件，例如通过通过支撑层的热接触。导电的，热隔离的抗耦合层（例如金或铬）可以减少导热结构和温度计元件或其它热传感器之间的电容耦合。

10. 发明申请

US20070065934A1 Amplification of enzymatic reactions for use with an enthalpy array 审中-公开
标题翻译：扩增用于焓阵列的酶反应
公开(公告)号：US20070065934A1
公开(公告)日：2007-03-22
申请号：US11604439
申请日：2006-11-27
申请人： Francisco Torres , Richard Bruce , James Williamson , Peter Kuhn , Ray Stevens
发明人： Francisco Torres , Richard Bruce , James Williamson , Peter Kuhn , Ray Stevens
IPC分类号： C12M3/00 , C12Q1/48 , C12Q1/34 , C12Q1/26
CPC分类号： G01N25/4846 , G01N25/4866
摘要： Provided is a method of detecting characteristics of a reaction of interest, including instituting the reaction of interest, obtaining an amplified heat related to the reaction of interest, measuring the amplified heat, and determining the characteristics of the reaction of interest, using the signal obtained in the step of measuring.
摘要翻译：本发明提供一种检测感兴趣特征的方法，包括进行感兴趣的反应，获得与感兴趣的反应相关的放大热，测量放大的热量，并使用获得的信号确定感兴趣的特性在测量的步骤。

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