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1. 发明授权

US5612002A Apparatus and method for multiple simultaneous synthesis 失效
标题翻译：多种同步合成的装置和方法
公开(公告)号：US5612002A
公开(公告)日：1997-03-18
申请号：US430696
申请日：1995-04-28
申请人： Donna R. Cody , Sheila H. H. DeWitt , John C. Hodges , John S. Kiely , Walter H. Moos , Michael R. Pavia , Bruce D. Roth , Mel C. Schroeder , Charles J. Stankovic
发明人： Donna R. Cody , Sheila H. H. DeWitt , John C. Hodges , John S. Kiely , Walter H. Moos , Michael R. Pavia , Bruce D. Roth , Mel C. Schroeder , Charles J. Stankovic
IPC分类号： B01J19/00 , C07B61/00 , C07C275/28 , C07K1/04 , C07K5/062 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01J8/00 , C07K17/00 , C12M1/00
CPC分类号： C07K1/047 , B01J19/0046 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures for supporting the reaction tubes, and a manifold member adjacent to the holder member and enclosing the upper ends of the reaction tubes; 2) charging the apparatus with reactants required for synthesis; 3) synthesizing the compounds in solution; or optionally 4) cleaving the compounds from a solid support within the apparatus.
摘要翻译：一种用于多次同时合成化合物的方法，包括以下步骤：1）提供一种装置，包括在其下端具有多个具有过滤器构件的反应管，用于容纳过滤构件的储存器构件，具有多个用于支撑反应管的孔，以及与保持器构件相邻并包围反应管的上端的歧管构件; 2）用合成所需的反应物对设备进行充电; 3）在溶液中合成化合物; 或任选地4）在装置内从固体支持物上切割化合物。

2. 发明授权

US5324483A Apparatus for multiple simultaneous synthesis 失效
标题翻译：多次同时合成的装置
公开(公告)号：US5324483A
公开(公告)日：1994-06-28
申请号：US12557
申请日：1993-02-02
申请人： Donna R. Cody , Sheila H. H. DeWitt , John C. Hodges , John S. Kiely , Walter H. Moos , Michael R. Pavia , Bruce D. Roth , Mel C. Schroeder , Charles J. Stankovic
发明人： Donna R. Cody , Sheila H. H. DeWitt , John C. Hodges , John S. Kiely , Walter H. Moos , Michael R. Pavia , Bruce D. Roth , Mel C. Schroeder , Charles J. Stankovic
IPC分类号： B01J19/00 , C07B61/00 , C07C275/28 , C07K1/04 , C07K5/062 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , C08F283/00
CPC分类号： C07K1/047 , B01J19/0046 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.
摘要翻译：提供合适的位置用于多次同时合成化合物的装置和方法。该装置包括：具有多个井的储存器块; 多个反应管，通常为气体分散管，在其下端具有过滤器; 具有多个孔的保持器块; 以及可以具有允许引入/维护受控环境的端口的歧管。歧管顶壁具有孔和具有相同孔的可拆卸板。该装置由适应加热，冷却，搅拌或腐蚀性试剂的材料构成。垫片放在组件之间。提供杆或夹具用于将部件固定在一起。设备操作涉及将过滤器放置在储存器块井中的反应管的下端，并且通过保持器的上端阻挡孔并进入歧管。该装置提供超过1mg每种产品的结构知识和对每种化合物的控制。使用该装置，一系列构建块共价连接到固体支持物上。然后通过共价添加其他不同的构建块或化学修饰一些现有功能来修改这些构建块，直到实现倒数第二个结构。然后通过另一种化学反应将固体支持物从该固体支持物中裂解成孔内的溶液，得到新合成的单独化合物的阵列，其在反应后修饰（如果需要）适于测试活性。

3. 发明授权

US5702672A Apparatus and method for multiple simultaneous synthesis 失效
标题翻译：多种同步合成的装置和方法
公开(公告)号：US5702672A
公开(公告)日：1997-12-30
申请号：US540512
申请日：1995-10-10
申请人： Sheila H. H. DeWitt , Michael Kell , Michael R. Pavia , John S. Kiely , Mel C. Schroeder , Charles J. Stankovic , Steven Ware
发明人： Sheila H. H. DeWitt , Michael Kell , Michael R. Pavia , John S. Kiely , Mel C. Schroeder , Charles J. Stankovic , Steven Ware
IPC分类号： B01J19/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01J8/00 , C07K17/00 , C12M1/00
CPC分类号： C07K1/047 , B01J19/0046 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： An apparatus for multiple, simultaneous synthesis of compounds which consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold.
摘要翻译：一种用于多次同时合成化合物的装置，其包括：具有多个孔的储存器块; 多个反应管，通常为气体分散管，在其下端具有过滤器; 具有多个孔的保持器块; 以及可以具有允许引入/维护受控环境的端口的歧管。歧管顶壁具有孔和具有相同孔的可拆卸板。该装置由适应加热，冷却，搅拌或腐蚀性试剂的材料构成。垫片放在组件之间。提供杆或夹具用于将部件固定在一起。设备操作涉及将过滤器放置在储存器块井中的反应管的下端，并且通过保持器的上端阻挡孔并进入歧管。

4. 发明授权

US5582801A Apparatus for multiple simultaneous synthesis 失效
标题翻译：多次同时合成的装置
公开(公告)号：US5582801A
公开(公告)日：1996-12-10
申请号：US463545
申请日：1995-06-05
申请人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
发明人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
IPC分类号： B01J19/00 , C07B61/00 , C07C275/28 , C07K1/04 , C07K5/062 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01J8/00 , C07K17/00 , C12M1/00
CPC分类号： C07K1/047 , B01J19/0046 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. The apparatus can be adapted to manual, semiautomatic or fully automatic performance. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.
摘要翻译：提供合适的位置用于多次同时合成化合物的装置和方法。该装置包括：具有多个井的储存器块; 多个反应管，通常为气体分散管，在其下端具有过滤器; 具有多个孔的保持器块; 以及可以具有允许引入/维护受控环境的端口的歧管。歧管顶壁具有孔和具有相同孔的可拆卸板。该装置由适应加热，冷却，搅拌或腐蚀性试剂的材料构成。垫片放在组件之间。提供杆或夹具用于将部件固定在一起。设备操作涉及将过滤器放置在储存器块井中的反应管的下端，并且通过保持器的上端阻挡孔并进入歧管。该装置提供超过1mg每种产品的结构知识和对每种化合物的控制。该装置可以适应于手动，半自动或全自动的性能。使用该装置，一系列构建块共价连接到固体支持物上。然后通过共价添加其他不同的构建块或化学修饰一些现有功能来修改这些构建块，直到实现倒数第二个结构。然后通过另一种化学反应将固体支持物从该固体支持物中裂解成孔内的溶液，得到新合成的单独化合物的阵列，其在反应后修饰（如果需要）适于测试活性。

5. 发明授权

US5714127A System for multiple simultaneous synthesis 失效
标题翻译：多个同步合成系统
公开(公告)号：US5714127A
公开(公告)日：1998-02-03
申请号：US475559
申请日：1995-06-07
申请人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
发明人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
IPC分类号： B01J19/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01J8/00 , C07K17/00 , C12M1/00
CPC分类号： C07K1/045 , B01J19/0046 , C07K1/047 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： A system for the multiple, simultaneous synthesis of compounds preferably uses a reaction apparatus comprising a reservoir rack having a plurality of reaction wells, a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends, a holder block, having a plurality of apertures, and a manifold, which has ports to allow introduction/maintenance of a controlled environment. The manifold top wall has a plurality of apertures in axial alignment with the reaction tubes and a gasket which allows penetration by a needle in order to dispense and aspirate materials from the reaction tubes. Sealing members, such as gaskets, are placed between the holder block, manifold and reservoir rack and the components are releasably fastened together. A robotic sample processor is used to automate the synthesis process using the reaction apparatus.
摘要翻译：用于多次同时合成化合物的系统优选使用包括具有多个反应孔的储器架的反应装置，多个反应管，通常为气体分散管，在其下端具有过滤器，保持器块，具有多个孔和歧管，其具有允许引入/维持受控环境的端口。歧管顶壁具有与反应管轴向对准的多个孔，以及允许针穿透以便从反应管分配和吸出材料的垫圈。诸如垫圈的密封件被放置在保持器块，歧管和贮存器架之间，并且部件可释放地紧固在一起。使用机器人样品处理器来使用反应装置使合成过程自动化。

6. 发明授权

US5593642A Apparatus for multiple simultaneous synthesis 失效
标题翻译：多次同时合成的装置
公开(公告)号：US5593642A
公开(公告)日：1997-01-14
申请号：US461475
申请日：1995-06-05
申请人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
发明人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
IPC分类号： B01J19/00 , C07B61/00 , C07C275/28 , C07K1/04 , C07K5/062 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01J8/00 , C07K17/00 , C12M1/00
CPC分类号： C07K1/047 , B01J19/0046 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which my have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. The apparatus can be adapted to manual, semiautomatic or fully automatic performance. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.
摘要翻译：提供合适的位置用于多次同时合成化合物的装置和方法。该装置包括：具有多个井的储存器块; 多个反应管，通常为气体分散管，在其下端具有过滤器; 具有多个孔的保持器块; 和一个多方面，我有端口允许引入/维护受控环境。歧管顶壁具有孔和具有相同孔的可拆卸板。该装置由适应加热，冷却，搅拌或腐蚀性试剂的材料构成。垫片放在组件之间。提供杆或夹具用于将部件固定在一起。设备操作涉及将过滤器放置在储存器块井中的反应管的下端，并且通过保持器的上端阻挡孔并进入歧管。该装置提供超过1mg每种产品的结构知识和对每种化合物的控制。该装置可以适应于手动，半自动或全自动的性能。使用该装置，一系列构建块共价连接到固体支持物上。然后通过共价添加其他不同的构建块或化学修饰一些现有功能来修改这些构建块，直到实现倒数第二个结构。然后通过另一种化学反应将固体支持物从该固体支持物中裂解成孔内的溶液，得到新合成的单独化合物的阵列，其在反应后修饰（如果需要）适于测试活性。

7. 发明授权

US5567391A Apparatus for multiple simultaneous synthesis 失效
公开(公告)号：US5567391A
公开(公告)日：1996-10-22
申请号：US464161
申请日：1995-06-05
申请人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
发明人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
IPC分类号： B01J19/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01J8/00 , C07K17/00 , C12M1/00
CPC分类号： C07K1/047 , B01J19/0046 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. The apparatus can be adapted to manual, semiautomatic or fully automatic performance. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.

8. 发明授权

US5565173A Apparatus and method for multiple simultaneous synthesis 失效
标题翻译：多种同步合成的装置和方法
公开(公告)号：US5565173A
公开(公告)日：1996-10-15
申请号：US461998
申请日：1995-06-05
申请人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
发明人： Sheila H. H. DeWitt , John S. Kiely , Michael R. Pavia , Mel C. Schroeder , Charles J. Stankovic
IPC分类号： B01J19/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14 , B01J8/00 , C07K17/00 , C12M1/00
CPC分类号： C07K1/047 , B01J19/0046 , C07K1/045 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00373 , B01J2219/00416 , B01J2219/00423 , B01J2219/00454 , B01J2219/00493 , B01J2219/00495 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B50/14 , C40B60/14
摘要： An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction cubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable place with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. The apparatus can be adapted to manual, semiautomatic or fully automatic performance. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.
摘要翻译：提供合适的位置用于多次同时合成化合物的装置和方法。该装置包括：具有多个井的储存器块; 多个反应立方体，通常为气体分散管，在其下端具有过滤器; 具有多个孔的保持器块; 以及可以具有允许引入/维护受控环境的端口的歧管。歧管顶壁具有孔和具有相同孔的可拆卸的位置。该装置由适应加热，冷却，搅拌或腐蚀性试剂的材料构成。垫片放在组件之间。提供杆或夹具用于将部件固定在一起。设备操作涉及将过滤器放置在储存器块井中的反应管的下端，并且通过保持器的上端阻挡孔并进入歧管。该装置提供超过1mg的每种产品的结构知识和对每种化合物的控制。该装置可以适应于手动，半自动或全自动的性能。使用该装置，一系列构建块共价连接到固体支持物上。然后通过共价添加其他不同的构建块或化学修饰一些现有功能来修改这些构建块，直到实现倒数第二个结构。然后通过另一种化学反应将固体支持物从该固体支持物中裂解成孔内的溶液，得到新合成的单独化合物的阵列，其在反应后修饰（如果需要）适于测试活性。

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