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1. 发明申请

US20070224128A1 Drug adherence monitoring system 审中-公开
标题翻译：药物依从性监测系统
公开(公告)号：US20070224128A1
公开(公告)日：2007-09-27
申请号：US11715197
申请日：2007-03-07
申请人： Donn Michael Dennis , Richard J. Melker , Matthew M. Booth , Laszlo Prokai
发明人： Donn Michael Dennis , Richard J. Melker , Matthew M. Booth , Laszlo Prokai
IPC分类号： A61K49/00 , G01N33/497
CPC分类号： A61B5/082 , A61B5/0022 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/4839 , A61B5/746 , A61B2562/028 , A61K49/0002 , A61K49/0004
摘要： The present invention provides novel methods for monitoring subject adherence in taking prescribed drugs by detecting markers in exhaled breath after a subject takes the prescribed drug. In particular, the present invention provides novel methods for making additives that are combined with the drug(s). Upon biological breakdown of the drug/additive formulation in a subject's body, markers resulting directly from the biological breakdown of the additives are detected in exhaled breath using sensor technology. In certain embodiments of the invention, the drug adherence monitoring systems and methods include a reporting system capable of tracking subject compliance (either remotely or proximately) and of providing necessary alerts to the subject, caregiver, healthcare provider, and the like.
摘要翻译：本发明提供了在受试者服用规定的药物后通过检测呼出呼吸中的标记物来监测受试者依从性的新方法。特别地，本发明提供了制备与药物组合的添加剂的新方法。在受试者的身体中药物/添加剂制剂的生物分解时，直接由添加剂的生物分解产生的标记物使用传感器技术在呼气中检测。在本发明的某些实施方案中，药物依从性监测系统和方法包括能够跟踪受试者依从性（远程或近似）并向对象，看护者，医疗保健提供者等提供必要警报的报告系统。

2. 发明申请

US20140294675A1 Marker Detection Method And Apparatus To Monitor Drug Compliance 审中-公开
标题翻译：用于监测药物依从性的标记检测方法和装置
公开(公告)号：US20140294675A1
公开(公告)日：2014-10-02
申请号：US14230043
申请日：2014-03-31
申请人： Richard J. Melker , Donn Michael Dennis , Laszlo Prokai
发明人： Richard J. Melker , Donn Michael Dennis , Laszlo Prokai
IPC分类号： G01N33/497
CPC分类号： G01N33/497 , A61B5/082 , A61B5/411 , A61B5/4833 , Y10T436/13
摘要： The present invention includes systems and methods for monitoring therapeutic drug concentration in blood by detecting markers, such as odors, upon exhalation by a patient after the drug is taken, wherein such markers result either directly from the drug itself or from an additive combined with the drug. In the case of olfactory markers, the invention preferably utilizes electronic sensor technology, such as the commercial devices referred to as “artificial” or “electronic” noses or tongues, to non-invasively monitor drug levels in blood. The invention further includes a reporting system capable of tracking drug concentrations in blood (remote or proximate locations) and providing the necessary alerts with regarding to ineffective or toxic drug dosages in a patient.
摘要翻译：本发明包括通过在药物摄取之后通过检测患者呼气时检测诸如气味的标记物来监测血液中的治疗药物浓度的系统和方法，其中这样的标记物直接从药物本身或与药物本身结合的添加剂药物。在嗅觉标记的情况下，本发明优选利用诸如被称为“人造”或“电子”鼻子或舌头的商业装置的电子传感器技术非侵入性地监测血液中的药物水平。本发明还包括能够跟踪血液（偏远或邻近位置）中的药物浓度并提供关于患者中无效或有毒药物剂量的必要警报的报告系统。

3. 发明申请

US20100216175A1 Condensate Glucose Analyzer 审中-公开
标题翻译：冷凝葡萄糖分析仪
公开(公告)号：US20100216175A1
公开(公告)日：2010-08-26
申请号：US12374564
申请日：2007-08-15
申请人： Richard J. Melker , David G. Bjoraker , Donn Michael Dennis , Jon Dale Stewart , Christopher D. Batich , Matthew M. Booth , John Frederick Horn , Ronald Youngblood , Timothy E. Morey
发明人： Richard J. Melker , David G. Bjoraker , Donn Michael Dennis , Jon Dale Stewart , Christopher D. Batich , Matthew M. Booth , John Frederick Horn , Ronald Youngblood , Timothy E. Morey
IPC分类号： C12Q1/54 , C12M1/34 , G01N33/497 , G01N27/26
CPC分类号： A61B5/083 , A61B5/1486 , A61B5/413 , Y10T436/144444
摘要： Systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments, electrochemical- or coulometnc-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose. Based on the detected glucose m EBC, the subject invention provides systems and methods for non-invasive, accurate assessment of blood glucose levels.
摘要翻译：用于分析呼出气凝缩物（EBC）中存在的葡萄糖的系统和方法。在某些实施方案中，使用基于电化学或库仑法的感测技术来分析葡萄糖的存在和/或浓度。基于检测到的葡萄糖EBC，本发明提供了用于非侵入性，准确评估血糖水平的系统和方法。

4. 发明申请

US20090005270A1 Systems and Methods for Evaluating Enzyme Competency 审中-公开
标题翻译：评价酶能力的系统和方法
公开(公告)号：US20090005270A1
公开(公告)日：2009-01-01
申请号：US11578323
申请日：2005-09-20
申请人： Richard J. Melker , Timothy E. Morey , Laszlo Prokai , Donn M. Dennis
发明人： Richard J. Melker , Timothy E. Morey , Laszlo Prokai , Donn M. Dennis
IPC分类号： C40B60/12 , C12Q1/00 , C12M1/00
CPC分类号： C12Q1/00 , C12Q1/26
摘要： The present invention provides systems and methods for determining enzymatic competency, which is important in determining whether a patient may suffer an adverse drug reaction, has a disease associated with defects in specific enzymatic function, and/or has an enzyme defect that is likely to cause pathophysiology. As contemplated herein, a parent molecular entity is administered to a patient in whom enzymatic competency is to be determined. A sample of the patient's bodily fluid is exposed to a sensor of the invention to distinguish, detect, and quantify a detectable entity in the bodily fluid. Sensor-acquired data regarding the detectable entity is used to determine enzymatic competency. Preferably, a sample of a patient's exhaled breath is collected and exposed to the sensor of the invention. Types of sensor systems of the invention include, but are not limited to, surface resonance arrays; microelectromechanical sensors (such as microcantilever-based technology); molecularly imprinted polymer sensors; amplifying fluorescent sensor technology; aptamer-based sensor technology; SAW sensors; infrared sensors; fuel cells; chemical reactors; and pH sensitive sensors.
摘要翻译：本发明提供了确定酶活性的系统和方法，其在确定患者是否可能遭受不良药物反应，具有与特定酶功能缺陷相关的疾病和/或具有可能导致的酶缺陷病理生理学。如本文所考虑的，将母体分子实体施用于要测定酶能力的患者。将患者体液的样品暴露于本发明的传感器以区分，检测和定量体液中的可检测实体。关于可检测实体的传感器获取的数据用于确定酶的能力。优选地，将患者呼出的呼吸的样品收集并暴露于本发明的传感器。本发明的传感器系统的类型包括但不限于表面共振阵列; 微机电传感器（如基于微型悬臂梁的技术）; 分子印迹聚合物传感器; 放大荧光传感器技术; 基于适体的传感器技术; SAW传感器; 红外传感器; 燃料电池; 化学反应堆和pH敏感传感器。

5. 发明授权

US07052854B2 Application of nanotechnology and sensor technologies for ex-vivo diagnostics 失效
标题翻译：应用纳米技术和传感器技术进行离体诊断
公开(公告)号：US07052854B2
公开(公告)日：2006-05-30
申请号：US10678506
申请日：2003-10-02
申请人： Richard J. Melker , Ronald L. Hayes , Ka-Wang Kevin Wang , Donn Michael Dennis
发明人： Richard J. Melker , Ronald L. Hayes , Ka-Wang Kevin Wang , Donn Michael Dennis
IPC分类号： G01N33/53
CPC分类号： G01N33/54306 , B82Y5/00 , G01N33/54346 , G01N33/54373
摘要： Systems and methods for the ex vivo diagnostic analysis of samples of bodily fluids, including exhaled breath and blood. The present invention uses nanostructure-based assemblies in combination with sensor technology to provide an efficient and accurate means for identifying the presence of a target analyte/biomarker in a sample of bodily fluid. In a preferred embodiment, the nanostructure-based assemblies of the present invention include detecting means such as RNA oligonucleotide chains or “apparatus” and releasable surrogate markers such as DMSO.
摘要翻译：用于体液样本的体外诊断分析的系统和方法，包括呼出的呼吸和血液。本发明使用基于纳米结构的组件与传感器技术结合，以提供用于识别体液样品中目标分析物/生物标志物的存在的有效且准确的方法。在优选的实施方案中，本发明的基于纳米结构的组合物包括诸如RNA寡核苷酸链或“装置”的检测手段和可释放的替代标志物，例如DMSO。

6. 发明申请

US20100265059A1 Handwashing Compliance Detection System 有权
标题翻译：洗手合格检测系统
公开(公告)号：US20100265059A1
公开(公告)日：2010-10-21
申请号：US12599743
申请日：2008-06-09
申请人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
发明人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
IPC分类号： G08B1/08 , G01F23/00
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of handwashing agents to determine compliance with hand hygiene guidelines. A handwashing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's handwashing technique. After the handwashing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the handwashing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用以确定是否符合手部卫生指南。洗手剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。在洗手事件之后，将受试者的手暴露于检测器（例如徽章），其包括能够检测挥发性化合物的传感器，以及指示挥发性化合物的检测，指示使用洗手剂和手卫生合规。

7. 发明申请

US20140364384A1 MEDICATION ADHERENCE MONITORING SYSTEM 审中-公开
标题翻译：药物辅助监测系统
公开(公告)号：US20140364384A1
公开(公告)日：2014-12-11
申请号：US14259521
申请日：2014-04-23
申请人： Richard J. Melker , Donn Michael Dennis , Christopher D. Batich , Mark S. Gold
发明人： Richard J. Melker , Donn Michael Dennis , Christopher D. Batich , Mark S. Gold
IPC分类号： G01N33/58
CPC分类号： G01N33/58 , A61B5/083 , A61B5/411 , A61B5/4833 , A61K49/0004 , A61K51/1206 , G01N2458/15 , Y10T436/22
摘要： The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. In certain related embodiments, the marker contain a deuterium label, which is also present in the breath upon metabolism of the therapeutic agent. In another embodiment of the invention, the therapeutic agent is associated with a taggant (that may be either labeled or unlabeled with deuterium), which in turn will generate a marker in the breath that is easily measurable.
摘要翻译：本发明涉及呼出呼吸中的标记物的检测，其中使用呼出呼吸中标记物的存在或不存在来检测各种临床数据，包括患者服用药物和患者酶促代谢（代谢）代谢药物的能力。本发明的一个实施方案包括用标记物标记的母体治疗剂，其中当代谢（例如通过酶促作用）治疗剂时），标记物变得挥发性或半挥发性并且存在于呼吸中。在某些相关实施方案中，标记物含有氘标记，其在治疗剂代谢时也存在于呼吸中。在本发明的另一个实施方案中，治疗剂与标记物（其可以是用氘标记或未标记）相关联，其又将在呼吸中产生容易测量的标记物。

8. 发明申请

US20100255598A1 Medication Adherence Monitoring System 审中-公开
标题翻译：药物依从性监测系统
公开(公告)号：US20100255598A1
公开(公告)日：2010-10-07
申请号：US12064673
申请日：2008-02-22
申请人： Richard J. Melker , Donn Michael Dennis , Christopher D. Batich , Mark S. Gold
发明人： Richard J. Melker , Donn Michael Dennis , Christopher D. Batich , Mark S. Gold
IPC分类号： G01N33/50
CPC分类号： G01N33/58 , A61B5/083 , A61B5/411 , A61B5/4833 , A61K49/0004 , A61K51/1206 , G01N2458/15 , Y10T436/22
摘要： The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. In certain related embodiments, the marker contain a deuterium label, which is also present in the breath upon metabolism of the therapeutic agent. In another embodiment of the invention, the therapeutic agent is associated with a taggant (that may be either labeled or unlabeled with deuterium), which in turn will generate a marker in the breath that is easily measurable.
摘要翻译：本发明涉及呼出呼吸中的标记物的检测，其中使用呼出呼吸中标记物的存在或不存在来检测各种临床数据，包括患者服用药物和患者酶促代谢（代谢）代谢药物的能力。本发明的一个实施方案包括用标记物标记的母体治疗剂，其中当代谢（例如通过酶促作用）治疗剂时），标记物变得挥发性或半挥发性并且存在于呼吸中。在某些相关实施方案中，标记物含有氘标记，其在治疗剂代谢时也存在于呼吸中。在本发明的另一个实施方案中，治疗剂与标记物（其可以是用氘标记或未标记）相关联，其又将在呼吸中产生容易测量的标记物。

9. 发明授权

US06974706B1 Application of biosensors for diagnosis and treatment of disease 失效
标题翻译：生物传感器在疾病诊断和治疗中的应用
公开(公告)号：US06974706B1
公开(公告)日：2005-12-13
申请号：US10345532
申请日：2003-01-16
申请人： Richard J. Melker , Donn Michael Dennis
发明人： Richard J. Melker , Donn Michael Dennis
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： B82Y30/00 , G01N33/5308 , Y10S436/805 , Y10S436/811 , Y10S436/815 , Y10S436/90
摘要： A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or “aptamers,” in combination with molecular beacons or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.
摘要翻译：一种用于检测体液中感兴趣的化合物的方法，包括呼出的呼吸和血液。本发明使用模仿天然存在的细胞机制的生物传感器，包括RNA寡核苷酸链或“适体”，与分子信标或纳米技术组合，以提供用于诊断患者内的病症和/或疾病的有效和有效的方法。本发明还提供了用于筛选可能存在于呼出气中的那些分析物/生物标志物的方法。

10. 发明授权

US08525666B2 Handwashing compliance detection system 有权
标题翻译：洗手法规检测系统
公开(公告)号：US08525666B2
公开(公告)日：2013-09-03
申请号：US12599743
申请日：2008-06-09
申请人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
发明人： Richard J. Melker , Nikolaus Gravenstein , Donn Michael Dennis , Christopher Batich
IPC分类号： G08B1/08
CPC分类号： G08B21/245
摘要： Systems and methods are provided for monitoring use of handwashing agents to determine compliance with hand hygiene guidelines. A handwashing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's handwashing technique. After the handwashing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the handwashing agent and hand hygiene compliance.
摘要翻译：提供了系统和方法，用于监控洗手剂的使用以确定是否符合手部卫生指南。洗手剂具有可检测的挥发性化合物，例如气味，然后使用受试者的洗手技术将其摩擦到受试者的手上。在洗手事件之后，将受试者的手暴露于检测器（例如徽章），其包括能够检测挥发性化合物的传感器，以及指示挥发性化合物的检测，指示使用洗手剂和手卫生合规。

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