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1. 发明授权

US08318156B2 Anti-cocaine compositions and treatment 有权
标题翻译：抗可卡因组合物和治疗
公开(公告)号：US08318156B2
公开(公告)日：2012-11-27
申请号：US12373510
申请日：2007-07-10
申请人： Donald W Landry , Joanne MacDonald , Shi-Xian Deng , Chang-Guo Zhan , Daquan Gao , James H. Woods , Roger K. Sunahara , Diwahar L. Narasimhan , Victor Yang , Mei-Chuan Holden Ko , John J. Tesmer , Tien-Yi Lee , Young Min Kwon
发明人： Donald W Landry , Joanne MacDonald , Shi-Xian Deng , Chang-Guo Zhan , Daquan Gao , James H. Woods , Roger K. Sunahara , Diwahar L. Narasimhan , Victor Yang , Mei-Chuan Holden Ko , John J. Tesmer , Tien-Yi Lee , Young Min Kwon
IPC分类号： A61K38/46 , A61K38/43 , C12N9/16 , C12N9/14 , C12P21/06 , C12P19/34 , C07H21/04
CPC分类号： C12N9/18 , A61K38/00 , A61K38/465 , C12Y301/01084
摘要： Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
摘要翻译：本文公开的本发明的实施方案通常涉及抗可卡因治疗剂。具体地，本发明的一些实施方案涉及可以防止可卡因在受试者中的有毒和增强作用的高效，耐热和持久的可卡因酯酶（CocE）突变体。本文提供显示耐热酯酶活性的突变型CocE多肽。还提供了通过施用突变体CocE处理需要的受试者中可卡因诱导的病症的方法以及候选酯酶多肽的高通量筛选方法。

2. 发明申请

US20160160195A1 ANTI-COCAINE COMPOSITIONS AND TREATMENT 审中-公开
公开(公告)号：US20160160195A1
公开(公告)日：2016-06-09
申请号：US14954813
申请日：2015-11-30
申请人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
发明人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
IPC分类号： C12N9/18 , A61K38/46
CPC分类号： C12N9/18 , A61K38/00 , A61K38/465 , C12Y301/01084
摘要： Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

3. 发明申请

US20100034799A1 ANTI-COCAINE COMPOSITIONS AND TREATMENT 有权
标题翻译：抗COCOINE组合物和治疗
公开(公告)号：US20100034799A1
公开(公告)日：2010-02-11
申请号：US12373510
申请日：2007-07-10
申请人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
发明人： Donald Landry , Chang-Guo Zhan , James H. Woods , Roger Sunahara , Diwahar L. Narasimhan , Joanne MacDonald , Victor Yang , Mei-Chuan Holden Ko , Shi-Xian Deng , John J. Tesmer , Tien-Yi Lee , Young Min Kwon , Daquan Gao
IPC分类号： A61K38/46 , C12N9/16 , C07H21/04 , A61P25/30
CPC分类号： C12N9/18 , A61K38/00 , A61K38/465 , C12Y301/01084
摘要： Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.
摘要翻译：本文公开的本发明的实施方案通常涉及抗可卡因治疗剂。具体地，本发明的一些实施方案涉及可以防止可卡因在受试者中的有毒和增强作用的高效，耐热和持久的可卡因酯酶（CocE）突变体。本文提供显示耐热酯酶活性的突变型CocE多肽。还提供了通过施用突变体CocE处理需要的受试者中可卡因诱导的病症的方法以及候选酯酶多肽的高通量筛选方法。

4. 发明授权

US09125854B2 Compositions and methods of enhancing immune responses to flagellated bacterium 有权
标题翻译：增强对鞭毛细菌的免疫应答的组合物和方法
公开(公告)号：US09125854B2
公开(公告)日：2015-09-08
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/02 , A61K39/112 , A61K39/00
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译：提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。

5. 发明申请

US20130084304A1 VACCINE AND METHODS TO REDUCE CAMPYLOBACTER INFECTION 有权
标题翻译：疫苗和减少细胞感染的方法
公开(公告)号：US20130084304A1
公开(公告)日：2013-04-04
申请号：US13702827
申请日：2011-06-09
申请人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
发明人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
IPC分类号： C07K14/205
CPC分类号： A61K39/12 , A61K39/105 , A61K2039/523 , A61K2039/53 , A61K2039/55516 , C07K14/205
摘要： Vaccine vectors and methods for enhancing resistance to Campylobacter infection or for enhancing the immune response to Campylobacter are provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.
摘要翻译：本文提供疫苗载体和用于增强对弯曲杆菌感染的抗性或增强对弯曲杆菌的免疫应答的方法。疫苗载体包括编码选自SEQ ID NO：7-9或其片段的抗原性多肽的第一多核苷酸。载体还可以包括免疫刺激多肽。所述方法包括向受试者施用疫苗载体。

6. 发明申请

US20110159026A1 COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO FLAGELLATED BACTERIUM 有权
标题翻译：增强对细菌细菌的免疫反应的组合物和方法
公开(公告)号：US20110159026A1
公开(公告)日：2011-06-30
申请号：US12740631
申请日：2008-10-30
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： A61K39/112 , A61P37/04 , A61P31/04
CPC分类号： A61K39/0275 , A61K2039/522 , A61K2039/552 , Y02A50/482
摘要： Vaccines comprising fliC and CD 154 polypeptides and Salmonella enteritidis vaccine vectors comprising fliC polypeptides are provided. Also provided arc methods of enhancing an immune response against flagellated bacteria and methods of reducing morbidity associated with infection with flagellated bacteria.
摘要翻译：提供了包含fliC和CD154多肽的疫苗和包含fliC多肽的肠炎沙门氏杆菌疫苗载体。还提供了增强针对鞭毛细菌的免疫应答的电弧法和减少与鞭毛细菌感染相关的发病率的方法。

7. 发明申请

US20090267734A1 MONITORING SYSTEM AND METHOD OF SMART KEY 审中-公开
标题翻译：智能钥匙的监控系统和方法
公开(公告)号：US20090267734A1
公开(公告)日：2009-10-29
申请号：US12331839
申请日：2008-12-10
申请人： Young Min Kwon
发明人： Young Min Kwon
IPC分类号： B60R25/00
CPC分类号： G08C17/02 , B60R25/2036 , B60R25/245 , G07C9/00309 , G07C2009/00333 , G07C2209/65
摘要： A smart key monitoring system for a vehicle comprises: a first LF output antenna which transmits an authentication low frequency (LF) signal within a preset distance from a portion of one side of the vehicle; an RF receiver which is installed in a portion of the vehicle and receives an authentication response radio frequency (RF) signal generated by a smart key in response to the authentication LF signal; and a monitoring controller which performs the authentication of the authentication response RF signal received by the RF receiver, receives a request signal for unlocking a first door provided on one side of the vehicle for which the authentication succeeds from an unlock sensor of the first door, and delivers the unlock request signal to a door unlock controller.
摘要翻译：一种用于车辆的智能钥匙监控系统包括：第一LF输出天线，其在距车辆一侧的一部分的预定距离内发送认证低频（LF）信号; RF接收机，其安装在所述车辆的一部分中，并且响应于所述认证LF信号而接收由智能钥匙产生的认证响应射频（RF）信号; 以及监视控制器，其执行由所述RF接收器接收到的所述认证响应RF信号的认证，接收用于解锁从所述第一门的解锁传感器成为认证成功的车辆的一侧设置的第一门的请求信号，并将解锁请求信号发送到门解锁控制器。

8. 外观设计

USD571919S1 Dental impression tray 有权
公开(公告)号：USD571919S1
公开(公告)日：2008-06-24
申请号：US29267864
申请日：2006-10-23
申请人： Hae Kyung Kwon , Young Min Kwon
设计人： Hae Kyung Kwon , Young Min Kwon

9. 发明授权

US08961990B2 Vaccine and methods to reduce campylobacter infection 有权
标题翻译：疫苗和减少弯曲杆菌感染的方法
公开(公告)号：US08961990B2
公开(公告)日：2015-02-24
申请号：US13702827
申请日：2011-06-09
申请人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
发明人： Billy Hargis , Neil R. Pumford , Young Min Kwon , Sherryll Layton
IPC分类号： C07K14/205 , A61K39/02 , A61K39/00
CPC分类号： A61K39/12 , A61K39/105 , A61K2039/523 , A61K2039/53 , A61K2039/55516 , C07K14/205
摘要： Vaccine vectors and methods for enhancing resistance to Campylobacter infection or for enhancing the immune response to Campylobacter are provided herein. The vaccine vectors include a first polynucleotide which encodes an antigenic polypeptide selected from SEQ ID NO 7-9 or a fragment thereof. The vector may also include an immunostimulatory polypeptide. The methods include administering the vaccine vectors to a subject.
摘要翻译：本文提供疫苗载体和用于增强对弯曲杆菌感染的抗性或增强对弯曲杆菌的免疫应答的方法。疫苗载体包括编码选自SEQ ID NO：7-9或其片段的抗原性多肽的第一多核苷酸。载体还可以包括免疫刺激多肽。所述方法包括向受试者施用疫苗载体。

10. 发明授权

US08604178B2 Compositions and methods of enhancing immune responses 有权
标题翻译：增强免疫反应的组合物和方法
公开(公告)号：US08604178B2
公开(公告)日：2013-12-10
申请号：US12441851
申请日：2007-09-18
申请人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
发明人： Walter Bottje , Billy Hargis , Luc Berghman , Young Min Kwon , Kimberly Cole , Mandy Cox , Sherryll Layton
IPC分类号： C07H21/02 , A61K49/00 , A61K39/112
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
摘要翻译：本文提供了肠炎沙门氏菌13A菌株和包含这些菌株的组合物。还提供了增强针对甲型流感的免疫应答的方法和降低与甲型流感感染相关的发病率的方法。还公开了通过表达能够结合CD40的CD154多肽增强对疫苗载体的免疫应答的方法。公开了开发细菌疫苗载体的方法。还公开了在细菌中产生无疤痕位点突变的方法。

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