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1. 发明申请

US20130053733A1 METHODS AND SYSTEMS FOR TREATING MEIBOMIAN GLAND DYSFUNCTION USING RADIO-FREQUENCY ENERGY 有权
标题翻译：使用无线电频率处理MEIBOMIAN GLAND DYSFUNCTION的方法和系统
公开(公告)号：US20130053733A1
公开(公告)日：2013-02-28
申请号：US13590828
申请日：2012-08-21
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
IPC分类号： A61N5/00 , A61N7/00 , A61M37/00
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.
摘要翻译：公开了治疗睑板腺功能障碍的方法。该方法包括将RF能量引导到睑板腺的内部部分，以施加的RF能量选择性地靶向睑板腺管道内的阻塞物，以熔化，松动或软化阻塞物，并且将来自管道的阻塞物睑板腺还公开了一种治疗睑板腺功能障碍的装置。该装置包括至少一个RF电极，其被配置为将RF能量引导到位于眼睛的眼睑中的睑板腺的内部部分，所述至少一个RF电极还被配置为选择性地将睑板腺的管道内的阻塞物对准，应用的射频能量来融化，松动或软化障碍物。该装置还包括至少一个构造成从睑板腺的管道表达梗阻的表达器。

2. 发明申请

US20120136285A1 SYSTEM FOR OUTER EYELID HEAT AND PRESSURE TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
标题翻译：用于治疗脑血管性功能障碍的外眼热疗和压力治疗系统
公开(公告)号：US20120136285A1
公开(公告)日：2012-05-31
申请号：US13367908
申请日：2012-02-07
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61F9/00
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force is also applied to the outside of the patient's eyelid during the application of heat to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的系统。控制器控制施加到眼睑外部的热量，以向睑板腺提供传导热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。在施加热量的同时也将力施加到患者眼皮的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

3. 发明授权

US08128674B2 System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction 有权
标题翻译：用于治疗睑板腺功能障碍的外眼睑热压治疗系统
公开(公告)号：US08128674B2
公开(公告)日：2012-03-06
申请号：US12015683
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force is also applied to the outside of the patient's eyelid during the application of heat to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的系统。控制器控制施加到眼睑外部的热量，以向睑板腺提供传导热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。在施加热量的同时也将力施加到患者眼皮的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

4. 发明授权

US09719977B2 Methods and systems for treating meibomian gland dysfunction using radio-frequency energy 有权
公开(公告)号：US09719977B2
公开(公告)日：2017-08-01
申请号：US13590828
申请日：2012-08-21
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely , Steven Bacich
IPC分类号： A61F7/08 , A61F9/00 , G01N33/22 , A61N1/40 , A61F9/007 , A61H7/00 , A61H9/00 , A61H23/02 , A61B5/00 , A61B18/12 , A61B18/04 , A61F7/00 , A61H39/08 , A61H15/00 , A61N7/00
CPC分类号： G01N33/227 , A61B5/4836 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61B2562/0247 , A61B2562/0271 , A61F9/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/003 , A61H7/005 , A61H9/0057 , A61H9/0071 , A61H9/0078 , A61H23/0236 , A61H23/0245 , A61H23/0263 , A61H39/086 , A61H2015/0014 , A61H2201/0176 , A61H2201/0207 , A61H2201/0214 , A61H2201/5038 , A61H2201/5043 , A61H2205/024 , A61N1/403 , A61N7/00 , Y10T436/170769 , Y10T436/173076 , Y10T436/173845 , Y10T436/178459 , Y10T436/19 , Y10T436/206664
摘要： A method of treating meibomian gland dysfunction is disclosed. The method includes directing RF energy to an internal portion of a meibomian gland, selectively targeting an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction, and expressing the obstruction from the duct of the meibomian gland. An apparatus for treating meibomian gland dysfunction is also disclosed. The apparatus comprises at least one RF electrode configured to direct RF energy to an internal portion of a meibomian gland located in an eyelid of an eye, the at least one RF electrode further configured to selectively target an obstruction within a duct of the meibomian gland with the applied RF energy to melt, loosen, or soften the obstruction. The apparatus also comprises at least one expressor configured to express the obstruction from the duct of the meibomian gland.

5. 发明申请

US20080132978A1 OUTER EYELID HEAT AND PRESSURE TREATMENT FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权
标题翻译：用于治疗脑血管功能障碍的外眼热治疗
公开(公告)号：US20080132978A1
公开(公告)日：2008-06-05
申请号：US12015576
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61B18/02 , A61K31/65 , A61K38/18 , A61K38/43
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61K31/65 , A61K38/1841 , A61N7/00
摘要： A method of treating meibomian gland dysfunction. Heat is applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的方法。将热量施加到眼睑的外侧，以向睑板腺提供导电热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者眼睑的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

6. 发明授权

US07981146B2 Inner eyelid treatment for treating meibomian gland dysfunction 有权
标题翻译：用于治疗睑板腺功能障碍的内眼睑治疗
公开(公告)号：US07981146B2
公开(公告)日：2011-07-19
申请号：US12015558
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A method of treating meibomian gland dysfunction. Heat is applied to the inside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. Temperatures at the meibomian glands reach desired levels more quickly and efficiently when heating the inside of the eyelid. Reaching such higher temperature levels may be instrumental in removing obstructions in the meibomian glands. Less time may also be required to reach desired temperature levels when applying heat to the inside of the eyelid. A force may also be applied to the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions.
摘要翻译：治疗睑板腺功能障碍的方法。将热量施加到眼睑内部以提供导热传递到睑板腺。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。在加热眼睑内部时，睑板腺的温度可以更快速有效地达到所需水平。达到更高的温度水平可能有助于消除睑板腺中的障碍物。当向眼睑内部施加热量时，也可能需要较少的时间达到所需的温度水平。也可以将力施加到患者眼睑的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。

7. 发明授权

US08617229B2 System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction 有权
标题翻译：用于治疗睑板腺功能障碍的外眼睑热压治疗系统
公开(公告)号：US08617229B2
公开(公告)日：2013-12-31
申请号：US13367908
申请日：2012-02-07
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction comprising a heating element that applies heat to the outside of the eyelid to provide conductive heat transfer to the meibomian glands, which assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force application device may also apply force to the patient's eyelid during the application of heat to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss, and to help express obstructions from the meibomian gland, including from a channel of the meibomian gland. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：一种用于治疗睑板腺功能障碍的系统，包括加热元件，该加热元件将热量施加到眼睑的外侧，以向睑板腺提供导电热传递，这有助于在睑板腺中表达障碍物或闭塞，以恢复足够的皮脂流脂质层治疗干眼症。力施加装置还可以在施加热量的同时对患者的眼皮施加力，以改善导电热传递并减少引起对流热损失的眼睑中的血流，并且帮助表达来自睑板腺的阻塞物，包括从睑板腺睑板腺。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

8. 发明授权

US07981147B2 Outer eyelid heat and pressure treatment for treating meibomian gland dysfunction 有权
标题翻译：外眼睑热压治疗睑板腺功能障碍
公开(公告)号：US07981147B2
公开(公告)日：2011-07-19
申请号：US12015576
申请日：2008-01-17
申请人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
发明人： Donald R. Korb , Stephen M. Grenon , Timothy R. Willis , Benjamin Tyson Gravely
IPC分类号： A61M35/00 , A61F7/02 , A61F7/08
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00718 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61K31/65 , A61K38/1841 , A61N7/00
摘要： A method of treating meibomian gland dysfunction. Heat is applied to the outside of the eyelid to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force may also be applied to the outside of the patient's eyelid to improve conductive heat transfer and reduce blood flow in the eyelid that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions or occlusions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands while reducing the amount of time to reach desired temperature levels and/or aid in reducing discomfort to the patient during treatment.
摘要翻译：治疗睑板腺功能障碍的方法。将热量施加到眼睑的外侧，以向睑板腺提供导电热传递。热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。也可以将力施加到患者眼睑的外侧，以改善导电传热并减少引起对流热损失的眼睑中的血流。因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物或闭塞的时间。达到增加的温度水平可以改善睑板腺中的阻塞物或闭塞的熔化，松动或软化，同时减少达到期望温度水平的时间量和/或有助于减轻治疗期间对患者的不适。

9. 发明授权

US09060843B2 Method and apparatus for treating gland dysfunction employing heated medium 有权
标题翻译：使用加热培养基治疗腺体功能障碍的方法和装置
公开(公告)号：US09060843B2
公开(公告)日：2015-06-23
申请号：US11931398
申请日：2007-10-31
申请人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
发明人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis , Benjamin T. Gravely
IPC分类号： A61B7/00 , A61F9/007 , A61H7/00 , A61B18/12 , A61B18/04 , A61F7/00 , A61H15/00 , A61N7/00
CPC分类号： A61N5/0625 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N1/403 , A61N5/025 , A61N7/00 , A61N2005/0643 , A61N2005/0659 , A61N2005/067
摘要： A method and apparatus for treating gland dysfunction caused by gland obstruction in order to restore the natural flow of secretion from the gland comprises the application of a combination of energy, suction, vibration, heat, aspiration, chemical agents and pharmacological agents to loosen and thereafter remove the obstructive material.
摘要翻译：用于治疗由腺体阻塞引起的腺体功能障碍以便恢复从腺体分泌的天然流动的方法和装置包括施加能量，吸力，振动，热，吸入，化学药剂和药理学物质的组合以松动其后清除阻塞物。

10. 发明授权

US08950405B2 Treatment of obstructive disorders of the eye or eyelid 有权
标题翻译：治疗眼睛或眼睑的阻塞性疾病
公开(公告)号：US08950405B2
公开(公告)日：2015-02-10
申请号：US11928681
申请日：2007-10-30
申请人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis
发明人： Stephen M. Grenon , Donald R. Korb , Timothy R. Willis
IPC分类号： A61F7/00 , A61F7/02 , A61F9/007
CPC分类号： A61B17/22004 , A61B17/22 , A61F7/02 , A61F9/00772 , A61F2007/0004 , A61F2007/0261
摘要： In accordance with certain illustrative embodiments, methods and apparatuses of treating obstructive disorders of the structure of an eye or eyelid are disclosed. The treating may involve applying heat to the structure containing the obstructive disorder to melt an obstruction in the structure and place the obstruction in a melted state. The heat may be maintained for a time period to melt the obstruction and place the obstruction in the melted state. The structure may be treated by expressing the melted obstruction from the structure. The treating may be carried out either during the time period or after the time period when heat is applied but while the obstruction is in the melted state. In certain embodiments, the method further involves subsequently treating the structure by use of a pharmacological agent. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译：根据某些示例性实施例，公开了治疗眼睛或眼睑结构的阻塞性疾病的方法和装置。治疗可以涉及对包含阻塞性病症的结构施加热量，以便熔化结构中的梗阻并将阻塞置于熔化状态。可以将热量保持一段时间以融化阻塞物并将阻塞物置于熔化状态。可以通过从结构中表达熔化的阻塞来处理结构。处理可以在施加热量但是阻塞处于熔化状态的时间段期间之后或者在施加热量的时间段之后进行。在某些实施方案中，该方法还涉及随后通过使用药理学剂处理该结构。该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。

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