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1. 发明申请

US20100307226A1 APPARATUS, KITS AND METHODS FOR DETERMINING THE PRESENCE OR ABSENCE OF MINERALOCORTICOIDS IN SAMPLES 审中-公开
标题翻译：测定矿物质在样品中存在或不存在的装置，试剂盒和方法
公开(公告)号：US20100307226A1
公开(公告)日：2010-12-09
申请号：US12743281
申请日：2008-11-14
申请人： Donald Peter Cooper , Michael Morris , Paul James Taylor
发明人： Donald Peter Cooper , Michael Morris , Paul James Taylor
IPC分类号： G01N30/00 , H01J49/26
CPC分类号： G01N30/7233 , G01N33/743 , G01N2030/8813 , G01N2030/8872 , H01J49/0431
摘要： Embodiments of the present invention feature apparatus, kits and methods for detecting the presence or absence of a mineralocorticoid in biological samples. The methods, apparatus and kits feature a high performance liquid chromatography system with a column for receiving one or more biological samples potentially having mineralocorticoid, said chromatography system receiving one or more biological samples at a first time and separating the compounds in retained peaks comprising at least mineral corticoid retained peak for a mineralocorticoid in the event said mineralocorticoid is present at a mineralocorticoid retention time. And, a mass spectrometer in fluid communication with the high performance liquid chromatography system receives one or more of said retained peaks including the mineralocorticoid retained peak at the mineralocorticoid retention time, and produces a signal to allow said mineralocorticoid to be identified by retention peak and mass charge values.
摘要翻译：本发明的实施方案用于检测生物样品中盐皮质激素的存在或不存在的装置，试剂盒和方法。方法，装置和试剂盒具有高效液相色谱系统，其具有用于接收一种或多种潜在地具有盐皮质激素的生物样品的色谱柱，所述色谱系统在第一次接收一种或多种生物样品，并将化合物分离至少包含至少如果盐皮质激素存在于盐皮质激素停留时间，矿物质皮质激素保留了盐皮质激素的峰值。并且，与高效液相色谱系统流体连通的质谱仪在盐皮质激素保留时间内接收一个或多个所述保留的峰，包括盐皮质激素保留峰，并产生信号，以允许所述盐皮质激素通过保留峰和质量收费值。

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