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1. 发明申请

US20130253035A1 CAMKK-BETA AS A TARGET FOR TREATING CANCER 审中-公开
标题翻译： CAMKK-BETA作为治疗癌症的目标
公开(公告)号：US20130253035A1
公开(公告)日：2013-09-26
申请号：US13817382
申请日：2011-08-16
申请人： Donald P. McDonnell , Daniel Frigo , Anthony R. Means
发明人： Donald P. McDonnell , Daniel Frigo , Anthony R. Means
IPC分类号： A61K31/7088 , A61K31/437 , G01N33/68 , C12Q1/68
CPC分类号： A61K31/4745 , A61K31/437 , A61K31/7088 , C07K16/3069 , C07K16/40 , C07K2317/76 , C12N15/1137 , C12N2310/14 , C12N2320/30 , C12Q1/485 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Y207/11017 , G01N33/57434 , G01N33/6893 , G01N2333/912 , G01N2500/04 , G01N2500/10 , G01N2500/20 , G01N2800/52
摘要： Provided herein are compounds, compositions, including pharmaceutical compositions, having anti-cancer activity. Also provided are methods for diagnosing, detecting, and treating cancer in a subject, as well as a method for evaluating cancer stage in a subject, wherein the methods include determining the amount of a Ca2+/calmodulin dependent kinase kinase (CaMKK) in a sample. Further provided are methods of screening and identifying a compound that inhibits CaMKK.
摘要翻译：本文提供具有抗癌活性的化合物，组合物，包括药物组合物。还提供了用于诊断，检测和治疗受试者中的癌症的方法，以及用于评估受试者的癌症阶段的方法，其中所述方法包括测定样品中Ca 2+ /钙调蛋白依赖性激酶激酶（CaMKK）的量。还提供了筛选和鉴定抑制CaMKK的化合物的方法。

2. 发明授权

US5935934A Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy 失效
公开(公告)号：US5935934A
公开(公告)日：1999-08-10
申请号：US454418
申请日：1995-05-30
申请人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley , William T. Schrader , Ming-Jer Tsai
发明人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley , William T. Schrader , Ming-Jer Tsai
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , C07H15/12 , C07H17/00 , C07H21/04 , C07K14/705 , C07K14/72 , C12N5/00 , C12N5/10 , C12N7/01 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/82 , C12P21/02 , C12R1/91 , G01N33/566 , G01N33/68 , G01N33/74
CPC分类号： C07K14/721 , C12N15/63 , C12N15/8237 , C12N15/8238 , G01N33/566 , G01N33/743 , A61K38/00 , G01N2333/723 , G01N2500/10 , Y10S514/01
摘要： The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy and methods of employing the molecular switch in humans, animals, transgenic animals and plants.

3. 发明授权

US5364791A Progesterone receptor having C. terminal hormone binding domain truncations 失效
标题翻译：具有C.末端激素结合域截短的孕酮受体
公开(公告)号：US5364791A
公开(公告)日：1994-11-15
申请号：US882771
申请日：1992-05-14
申请人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley
发明人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley
IPC分类号： A61K38/00 , C07K14/72 , C12N15/63 , C12N15/82 , G01N33/566 , G01N33/74 , C12N15/00 , C07H17/00 , C07K13/00 , G01N33/53
CPC分类号： G01N33/566 , C07K14/721 , C12N15/63 , C12N15/8237 , C12N15/8238 , G01N33/743 , A61K38/00 , G01N2333/723 , G01N2500/10
摘要： The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors.
摘要翻译：本发明提供类固醇激素受体的突变蛋白。这些突变蛋白可用于区分类固醇激素受体拮抗剂与类固醇激素受体激动剂的方法。本发明还提供含有突变的类固醇激素受体蛋白质的质粒和用这些质粒转染的细胞。此外，本发明提供了确定化合物是类固醇激素受体拮抗剂还是激动剂的方法。此外，本发明提供了确定类固醇激素受体的内源性配体的方法。

4. 发明授权

US07307102B2 Method of preventing or treating estrogen-dependent diseases and disorders 失效
标题翻译：预防或治疗雌激素依赖性疾病和病症的方法
公开(公告)号：US07307102B2
公开(公告)日：2007-12-11
申请号：US10390032
申请日：2003-03-18
申请人： Donald P. McDonnell , John Norris , Caroline Connor , Ashini Wijayaratne
发明人： Donald P. McDonnell , John Norris , Caroline Connor , Ashini Wijayaratne
IPC分类号： A61K31/235
CPC分类号： A61K31/192
摘要： The present invention relates, in general, to the treatment of estrogen-dependent diseases and disorders and, in particular, to a method of treating estrogen-dependent cancers, particularly breast cancer, with antiestrogens.
摘要翻译：本发明一般涉及治疗雌激素依赖性疾病和病症，特别涉及一种用抗雌激素治疗雌激素依赖性癌症，特别是乳腺癌的方法。

5. 发明授权

US06599698B1 Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy 有权
标题翻译：突变的类固醇激素受体，其使用方法和基因治疗的分子切换
公开(公告)号：US06599698B1
公开(公告)日：2003-07-29
申请号：US09209981
申请日：1998-12-09
申请人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley , William T. Schrader , Ming-Jer Tsai
发明人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley , William T. Schrader , Ming-Jer Tsai
IPC分类号： C12Q163
CPC分类号： C07K14/721 , A61K38/00 , C12N15/63 , C12N15/8237 , C12N15/8238 , G01N33/566 , G01N33/743 , G01N2333/723 , G01N2500/10 , Y10S514/01
摘要： The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy and methods of employing the molecular switch in humans, animals, transgenic animals and plants.
摘要翻译：本发明提供类固醇激素受体的突变蛋白。这些突变蛋白可用于区分类固醇激素受体拮抗剂与类固醇激素受体激动剂的方法。本发明还提供含有突变的类固醇激素受体蛋白质的质粒和用这些质粒转染的细胞。此外，本发明提供了确定化合物是类固醇激素受体拮抗剂还是激动剂的方法。此外，本发明提供了确定类固醇激素受体的内源性配体的方法。本发明还提供了用于调节基因治疗表达的分子开关和在人，动物，转基因动物和植物中使用分子开关的方法。

6. 发明授权

US5506102A Methods of using the A form of the progesterone receptor to screen for antagonists of steroid intracellar receptor-mediated transcription 失效
标题翻译：使用A形式的孕酮受体的方法筛选类固醇细胞内受体介导的转录的拮抗剂
公开(公告)号：US5506102A
公开(公告)日：1996-04-09
申请号：US144554
申请日：1993-10-28
申请人： Donald P. McDonnell
发明人： Donald P. McDonnell
IPC分类号： G01N33/566 , C07K14/72 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/74
CPC分类号： C07K14/721 , C12Q1/6897 , G01N33/743 , G01N2333/723 , Y10S435/81
摘要： Methods to screen for antagonists of steroid IR transcription as mediated by the PR-A isoform of the progesterone receptor are provided. Such cell-based methods include a cell in which PR-A is transcriptionally inactive containing asteroid IR other than PR, PR-A and a reporter vector that includes a promoter which is transcriptionally active in the presence of the steroid IR and an activator of said steroid IR, but is substantially transcriptionally inactive in the presence of PR-A. This cell is contacted with the activator of the steroid IR and a compound to be assayed, and the level of reporter product produced in the cell is measured and compared to the level of reporter product expressed in a similar cellular system absent PR-A as an indication of the potential antagonist activity of the compound being assayed. Also provided are an assay kit, a method of screening PR active compounds as ER antagonists and compounds that inhibit the transcriptional activity of asteroid IR in the presence of PR-A in a cellular context where PR-A is substantially transcriptionally inactive.
摘要翻译：提供了筛选由孕激素受体的PR-A同种型介导的类固醇IR转录拮抗剂的方法。这种基于细胞的方法包括其中PR-A转录失活的细胞，其含有除PR，PR-A之外的小行星IR，以及包含在类固醇IR存在下具有转录活性的启动子的报告载体和所述类固醇IR，但在PR-A存在下基本上转录无活性。将该细胞与类固醇IR的活化剂和待测化合物接触，并测量在细胞中产生的报道产物的水平，并与不存在PR-A的类似细胞系统中表达的报道产物的水平进行比较所测化合物潜在的拮抗剂活性的指示。还提供了测定试剂盒，在PR-A基本上转录无活性的细胞环境中，PR-A存在下抑制PR活性化合物作为ER拮抗剂和抑制小行星IR的转录活性的化合物的方法。

7. 发明申请

US20100034778A1 STEM CELLS 审中-公开
标题翻译：干细胞
公开(公告)号：US20100034778A1
公开(公告)日：2010-02-11
申请号：US12066957
申请日：2006-09-14
申请人： Donald P. McDonnell , John P. Chute
发明人： Donald P. McDonnell , John P. Chute
IPC分类号： A61K35/12 , C12N5/02 , C12N5/071 , C12Q1/02
CPC分类号： C12N5/0647 , C12N2501/125 , C12N2501/145 , C12N2501/26 , C12N2501/385
摘要： The present invention relates, in general, to stem cells and, in particular, to a method of expanding human stem cells using a retinoic acid receptor modulator.
摘要翻译：本发明一般涉及干细胞，特别涉及使用视黄酸受体调节剂扩增人类干细胞的方法。

8. 发明授权

US07238793B2 Estrogen receptor modulators 失效
标题翻译：雌激素受体调节剂
公开(公告)号：US07238793B2
公开(公告)日：2007-07-03
申请号：US10108992
申请日：2002-03-29
申请人： Donald P. McDonnell , John D. Norris , Daju Fan
发明人： Donald P. McDonnell , John D. Norris , Daju Fan
IPC分类号： C07H21/00
CPC分类号： C07K14/4703
摘要： The present invention relates to an estrogen receptor co-regulator and to antibodies specific therefor. The invention further relates to methods of screening test compounds for their suitability as estrogen receptor modulators and to methods of using same in disease treatment.
摘要翻译：本发明涉及雌激素受体共调节因子及其特异性抗体。本发明还涉及筛选测试化合物作为雌激素受体调节剂的适用性的方法以及在疾病治疗中使用它们的方法。

9. 发明授权

US5874534A Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy 失效
公开(公告)号：US5874534A
公开(公告)日：1999-02-23
申请号：US479846
申请日：1995-06-06
申请人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley , William T. Schrader , Ming-Jer Tsai
发明人： Elisabetta Vegeto , Donald P. McDonnell , Bert W. O'Malley , William T. Schrader , Ming-Jer Tsai
IPC分类号： A61K31/70 , A61K38/00 , A61K48/00 , C07H15/12 , C07H17/00 , C07H21/04 , C07K14/705 , C07K14/72 , C12N5/00 , C12N5/10 , C12N7/01 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/82 , C12P21/02 , C12R1/91 , G01N33/566 , G01N33/68 , G01N33/74 , C07K13/00
CPC分类号： C07K14/721 , C12N15/63 , C12N15/8237 , C12N15/8238 , G01N33/566 , G01N33/743 , A61K38/00 , G01N2333/723 , G01N2500/10 , Y10S514/01
摘要： The present invention provides mutant proteins of steroid hormone receptors. These mutant proteins are useful in methods of distinguishing a steroid hormone receptor antagonist from a steroid hormone receptor agonist. The present invention also provides plasmids containing mutated steroid hormone receptor proteins and cells transfected with those plasmids. In addition, the present invention provides methods for determining whether a compound is a steroid hormone receptor antagonist or agonist. Also, the present invention provides methods of determining endogenous ligands for steroid hormone receptors. The invention further provides a molecular switch for regulating expression in gene therapy and methods of employing the molecular switch in humans, animals, transgenic animals and plants.

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