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1. 发明授权

US5102867A Therapeutic treatment of abnormal cell growth with follicle regulatory protein 失效
标题翻译：用卵泡调节蛋白治疗异常细胞生长
公开(公告)号：US5102867A
公开(公告)日：1992-04-07
申请号：US379995
申请日：1989-07-14
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , Y10S530/853
摘要： A method of treating a patient exhibiting a neoplasm is provided comprising administering a therapeutically effective dose of Follicle Regulatory Protein (FRP), or a polypeptide analog thereof. The method may be used both pre- and post-operatively.
摘要翻译：提供了治疗呈现肿瘤的患者的方法，包括施用治疗有效剂量的卵泡调节蛋白（FRP）或其多肽类似物。该方法可以在手术前和手术后使用。

2. 发明授权

US4849402A Therapeutic treatment of abnormal cell growth with follicle regulatory protein 失效
标题翻译：用卵泡调节蛋白治疗异常细胞生长
公开(公告)号：US4849402A
公开(公告)日：1989-07-18
申请号：US915074
申请日：1986-10-03
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： A61K38/22 , A61P35/00 , C07K14/575
CPC分类号： C07K14/575 , Y10S530/853
摘要： A method of treating patients exhibiting neoplasms of gonadal origin is provided comprising administering a therapeutically effective dose of Follicle Regulatory Protein (FRP). The method may be used both pre- and post-operatively.
摘要翻译：提供一种治疗表现出性腺发生肿瘤的患者的方法，包括施用治疗有效剂量的卵泡调节蛋白（FRP）。该方法可以在手术前和手术后使用。

3. 发明授权

US06815170B1 Methods for lymph node identification 有权
标题翻译：淋巴结识别方法
公开(公告)号：US06815170B1
公开(公告)日：2004-11-09
申请号：US09609301
申请日：2000-06-30
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： G01N33574
CPC分类号： G01N1/30 , G01N33/574 , G01N33/585
摘要： The present invention describes a method for identification of lymph nodes and the presence or absence of lymph node metastases as an important prognostic factor in early stage cancers of all types. A carbon black suspension is administered in combination with a second compound to a region associated with a neoplastic tumor in a patient. The sentinel lymph node associated with the disease-associated region is identified by the accumulation of carbon particles. The region associated with the accumulation of carbon black particles is then subject to histopathology for the purpose of identification, diagnosing, staging or predicting the presence of neoplastic tissue. The neoplastic tumor is any neoplasm that metastasizes via the lymphatic channels.
摘要翻译：本发明描述了淋巴结的识别方法和淋巴结转移的存在或不存在，作为所有类型早期癌症的重要预后因素。将炭黑悬浮液与第二化合物组合施用于患者中与肿瘤肿瘤相关的区域。与疾病相关区域相关的前哨淋巴结由碳颗粒的积累来鉴定。为了识别，诊断，分期或预测肿瘤组织的存在，与炭黑颗粒的积累相关的区域然后经历组织病理学。肿瘤肿瘤是通过淋巴管转移的任何肿瘤。

4. 发明授权

US5840317A Composition comprising tumor cell lines containing GD2 ganglioside GM2 ganglioside, M-TAA, and either M-urinary antigen or M-fetal antigen 失效
标题翻译：包含含有GD2神经节苷脂，GM2神经节苷脂，M-TAA和M-尿抗原或M-胎儿抗原的肿瘤细胞系的组合物
公开(公告)号：US5840317A
公开(公告)日：1998-11-24
申请号：US468029
申请日：1995-06-06
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： A61K38/00 , A61K39/00 , A61K47/48 , A61K49/00 , A61P35/00 , C07K14/47 , C07K16/30 , C07K16/42 , G01N33/574
CPC分类号： C07K14/4748 , A61K47/48569 , A61K47/48653 , A61K49/00 , C07K14/47 , C07K16/30 , C07K16/3053 , C07K16/4266 , G01N33/57407 , G01N33/57484 , A61K38/00 , A61K39/00 , Y10S530/828
摘要： A new polyvalent melanoma cell vaccine is disclosed comprised of one or more allogeneic melanoma cell lines which contain effective concentrations of melanoma associated antigens. Further disclosed are a method of stimulating an immunological response by administering the described vaccine as well as a method of prognosticating a patient.
摘要翻译：公开了一种新的多价黑素瘤细胞疫苗，其包含含有有效浓度的黑素瘤相关抗原的一种或多种同种异体黑素瘤细胞系。进一步公开的是通过施用所述疫苗来刺激免疫应答的方法以及预测患者的方法。

5. 发明授权

US5700649A Method of detection of urinary tumor associated antigen 失效
标题翻译：尿肿瘤相关抗原检测方法
公开(公告)号：US5700649A
公开(公告)日：1997-12-23
申请号：US462264
申请日：1995-06-05
申请人： Donald L. Morton , Rishab K. Gupta , David M. Euhus
发明人： Donald L. Morton , Rishab K. Gupta , David M. Euhus
IPC分类号： A61K39/00 , A61K38/00 , A61K39/395 , A61K47/48 , A61K49/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/30 , C07K16/42 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/535 , G01N33/564 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57484 , A61K47/48569 , A61K47/48653 , A61K49/00 , C07K14/4748 , C07K16/30 , C07K16/4266 , G01N33/57407 , A61K38/00 , A61K39/00 , C07K2317/734 , Y10S530/828
摘要： The present invention describes Urinary Tumor Associated Antigen (UTAA), its isolation and use in diagnostic assays. In particular, UTAA has been identified in samples from cancer patients, in some cases as part of an immune complex of UTAA and UTAA-specific immunoglobulin. Isolated UTAA also may be formulated as a pharmaceutical for production of antibodies or as a vaccine.
摘要翻译：本发明描述了尿肿瘤相关抗原（UTAA），其在诊断测定中的分离和应用。具体来说，已经在癌症患者的样品中鉴定了UTAA，在某些情况下，作为UTAA和UTAA特异性免疫球蛋白免疫复合物的一部分。分离的UTAA也可以配制成用于生产抗体或疫苗的药物。

6. 发明授权

US08557257B2 Mycobacterial immunotherapy for cancer treatment 有权
标题翻译：分枝杆菌免疫治疗癌症治疗
公开(公告)号：US08557257B2
公开(公告)日：2013-10-15
申请号：US12293766
申请日：2007-03-23
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： A61K49/00 , A61K39/02 , A61K39/04
CPC分类号： A61K35/74 , A61K45/06 , G01N33/57484 , G01N2800/52 , A61K2300/00
摘要： Methods of Mycobacterial immunotherapy for the treatment of cancer are described. In certain cases, these methods concern administration of attenuated Mycobacteria by intradermal injection into non tumor tissues. Methods of the invention, provide safe and effective treatments for malignant tumors and the compositions for use in such treatments. Methods for determine the effectiveness of such immunotherapies are also described.
摘要翻译：描述了分枝杆菌免疫治疗癌症的方法。在某些情况下，这些方法涉及通过皮下注射到非肿瘤组织中来施用减毒的分枝杆菌。本发明的方法为恶性肿瘤提供安全有效的治疗和用于这种治疗的组合物。还描述了确定这种免疫疗法有效性的方法。

7. 发明授权

US06491926B1 35 kD tumor associated protein antigen: uses and methods of detection 失效
标题翻译： 35 kD肿瘤相关蛋白抗原：用途和检测方法
公开(公告)号：US06491926B1
公开(公告)日：2002-12-10
申请号：US09519920
申请日：2000-03-07
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： A61K3900
CPC分类号： C07K14/47 , C07K16/3053
摘要： This invention provides the isolation and characterization of a tumor associated antigen which can be used for immunodiagnosis, immunoprognosis, and therapy of human cancer. The antigen is a protein molecule with a molecular weight of about 35 kD after reduction and separation by SDS-polyacrylamide gel electrophoresis. The antigen has been detected in serum of cancer patients.
摘要翻译：本发明提供可用于免疫诊断，免疫预后和人类癌症治疗的肿瘤相关抗原的分离和表征。抗原是通过SDS-聚丙烯酰胺凝胶电泳还原和分离后的分子量约35kD的蛋白质分子。已经在癌症患者的血清中检测到抗原。

8. 发明授权

US06218166B1 Adjuvant incorporation into antigen carrying cells: compositions and methods 失效
标题翻译：佐剂掺入抗原携带细胞：组合物和方法
公开(公告)号：US06218166B1
公开(公告)日：2001-04-17
申请号：US08462106
申请日：1995-06-05
申请人： Mepur H. Ravindranath , Donald L. Morton
发明人： Mepur H. Ravindranath , Donald L. Morton
IPC分类号： A61K3900
CPC分类号： A61K39/0011 , A61K9/5068 , A61K2039/55572
摘要： Disclosed are compositions and methods for enhancing the antibody and T cell response to cellular antigens by incorporating an immunopotentiating agent into the cellular membrane or into an intracellular compartment. Such adjuvant-incorporated cell compositions are useful in methods to increase immune responses against antigens, including immunologically cryptic tumor cell antigens, and may be employed to generate useful diagnostic antibodies, to elicit anti-tumor effects in immunized animals, and to significantly prolong survival in animals with cancer.
摘要翻译：公开了通过将免疫增强剂掺入细胞膜或细胞内区室来增强抗体和T细胞对细胞抗原的应答的组合物和方法。这种佐剂掺入的细胞组合物可用于增加针对抗原的免疫应答的方法，包括免疫隐匿性肿瘤细胞抗原，并且可用于产生有用的诊断抗体，以在免疫动物中引起抗肿瘤作用，并显着延长生存有癌症的动物

9. 发明授权

US5993828A Tumor associated antigen compositions and methods 失效
标题翻译：肿瘤相关抗原组合物和方法
公开(公告)号：US5993828A
公开(公告)日：1999-11-30
申请号：US462570
申请日：1995-06-05
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： A61K39/00 , A61K38/00 , A61K39/395 , A61K47/48 , A61K49/00 , A61P35/00 , C07K14/435 , C07K14/47 , C07K16/00 , C07K16/30 , C07K16/42 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/68 , C12R1/91 , G01N33/53 , G01N33/531 , G01N33/535 , G01N33/564 , G01N33/574 , G01N33/577 , A61K35/12
CPC分类号： G01N33/57484 , A61K47/48569 , A61K47/48653 , A61K49/00 , C07K14/4748 , C07K16/30 , C07K16/4266 , G01N33/57407 , A61K38/00 , A61K39/00 , C07K2317/734 , Y10S530/828
摘要： A method for inducing or enhancing in a human subject the production of antibodies reactive with the polypeptide subunit of Urinary Tumor Associated Antigen having a molecular weight of about 90 to 100 kD after reduction by .beta.-mercaptoethanol and separation by SDS-polyacrylamide gel electrophoresis is disclosed. The method comprises administering to the subject an effective dose of a composition comprising inactivated tumor cells having Urinary Tumor Associated Antigen on the cell surface and at least one tumor associated antigen selected from the group consisting of GM-2, GD-2, Fetal Antigen and Melanoma Associated Antigen.
摘要翻译：公开了一种用于在人受试者中诱导或增强与通过β-巯基乙醇还原后分子量为约90至100kD的尿肿瘤相关抗原的多肽亚基反应的抗体的产生并通过SDS-聚丙烯酰胺凝胶电泳分离的方法。该方法包括向受试者施用有效剂量的组合物，其包含在细胞表面上具有尿肿瘤相关抗原的灭活的肿瘤细胞和至少一种肿瘤相关抗原，所述抗原选自GM-2，GD-2，胎儿抗原和黑色素瘤相关抗原。

10. 发明申请

US20100247440A1 MYCOBACTERIAL IMMUNOTHERAPY FOR CANCER TREATMENT 有权
标题翻译：用于癌症治疗的MYCOBACTERIAL IMMUNOTHERAPY
公开(公告)号：US20100247440A1
公开(公告)日：2010-09-30
申请号：US12293766
申请日：2007-03-23
申请人： Donald L. Morton
发明人： Donald L. Morton
IPC分类号： A61K49/00 , A61K39/04 , A61P35/00 , A61P37/04
CPC分类号： A61K35/74 , A61K45/06 , G01N33/57484 , G01N2800/52 , A61K2300/00
摘要： Methods of Mycobacterial immunotherapy for the treatment of cancer are described. In certain cases, these methods concern administration of attenuated Mycobacteria by intradermal injection into non tumor tissues. Methods of the invention, provide safe and effective treatments for malignant tumors and the compositions for use in such treatments. Methods for determine the effectiveness of such immunotherapies are also described.
摘要翻译：描述了分枝杆菌免疫治疗癌症的方法。在某些情况下，这些方法涉及通过皮下注射到非肿瘤组织中来施用减毒的分枝杆菌。本发明的方法为恶性肿瘤提供安全有效的治疗和用于这种治疗的组合物。还描述了确定这种免疫疗法有效性的方法。

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