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1. 发明授权

US07955258B2 External data processing device to interface with an ambulatory repeater and method thereof 有权
标题翻译：外部数据处理装置与移动中继器接口及其方法
公开(公告)号：US07955258B2
公开(公告)日：2011-06-07
申请号：US11901520
申请日：2007-09-17
申请人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
发明人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , G06F19/00
摘要： An external data processing device to interface with an ambulatory repeater and method thereof is presented. An external data processing device is interfaced in far field telemetric communication with an ambulatory repeater. The external data processing device receives sensitive information preencrypted prior to implant under a cryptographic key uniquely assigned to an implantable medical device over a secure connection from the ambulatory repeater. Physiological measures retrieved from the implantable medical device by the ambulatory repeater are received by the external data processing device over a non-secure connection.
摘要翻译：提出了一种与移动中继器进行接口的外部数据处理装置及其方法。外部数据处理装置与远程中继器进行远场遥测通信。外部数据处理设备在通过来自移动中继器的安全连接之下，在通过唯一地分配给可植入医疗设备的密码密钥进行植入之前接收预先加密的敏感信息。由移动式中继器从可植入医疗装置检索的生理测量由外部数据处理装置通过非安全连接接收。

2. 发明授权

US08216135B2 Ambulatory repeater for use in automated patient care 有权
标题翻译：动态中继器，用于自动化病人护理
公开(公告)号：US08216135B2
公开(公告)日：2012-07-10
申请号：US13095204
申请日：2011-04-27
申请人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
发明人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , G06F19/00
摘要： An ambulatory repeater for use in automated patient care is presented. A local memory store includes a cryptographic key, sensitive information, and physiological measures. The cryptographic key is uniquely assigned to the implantable medical device prior to implant of the implantable medical device into a patient. The sensitive information is preencrypted under the cryptographic key and physiological measures are measured by the implantable medical device. An authentication module is in receipt of the cryptographic key. A permissions module confirms authorization of an external data processing device against the cryptographic key. A decryption module decrypts the sensitive information with the cryptographic key into decrypted information. A processor is operatively coupled to the local memory store. A communications module exchanges the decrypted information and the physiological measures with the external data processing device over a wireless interface contingent upon the authorization confirmation. An internal power supply supplies power to the foregoing components.
摘要翻译：提出了一种用于自动病人护理的移动中继器。本地存储器包括加密密钥，敏感信息和生理措施。在将可植入医疗装置植入病人之前，将密码密钥唯一地分配给可植入医疗装置。敏感信息在加密密钥下加密，生理测量由可植入医疗设备测量。认证模块正在接收加密密钥。权限模块根据加密密钥确认外部数据处理设备的授权。解密模块将具有加密密钥的敏感信息解密为解密信息。处理器可操作地耦合到本地存储器存储器。通信模块根据授权确认，通过无线接口与外部数据处理装置交换解密信息和生理测量。内部电源为上述组件供电。

3. 发明申请

US20110200194A1 AMBULATORY REPEATER FOR USE IN AUTOMATED PATIENT CARE 有权
标题翻译：在自动化患者护理中使用的辅助重复器
公开(公告)号：US20110200194A1
公开(公告)日：2011-08-18
申请号：US13095204
申请日：2011-04-27
申请人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
发明人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
IPC分类号： H04L9/28 , H04L9/08
CPC分类号： A61B5/0031 , G06F19/00
摘要： An ambulatory repeater for use in automated patient care is presented. A local memory store includes a cryptographic key, sensitive information, and physiological measures. The cryptographic key is uniquely assigned to the implantable medical device prior to implant of the implantable medical device into a patient. The sensitive information is preencrypted under the cryptographic key and physiological measures are measured by the implantable medical device. An authentication module is in receipt of the cryptographic key. A permissions module confirms authorization of an external data processing device against the cryptographic key. A decryption module decrypts the sensitive information with the cryptographic key into decrypted information. A processor is operatively coupled to the local memory store. A communications module exchanges the decrypted information and the physiological measures with the external data processing device over a wireless interface contingent upon the authorization confirmation. An internal power supply supplies power to the foregoing components.
摘要翻译：提出了一种用于自动病人护理的移动中继器。本地存储器包括加密密钥，敏感信息和生理措施。在将可植入医疗装置植入病人之前，将密码密钥唯一地分配给可植入医疗装置。敏感信息在加密密钥下加密，生理测量由可植入医疗设备测量。认证模块正在接收加密密钥。权限模块根据加密密钥确认外部数据处理设备的授权。解密模块将具有加密密钥的敏感信息解密为解密信息。处理器可操作地耦合到本地存储器存储器。通信模块根据授权确认，通过无线接口与外部数据处理装置交换解密信息和生理测量。内部电源为上述组件供电。

4. 发明授权

US07967751B2 Ambulatory repeater for use in automated patient care 有权
标题翻译：动态中继器，用于自动化病人护理
公开(公告)号：US07967751B2
公开(公告)日：2011-06-28
申请号：US11893704
申请日：2007-08-17
申请人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
发明人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , G06F19/00
摘要： An ambulatory repeater for use in automated patient care is presented. A local memory store includes a cryptographic key, sensitive information, and physiological measures. The cryptographic key is uniquely assigned to the implantable medical device prior to implant of the implantable medical device into a patient. The sensitive information is preencrypted under the cryptographic key and physiological measures are measured by the implantable medical device. An authentication module is in receipt of the cryptographic key. A permissions module confirms authorization of an external data processing device against the cryptographic key. A decryption module decrypts the sensitive information with the cryptographic key into decrypted information. A processor is operatively coupled to the local memory store. A communications module exchanges the decrypted information and the physiological measures with the external data processing device over a wireless interface contingent upon the authorization confirmation. An internal power supply supplies power to the foregoing components.
摘要翻译：提出了一种用于自动病人护理的移动中继器。本地存储器包括加密密钥，敏感信息和生理措施。在将可植入医疗装置植入病人之前，将密码密钥唯一地分配给可植入医疗装置。敏感信息在加密密钥下加密，生理测量由可植入医疗设备测量。认证模块正在接收加密密钥。权限模块根据加密密钥确认外部数据处理设备的授权。解密模块将具有加密密钥的敏感信息解密为解密信息。处理器可操作地耦合到本地存储器存储器。通信模块根据授权确认，通过无线接口与外部数据处理装置交换解密信息和生理测量。内部电源为上述组件供电。

5. 发明授权

US07270633B1 Ambulatory repeater for use in automated patient care and method thereof 有权
标题翻译：用于自动病人护理的动态中继器及其方法
公开(公告)号：US07270633B1
公开(公告)日：2007-09-18
申请号：US11113206
申请日：2005-04-22
申请人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
发明人： Donald L. Goscha , Lisa D. Haeder , Veerichetty A. Kadhiresan , David C. Johnson , Muralidharan Srivathsa , Marina Brockway
IPC分类号： A61B5/00
CPC分类号： A61B5/0031 , G06F19/00
摘要： An ambulatory repeater for use in automated patient care and method thereof is presented. At least one sensor is communicatively interfaced to measure and collect patient health information on an ad hoc basis. A cryptographic key is uniquely assigned to an implantable medical device. Authorization to access patient health information stored on the implantable medical device is authenticated using an ambulatory repeater. The ambulatory repeater is interfaced to the at least one sensor and implantable medical device through wireless telemetry and interfaced to an external data processing device through wireless communications. The patient health information is exchanged with the at least one sensor, implantable medical device and external data processing device via the ambulatory repeater.
摘要翻译：提出了一种用于自动化病人护理的移动式中继器及其方法。至少有一个传感器通信接口，以便临时地测量和收集患者健康信息。密码密钥被唯一地分配给可植入医疗设备。访问存储在可植入医疗设备上的患者健康信息的授权使用移动中继器进行认证。移动中继器通过无线遥测与至少一个传感器和可植入医疗设备接口，并通过无线通信与外部数据处理设备连接。患者健康信息通过移动中继器与至少一个传感器，可植入医疗装置和外部数据处理装置进行交换。

6. 发明授权

US08740789B2 Automatic etiology sequencing system and method 有权
标题翻译：自动病因测序系统及方法
公开(公告)号：US08740789B2
公开(公告)日：2014-06-03
申请号：US11071646
申请日：2005-03-03
申请人： Marina Brockway , David Johnson , Don Goscha , Veerichetty A. Kadhiresan , Muralidharan Srivathsa , Lisa Haeder
发明人： Marina Brockway , David Johnson , Don Goscha , Veerichetty A. Kadhiresan , Muralidharan Srivathsa , Lisa Haeder
IPC分类号： A61B5/00 , G06N3/02 , G06N3/04 , G06Q50/24 , G06F19/00 , G06N3/00 , G06Q50/00
CPC分类号： G06F19/345 , A61B5/00 , A61B5/0002 , A61B5/0022 , A61B5/686 , A61B5/7264 , A61B5/7267 , A61B5/7275 , A61B5/7282 , G06F19/00 , G06F19/30 , G06F19/32 , G06F19/34 , G06F19/3418 , G06N3/02 , G06N3/0427 , G06Q50/24 , G16H10/20 , G16H15/00 , G16H40/63 , G16H50/20 , Y10S128/92 , Y10S128/924 , Y10S128/925 , Y10S706/924
摘要： A system and related method for identifying a trigger event to a patient health-related exacerbation. The system includes at least one sensor configured to collect data related to the patient health-related exacerbation, an analyzer configured to validate the collected data, a patient interface device configured to receive patient inputs to at least one question, and an identifier device configured to receive the patient inputs and collected data and identify the trigger event. The system may also include an expert system configured to receive the patient inputs and the validated collected data and identify a primary patient disease, and a reporting device configured to generate reports related to the identified primary patient disease, patient inputs, and sensed patient conditions.
摘要翻译：用于识别患者健康相关恶化的触发事件的系统和相关方法。所述系统包括至少一个传感器，其被配置为收集与患者健康相关的恶化相关的数据，被配置为验证所收集的数据的分析器，被配置为接收患者对至少一个问题的输入的患者接口装置，以及被配置为接收患者输入和收集的数据并识别触发事件。该系统还可以包括被配置为接收患者输入和验证的收集的数据并识别主要患者疾病的专家系统，以及被配置为生成与所识别的主要患者疾病，患者输入和感测到的患者状况相关的报告的报告装置。

7. 发明授权

US06529772B2 Heart rate variability as an indicator of exercise capacity 失效
标题翻译：心率变异性作为运动能力的指标
公开(公告)号：US06529772B2
公开(公告)日：2003-03-04
申请号：US09888726
申请日：2001-06-25
申请人： Gerrard M. Carlson , Veerichetty A. Kadhiresan , Julio C. Spinelli
发明人： Gerrard M. Carlson , Veerichetty A. Kadhiresan , Julio C. Spinelli
IPC分类号： A61B504
CPC分类号： A61N1/365 , A61B5/0245 , A61B5/222 , A61N1/3627 , A61N1/36514 , A61N1/36592
摘要： Based upon patient studies indices a high degree of correlation was found between HRV and VO2max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient's heart with a pacemaker programmed to operate in a first mode for a predetermined time period and then collecting electrogram data from which a HRV index is derived. The mode is then changed and the steps repeated until all possible modes have been utilized. At that time, a determination is made as to which of the modes is associated with the largest HRV index and the pacemaker is then programmed to function in that mode. Alternatively, the method of the present invention can be applied to changes in drug therapy instead of or in combination with pacing therapy. By the plotting the HRV index computed in the manner described, the efficacy of a change in therapy on patient exercise capacity can be assessed.
摘要翻译：根据患者研究指标，发现HRV和VO2max之间存在高度相关性，即患者的运动能力。基于这一发现，已经设计了用于治疗CHF患者的起搏治疗优化方案。该方案涉及首先用编程为在第一模式中操作预定时间段的起搏器起搏患者的心脏，然后收集从其导出HRV指数的电描记图数据。然后改变模式，重复步骤直到所有可能的模式被使用。此时，确定哪个模式与最大HRV指数相关联，并且起搏器然后被编程为在该模式下起作用。或者，本发明的方法可以应用于药物治疗的变化，而不是起搏治疗或与起搏治疗组合。通过绘制以所述方式计算的HRV指数，可以评估治疗改变对患者运动能力的功效。

8. 发明授权

US06761716B2 System and method for assessing electrode-tissue contact and lesion quality during RF ablation by measurement of conduction time 有权
标题翻译：通过测量传导时间来评估RF消融期间电极组织接触和病变质量的系统和方法
公开(公告)号：US06761716B2
公开(公告)日：2004-07-13
申请号：US09955551
申请日：2001-09-18
申请人： Veerichetty A. Kadhiresan , Marshall L. Sherman , Wade A. Bowe
发明人： Veerichetty A. Kadhiresan , Marshall L. Sherman , Wade A. Bowe
IPC分类号： A61B1812
CPC分类号： A61B18/1206 , A61B18/12 , A61B2018/00642 , A61B2018/0066
摘要： The efficacy of a lesion produced between a pair of ablation electrodes is assessed by analyzing the time it takes for a pulse of energy to travel from one electrode to the other. During a first time period, a first pulse of energy is applied to a first electrode. The time it takes for the pulse to conduct through the tissue to a second electrode is determined. During a time period subsequent to the first time, a subsequent pulse of energy is applied to the first electrode and the time it takes for the subsequent pulse to conduct through the tissue to the second electrode is determined. Changes in the conduction times are monitored by calculating the difference between consecutive conduction times and comparing the difference to a preset value. If the difference is below the preset value the lesion is considered adequate.
摘要翻译：通过分析能量脉冲从一个电极传播到另一个电极所花费的时间来评估在一对消融电极之间产生的损伤的功效。在第一时间段期间，向第一电极施加第一能量脉冲。确定脉冲通过组织传导到第二电极所花费的时间。在第一次之后的时间段期间，确定随后的能量脉冲到第一电极并且随后的脉冲通过组织传导到第二电极所花费的时间。通过计算连续传导时间之间的差异并将差值与预设值进行比较来监测传导时间的变化。如果差异低于预设值，则认为病变足够。

9. 发明授权

US06301499B1 Heart rate variability as an indicator of exercise capacity 有权
标题翻译：心率变异性作为运动能力的指标
公开(公告)号：US06301499B1
公开(公告)日：2001-10-09
申请号：US09419659
申请日：1999-10-18
申请人： Gerrard M. Carlson , Veerichetty A. Kadhiresan , Julio C. Spinelli
发明人： Gerrard M. Carlson , Veerichetty A. Kadhiresan , Julio C. Spinelli
IPC分类号： A61B50456
CPC分类号： A61N1/365 , A61B5/0245 , A61B5/222 , A61N1/3627 , A61N1/36514 , A61N1/36592
摘要： Based upon patient studies indices a high degree of correlation was found between HRV and VO2max, i.e., the patient's exercise capacity. Based on this finding, a pacing therapy optimization protocol for treating patients with CHF has been devised. The protocol involves first pacing the patient's heart with a pacemaker programmed to operate in a first mode for a predetermined time period and then collecting electrogram data from which a HRV index is derived. The mode is then changed and the steps repeated until all possible modes have been utilized. At that time, a determination is made as to which of the modes is associated with the largest HRV index and the pacemaker is then programmed to function in that mode. Alternatively, the method of the present invention can be applied to changes in drug therapy instead of or in combination with pacing therapy. By the plotting the HRV index computed in the manner described, the efficacy of a change in therapy on patient exercise capacity can be assessed.
摘要翻译：根据患者研究指标，发现HRV和VO2max之间存在高度相关性，即患者的运动能力。基于这一发现，已经设计了用于治疗CHF患者的起搏治疗优化方案。该方案涉及首先用编程为在第一模式中操作预定时间段的起搏器起搏病人的心脏，然后收集从其导出HRV指数的电描记图数据。然后改变模式，重复步骤直到所有可能的模式被使用。此时，确定哪个模式与最大HRV指数相关联，并且起搏器然后被编程为在该模式下起作用。或者，本发明的方法可以应用于药物治疗的变化，而不是起搏治疗或与起搏治疗组合。通过绘制以所述方式计算的HRV指数，可以评估治疗改变对患者运动能力的功效。

10. 发明授权

US06876881B2 Cardiac rhythm management system with respiration synchronous optimization of cardiac performance using atrial cycle length 有权
标题翻译：心脏节律管理系统与呼吸同步优化心脏性能使用心房周期长度
公开(公告)号：US06876881B2
公开(公告)日：2005-04-05
申请号：US10222153
申请日：2002-08-16
申请人： Lawrence S. Baumann , Veerichetty A. Kadhiresan
发明人： Lawrence S. Baumann , Veerichetty A. Kadhiresan
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： A cardiac rhythm management device includes a dual chamber pacemaker, especially designed for treating congestive heart failure. The device incorporates a program microcontroller which is operative to adjust the pacing site, AV delay and interventricular delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the site, AV delay and interventricular delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Paced transient beats following periods of baseline beats are synchronized to the patient's respiratory cycle to minimize effects of respiratory noise on atrial cycle length measurements.
摘要翻译：心律管理装置包括双室起搏器，特别设计用于治疗充血性心力衰竭。该装置包括程序微控制器，其可操作以调节起搏器的起搏部位，AV延迟和心室间延迟，以实现最佳血液动力学性能。在场地变化，AV延迟和室间延迟之间的瞬时（即时）时间间隔期间测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。基线节拍时间间隔的瞬时搏动与患者的呼吸周期同步，以尽量减少呼吸噪声对心房周期长度测量的影响。

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