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1. 发明授权

US08463380B2 Automatic adaptation of A-V delay and HR for heart failure using beat to beat measures 有权
标题翻译：自动适应心律失常的A-V延迟和人力资源
公开(公告)号：US08463380B2
公开(公告)日：2013-06-11
申请号：US13357259
申请日：2012-01-24
申请人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
发明人： Donald Hopper , Yinghong Yu , Allan C. Shuros , Shantha Arcot-Krishnamurthy , Gerrard M. Carlson , Jeffrey E. Stahmann
IPC分类号： A61N1/362
CPC分类号： A61N1/36585 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： Methods and systems to modulate timing intervals for pacing therapy are described. For each cardiac cycle, one or both of an atrioventricular (A-V) timing interval and an atrial (A-A) timing interval are modulated to oppose beat-to-beat ventricular (V-V) timing variability. Pacing therapy is delivered using the modulated timing intervals.
摘要翻译：描述了调节起搏治疗时间间隔的方法和系统。对于每个心动周期，房室（A-V）定时间隔和心房（A-A）定时间隔中的一个或两个被调制以抵抗搏动到心室（V-V）的时间变异性。使用调制的定时间隔来提供起搏治疗。

2. 发明授权

US08483826B2 Deactivation of intermittent pacing therapy 失效
标题翻译：间歇性起搏治疗的停用
公开(公告)号：US08483826B2
公开(公告)日：2013-07-09
申请号：US12405990
申请日：2009-03-17
申请人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
发明人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3688 , A61N1/3962
摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when pacing is changed from the normal operating mode to a stress augmentation mode. The pacing mode controller suspends the change from the normal operating mode to the stress augmentation mode when a condition to prevent the change is detected.
摘要翻译：本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当起搏从正常操作模式改变为应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。当检测到防止变化的条件时，起搏模式控制器将更改从正常操作模式暂停到应力增强模式。

3. 发明授权

US08140155B2 Intermittent pacing therapy delivery statistics 有权
标题翻译：间歇性起搏治疗递送统计
公开(公告)号：US08140155B2
公开(公告)日：2012-03-20
申请号：US12401194
申请日：2009-03-10
申请人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
发明人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode and stores a statistic related to the stress augmentation mode in a stress augmentation cycle memory area.
摘要翻译：本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替，并将与应力增加模式相关的统计量存储在应力增加周期存储区域中。

4. 发明申请

US20090234416A1 INTERMITTENT PACING THERAPY DELIVERY STATISTICS 有权
标题翻译：间歇性治疗传播统计
公开(公告)号：US20090234416A1
公开(公告)日：2009-09-17
申请号：US12401194
申请日：2009-03-10
申请人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
发明人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode and stores a statistic related to the stress augmentation mode in a stress augmentation cycle memory area.
摘要翻译：本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替，并将与应力增加模式相关的统计量存储在应力增加周期存储区域中。

5. 发明授权

US08548586B2 Configurable intermittent pacing therapy 失效
标题翻译：可配置的间歇性起搏治疗
公开(公告)号：US08548586B2
公开(公告)日：2013-10-01
申请号：US12361353
申请日：2009-01-28
申请人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
发明人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising at least one implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The implantable cardiac depolarization sensing circuit is configured to obtain a sensed depolarization signal from a ventricle and the electrical stimulation circuit is configured to provide pacing electrical stimulation energy to at least one implantable ventricular electrode. The pacing mode controller delivers pacing therapy according to a first pacing mode that is a normal operating mode, and delivers pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode.
摘要翻译：本文件尤其涉及包括至少一个可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。可植入心脏去极化感测电路被配置为从心室获得感测的去极化信号，并且电刺激电路被配置为向至少一个可植入心室电极提供起搏电刺激能量。起搏模式控制器按照正常运行模式的第一起搏模式提供起搏治疗，并根据第二和第三起搏模式提供起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。

6. 发明申请

US20090234401A1 DEACTIVATION OF INTERMITTENT PACING THERAPY 失效
标题翻译：间歇性治疗的绝食
公开(公告)号：US20090234401A1
公开(公告)日：2009-09-17
申请号：US12405990
申请日：2009-03-17
申请人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
发明人： John R. Zielinski , Shantha Arcot-Krishnamurthy , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros
IPC分类号： A61N1/39 , A61N1/365 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3688 , A61N1/3962
摘要： This document discusses, among other things, an apparatus comprising an implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The pacing mode controller is configured to deliver pacing therapy according to a first pacing mode that is a normal operating mode, and to deliver pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when pacing is changed from the normal operating mode to a stress augmentation mode. The pacing mode controller suspends the change from the normal operating mode to the stress augmentation mode when a condition to prevent the change is detected.
摘要翻译：本文件尤其涉及包括可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。起搏模式控制器被配置为根据作为正常操作模式的第一起搏模式提供起搏治疗，并且根据第二和第三起搏模式输送起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当起搏从正常操作模式改变为应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。当检测到防止变化的条件时，起搏模式控制器将更改从正常操作模式暂停到应力增强模式。

7. 发明申请

US20090192560A1 CONFIGURABLE INTERMITTENT PACING THERAPY 失效
标题翻译：配置间歇性治疗
公开(公告)号：US20090192560A1
公开(公告)日：2009-07-30
申请号：US12361353
申请日：2009-01-28
申请人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
发明人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising at least one implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The implantable cardiac depolarization sensing circuit is configured to obtain a sensed depolarization signal from a ventricle and the electrical stimulation circuit is configured to provide pacing electrical stimulation energy to at least one implantable ventricular electrode. The pacing mode controller delivers pacing therapy according to a first pacing mode that is a normal operating mode, and delivers pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode.
摘要翻译：本文件尤其涉及包括至少一个可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。可植入心脏去极化感测电路被配置为从心室获得感测的去极化信号，并且电刺激电路被配置为向至少一个可植入心室电极提供起搏电刺激能量。起搏模式控制器按照正常运行模式的第一起搏模式提供起搏治疗，并根据第二和第三起搏模式提供起搏治疗。与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。

8. 发明申请

US20120277607A1 METHOD AND APPARATUS FOR IDENTIFICATION OF ISCHEMIC/INFARCTED REGIONS AND THERAPY OPTIMIZATION 有权
标题翻译：用于鉴别化学/感染性地区和治疗优化的方法和装置
公开(公告)号：US20120277607A1
公开(公告)日：2012-11-01
申请号：US13544007
申请日：2012-07-09
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
IPC分类号： A61B5/0452 , A61N1/365
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激。

9. 发明授权

US08219210B2 Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权
标题翻译：用于鉴别缺血/梗死区域的方法和装置以及治疗优化
公开(公告)号：US08219210B2
公开(公告)日：2012-07-10
申请号：US11541837
申请日：2006-10-02
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Chris Hartemink
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑的刺激。

10. 发明授权

US08489204B2 Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权
标题翻译：用于鉴别缺血/梗死区域的方法和装置以及治疗优化
公开(公告)号：US08489204B2
公开(公告)日：2013-07-16
申请号：US13544007
申请日：2012-07-09
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
IPC分类号： A61N1/00 , A61B5/02
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激。

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