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1. 发明授权

US07811787B2 Polynucleotides encoding human SLAP-2 variant, hSLAP-2v3 有权
标题翻译：编码人SLAP-2变体的多核苷酸，hSLAP-2v3
公开(公告)号：US07811787B2
公开(公告)日：2010-10-12
申请号：US11789322
申请日：2007-04-24
申请人： Donald G. Jackson , Stanley R. Krystek, Jr. , Donna A. Bassolino , Rolf-Peter Ryseck , Thomas C. Nelson , Gena S. Whitney
发明人： Donald G. Jackson , Stanley R. Krystek, Jr. , Donna A. Bassolino , Rolf-Peter Ryseck , Thomas C. Nelson , Gena S. Whitney
IPC分类号： C12P21/06 , C12N15/00 , C12N5/02 , C12N1/20 , C07H21/04
CPC分类号： G01N33/6893 , C07K14/47 , G01N33/564 , G01N33/57407 , G01N33/57426 , G01N33/57484 , G01N2800/065 , G01N2800/102 , G01N2800/104 , G01N2800/12 , G01N2800/122 , G01N2800/205 , G01N2800/24 , G01N2800/245
摘要： The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.
摘要翻译：本发明涉及两种新型全长人SLAP-2变体及其编码多肽hSLAP-2v3和hSLAP-2v4的鉴定和克隆。 hSLAP-2v3和hSLAP-2v4是SLAP家族接头蛋白的成员，并且参与细胞内T细胞信号转导的负调控。本发明还涉及这些新型hSLAP-2v3和hSLAP-2v4多核苷酸及其编码多肽作为免疫学和炎症性疾病，自身免疫疾病，肺部疾病，增殖性免疫病症和癌症中的治疗性干预的靶标的用途。

2. 发明授权

US07713699B2 Methods of diagnosing colon adenocarcinoma using mRNA encoding the human g-protein coupled receptor, HGPRBMY23 有权
标题翻译：使用编码人g-蛋白偶联受体HGPRBMY23的mRNA诊断结肠腺癌的方法
公开(公告)号：US07713699B2
公开(公告)日：2010-05-11
申请号：US11897997
申请日：2007-08-31
申请人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
发明人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Kornacker
IPC分类号： C12N1/68 , G01N33/48 , C07K14/705
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法以及与异常NFκB调节相关的疾病和病症。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

3. 发明授权

US07312086B2 Methods of diagnosing colon adenocarcinoma using the human g-protein coupled receptor hgprbmy23 有权
标题翻译：使用人类g-蛋白偶联受体hgprbmy23诊断结肠腺癌的方法
公开(公告)号：US07312086B2
公开(公告)日：2007-12-25
申请号：US10375157
申请日：2003-02-26
申请人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Neubauer
发明人： John N. Feder , Thomas C. Nelson , Chandra S. Ramanathan , Rolf-Peter Ryseck , Michael G. Neubauer
IPC分类号： G01N33/48
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法以及与异常NFκB调节相关的疾病和病症。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

4. 发明申请

US20080014593A1 Novel human G-protein coupled receptor, HGPRBMY23, expressed highly in kidney 有权
标题翻译：新型人类G蛋白偶联受体HGPRBMY23在肾脏中表达很高
公开(公告)号：US20080014593A1
公开(公告)日：2008-01-17
申请号：US11897997
申请日：2007-08-31
申请人： Lauren Barber , Angela Cacace , John Feder , Thomas Nelson , Chandra Ramanathan , Rolf-Peter Ryseck , Michael Neubauer , Michael Kornacker
发明人： Lauren Barber , Angela Cacace , John Feder , Thomas Nelson , Chandra Ramanathan , Rolf-Peter Ryseck , Michael Neubauer , Michael Kornacker
IPC分类号： C12Q1/68
CPC分类号： G01N33/5008 , A61K38/00 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2319/30 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N33/5091 , G01N33/566 , G01N33/57415 , G01N33/57419 , G01N33/6893 , G01N2333/726 , G01N2500/04 , G01N2510/00 , G01N2800/347 , Y10T436/143333
摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法以及与异常NFκB调节相关的疾病和病症。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

5. 发明申请

US20070264662A1 Polynucleotides encoding human SLAP-2 variants, hSLAP-2v3 and hSLAP-2v4 有权
标题翻译：编码人SLAP-2变体的多核苷酸，hSLAP-2v3和hSLAP-2v4
公开(公告)号：US20070264662A1
公开(公告)日：2007-11-15
申请号：US11789322
申请日：2007-04-24
申请人： Donald Jackson , Stanley Krystek , Donna Bassolino , Rolf-Peter Ryseck , Thomas Nelson , Gena Whitney
发明人： Donald Jackson , Stanley Krystek , Donna Bassolino , Rolf-Peter Ryseck , Thomas Nelson , Gena Whitney
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： G01N33/6893 , C07K14/47 , G01N33/564 , G01N33/57407 , G01N33/57426 , G01N33/57484 , G01N2800/065 , G01N2800/102 , G01N2800/104 , G01N2800/12 , G01N2800/122 , G01N2800/205 , G01N2800/24 , G01N2800/245
摘要： The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further relates to the use of these novel hSLAP-2v3 and hSLAP-2v4 polynucleotides and their encoded polypeptides as targets for therapeutic intervention in immunological and inflammatory disorders, autoimmune diseases, pulmonary diseases, proliferative immune disorders, and cancer.
摘要翻译：本发明涉及两种新型全长人SLAP-2变体及其编码多肽hSLAP-2v3和hSLAP-2v4的鉴定和克隆。 hSLAP-2v3和hSLAP-2v4是SLAP家族接头蛋白的成员，并且参与细胞内T细胞信号转导的负调控。本发明还涉及这些新型hSLAP-2v3和hSLAP-2v4多核苷酸及其编码多肽作为免疫学和炎症性疾病，自身免疫疾病，肺部疾病，增殖性免疫病症和癌症中的治疗性干预的靶标的用途。

6. 发明授权

US07226791B2 Polynucleotides encoding novel guanylate binding proteins (GBP's) 失效
标题翻译：编码新型鸟苷酸结合蛋白的多核苷酸（GBP）
公开(公告)号：US07226791B2
公开(公告)日：2007-06-05
申请号：US10858367
申请日：2004-06-01
申请人： Julie Carman , Stephen J. Warner , Rolf-Peter Ryseck
发明人： Julie Carman , Stephen J. Warner , Rolf-Peter Ryseck
IPC分类号： C12N1/20 , C12N15/00 , C12N5/00 , C12Q1/68 , C12P21/06
CPC分类号： C07K14/47
摘要： The present invention provides polynucleotides encoding human and murine guanylate binding protein polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The present invention further relates to diagnostic and therapeutic methods for applying the guanylate binding protein polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, such as rheumatoid arthritis and/or conditions related to aberrant NF-κB activity, guanylate binding activity and GTPase activity. The present invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供编码人和鼠鸟苷酸结合蛋白多肽的多核苷酸，其片段和同系物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及用于将鸟苷酸结合蛋白多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法，所述疾病和/或病症例如类风湿性关节炎和/或与异常相关的病症 NF-κB活性，鸟苷酸结合活性和GTPase活性。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

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