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1. 发明授权

US6086909A Device and method for treatment of dysmenorrhea 有权
标题翻译：用于治疗痛经的装置和方法
公开(公告)号：US6086909A
公开(公告)日：2000-07-11
申请号：US249963
申请日：1999-02-12
申请人： Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Roger A. Stern
发明人： Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Roger A. Stern
IPC分类号： A61M31/00 , A61F6/08 , A61F13/20 , A61K9/00 , A61K9/02 , A61K9/08 , A61K31/192 , A61K31/21 , A61K31/27 , A61K31/405 , A61K45/00 , A61P15/00 , A61F6/06 , A61F6/14 , A61F13/02
CPC分类号： A61K9/0034 , A61F6/08 , A61K9/0036
摘要： Methods, devices, and compositions for treatment of dysmenorrhea comprise an intravaginal drug delivery system containing an appropriate pharmaceutical agent incorporated into a pharmaceutically acceptable carrier whereby the pharmaceutical agent is released into the vagina and absorbed through the vaginal mucosa to provide relief of dysmenorrhea. The drug delivery system can be a tampon device, vaginal ring, pessary, tablet, suppository, vaginal medicated tampon, vaginal sponge, bioadhesive tablet, bioadhesive microparticle, cream, lotion, foam, ointment, paste, solution or gel. The system delivers a higher concentration to the muscle of the uterus, the primary site for the dyskinetic muscle contraction, which is the pathophysiologic cause of dysmenorrhea.
摘要翻译：用于治疗痛经的方法，装置和组合物包括阴道内药物递送系统，其包含掺入药学上可接受的载体中的合适的药剂，由此将药剂释放到阴道中并通过阴道粘膜吸收以缓解痛经。药物输送系统可以是棉塞装置，阴道环，子宫托，片剂，栓剂，阴道药物棉塞，阴道海绵，生物粘附片，生物粘附微粒，霜剂，洗剂，泡沫，软膏，糊剂，溶液或凝胶。该系统向子宫肌肉提供更高的浓度，这是运动障碍肌肉收缩的主要部位，这是痛经的病理生理原因。

2. 发明授权

US06197327B1 Device and method for treatment of dysmenorrhea 失效
标题翻译：用于治疗痛经的装置和方法
公开(公告)号：US06197327B1
公开(公告)日：2001-03-06
申请号：US09079897
申请日：1998-05-15
申请人： Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Roger A. Stern
发明人： Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Roger A. Stern
IPC分类号： A61F606
CPC分类号： A61K9/0034 , A61F6/08 , A61K9/0036
摘要： Methods, devices, and compositions for treatment of dysmenorrhea comprise an intravaginal drug delivery system containing an appropriate pharmaceutical agent incorporated into a pharmaceutically acceptable carrier whereby the pharmaceutical agent is released into the vagina and absorbed through the vaginal mucosa to provide relief of dysmenorrhea. The drug delivery system can be a tampon device, vaginal ring, pessary, tablet, suppository, vaginal sponge, bioadhesive tablet, bioadhesive microparticle, cream, lotion, foam, ointment, paste, solution or gel. The system delivers a higher concentration to the muscle of the uterus, the primary site for the dyskinetic muscle contraction, which is the pathophysiologic cause of dysmenorrhea.
摘要翻译：用于治疗痛经的方法，装置和组合物包括阴道内药物递送系统，其包含掺入药学上可接受的载体中的合适的药剂，由此将药剂释放到阴道中并通过阴道粘膜吸收以缓解痛经。药物递送系统可以是棉塞装置，阴道环，子宫托，片剂，栓剂，阴道海绵，生物粘附片，生物粘附微粒，霜剂，洗剂，泡沫，软膏，糊剂，溶液或凝胶。该系统向子宫肌肉提供更高的浓度，这是运动障碍肌肉收缩的主要部位，这是痛经的病理生理原因。

3. 发明授权

US07341737B2 Medicated tampon 有权
标题翻译：药物卫生棉条
公开(公告)号：US07341737B2
公开(公告)日：2008-03-11
申请号：US10335759
申请日：2002-12-31
申请人： Steven Craig Gehling , Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Chris Clendening , Giovanni M. Pauletti
发明人： Steven Craig Gehling , Donald C. Harrison , James H. Liu , Wolfgang A. Ritschel , Chris Clendening , Giovanni M. Pauletti
IPC分类号： A61F13/02 , A61F9/02 , A61F13/20
CPC分类号： A61M31/00 , A61F13/202 , A61F13/2051 , A61F13/2074 , A61F13/28 , A61F13/8405 , A61F2013/8414 , A61F2013/8417 , A61K9/0036 , A61K9/025 , A61M2210/1475 , Y10S514/966 , Y10S514/967
摘要： A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body having a distal end; and a dosage form affixed to the distal end of the tampon body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form comprises a plurality of layers. Also, a method for manufacturing a medicated tampon adapted to deliver a therapeutic agent, the method including manufacturing a tampon body having a distal end; producing a dosage form having a plurality of layers, wherein the dosage form includes a formulation including a therapeutic agent; and affixing the dosage form to the distal end of the tampon body.
摘要翻译：一种适于递送治疗剂的卫生棉条，所述棉塞包括具有远端的棉塞本体; 以及固定在卫生栓体的远端的剂型，其中所述剂型包括包含治疗剂的制剂，并且其中所述剂型包含多个层。另外，一种适于输送治疗剂的药物棉塞的制造方法，其特征在于，包括制造具有前端的棉塞体; 制备具有多个层的剂型，其中所述剂型包括包含治疗剂的制剂; 并将剂型固定在棉塞体的远端。

4. 发明授权

US06572874B1 Vaginal delivery of bisphosphonates 失效
标题翻译：阴道分泌双膦酸盐
公开(公告)号：US06572874B1
公开(公告)日：2003-06-03
申请号：US09626025
申请日：2000-07-27
申请人： Donald C. Harrison , James H. Liu , Giovanni M. Pauletti , Wolfgang A. Ritschel
发明人： Donald C. Harrison , James H. Liu , Giovanni M. Pauletti , Wolfgang A. Ritschel
IPC分类号： A61F606
CPC分类号： A61K9/0036 , A61F6/08 , A61K9/0034 , A61K9/02
摘要： Devices, methods, and compositions for vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the vagina using a medicated intravaginal device comprising a bisphosphonate composition formulated for transvaginal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transvaginal delivery of bisphosphonates to the general circulation.
摘要翻译：双膦酸盐阴道分泌物的装置，方法和组合物。使用包含配制用于经阴道递送的二膦酸盐组合物的药物阴道装置将双膦酸盐靶向位点递送至阴道。一种治疗骨质疏松症和相关骨骼和骨骼疾病的方法，用于通过阴道内给予双膦酸盐至阴道和经阴道分泌双膦酸盐至一般循环来预防骨质破坏和骨量丧失和强度。

5. 发明授权

US06982091B2 Vaginal delivery of chemotherapeutic agents and inhibitors of membrane efflux systems for cancer therapy 失效
公开(公告)号：US06982091B2
公开(公告)日：2006-01-03
申请号：US10226667
申请日：2002-08-21
申请人： Giovanni M. Pauletti , James H. Liu , Leslie Z. Benet , Wolfgang A. Ritschel
发明人： Giovanni M. Pauletti , James H. Liu , Leslie Z. Benet , Wolfgang A. Ritschel
IPC分类号： A61F6/06 , A61F13/02 , A61K9/50
CPC分类号： A61K9/0034 , A61K9/0036
摘要： Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.

6. 发明授权

US06365185B1 Self-destructing, controlled release peroral drug delivery system 失效
标题翻译：自我毁灭，控释药物输送系统
公开(公告)号：US06365185B1
公开(公告)日：2002-04-02
申请号：US09277258
申请日：1999-03-26
申请人： Wolfgang A. Ritschel , Mukul A. Agrawal
发明人： Wolfgang A. Ritschel , Mukul A. Agrawal
IPC分类号： A61K924
CPC分类号： A61K9/0004
摘要： The present invention relates to tablets which are time-controlled to release active agent at different rates in different regions of the digestive tract in order to maintain a substantially constant concentration in the blood. In one embodiment, a new modified release drug delivery system, for once a day peroral use, consisting of a solid core comprising an active agent together with a hydrogel, with the solid core being coated with a semi-permeable, self-destructing membrane which is optionally drilled to provide a release orifice, and then optionally further coated with the same or different active agent material. The device delivers the active agent in a substantially constant effective dose for the duration of the transit through the stomach and small intestine, followed by accelerated release when reaching the large intestine.
摘要翻译：本发明涉及时间控制以在消化道的不同区域以不同速率释放活性剂以维持血液中基本上恒定的浓度的片剂。在一个实施方案中，一种新的改良释放药物递送系统，每天一次口服使用，由包含活性剂和水凝胶的固体核心组成，其中固体核心被半渗透的自破坏膜可选地钻出以提供释放孔，然后任选地进一步用相同或不同的活性剂材料涂覆。该设备在通过胃和小肠的转运期间以基本上恒定的有效剂量递送活性剂，随后在到达大肠时加速释放。

7. 发明授权

US07744916B2 Coated vaginal device for delivery of anti-migraine and anti-nausea drugs 有权
标题翻译：用于输送抗偏头痛和抗恶心药物的涂层阴道装置
公开(公告)号：US07744916B2
公开(公告)日：2010-06-29
申请号：US11126863
申请日：2005-05-10
申请人： Giovanni M. Pauletti , Michelle Wilson , Richard Soderstrom , Desai J. Kishorkumar , Wolfgang A. Ritschel
发明人： Giovanni M. Pauletti , Michelle Wilson , Richard Soderstrom , Desai J. Kishorkumar , Wolfgang A. Ritschel
IPC分类号： A61F6/06 , A61F6/14 , A61F13/02
CPC分类号： A61F6/06 , A61F6/08 , A61F13/2051 , A61K9/0034 , A61K9/0036 , A61K9/02 , A61K9/122 , A61K9/7007
摘要： A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and/or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.
摘要翻译：用于通过阴道粘膜递送抗偏头痛或抗恶心药物到子宫和/或一般循环的阴道装置。该装置至少部分地涂覆有形成具有包含抗偏头痛或抗恶心药物的粘膜粘附组合物的帽，膜，泡沫，箔或条的一层或几层流体不可渗透材料。

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