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1. 发明授权

US5714166A Bioactive and/or targeted dendrimer conjugates 失效
标题翻译：生物活性和/或靶向树枝状大分子缀合物
公开(公告)号：US5714166A
公开(公告)日：1998-02-03
申请号：US400203
申请日：1995-03-07
申请人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
发明人： Donald A. Tomalia , James R. Baker , Roberta C. Cheng , Anna U. Bielinska , Michael J. Fazio , David M. Hedstrand , Jennifer A. Johnson , Donald A. Kaplan, deceased , Scott L. Klakamp , William J. Kruper, Jr. , Jolanta Kukowska-Latallo , Bartley D. Maxon , Lars T. Piehler , Ian A. Tomlinson , Larry R. Wilson , Rui Yin , Herbert M. Brothers, II
IPC分类号： C12N15/02 , A01N25/10 , A61K20060101 , A61K31/70 , A61K38/00 , A61K39/385 , A61K39/44 , A61K45/00 , A61K47/34 , A61K47/48 , A61K48/00 , A61K49/00 , A61K51/00 , C07C211/29 , C07C233/11 , C07C237/20 , C07K20060101 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/555 , C07K17/06 , C07K17/08 , C08G73/00 , C08G83/00 , C08L101/00 , C12N20060101 , C12N5/10 , C12N15/09 , C12N15/57 , C12N15/87 , C12P21/02 , C12P21/08 , C12R1/91 , A61K31/74 , A61K9/14 , A61K31/785
CPC分类号： A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/4823 , A61K47/48961 , A61K49/085 , A61K49/124 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present then the carried material may be a bioactive agent. Preferred dendritic polymers are dense star polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.
摘要翻译：已经制备了由载体材料可以是生物反应调节剂的至少一种携带材料的至少一个单元组成的树枝状聚合物共轭物。缀合物还可以存在目标导向剂，并且当其存在时，所携带的材料可以是生物活性剂。优选的树枝状聚合物是与生物反应调节剂复合的致密星形聚合物。这些共轭物和配合物由于其独特的特性而具有特别有利的性质。

2. 发明授权

US06177414B1 Starburst conjugates 失效
标题翻译：星爆共轭体
公开(公告)号：US06177414B1
公开(公告)日：2001-01-23
申请号：US09521409
申请日：2000-03-08
申请人： Donald A. Tomalia , William J. Kruper , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson , Donald A. Kaplan
发明人： Donald A. Tomalia , William J. Kruper , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson , Donald A. Kaplan
IPC分类号： A61K3160
CPC分类号： A01N25/10 , A61K47/59 , A61K47/6885 , A61K47/6949 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由至少一种树枝状大分子与携带的农业，药物或其它材料的至少一个单元组合的星状共轭体。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

3. 发明授权

US5527524A Dense star polymer conjugates 失效
标题翻译：密集聚合物共轭物
公开(公告)号：US5527524A
公开(公告)日：1996-06-18
申请号：US43198
申请日：1993-04-05
申请人： Donald A. Tomalia , Larry R. Wilson , David M. Hedstrand , Ian A. Tomlinson , Michael J. Fazio , William J. Kruper, Jr. , Donald A. Kaplan , Roberta C. Cheng , David S. Edwards , Chu W. Jung
发明人： Donald A. Tomalia , Larry R. Wilson , David M. Hedstrand , Ian A. Tomlinson , Michael J. Fazio , William J. Kruper, Jr. , Donald A. Kaplan , Roberta C. Cheng , David S. Edwards , Chu W. Jung
IPC分类号： A01N25/10 , A61K47/48 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/00 , C08L101/00 , C12N15/87 , A61K31/74 , A61K9/14 , A61K31/785
CPC分类号： A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/487 , A61K47/48961 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Dense star polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由携带的农业，药物或其它材料的至少一个单元组成的至少一个树枝状大分子组成的密集聚合物共轭物。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

4. 发明授权

US06312679B1 Dense star polymer conjugates as dyes 失效
标题翻译：密集星形聚合物共轭物作为染料
公开(公告)号：US06312679B1
公开(公告)日：2001-11-06
申请号：US08036644
申请日：1993-03-24
申请人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
发明人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
IPC分类号： A61K31785
CPC分类号： A01N25/10 , A61K47/59 , A61K47/6885 , A61K47/6949 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S424/16
摘要： Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由至少一种树枝状大分子与携带的农业，药物或其它材料的至少一个单元组合的星状共轭体。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

5. 发明授权

US5338532A Starburst conjugates 失效
标题翻译：星爆共轭体
公开(公告)号：US5338532A
公开(公告)日：1994-08-16
申请号：US654851
申请日：1991-02-13
申请人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
发明人： Donald A. Tomalia , Donald A. Kaplan , William J. Kruper, Jr. , Roberta C. Cheng , Ian A. Tomlinson , Michael J. Fazio , David M. Hedstrand , Larry R. Wilson
IPC分类号： A01N25/10 , A61K47/48 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/00 , C08L101/00 , C12N15/87 , A61K43/00 , A61K31/74 , A61K31/785 , A61K31/80
CPC分类号： B82Y5/00 , A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/487 , A61K47/48961 , C07C211/29 , C07C233/11 , C07C237/20 , C08G73/02 , C08G83/003 , C08L101/005 , C12N15/87 , Y10S436/806 , Y10T436/24
摘要： Starburst conjugates which are composed of at least one dendrimer in association with at least one unit of a carried agricultural, pharmaceutical, or other material have been prepared. These conjugates have particularly advantageous properties due to the unique characteristics of the dendrimer.
摘要翻译：已经制备了由至少一种树枝状大分子与携带的农业，药物或其它材料的至少一个单元组合的星状共轭体。由于树枝状聚合物的独特特征，这些共轭物具有特别有利的性质。

6. 发明授权

US5773527A Non-crosslinked, polybranched polymers 失效
标题翻译：非交联的聚支链聚合物
公开(公告)号：US5773527A
公开(公告)日：1998-06-30
申请号：US376100
申请日：1995-01-20
申请人： Donald A. Tomalia , David M. Hedstrand , Rui Yin
发明人： Donald A. Tomalia , David M. Hedstrand , Rui Yin
IPC分类号： A61K47/48 , C08F283/00 , C08F291/00 , C08G69/44 , C08G69/48 , C08G73/02 , C08G73/04 , C08G83/00 , C08G85/00
CPC分类号： B82Y5/00 , A61K47/48961 , C08F283/00 , C08F291/00 , C08G69/44 , C08G69/48 , C08G73/0206 , C08G73/0233 , C08G83/005 , C08G85/00
摘要： This invention discloses non-crosslinked, poly-branched polymers having a comb-burst configuration and a process for preparing such polymers.
摘要翻译：本发明公开了具有梳状突起构型的非交联，多支化聚合物和制备这种聚合物的方法。

7. 发明授权

US5631329A Process for producing hyper-comb-branched polymers 失效
标题翻译：生产超梳型支化聚合物的方法
公开(公告)号：US5631329A
公开(公告)日：1997-05-20
申请号：US408833
申请日：1995-03-21
申请人： Rui Yin , Donald A. Tomalia , David M. Hedstrand , Douglas R. Swanson
发明人： Rui Yin , Donald A. Tomalia , David M. Hedstrand , Douglas R. Swanson
IPC分类号： A61K47/48 , C08G69/44 , C08G69/48 , C08G73/02 , C08G83/00 , C08G85/00 , C08F293/00
CPC分类号： B82Y5/00 , A61K47/48961 , C08G69/44 , C08G69/48 , C08G73/0206 , C08G73/0233 , C08G83/005 , C08G85/00 , Y10S525/902
摘要： The specification discloses a process for producing poly-branched polymer having relatively high molecular weight by forming a first set of branches by polymerizing monomers which are either protected against or are non-reactive to branching and grafting during polymerization, grafting that first set of branches to a core having a plurality of reactive sites capable of reacting with the reactive end units of said branches, either deprotecting or activating a plurality of monomeric units on each of said branches to create branch reactive sites, forming a second set of branches in the same manner as the first set of branches were formed, grafting the second set of branches to the first set of branches by reacting the reactive end units of the second set of branches with each said branch reactive site on said first set of branches and repeating the foregoing steps reiteratively to form and attach subsequent sets of branches to prior branch sets until a desired number of iterations has been effected.
摘要翻译：本说明书公开了一种制备具有相对较高分子量的多支化聚合物的方法，通过聚合单体聚合形成第一组分支，所述单体在聚合过程中被保护为不支化或不反应支化和接枝，将第一组分支移植到具有能够与所述分支的反应性末端单元反应的多个反应性位点的核心，在每个所述分支上去保护或活化多个单体单元以产生分支反应位点，以相同方式形成第二组分支作为第一组分支形成，通过使第二组分支的反应性末端单元与所述第一组分支上的每个所述分支反应位点反应，将第二组分支移植到第一组分支，并重复上述步骤重复地将随后的分支集合形成并附加到先前的分支集合，直到所需的迭代次数为蜜蜂 n影响。

8. 发明授权

US5560929A Structured copolymers and their use as absorbents, gels and carriers of metal ions 失效
标题翻译：结构共聚物及其作为金属离子的吸收剂，凝胶和载体的用途
公开(公告)号：US5560929A
公开(公告)日：1996-10-01
申请号：US152335
申请日：1993-11-12
申请人： David M. Hedstrand , Bradley J. Helmer , Donald A. Tomalia
发明人： David M. Hedstrand , Bradley J. Helmer , Donald A. Tomalia
IPC分类号： C08G69/48 , A01N25/10 , A61K47/48 , C07C211/29 , C07C233/11 , C07C237/20 , C08G65/00 , C08G65/26 , C08G65/32 , C08G65/332 , C08G73/00 , C08G73/02 , C08G83/00 , C08L25/06 , C08L71/02 , C08L73/00 , C08L77/00 , C08L79/02 , C08L101/00 , C12N15/87 , A61K31/78
CPC分类号： C08G83/003 , A01N25/10 , A61K47/48192 , A61K47/48207 , A61K47/48961 , B82Y5/00 , C07C211/29 , C07C233/11 , C07C237/20 , C08G65/26 , C08G65/332 , C08G73/02 , C08G73/0206 , C08G73/024 , C08G73/028 , C08L101/005 , C08L71/02 , C08L79/02 , C12N15/87 , C08L25/06
摘要： Dense star polymers or dendrimers having a highly branched interior structure capable of associating or chelating with metal ions are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell. The modified dendrimers are useful for dispersing metal ions in a non-aqueous polymer matrix. Also dense star polymers or dendrimers having a highly branched hydrophilic interior structure are modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, which modified polymers are useful as gels and surfactants.
摘要翻译：具有能够与金属离子缔合或螯合的高度支化的内部结构的密集星形聚合物或树枝状大分子通过用能够提供疏水性外壳的疏水基团进行加帽来改性。改性的树枝状大分子可用于将金属离子分散在非水性聚合物基质中。具有高度支化的亲水性内部结构的致密的星形聚合物或树枝状大分子也可通过用能够提供疏水性外壳的疏水性基团进行封端来改性，该改性聚合物可用作凝胶和表面活性剂。

9. 发明授权

US5393795A Polymer blend containing a modified dense star polymer or dendrimer and a matrix polymer 失效
标题翻译：含有改性致密星形聚合物或树枝状聚合物和基质聚合物的聚合物共混物
公开(公告)号：US5393795A
公开(公告)日：1995-02-28
申请号：US259089
申请日：1994-06-13
申请人： David M. Hedstrand , Donald A. Tomalia
发明人： David M. Hedstrand , Donald A. Tomalia
IPC分类号： C08J9/12 , C08G73/02 , C08J9/00 , C08L101/00 , C08G6/00
CPC分类号： C08J9/0061 , C08G73/028 , C08J2479/00
摘要： Dense star polymers or dendrimers, modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, act as molecular nucleating agents in forming a polymer blend.
摘要翻译：通过用能够提供疏水性外壳的疏水基团加成改性的密集星形聚合物或树枝状大分子在形成聚合物共混物时用作分子成核剂。

10. 发明授权

US5387617A Small cell foams and blends and a process for their preparation 失效
标题翻译：小泡沫和混合物及其制备方法
公开(公告)号：US5387617A
公开(公告)日：1995-02-07
申请号：US148440
申请日：1993-11-08
申请人： David M. Hedstrand , Donald A. Tomalia
发明人： David M. Hedstrand , Donald A. Tomalia
IPC分类号： C08J9/12 , C08G73/02 , C08J9/00 , C08L101/00 , C08G6/00
CPC分类号： C08J9/0061 , C08G73/028 , C08J2479/00
摘要： Dense star polymers or dendrimers, modified by capping with a hydrophobic group capable of providing a hydrophobic outer shell, act as molecular nucleating agents. These modified dense star polymers or dendrimers are particularly effective for the production of small cell foams.
摘要翻译：通过用能够提供疏水性外壳的疏水基团加成改性的密集星形聚合物或树枝状大分子作为分子成核剂。这些改性的致密星形聚合物或树枝状大分子对于生产小泡沫体是特别有效的。

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