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1. 发明申请

US20100252470A1 Packaging Systems for Percutaneously Deliverable Bioprosthetic Valves 有权
标题翻译：用于经皮递送的生物麻醉阀的包装系统
公开(公告)号：US20100252470A1
公开(公告)日：2010-10-07
申请号：US12418668
申请日：2009-04-06
申请人： Timothy Ryan , Don Tran , Jeffrey Allen , Melissa Denton , Adam Podbelski
发明人： Timothy Ryan , Don Tran , Jeffrey Allen , Melissa Denton , Adam Podbelski
IPC分类号： A61B19/02 , A61F2/24
CPC分类号： A61F2/0095 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/958 , A61F2002/9505 , A61F2002/9522
摘要： A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prosthetic tissue valve that is in a pre-loaded position on the delivery catheter during shipment and storage. The prosthetic tissue valve may include an attachment mechanism that attaches to the delivery catheter to properly position the tissue valve for loading within the delivery catheter. In another embodiment where the prosthetic tissue valve is not attached to the delivery catheter during shipment, the attachment mechanism may interact with the prosthetic tissue valve shipping container to prevent the bioprosthetic valve from moving during shipment.
摘要翻译：公开了一种用于在存储溶液中运送假体组织瓣膜并且将生物假体瓣膜准备和装载到基于导管的输送系统上的包装系统。包装系统包括填充有附着到输送导管的储存溶液的流体密封容器，其中容器围绕在装运和储存期间处于输送导管的预加载位置的假肢组织瓣膜。假体组织瓣膜可以包括附接到输送导管以将组织瓣膜正确定位以装载在输送导管内的附接机构。在假体组织瓣膜在运输期间未附着到输送导管的另一实施例中，附接机构可与假体组织瓣膜运输容器相互作用，以防止生物假体瓣膜在运输期间移动。

2. 发明授权

US09066785B2 Packaging systems for percutaneously deliverable bioprosthetic valves 有权
标题翻译：用于经皮输送的生物假体瓣膜的包装系统
公开(公告)号：US09066785B2
公开(公告)日：2015-06-30
申请号：US12418684
申请日：2009-04-06
申请人： Don Tran , Timothy Ryan , Jeffrey Allen , Melissa Denton , Adam Podbelski
发明人： Don Tran , Timothy Ryan , Jeffrey Allen , Melissa Denton , Adam Podbelski
IPC分类号： A61F2/24 , A61F2/00 , A61F2/958 , A61F2/95
CPC分类号： A61F2/0095 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/958 , A61F2002/9505 , A61F2002/9522
摘要： A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prosthetic tissue valve that is in a pre-loaded position on the delivery catheter during shipment and storage. The prosthetic tissue valve may include an attachment mechanism that attaches to the delivery catheter to properly position the tissue valve for loading within the delivery catheter. In another embodiment where the prosthetic tissue valve is not attached to the delivery catheter during shipment, the attachment mechanism may interact with the prosthetic tissue valve shipping container to prevent the bioprosthetic valve from moving during shipment.
摘要翻译：公开了一种用于在存储溶液中运送假体组织瓣膜并且将生物假体瓣膜准备和装载到基于导管的输送系统上的包装系统。包装系统包括填充有附着到输送导管的储存溶液的流体密封容器，其中容器围绕在装运和储存期间处于输送导管的预加载位置的假肢组织瓣膜。假体组织瓣膜可以包括附接到输送导管以将组织瓣膜正确定位以装载在输送导管内的附接机构。在假体组织瓣膜在运输期间未附着到输送导管的另一实施例中，附接机构可与假体组织瓣膜运输容器相互作用，以防止生物假体瓣膜在运输期间移动。

3. 发明授权

US07967138B2 Packaging systems for percutaneously deliverable bioprosthetic valves 有权
标题翻译：用于经皮输送的生物假体瓣膜的包装系统
公开(公告)号：US07967138B2
公开(公告)日：2011-06-28
申请号：US12418668
申请日：2009-04-06
申请人： Timothy Ryan , Don Tran , Jeffrey Allen , Melissa Denton , Adam Podbelski
发明人： Timothy Ryan , Don Tran , Jeffrey Allen , Melissa Denton , Adam Podbelski
IPC分类号： A61B17/06 , B65D83/10 , A61F2/24
CPC分类号： A61F2/0095 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/958 , A61F2002/9505 , A61F2002/9522
摘要： A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prosthetic tissue valve that is in a pre-loaded position on the delivery catheter during shipment and storage. The prosthetic tissue valve may include an attachment mechanism that attaches to the delivery catheter to properly position the tissue valve for loading within the delivery catheter. In another embodiment where the prosthetic tissue valve is not attached to the delivery catheter during shipment, the attachment mechanism may interact with the prosthetic tissue valve shipping container to prevent the bioprosthetic valve from moving during shipment.
摘要翻译：公开了一种用于在存储溶液中运送假体组织瓣膜并且将生物假体瓣膜准备和装载到基于导管的输送系统上的包装系统。包装系统包括填充有附着到输送导管的储存溶液的流体密封容器，其中容器围绕在装运和储存期间处于输送导管的预加载位置的假肢组织瓣膜。假体组织瓣膜可以包括附接到输送导管以将组织瓣膜正确定位以装载在输送导管内的附接机构。在假体组织瓣膜在运输期间未附着到输送导管的另一实施例中，附接机构可与假体组织瓣膜运输容器相互作用，以防止生物假体瓣膜在运输期间移动。

4. 发明申请

US20100256749A1 Packaging Systems for Percutaneously Deliverable Bioprosthetic Valves 有权
公开(公告)号：US20100256749A1
公开(公告)日：2010-10-07
申请号：US12418684
申请日：2009-04-06
申请人： Don Tran , Timothy Ryan , Jeffrey Allen , Melissa Denton , Adam Podbelski
发明人： Don Tran , Timothy Ryan , Jeffrey Allen , Melissa Denton , Adam Podbelski
IPC分类号： A61F2/24 , A61B19/02
CPC分类号： A61F2/0095 , A61F2/2412 , A61F2/2418 , A61F2/2436 , A61F2/958 , A61F2002/9505 , A61F2002/9522
摘要： A packaging system is disclosed for shipping a prosthetic tissue valve in a storage solution and preparing and loading of the bioprosthetic valve onto a catheter-based delivery system. The packaging system includes a fluid tight container filled with the storage solution attached to a delivery catheter, wherein the container surrounds the prosthetic tissue valve that is in a pre-loaded position on the delivery catheter during shipment and storage. The prosthetic tissue valve may include an attachment mechanism that attaches to the delivery catheter to properly position the tissue valve for loading within the delivery catheter. In another embodiment where the prosthetic tissue valve is not attached to the delivery catheter during shipment, the attachment mechanism may interact with the prosthetic tissue valve shipping container to prevent the bioprosthetic valve from moving during shipment.

5. 发明申请

US20090292350A1 Stents for Prosthetic Heart Valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US20090292350A1
公开(公告)日：2009-11-26
申请号：US12358980
申请日：2009-01-23
申请人： Carol E. Eberhardt , Charles Tabor , Carolyn Majkrzak , Timothy R. Ryan , Melissa Denton , Maria Botrous , Janice L. Shay
发明人： Carol E. Eberhardt , Charles Tabor , Carolyn Majkrzak , Timothy R. Ryan , Melissa Denton , Maria Botrous , Janice L. Shay
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2220/0075
摘要： A stented valve including a stent structure including a generally tubular body portion having a first end, a second end, an interior area, a longitudinal axis, and a plurality of vertical wires extending generally parallel to the longitudinal axis around a periphery of the body portion, wherein the plurality of vertical wires includes multiple commissure wires and at least one structural wire positioned between adjacent commissure wires, and a plurality of V-shaped wire structures having a first end, a second end, and a peak between the first and second ends, wherein a first end of each V-shaped structure extends from a first vertical wire and a second end of each V-shaped structure extends from a second vertical wire that is adjacent to the first vertical wire, wherein each V-shaped structure is oriented so that its peak is facing in the same direction relative to the first and second ends of the body portion, and a valve structure including a plurality of leaflets attached to the stent structure within the tubular body portion.
摘要翻译：一种支架式阀，包括支架结构，该支架结构包括大体上管状的主体部分，该主体部分具有第一端部，第二端部，内部区域，纵向轴线以及大致平行于纵向轴线围绕主体部分的周边延伸的多个垂直线，其中所述多个垂直导线包括多个连合线和位于相邻合金线之间的至少一个结构线，以及多个V形线结构，其具有第一端，第二端和在所述第一和第二端之间的峰其中，每个V形结构的第一端从第一垂直线延伸，并且每个V形结构的第二端从与所述第一垂直线相邻的第二垂直线延伸，其中每个V形结构被定向使得其峰值相对于主体部分的第一和第二端面向相同的方向，以及阀结构，其包括附接到ste的多个传单 nt结构在管状体部分内。

6. 发明授权

US07318278B2 Method of manufacture of a heart valve support frame 有权
标题翻译：心脏瓣膜支架的制造方法
公开(公告)号：US07318278B2
公开(公告)日：2008-01-15
申请号：US11028878
申请日：2005-01-03
申请人： Xiangyang Zhang , Melissa Denton , Sanjay Shrivastava , Pranav Desai
发明人： Xiangyang Zhang , Melissa Denton , Sanjay Shrivastava , Pranav Desai
IPC分类号： B21D51/16 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2415 , A61F2220/0075 , Y10T29/49405 , Y10T29/49865 , Y10T29/49885 , Y10T29/49895 , Y10T29/49904 , Y10T29/49906 , Y10T29/49995
摘要： Methods for forming a support frame for flexible leaflet heart valves from a starting blank include converting a two-dimensional starting blank into the three-dimensional support frame. The material may be superelastic, such as NITINOL, and the method may include bending the 2-D blank into the 3-D form and shape setting it. A merely elastic material such as ELGILOY may be used and plastically deformed in stages, possibly accompanied by annealing, to obtain the 3-D shape. Alternatively, a tubular blank could be formed to define a non-tubular shape, typically conical. A method for calculating the precise 2-D blank shape is also disclosed. A mandrel assembly includes a mandrel and ring elements for pressing the blank against the external surface of the mandrel prior to shape setting.
摘要翻译：从起始毛坯形成用于柔性小叶心脏瓣膜的支撑框架的方法包括将二维起始毛坯转换成三维支撑框架。该材料可能是超弹性的，例如NITINOL，并且该方法可以包括将2-D坯料弯曲成3-D形状并使其成形。可以使用诸如ELGILOY的仅弹性材料并且可能伴随着退火而逐级塑性变形以获得3-D形状。或者，可以形成管状坯料以限定非管状形状，通常为圆锥形。还公开了一种用于计算精确的2-D空白形状的方法。心轴组件包括心轴和环形元件，用于在形状设定之前将坯料压靠在心轴的外表面上。

7. 发明申请

US20090093876A1 RECOIL INHIBITOR FOR PROSTHETIC VALVE 审中-公开
标题翻译：用于预制阀的回收抑制剂
公开(公告)号：US20090093876A1
公开(公告)日：2009-04-09
申请号：US12202131
申请日：2008-08-29
申请人： Yacov Nitzan , Benjamin Spenser , Yaron Keidar , Tamir Levi , Melissa Denton
发明人： Yacov Nitzan , Benjamin Spenser , Yaron Keidar , Tamir Levi , Melissa Denton
IPC分类号： A61F2/24
CPC分类号： A61F2/2427 , A61F2/2433 , A61F2002/9522
摘要： A valve loading apparatus is provided for loading a crimped prosthetic valve into a lumen of a delivery system. The valve recoil adapter can counteract recoil of a compressed prosthetic valve, and maintain the valve at its desired crimp diameter. An integrated bioprosthesis/delivery system is provided for delivering a bioprosthesis to a target area within a body lumen is provided. The delivery system includes a valve covering member and a compressing member, which compresses the valve covering member to surround, hold, and/or compress the valve during delivery to the target area.
摘要翻译：提供一种阀装载装置，用于将卷曲的假肢瓣装载到输送系统的内腔中。阀反冲适配器可以抵消压缩的人造瓣膜的反冲，并将阀保持在其所需的卷曲直径。提供了一种用于将生物假体递送到体腔内的目标区域的综合生物假体/递送系统。输送系统包括阀盖部件和压缩部件，压缩部件在输送到目标区域期间压缩阀盖部件以围绕，保持和/或压缩阀。

8. 发明申请

US20050150775A1 Method of manufacture of a heart valve support frame 有权
标题翻译：心脏瓣膜支架的制造方法
公开(公告)号：US20050150775A1
公开(公告)日：2005-07-14
申请号：US11028878
申请日：2005-01-03
申请人： Xiangyang Zhang , Melissa Denton , Sanjay Shrivastava , Pranav Desai
发明人： Xiangyang Zhang , Melissa Denton , Sanjay Shrivastava , Pranav Desai
IPC分类号： A61F2/24 , C25F3/22
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2415 , A61F2220/0075 , Y10T29/49405 , Y10T29/49865 , Y10T29/49885 , Y10T29/49895 , Y10T29/49904 , Y10T29/49906 , Y10T29/49995
摘要： Methods for forming a support frame for flexible leaflet heart valves from a starting blank include converting a two-dimensional starting blank into the three-dimensional support frame. The material may be superelastic, such as NITINOL, and the method may include bending the 2-D blank into the 3-D form and shape setting it. A merely elastic material such as ELGILOY may be used and plastically deformed in stages, possibly accompanied by annealing, to obtain the 3-D shape. Alternatively, a tubular blank could be formed to define a non-tubular shape, typically conical. A method for calculating the precise 2-D blank shape is also disclosed. A mandrel assembly includes a mandrel and ring elements for pressing the blank against the external surface of the mandrel prior to shape setting.
摘要翻译：从起始毛坯形成用于柔性小叶心脏瓣膜的支撑框架的方法包括将二维起始毛坯转换成三维支撑框架。该材料可能是超弹性的，例如NITINOL，并且该方法可以包括将2-D坯料弯曲成3-D形状并使其成形。可以使用诸如ELGILOY的仅弹性材料并且可能伴随着退火而逐级塑性变形以获得3-D形状。或者，可以形成管状坯料以限定非管状形状，通常为圆锥形。还公开了一种用于计算精确的2-D空白形状的方法。心轴组件包括心轴和环形元件，用于在形状设定之前将坯料压靠在心轴的外表面上。

9. 发明授权

US08628566B2 Stents for prosthetic heart valves 有权
标题翻译：假体心脏瓣膜支架
公开(公告)号：US08628566B2
公开(公告)日：2014-01-14
申请号：US12358980
申请日：2009-01-23
申请人： Carol E. Eberhardt , Charles Tabor , Carolyn Majkrzak , Timothy R. Ryan , Melissa Denton , Maria Botrous , Janice L. Shay
发明人： Carol E. Eberhardt , Charles Tabor , Carolyn Majkrzak , Timothy R. Ryan , Melissa Denton , Maria Botrous , Janice L. Shay
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2220/0075
摘要： A stented valve including a stent structure including a generally tubular body portion having a first end, a second end, an interior area, a longitudinal axis, and a plurality of vertical wires extending generally parallel to the longitudinal axis around a periphery of the body portion, wherein the plurality of vertical wires includes multiple commissure wires and at least one structural wire positioned between adjacent commissure wires, and a plurality of V-shaped wire structures having a first end, a second end, and a peak between the first and second ends, wherein a first end of each V-shaped structure extends from a first vertical wire and a second end of each V-shaped structure extends from a second vertical wire that is adjacent to the first vertical wire, wherein each V-shaped structure is oriented so that its peak is facing in the same direction relative to the first and second ends of the body portion, and a valve structure including a plurality of leaflets attached to the stent structure within the tubular body portion.
摘要翻译：一种支架式阀，包括支架结构，该支架结构包括大体上管状的主体部分，该主体部分具有第一端部，第二端部，内部区域，纵向轴线以及大致平行于纵向轴线围绕主体部分的周边延伸的多个垂直线，其中所述多个垂直导线包括多个连合线和位于相邻合金线之间的至少一个结构线，以及多个V形线结构，其具有第一端，第二端和在所述第一和第二端之间的峰其中，每个V形结构的第一端从第一垂直线延伸，并且每个V形结构的第二端从与所述第一垂直导线相邻的第二垂直导线延伸，其中每个V形结构被定向使得其峰值相对于主体部分的第一和第二端面向相同的方向，以及阀结构，其包括附接到ste的多个传单 nt结构在管状体部分内。

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