专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09655983B2 Process for preparing a pharmaceutical formulation of contrast agents 有权
公开(公告)号：US09655983B2
公开(公告)日：2017-05-23
申请号：US12918259
申请日：2009-02-18
申请人： Dominique Meyer , Claire Corot , Marc Port , Vincent Barbotin , Bruno Bonnemain
发明人： Dominique Meyer , Claire Corot , Marc Port , Vincent Barbotin , Bruno Bonnemain
IPC分类号： A61K49/10 , A61K45/06 , A61K9/00
CPC分类号： A61K49/108 , A61K9/0019 , A61K31/28 , A61K45/06 , A61K47/18 , A61K49/106 , G01N33/15
摘要： The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, advantageously between 0.02% and 0.3% and very advantageously between 0.025% and 0.25%, the macrocyclic chelate advantageously being chosen from DOTA, NOTA, DOTAGA, DO3A, BT-DO3A, HP-DO3A and PCTA, and is preferably DOTA, the said process comprising the following successive steps: b) preparation of a liquid pharmaceutical composition containing, firstly, the complex of macrocyclic chelate with a lanthanide, and, secondly, free macrocyclic chelate and/or free lanthanide; c) measurement in the pharmaceutical formulation obtained in step b) of the concentration of free macrocyclic chelate C ch1 and/or of free lanthanide C lan1; d) adjustment of C ch1 and/or of C lan1 so as to obtain C ch1=C tch1 and C lan1=0, wherein C t ch1 is the target concentration of free macrocyclic chelate in the final liquid pharmaceutical formulation.

2. 发明申请

US20110129425A1 PROCESS FOR PREPARING A PHARMACEUTICAL FORMULATION OF CONTRAST AGENTS 有权
标题翻译：制备药物制剂的方法
公开(公告)号：US20110129425A1
公开(公告)日：2011-06-02
申请号：US12918259
申请日：2009-02-18
申请人： Dominique Meyer , Claire Corot , Marc Port , Vincent Barbotin , Bruno Bonnemain
发明人： Dominique Meyer , Claire Corot , Marc Port , Vincent Barbotin , Bruno Bonnemain
IPC分类号： A61K49/12 , C07D257/02 , A61P43/00
CPC分类号： A61K49/108 , A61K9/0019 , A61K31/28 , A61K45/06 , A61K47/18 , A61K49/106 , G01N33/15
摘要： The invention relates to a process for preparing a liquid pharmaceutical formulation containing a complex of macrocyclic chelate with a lanthanide and a mol/mol amount of free macrocyclic chelate of between 0.002% and 0.4%, advantageously between 0.02% and 0.3% and very advantageously between 0.025% and 0.25%, the macrocyclic chelate advantageously being chosen from DOTA, NOTA, DOTAGA, DO3A, BT-DO3A, HP-DO3A and PCTA, and is preferably DOTA, the said process comprising the following successive steps: b) preparation of a liquid pharmaceutical composition containing, firstly, the complex of macrocyclic chelate with a lanthanide, and, secondly, free macrocyclic chelate and/or free lanthanide; c) measurement in the pharmaceutical formulation obtained in step b) of the concentration of free macrocyclic chelate C ch1 and/or of free lanthanide C lan1; d) adjustment of C ch1 and/or of C lan1 so as to obtain C ch1=C tch1 and C lan1=0, wherein C t ch1 is the target concentration of free macrocyclic chelate in the final liquid pharmaceutical formulation.
摘要翻译：本发明涉及制备含有大环螯合物与镧系元素络合物和摩尔/摩尔量的游离大环螯合物的液体药物制剂的方法，其含量为0.002％至0.4％，有利地为0.02％至0.3％，非常有利地介于 0.025％和0.25％，大环螯合物有利地选自DOTA，NOTA，DOTAGA，DO3A，BT-DO3A，HP-DO3A和PCTA，并且优选为DOTA，所述方法包括以下连续步骤：b）液体药物组合物首先含有大环螯合物与镧系元素的复合物，其次是游离的大环螯合物和/或游离的镧系元素; c）在步骤b）中获得的药物制剂中测量游离大环螯合物C ch1和/或游离镧系元素C lan1的浓度; d）调整C ch1和/或C lan1，以获得C ch1 = C tch1和C lan1 = 0，其中C t ch1是最终液体药物制剂中游离大环螯合物的目标浓度。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式