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1. 发明授权

US08831320B2 Device and computed tomography scanner for determining and visualizing the perfusion of the myocardial muscle 有权
标题翻译：用于确定和可视化心肌灌注的装置和计算机断层扫描仪
公开(公告)号：US08831320B2
公开(公告)日：2014-09-09
申请号：US13293172
申请日：2011-11-10
申请人： Dominik Bernhardt , Michael Scheuering , Fernando Vega-Higuera
发明人： Dominik Bernhardt , Michael Scheuering , Fernando Vega-Higuera
IPC分类号： G06K9/00 , A61B6/03 , G06T7/00 , A61B6/00
CPC分类号： G06F19/12 , A61B6/03 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , G06F17/18 , G06F19/00 , G06T7/0012 , G06T2207/10076 , G06T2207/10081 , G06T2207/30048 , G06T2207/30104 , G16H50/50
摘要： A device is disclosed for determining and visualizing the perfusion of the myocardial muscle with the aid of static CCTA images. In at least one embodiment, the device includes a segmentation unit for segmenting the coronary blood vessels and the left myocardial muscle from a CCTA image of the heart; a first simulation unit for simulating the blood flow through the coronary blood vessels; and a second simulation unit by which the local perfusion of the myocardial muscle is determined on the basis of the ascertained blood flow into different regions of the myocardial muscle. The perfusion of the different regions of the myocardial muscle is visualized in a schematized image on a visualization unit. By virtue of the proposed device it is possible to dispense with further imaging examinations after the performance of a CCTA scan, thereby relieving the pressure both on the part of the physician and on the part of the patient.
摘要翻译：公开了一种借助于静态CCTA图像来确定和可视化心肌肌灌注的装置。在至少一个实施例中，该装置包括用于从心脏的CCTA图像分割冠状动脉血管和左心肌的分割单元; 用于模拟通过冠状血管的血流的第一模拟单元; 以及第二模拟单元，通过该第二模拟单元，基于确定的进入心肌的不同区域的血液流量来确定心肌的局部灌注。在可视化单元上的示意图像中可视化心肌的不同区域的灌注。凭借所提出的装置，可以在执行CCTA扫描之后免除进一步的成像检查，从而减轻了医师和患者部分的压力。

2. 发明授权

US08594399B2 Method for actuating an image output device, method for determining tangential slice planes, actuation module and slice plane determination unit 有权
标题翻译：用于致动图像输出装置的方法，用于确定切向切片平面的方法，致动模块和切片平面确定单元
公开(公告)号：US08594399B2
公开(公告)日：2013-11-26
申请号：US12695206
申请日：2010-01-28
申请人： Dominik Bernhardt , Michael Scheuering , Johann Uebler
发明人： Dominik Bernhardt , Michael Scheuering , Johann Uebler
IPC分类号： G06K9/00
CPC分类号： G06T19/00 , G06T2219/008 , G06T2219/028
摘要： A method is disclosed for actuating an image output device for the output of slice images, obtained from volume data, of a tissue region including at least one hollow organ section. In at least one embodiment, tangential slice planes at observation points along at least one profile line section through the hollow organ section are determined on the basis of provided volume data. In the process, the profile line section is decomposed into shorter profile line sections such that the generated profile line sections are each situated at least approximately in a plane assigned to the respective profile line section as per a predetermined quality criterion. First tangential slice planes are each assigned to the possible observation points on the associated profile line sections on the basis of these planes. A first tangential slice image is then generated from the volume data for a current observation point on the profile line section on the basis of a first tangential slice plane determined for this observation point. Control commands for the image output device are generated for the output of this slice image and transmitted to the image output device. Moreover, at least one embodiment of the invention relates to an actuation module suitable for this purpose.
摘要翻译：公开了一种用于致动图像输出装置以从包括至少一个中空器官部分的组织区域的体积数据获得的切片图像的输出的方法。在至少一个实施例中，基于提供的体积数据确定通过中空器官部分的至少一个轮廓线部分的观察点处的切向切片平面。在该过程中，轮廓线部分被分解成较短轮廓线部分，使得所生成的轮廓线部分每个至少大致位于根据预定质量标准分配给相应轮廓线部分的平面中。基于这些平面，将第一切向切片平面分配给相关的轮廓线部分上的可能的观察点。然后根据为该观察点确定的第一切向切片平面，从轮廓线部分上的当前观察点的体积数据生成第一切向切片图像。生成用于图像输出装置的控制命令，用于该切片图像的输出并发送到图像输出装置。此外，本发明的至少一个实施例涉及适合于此目的的致动模块。

3. 发明申请

US20110158495A1 METHOD AND DEVICE FOR AUTOMATED DETECTION OF THE CENTRAL LINE OF AT LEAST ONE PORTION OF A TUBULAR TISSUE STRUCTURE 有权
标题翻译：用于自动检测管状组织结构至少一个部分的中心线的方法和装置
公开(公告)号：US20110158495A1
公开(公告)日：2011-06-30
申请号：US12828364
申请日：2010-07-01
申请人： Dominik Bernhardt , Christina Biermann , Michael Scheuering
发明人： Dominik Bernhardt , Christina Biermann , Michael Scheuering
IPC分类号： G06K9/00 , A61B5/05
CPC分类号： A61B6/504 , A61B5/055 , A61B6/506 , G06T7/13 , G06T19/00 , G06T2207/10072 , G06T2207/10132 , G06T2207/20164 , G06T2207/30172
摘要： A method and a device are disclosed for automated detection of at least one part of the central line of at least one portion of a tubular tissue structure. In at least one embodiment of the method, characteristic landmarks of the tubular tissue structure are detected in a 3D data record of the tubular tissue structure; the detected characteristic landmarks of the tubular tissue structure and landmarks of a model of landmarks, which model belongs to the tubular tissue structure and takes into account the position of the landmarks relative to one another, are related to one another such that at least one portion of the tubular tissue structure is identified in the 3D data record of the tubular tissue structure. The central line of the identified portion of the tubular tissue structure is determined at least in part on the basis of at least one detected characteristic landmark and/or at least one landmark of the model of landmarks.
摘要翻译：公开了用于自动检测管状组织结构的至少一部分的至少一部分中心线的方法和装置。在该方法的至少一个实施例中，管状组织结构的特征标记在管状组织结构的3D数据记录中被检测到; 管状组织结构的检测到的特征标记和模型属于管状组织结构并考虑到地标相对于彼此的位置的地标模型的地标彼此关联，使得至少一部分在管状组织结构的3D数据记录中识别管状组织结构。管状组织结构的识别部分的中心线至少部分地基于至少一个检测到的特征地标和/或地标模型的至少一个地标来确定。

4. 发明授权

US09504435B2 Method and device for automated detection of the central line of at least one portion of a tubular tissue structure 有权
标题翻译：用于自动检测管状组织结构的至少一部分的中心线的方法和装置
公开(公告)号：US09504435B2
公开(公告)日：2016-11-29
申请号：US12828364
申请日：2010-07-01
申请人： Dominik Bernhardt , Christina Biermann , Michael Scheuering
发明人： Dominik Bernhardt , Christina Biermann , Michael Scheuering
IPC分类号： G06K9/00 , A61B5/05 , A61B6/00 , G06T7/00 , G06T19/00 , A61B5/055
CPC分类号： A61B6/504 , A61B5/055 , A61B6/506 , G06T7/13 , G06T19/00 , G06T2207/10072 , G06T2207/10132 , G06T2207/20164 , G06T2207/30172
摘要： A method and a device are disclosed for automated detection of at least one part of the central line of at least one portion of a tubular tissue structure. In at least one embodiment of the method, characteristic landmarks of the tubular tissue structure are detected in a 3D data record of the tubular tissue structure; the detected characteristic landmarks of the tubular tissue structure and landmarks of a model of landmarks, which model belongs to the tubular tissue structure and takes into account the position of the landmarks relative to one another, are related to one another such that at least one portion of the tubular tissue structure is identified in the 3D data record of the tubular tissue structure. The central line of the identified portion of the tubular tissue structure is determined at least in part on the basis of at least one detected characteristic landmark and/or at least one landmark of the model of landmarks.
摘要翻译：公开了用于自动检测管状组织结构的至少一部分的至少一部分中心线的方法和装置。在该方法的至少一个实施例中，管状组织结构的特征标记在管状组织结构的3D数据记录中被检测到; 管状组织结构的检测到的特征标记和模型属于管状组织结构并考虑到地标相对于彼此的位置的地标模型的地标彼此关联，使得至少一部分在管状组织结构的3D数据记录中识别管状组织结构。管状组织结构的识别部分的中心线至少部分地基于至少一个检测到的特征地标和/或地标模型的至少一个地标来确定。

5. 发明授权

US08825139B2 Method for automatic detection of a contrast agent inflow in a blood vessel of a patient with a CT system and CT system for carrying out this method 有权
标题翻译：用于自动检测患有CT系统和CT系统的患者的血管中造影剂流入的方法
公开(公告)号：US08825139B2
公开(公告)日：2014-09-02
申请号：US13093213
申请日：2011-04-25
申请人： Dominik Bernhardt , Ute Feuerlein , Stefan Groβkopf , Michael Scheuering
发明人： Dominik Bernhardt , Ute Feuerlein , Stefan Groβkopf , Michael Scheuering
IPC分类号： A61B6/00 , A61B6/03
CPC分类号： A61B6/481 , A61B6/032 , A61B6/4441 , A61B6/4447 , A61B6/482 , A61B6/486 , A61B6/488 , A61B6/5217 , A61B6/541
摘要： A method for automatic detection of a contrast agent inflow in a blood vessel of a patient with a CT system, and CT system for carrying out this method, are disclosed. At least one embodiment of the invention relates to a method which determines the position of at least one blood vessel in section image representations in a CT examination without external intervention with the aid of an active shape or active appearance model, measures the inflow of contrast agent in this region in a targeted way and automatically initiates at least one action in the event of inflowing contrast agent.
摘要翻译：公开了一种用于自动检测CT系统的患者的血管中造影剂流入的方法，以及用于实施该方法的CT系统。本发明的至少一个实施例涉及一种在CT检查中确定截面图像中至少一个血管的位置的方法，而无需借助于主动形状或活动外观模型的外部干预，测量造影剂的流入在该区域以有针对性的方式，并且在流入造影剂的情况下自动启动至少一个动作。

6. 发明申请

US20120121151A1 Device And Computed Tomography Scanner For Determining And Visualizing The Perfusion Of The Myocardial Muscle 有权
标题翻译：装置和计算机断层扫描仪用于确定和可视化心肌肌灌注
公开(公告)号：US20120121151A1
公开(公告)日：2012-05-17
申请号：US13293172
申请日：2011-11-10
申请人： Dominik Bernhardt , Michael Scheuering , Fernando Vega-Higuera
发明人： Dominik Bernhardt , Michael Scheuering , Fernando Vega-Higuera
IPC分类号： G06K9/00
CPC分类号： G06F19/12 , A61B6/03 , A61B6/032 , A61B6/481 , A61B6/503 , A61B6/504 , A61B6/507 , G06F17/18 , G06F19/00 , G06T7/0012 , G06T2207/10076 , G06T2207/10081 , G06T2207/30048 , G06T2207/30104 , G16H50/50
摘要： A device is disclosed for determining and visualizing the perfusion of the myocardial muscle with the aid of static CCTA images. In at least one embodiment, the device includes a segmentation unit for segmenting the coronary blood vessels and the left myocardial muscle from a CCTA image of the heart; a first simulation unit for simulating the blood flow through the coronary blood vessels; and a second simulation unit by which the local perfusion of the myocardial muscle is determined on the basis of the ascertained blood flow into different regions of the myocardial muscle. The perfusion of the different regions of the myocardial muscle is visualized in a schematized image on a visualization unit. By virtue of the proposed device it is possible to dispense with further imaging examinations after the performance of a CCTA scan, thereby relieving the pressure both on the part of the physician and on the part of the patient.
摘要翻译：公开了一种借助于静态CCTA图像来确定和可视化心肌肌灌注的装置。在至少一个实施例中，该装置包括用于从心脏的CCTA图像分割冠状动脉血管和左心肌的分割单元; 用于模拟通过冠状血管的血流的第一模拟单元; 以及第二模拟单元，通过该第二模拟单元，基于确定的进入心肌的不同区域的血液流量来确定心肌的局部灌注。在可视化单元上的示意图像中可视化心肌的不同区域的灌注。凭借所提出的装置，可以在执行CCTA扫描之后免除进一步的成像检查，从而减轻了医师和患者部分的压力。

7. 发明授权

US08542894B2 Method and device for post-processing measured values registered by way of an imaging system 有权
标题翻译：用于后处理通过成像系统登记的测量值的方法和装置
公开(公告)号：US08542894B2
公开(公告)日：2013-09-24
申请号：US12827275
申请日：2010-06-30
申请人： Dominik Bernhardt , Michael Scheuering
发明人： Dominik Bernhardt , Michael Scheuering
IPC分类号： G06K9/00
CPC分类号： G06T11/206 , A61B6/503 , A61B6/507
摘要： A method is disclosed for post-processing measured values of a tissue region including at least part of a heart, which measured values were registered by way of an imaging system. In at least one embodiment, the method includes at least: generating an at least three-dimensional data record from the measured values; analyzing the at least three-dimensional data record and generating parameter maps in respect of at least two of the following parameters: thickness and/or change in thickness of a myocardial wall, movement of the myocardial wall, local blood-supply values for defined spatial regions of the heart; automatically generating a results parameter map on the basis of the generated parameter maps according to fixed rules; and outputting the results parameter map. Moreover, at least one embodiment of the invention relates to a correspondingly designed device.
摘要翻译：公开了一种用于后处理包括至少部分心脏的组织区域的测量值的方法，该测量值通过成像系统登记。在至少一个实施例中，该方法至少包括：从测量值生成至少三维数据记录; 分析所述至少三维数据记录并针对以下参数中的至少两个生成参数图：心肌壁的厚度和/或厚度变化，心肌壁的运动，用于定义的空间的局部血液供应值心脏地区根据固定规则，根据生成的参数图自动生成结果参数图; 并输出结果参数图。此外，本发明的至少一个实施例涉及相应设计的装置。

8. 发明申请

US20140058715A1 Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis 审中-公开
标题翻译：冠状动脉狭窄无创功能评估方法与系统
公开(公告)号：US20140058715A1
公开(公告)日：2014-02-27
申请号：US14070810
申请日：2013-11-04
申请人： Puneet Sharma , Lucian Mihai Itu , Ali Kamen , Bogdan Georgescu , Xudong Zheng , Huseyin Tek , Dorin Comaniciu , Dominik Bernhardt , Fernando Vega-Higuera , Michael Scheuering
发明人： Puneet Sharma , Lucian Mihai Itu , Ali Kamen , Bogdan Georgescu , Xudong Zheng , Huseyin Tek , Dorin Comaniciu , Dominik Bernhardt , Fernando Vega-Higuera , Michael Scheuering
IPC分类号： G06F19/00
CPC分类号： G16B5/00 , A61B5/02007 , A61B5/1128 , A61B6/032 , A61B6/503 , A61B6/5217 , A61B2576/023 , G16H50/50
摘要： A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.
摘要翻译：公开了冠状动脉狭窄非侵入性评估的方法和系统。从休息状态下获得的患者的医学图像数据中提取冠状动脉的患者特异性解剖学测量。基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。使用冠状动脉循环模型和患者特异性充血边界条件模拟冠状动脉至少一个狭窄区域的血流量和压力。基于模拟的充血血流量和压力计算至少一个狭窄区域的分数流量储备（FFR）。

9. 发明申请

US20130246034A1 Method and System for Non-Invasive Functional Assessment of Coronary Artery Stenosis 审中-公开
标题翻译：冠状动脉狭窄无创功能评估方法与系统
公开(公告)号：US20130246034A1
公开(公告)日：2013-09-19
申请号：US13794113
申请日：2013-03-11
申请人： Puneet Sharma , Lucian Mihai Itu , Ali Kamen , Bogdan Georgescu , Xudong Zheng , Huseyin Tek , Dorin Comaniciu , Dominik Bernhardt , Fernando Vega-Higuera , Michael Scheuering
发明人： Puneet Sharma , Lucian Mihai Itu , Ali Kamen , Bogdan Georgescu , Xudong Zheng , Huseyin Tek , Dorin Comaniciu , Dominik Bernhardt , Fernando Vega-Higuera , Michael Scheuering
IPC分类号： G06F19/12
CPC分类号： G16B5/00 , A61B5/02007 , A61B5/1128 , A61B6/032 , A61B6/503 , A61B6/5217 , A61B2576/023 , G16H50/50
摘要： A method and system for non-invasive assessment of coronary artery stenosis is disclosed. Patient-specific anatomical measurements of the coronary arteries are extracted from medical image data of a patient acquired during rest state. Patient-specific rest state boundary conditions of a model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Patient-specific rest state boundary conditions of the model of coronary circulation representing the coronary arteries are calculated based on the patient-specific anatomical measurements and non-invasive clinical measurements of the patient at rest. Hyperemic blood flow and pressure across at least one stenosis region of the coronary arteries are simulated using the model of coronary circulation and the patient-specific hyperemic boundary conditions. Fractional flow reserve (FFR) is calculated for the at least one stenosis region based on the simulated hyperemic blood flow and pressure.
摘要翻译：公开了冠状动脉狭窄非侵入性评估的方法和系统。从休息状态下获得的患者的医学图像数据中提取冠状动脉的患者特异性解剖学测量。基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。基于患者特异性解剖学测量和静息患者的非侵入性临床测量，计算代表冠状动脉的冠状动脉循环模型的患者特异性休息状态边界条件。使用冠状动脉循环模型和患者特异性充血边界条件模拟冠状动脉至少一个狭窄区域的血流量和压力。基于模拟的充血血流量和压力计算至少一个狭窄区域的分数流量储备（FFR）。

10. 发明申请

US20110007953A1 METHOD AND DEVICE FOR POST-PROCESSING MEASURED VALUES REGISTERED BY WAY OF AN IMAGING SYSTEM 有权
标题翻译：用于后处理通过成像系统方式记录的测量值的方法和装置
公开(公告)号：US20110007953A1
公开(公告)日：2011-01-13
申请号：US12827275
申请日：2010-06-30
申请人： Dominik Bernhardt , Michael Scheuering
发明人： Dominik Bernhardt , Michael Scheuering
IPC分类号： G06K9/00
CPC分类号： G06T11/206 , A61B6/503 , A61B6/507
摘要： A method is disclosed for post-processing measured values of a tissue region including at least part of a heart, which measured values were registered by way of an imaging system. In at least one embodiment, the method includes at least: generating an at least three-dimensional data record from the measured values; analyzing the at least three-dimensional data record and generating parameter maps in respect of at least two of the following parameters: thickness and/or change in thickness of a myocardial wall, movement of the myocardial wall, local blood-supply values for defined spatial regions of the heart; automatically generating a results parameter map on the basis of the generated parameter maps according to fixed rules; and outputting the results parameter map. Moreover, at least one embodiment of the invention relates to a correspondingly designed device.
摘要翻译：公开了一种用于后处理包括至少部分心脏的组织区域的测量值的方法，该测量值通过成像系统登记。在至少一个实施例中，该方法至少包括：从测量值生成至少三维数据记录; 分析所述至少三维数据记录并针对以下参数中的至少两个生成参数图：心肌壁的厚度和/或厚度变化，心肌壁的运动，用于定义的空间的局部血液供应值心脏地区根据固定规则，根据生成的参数图自动生成结果参数图; 并输出结果参数图。此外，本发明的至少一个实施例涉及相应设计的装置。

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