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1. 发明申请

US20050002894A1 Novel uses of apple seed extracts in cosmetic or pharmaceutical compositions 审中-公开
标题翻译：苹果籽提取物在化妆品或药物组合物中的新用途
公开(公告)号：US20050002894A1
公开(公告)日：2005-01-06
申请号：US10872597
申请日：2004-06-21
申请人： Dirk Petersohn , Kordula Schlotmann , Claudia Jassoy , Marianne Waldmann-Laue , Sevda Yuecel
发明人： Dirk Petersohn , Kordula Schlotmann , Claudia Jassoy , Marianne Waldmann-Laue , Sevda Yuecel
IPC分类号： A61K8/60 , A61K8/64 , A61K8/73 , A61K36/00 , A61K36/73 , A61Q5/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61K7/06 , A61K35/78
CPC分类号： A61Q19/08 , A61K8/60 , A61K8/64 , A61K8/645 , A61K8/73 , A61K36/73 , A61Q5/00 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： Novel topical cosmetic and pharmaceutical compositions containing apple core extracts, and novel uses of apple core extracts in topical cosmetic or pharmaceutical compositions.
摘要翻译：含有苹果核心提取物的新型局部化妆品和药物组合物，以及苹果核提取物在局部化妆品或药物组合物中的新用途。

2. 发明申请

US20050089512A1 Skin/hair equivalent with reconstructed papillae 审中-公开
标题翻译：皮肤/头发等同于重建乳头
公开(公告)号：US20050089512A1
公开(公告)日：2005-04-28
申请号：US10871119
申请日：2004-06-18
申请人： Kordula Schlotmann , Thomas Gassenmeier , Ralf Paus , Melanie Giesen , Dirk Petersohn
发明人： Kordula Schlotmann , Thomas Gassenmeier , Ralf Paus , Melanie Giesen , Dirk Petersohn
IPC分类号： A61F2/10 , A61L27/24 , A61L27/38 , A61L27/60 , C12N5/071 , C12N5/08 , A61K45/00
CPC分类号： A61F2/10 , A61L27/24 , A61L27/3804 , A61L27/3869 , A61L27/3891 , A61L27/60 , A61L2430/18 , C12N5/0627 , C12N5/0698 , C12N2502/094 , C12N2502/1323
摘要： The invention relates to a skin/hair equivalent, more particularly a hair model with reconstructed papillae (pseudopapillae; PP) in a reconstructed dermis (pseudodermis; PD), to its production and to its use, more particularly for medical/pharmaceutical purposes and for application in the cosmetics industry.
摘要翻译：本发明涉及一种皮肤/头发当量，更具体地说，在重建的真皮（假性皮肤; PD）中具有重建的乳头（pseudopapillae; PP）的毛发模型，其生产和使用，更特别地用于医疗/药物目的，以及用于在化妆品行业的应用。

3. 发明申请

US20060088852A1 Method for determining the homeostasis of hairy skin 审中-公开
标题翻译：确定毛皮皮肤动态平衡的方法
公开(公告)号：US20060088852A1
公开(公告)日：2006-04-27
申请号：US11158209
申请日：2005-06-20
申请人： Dirk Petersohn , Kordula Schlotmann , Thomas Gassenmeier , Olaf Holtkoetter , Marcus Conradt , Kay Hofmann
发明人： Dirk Petersohn , Kordula Schlotmann , Thomas Gassenmeier , Olaf Holtkoetter , Marcus Conradt , Kay Hofmann
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/148 , C12Q2600/158
摘要： The invention relates to a method for determining the homeostasis of hairy skin in vitro, to test kits and biochips for determining markers of hairy skin, in addition to the use of proteins, mRNA molecules or fragments thereof as markers of hairy skin. The invention also relates to a test method for detecting the effectiveness of cosmetic or pharmaceutical active substances for treating hairy skin in addition to a screening method for identifying cosmetic or pharmaceutical active substances for treating hairy skin and to a method for producing a cosmetic or pharmaceutical preparation for treating hairy skin.
摘要翻译：本发明涉及一种用于确定体外毛皮的体内平衡的方法，以及用于测定用于确定毛皮皮肤标记物的试剂盒和生物芯片，以及使用蛋白质，mRNA分子或其片段作为毛皮皮肤的标记物。本发明还涉及用于检测用于治疗毛皮的化妆品或药物活性物质的有效性的试验方法，以及用于鉴定用于治疗毛发皮肤的化妆品或药物活性物质的筛选方法以及化妆品或药物制剂的制备方法用于治疗毛皮。

4. 发明申请

US20080176811A1 NOVEL FLAVONE GLYCOSIDE DERIVATIVES FOR USE IN COSMETICS, PHARMACEUTICALS AND NUTRITION 审中-公开
标题翻译：用于化妆品，药物和营养物质的新型FLAVONE GLYCONE衍生物
公开(公告)号：US20080176811A1
公开(公告)日：2008-07-24
申请号：US12057425
申请日：2008-03-28
申请人： Bernadette Geers , Ralf Otto , Albrecht Weiss , Dirk Petersohn , Klaus Rudolf Schroeder , Kordula Schlotmann
发明人： Bernadette Geers , Ralf Otto , Albrecht Weiss , Dirk Petersohn , Klaus Rudolf Schroeder , Kordula Schlotmann
IPC分类号： A61K31/7048 , C07H17/06 , C12P19/60 , A61P17/00 , A61Q19/02
CPC分类号： A61K8/602 , A23L33/105 , A23V2002/00 , A61K8/73 , A61Q19/02 , C07H17/07 , C12P7/62 , C12P17/06 , C12P19/60 , A23V2250/2116 , A23V2250/1866
摘要： Substituted and unsubstituted flavone or isoflavone glycoside derivatives of the formula [A1-C(═O)O]m—[X—O-Z]—[O—C(═O)-A2]n, wherein [X—O-Z] represents a flavone or isoflavone glycoside structure, particularly a naringin residue, X is a flavone or isoflavone corresponding to formula (IIa) or formula (IIb): wherein the flavone or isoflavone residue is substituted one or more times and/or reduced one or more times; Z represents a mono-, di- or polysaccharide, which is acetally-bound at the benzopyran group to X and ester-substituted by —O—C(═O)-A2; [A1-C(═O)] is an acyl group on the flavone or isoflavone; A1 and A2 independently, represent a polyunsaturated C15-26 alkenyl group containing at least four isolated and/or at least two conjugated double bonds, or an arylaliphatic radical with 1-to-4 methylene groups between the ester group and the aromatic ring; [C(═O)A2] is an acyl group; n is an integer other than 0; m is an integer, including 0; and R1, R2 and R are hydroxyl groups or hydrogen atoms.
摘要翻译：取代和未取代的式[A-1-C（-O）O] - [XOZ] - [OC（-O）-A）的黄酮或异黄酮糖苷衍生物其中[XOZ]表示黄酮或异黄酮糖苷结构，特别是柚皮苷残基，X是与式（IIa）或式（IIa）相应的黄酮或异黄酮 IIb）：其中所述黄酮或异黄酮残基被一次或多次取代和/或还原一次或多次; Z表示一种，二或多糖，其在苯并吡喃基团处与X缩合而X和被-O-C（-O）-A 2 - 被酯取代。 [A-1] -C（-O）]是黄酮或异黄酮上的酰基; A 1和A 2独立地表示含有至少四个分离和/或至少两个共轭双键的多不饱和C 15-26亚烯基或在酯基和芳香环之间具有1至4个亚甲基的芳基脂族基; [C（-O）A 2]是酰基; n是0以外的整数; m是整数，包括0; 并且R 1，R 2和R 2是羟基或氢原子。

5. 发明申请

US20060204992A1 Method for determining hair cycle markers 审中-公开
标题翻译：确定毛发循环标记的方法
公开(公告)号：US20060204992A1
公开(公告)日：2006-09-14
申请号：US11364118
申请日：2006-02-28
申请人： Olaf Holtkotter , Dirk Petersohn , Kordula Schlotmann , Melanie Giesen , Danlala Kessler-Becker
发明人： Olaf Holtkotter , Dirk Petersohn , Kordula Schlotmann , Melanie Giesen , Danlala Kessler-Becker
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The invention relates to a method for determining hair cycle markers in vitro, test kits and biochips which are used to determine hair cycle markers and to the use of proteins, mRNA molecules, proteins or fragments thereof as hair cycle markers. The invention also relates to a test method which is used to detect the effectiveness of cosmetic and pharmaceutical active ingredients which influence the hair cycle, in addition to a screening method which is used to identify cosmetic or pharmaceutical active ingredients which influence the hair cycle and to a method for the production of a cosmetic and pharmaceutical preparation which influences the hair cycle.
摘要翻译：本发明涉及一种用于测定体外毛发循环标记物的方法，用于确定毛发循环标记物的测试试剂盒和生物芯片，以及蛋白质，mRNA分子，蛋白质或其片段作为毛发循环标记物的用途。本发明还涉及一种用于检测影响毛发循环的化妆品和药物活性成分的有效性的测试方法，以及用于鉴定影响毛发循环的化妆品或药物活性成分的筛选方法，以及用于生产影响毛发循环的化妆品和药物制剂的方法。

6. 发明申请

US20070020623A1 Method for determining homeostasis of the skin 审中-公开
标题翻译：确定皮肤体内平衡的方法
公开(公告)号：US20070020623A1
公开(公告)日：2007-01-25
申请号：US10250691
申请日：2001-12-20
申请人： Dirk Petersohn , Marcus Conradt , Kay Hoffmann
发明人： Dirk Petersohn , Marcus Conradt , Kay Hoffmann
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： Described herein are processes and devices useful for the identification of genes differentially expressed in skin. Preferably, the processes and devices are useful for the in vitro determination of skin homeostasis. Also described is a combination having a plurality of genes differentially expressed in skin compared to other tissues. Biochips and test kits useful in processes for the identification of genes expressed in skin homeostasis as well as in processes for screening substances useful in maintaining or promoting homeostasis of the skin are also described. Also described are processes for identifying substances useful in maintaining or promoting homeostasis of the skin as well as processes for making cosmetic and/or pharmaceutical preparations comprising such substances.
摘要翻译：本文描述了可用于鉴定在皮肤中差异表达的基因的方法和装置。优选地，所述方法和装置可用于体外测定皮肤内稳态。还描述了与其他组织相比，在皮肤中具有差异表达的多种基因的组合。还描述了可用于鉴定在皮肤内稳态中表达的基因的方法中的生物芯片和测试试剂盒，以及用于筛选可用于维持或促进皮肤的体内平衡的物质的方法。还描述了用于鉴定可用于维持或促进皮肤的体内平衡的物质的方法以及制备包含这些物质的化妆品和/或药物制剂的方法。

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