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1. 发明申请

US20070264277A1 Compositions and Methods of Use for Mgd-Csf in Disease Treatment 审中-公开
标题翻译：疾病治疗中Mgd-Csf的组成和使用方法
公开(公告)号：US20070264277A1
公开(公告)日：2007-11-15
申请号：US11632319
申请日：2005-07-21
申请人： Dirk Behrens , Elizabeth Bosch , Stephen Doberstein , Robert Halenbeck , Kevin Hestir , Min Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin Wong , Ge Wu , Aileen Zhou
发明人： Dirk Behrens , Elizabeth Bosch , Stephen Doberstein , Robert Halenbeck , Kevin Hestir , Min Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin Wong , Ge Wu , Aileen Zhou
IPC分类号： A61K39/00 , A61K38/00 , C07H21/00 , C07K14/00 , C07K16/18 , C12N15/00 , C12N15/87 , C12N5/06 , C12P1/00 , G01N33/53
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译：公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。

2. 发明授权

US08575312B2 Compositions and methods of use for MGD-CSF in disease treatment 有权
标题翻译： MGD-CSF在疾病治疗中的组成和使用方法
公开(公告)号：US08575312B2
公开(公告)日：2013-11-05
申请号：US13446254
申请日：2012-04-13
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： C07K14/00
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译：公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。

3. 发明授权

US08178109B2 Compositions and methods of use for MGD-CSF in disease treatment 有权
标题翻译： MGD-CSF在疾病治疗中的组成和使用方法
公开(公告)号：US08178109B2
公开(公告)日：2012-05-15
申请号：US12370559
申请日：2009-02-12
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： A61K39/00
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译：公开了一种新鉴定的分泌型分子，本文称为“单核细胞，粒细胞和树突细胞集落刺激因子”（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。

4. 发明申请

US20120258071A1 Compositions and Methods of Use for MGD-CSF in Disease Treatment 有权
标题翻译： MGD-CSF在疾病治疗中的组成和使用方法
公开(公告)号：US20120258071A1
公开(公告)日：2012-10-11
申请号：US13446254
申请日：2012-04-13
申请人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
发明人： Dirk Behrens , Elizabeth Bosch , Stephen K. Doberstein , Robert Forgan Halenbeck , Kevin Hestir , Min Mei Huang , Ernestine Lee , Haishan Lin , Thomas Linnemann , Shannon Marshall , Justin G. P. Wong , Ge Wu , Aileen Zhou , Cindy Leo , Lewis T. Williams
IPC分类号： A61K38/19 , C07K17/02 , A61P35/00 , A61P37/00 , A61P31/00 , C07K17/00 , C07K19/00
CPC分类号： C07K16/243 , A61K38/00 , C07K14/53
摘要： Disclosed is a newly identified secreted molecule, identified herein as “monocyte, granulocyte, and dendritic cell colony stimulating factor” (MGD-CSF), the polypeptide sequence, and polynucleotides encoding the polypeptide sequence. Also provided is a procedure for producing the polypeptide by recombinant techniques employing, for example, vectors and host cells. Additionally, procedures are described to modify the disclosed novel molecules of the invention to prepare fusion molecules. Also disclosed are methods for using the polypeptides and active fragments thereof for treatment of a variety of diseases, including, for example, cancer, autoimmune and inflammatory diseases, infectious diseases, and recurrent pregnancy loss.
摘要翻译：公开了一种新鉴定的分泌型分子，本文鉴定为单核细胞，粒细胞和树突细胞集落刺激因子（MGD-CSF），多肽序列和编码多肽序列的多核苷酸。还提供了通过使用例如载体和宿主细胞的重组技术产生多肽的方法。另外，描述了修饰所公开的本发明新颖分子以制备融合分子的方法。还公开了将多肽及其活性片段用于治疗各种疾病（包括例如癌症，自身免疫性和炎性疾病，感染性疾病和复发性妊娠损失）的方法。

5. 发明授权

US07339837B2 Configurable embedded processor 有权
标题翻译：可配置嵌入式处理器
公开(公告)号：US07339837B2
公开(公告)日：2008-03-04
申请号：US10848997
申请日：2004-05-18
申请人： Klaus J. Oberlaender , Ralph Haines , Eric Chesters , Dirk Behrens
发明人： Klaus J. Oberlaender , Ralph Haines , Eric Chesters , Dirk Behrens
IPC分类号： G11C7/10
CPC分类号： G06F17/5045
摘要： A configurable processor architecture uses a common simulation database for multiple processor configurations to reduce the cost of producing customized processor configurations. An unchanging core portion is used in each processor configuration. To support different memory modules, identification signals are provided from the memory modules or an identification module to configure the core portion.
摘要翻译：可配置的处理器架构使用多个处理器配置的通用模拟数据库来降低生产定制处理器配置的成本。在每个处理器配置中使用不变的核心部分。为了支持不同的存储器模块，从存储器模块或识别模块提供识别信号以配置核心部分。

6. 发明授权

US07821849B2 Configurable embedded processor 有权
标题翻译：可配置嵌入式处理器
公开(公告)号：US07821849B2
公开(公告)日：2010-10-26
申请号：US12028302
申请日：2008-02-08
申请人： Klaus J. Oberlaender , Ralph Haines , Eric Chesters , Dirk Behrens
发明人： Klaus J. Oberlaender , Ralph Haines , Eric Chesters , Dirk Behrens
IPC分类号： G11C7/10
CPC分类号： G06F17/5045
摘要： A configurable processor architecture uses a common simulation database for multiple processor configurations to reduce the cost of producing customized processor configurations. An unchanging core portion is used in each processor configuration. To support different memory modules, identification signals are provided from the memory modules or an identification module to configure the core portion.
摘要翻译：可配置的处理器架构使用多个处理器配置的通用模拟数据库来降低生产定制处理器配置的成本。在每个处理器配置中使用不变的核心部分。为了支持不同的存储器模块，从存储器模块或识别模块提供识别信号以配置核心部分。

7. 发明授权

US08270231B2 Configurable embedded processor 有权
标题翻译：可配置嵌入式处理器
公开(公告)号：US08270231B2
公开(公告)日：2012-09-18
申请号：US12912336
申请日：2010-10-26
申请人： Klaus J. Oberlaender , Ralph Haines , Eric Chesters , Dirk Behrens
发明人： Klaus J. Oberlaender , Ralph Haines , Eric Chesters , Dirk Behrens
IPC分类号： G11C7/10
CPC分类号： G06F17/5045
摘要： A configurable processor architecture uses a common simulation database for multiple processor configurations to reduce the cost of producing customized processor configurations. An unchanging core portion is used in each processor configuration. To support different memory modules, identification signals are provided from the memory modules or an identification module to configure the core portion.
摘要翻译：可配置的处理器架构使用多个处理器配置的通用模拟数据库来降低生产定制处理器配置的成本。在每个处理器配置中使用不变的核心部分。为了支持不同的存储器模块，从存储器模块或识别模块提供识别信号以配置核心部分。

8. 发明授权

US08596475B2 Adapter coupler for adapting couplings of different design 有权
标题翻译：适配器适配器不同设计的联轴器
公开(公告)号：US08596475B2
公开(公告)日：2013-12-03
申请号：US13099537
申请日：2011-05-03
申请人： Siegfried Kobert , Kay Uwe Kolshorn , Dirk Behrens
发明人： Siegfried Kobert , Kay Uwe Kolshorn , Dirk Behrens
IPC分类号： B61G1/00
CPC分类号： B61G5/04
摘要： An adapter coupler (1) for adapting couplings of different design, wherein the adapter coupler (1) comprises a first connecting mechanism for releasably connecting the adapter coupler (1) to a first coupling, a second connecting mechanism for releasably connecting the adapter coupler (1) to the drawhook (50) of a second coupling, and a coupler housing (2) for connecting the first connecting mechanism to the second connecting mechanism, and wherein the second connecting mechanism comprises a tension yoke (8) with which to engage with the drawhook (50) of the second coupling. The adapter coupler (1) having a mechanism for height centering, comprising a drawbar eye (14) connected to the coupler housing (2), wherein the drawbar eye (14) is arranged and configured relative the tension yoke (8) such that upon the adapter coupler (1) being inserted into the jaw of the drawhook (50) of the second coupling, the drawhook (50) can engage in one joint process with both the accommodation formed by the tension yoke (8) as well as with the drawbar eye (14).
摘要翻译： 1.一种用于适应不同设计的联接器的适配器联接器（1），其中适配器联接器（1）包括用于将适配器联接器（1）可释放地连接到第一联接器的第一连接机构，用于可释放地连接适配器联接器 1）连接到第二联轴器的牵引杆（50），以及用于将第一连接机构连接到第二连接机构的联接器壳体（2），并且其中第二连接机构包括张紧架（8）所述第二联接器的所述牵引件（50）。具有高度居中的机构的适配器联接器（1）包括连接到联接器壳体（2）的拉杆眼（14），其中拉杆眼（14）相对于张力轭（8）布置和构造，使得在适配器联接器（1）插入到第二联轴器的牵引钩（50）的钳口中，牵引钩（50）可以与由张紧轭（8）形成的容纳以及与拉杆眼（14）。

9. 发明申请

US20110274480A1 ADAPTER COUPLER FOR ADAPTING COUPLINGS OF DIFFERENT DESIGN 有权
标题翻译：适应不同设计联轴器的适配器联轴器
公开(公告)号：US20110274480A1
公开(公告)日：2011-11-10
申请号：US13099537
申请日：2011-05-03
申请人： Siegfried Kobert , Kay-Uwe Kolshorn , Dirk Behrens
发明人： Siegfried Kobert , Kay-Uwe Kolshorn , Dirk Behrens
IPC分类号： B60D1/00
CPC分类号： B61G5/04
摘要： An adapter coupler (1) for adapting couplings of different design, wherein the adapter coupler (1) comprises a first connecting mechanism for releasably connecting the adapter coupler (1) to a first coupling, a second connecting mechanism for releasably connecting the adapter coupler (1) to the drawhook (50) of a second coupling, and a coupler housing (2) for connecting the first connecting mechanism to the second connecting mechanism, and wherein the second connecting mechanism comprises a tension yoke (8) with which to engage with the drawhook (50) of the second coupling. The adapter coupler (1) having a mechanism for height centering, comprising a drawbar eye (14) connected to the coupler housing (2), wherein the drawbar eye (14) is arranged and configured relative the tension yoke (8) such that upon the adapter coupler (1) being inserted into the jaw of the drawhook (50) of the second coupling, the drawhook (50) can engage in one joint process with both the accommodation formed by the tension yoke (8) as well as with the drawbar eye (14).
摘要翻译： 1.一种用于适应不同设计的联接器的适配器联接器（1），其中适配器联接器（1）包括用于将适配器联接器（1）可释放地连接到第一联接器的第一连接机构，用于可释放地连接适配器联接器 1）连接到第二联轴器的牵引杆（50），以及用于将第一连接机构连接到第二连接机构的联接器壳体（2），并且其中第二连接机构包括张紧架（8）所述第二联接器的所述牵引件（50）。具有高度居中的机构的适配器联接器（1）包括连接到联接器壳体（2）的拉杆眼（14），其中拉杆眼（14）相对于张力轭（8）布置和构造，使得在适配器联接器（1）插入到第二联轴器的牵引钩（50）的钳口中，牵引钩（50）可以与由张紧轭（8）形成的容纳以及与拉杆眼（14）。

10. 发明授权

US07038169B2 Electric heater for the coupling head of a central buffer coupling 失效
标题翻译：用于中央缓冲耦合联轴器的电加热器
公开(公告)号：US07038169B2
公开(公告)日：2006-05-02
申请号：US10242384
申请日：2002-09-12
申请人： Goetz Dittmar , Dirk Behrens
发明人： Goetz Dittmar , Dirk Behrens
IPC分类号： H05B3/00 , B61G1/00 , B61G5/00
CPC分类号： B61G7/00
摘要： The invention relates to a heater for an electric central buffer coupling in which at least one heating element (3) is placed in a recess of the coupling head (1) and is covered toward the outside. To improve the transfer of heat from the heating element (3) into the coupling head (1) and to reduce the expense of assembling and dismantling the heating element (3), the recess is precision fitted to the diameter of the heating element (3) and the recess is constructed in such a way that after completion of the recess the heating element (3), including its seal to the front side, can be introduced into the recess and is to be removably affixed to the coupling head (1).
摘要翻译：本发明涉及一种用于电中央缓冲器联接器的加热器，其中至少一个加热元件（3）放置在联接头（1）的凹部中并被朝向外部覆盖。为了改善从加热元件（3）传递到联接头（1）中的热量并且减少组装和拆除加热元件（3）的费用，凹部精确地配合到加热元件（3）的直径），并且凹部被构造成使得在完成凹部之后，包括其前侧的密封件的加热元件（3）可以被引入到凹部中并且可移除地固定到联接头（1）上，。

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