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1. 发明申请

WO2022216330A1 COATED POLYOLEFINS 审中-公开
公开(公告)号：WO2022216330A1
公开(公告)日：2022-10-13
申请号：PCT/US2021/065193
申请日：2021-12-27
申请人： DIONEX CORPORATION
发明人： RIVIELLO, John M. , POHL, Christopher A.
IPC分类号： C08L23/08
摘要： A coated substrate that comprises a polyolefin substrate having a functional polymer layer disposed thereon. The polyolefin substrate has a flow through pore structure with a pore size ranging from about 5 microns to about 250 microns. The functional polymer layer has a thickness ranging from about 1 micron to about 20 microns and a layer pore structure having a pore size ranging from about 1 nm to about 100 nm.

2. 发明申请

WO2015118105A1 CHROMATOGRAPHIC MATERIAL AND METHODS FOR THE SYNTHESIS THEREOF 审中-公开
标题翻译：色谱材料及其合成方法
公开(公告)号：WO2015118105A1
公开(公告)日：2015-08-13
申请号：PCT/EP2015/052511
申请日：2015-02-06
申请人： THERMO ELECTRON MANUFACTURING LIMITED , DIONEX CORPORATION
发明人： SKINLEY, Kevin , POHL, Christopher A. , LIU, Xiaodong , RITCHIE, Harald
IPC分类号： B01J20/283 , B01J20/287 , B01J20/28 , B01J20/10
CPC分类号： B01J20/283 , B01J20/103 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28019 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/287 , B01J20/3071 , B01J20/3078 , B01J20/3085 , B01J2220/42 , B01J2220/44
摘要： A particulate material for chromatographic use comprising silica particles is provided having a skeleton structure containing silsesquioxane cage moieties. The material is useful as a chromatographic material, for example in HPLC. The silica particles may be hybrid organo-silica particles wherein the silsesquioxane moieties comprise a cage structure having silicon atoms positioned at corners of the cage wherein one or more silicon atoms positioned at the corners of the cagecarry an organic group. A preferred method of preparing the particulate material comprises hydrolysing a silsesquioxane as a co-component of a hydrolysis mixture, especially ina Stöber or modified Stöber process.
摘要翻译：提供了包含二氧化硅颗粒的用于色谱用途的颗粒材料，其具有含有倍半硅氧烷笼部分的骨架结构。该材料可用作色谱材料，例如在HPLC中。二氧化硅颗粒可以是杂化有机二氧化硅颗粒，其中倍半硅氧烷部分包含具有位于笼的拐角处的硅原子的笼结构，其中位于笼的拐角处的一个或多个硅原子位于有机基团。制备颗粒材料的优选方法包括水解作为水解混合物的共组分的倍半硅氧烷，特别是在Stöber或改性Stöber方法中。

3. 发明授权

EP2279034B1 FUNCTIONALIZED SUBSTRATES WITH ION-EXCHANGE PROPERTIES 有权
公开(公告)号：EP2279034B1
公开(公告)日：2019-05-22
申请号：EP09743262.9
申请日：2009-04-23
申请人： DIONEX CORPORATION
发明人： LIU, Xiaodong , POHL, Christopher A. , CHEN, Jinhua , WOODRUFF, Andy L.
IPC分类号： B01D15/36 , B01J20/287 , B01J43/00

4. 发明授权

EP3040722B1 CURRENT-EFFICIENT SUPPRESSOR AND PRETREATMENT DEVICE AND METHOD 有权
标题翻译：有效的抑制器和预处理装置和方法
公开(公告)号：EP3040722B1
公开(公告)日：2017-09-20
申请号：EP15201964.2
申请日：2015-12-22
申请人： Dionex Corporation
发明人： SRINIVASAN, Kannan , LIN, Rong , POHL, Christopher A. , MADDEN, John Edward
IPC分类号： G01N30/96 , B01D15/36 , B01D61/46 , B01D61/52
CPC分类号： G01N30/48 , B01D15/08 , B01D15/36 , B01D61/46 , B01D61/52 , G01N30/96 , G01N2030/027 , G01N2030/488 , G01N2030/965

5. 发明公开

EP2279034A1 FUNCTIONALIZED SUBSTRATES WITH ION-EXCHANGE PROPERTIES 有权
标题翻译：功能性基底具有离子交换性能
公开(公告)号：EP2279034A1
公开(公告)日：2011-02-02
申请号：EP09743262.9
申请日：2009-04-23
申请人： DIONEX CORPORATION
发明人： LIU, Xiaodong , POHL, Christopher A. , CHEN, Jinhua , WOODRUFF, Andy L.
IPC分类号： B01D15/36 , B01J20/287 , B01J43/00
CPC分类号： B01D15/362 , B01D15/325 , B01D15/361 , B01D15/363 , B01D15/3847 , B01J20/28097 , B01J20/3221 , B01J20/3285 , B01J20/3295 , B01J39/26 , B01J43/00 , B01J41/20
摘要： The current invention provides compositions, which are useful as stationary phases for a variety of chromatographic applications, such as high performance liquid chromatography (HPLC) and solid-phase extraction (SPE). The compositions include a porous solid support (e.g., silica gels, silica monoliths or synthetic organic resins) having an exterior surface and pore openings defined by “interior walls”. To the solid support are covalently bound organic ion-exchange ligands (e.g., silyl ligands), which incorporate at least one ion-exchange group (e.g., ionic or ionizable group). The compositions further include micro-particles (e.g., latex particles) incorporating ion-exchange groups having a charge that is opposite to the charge found on the support. The micro-particles are bound to the exterior surface of the support (e.g., via electrostatic forces). The micro-particles have a size that is sufficient to minimize the number of particles that can enter the pores of the support thereby reducing or essentially preventing binding of the micro-particles to the interior walls of the pores. While the pores are essentially too small for the micro-particles, they can still be accessed by the analytes present in a chromatographic sample. The physical separation of ion-exchange groups located within the pores and the surface of the micro-particles, respectively, prevents reactions (e.g., formation of salt-bridges) between the oppositely charged groups and provides compositions with both anion-exchange and cation-exchange capabilities within the same stationary phase. The ligands bound to the solid support can optionally include additional (e.g., reverse-phase) functionalities creating multi-modal (e.g., trimodal) stationary phases.

6. 发明授权

EP3106224B1 ION EXCHANGE CHROMATOGRAPHY COLUMN, METHOD, AND SYSTEM THEREOF 有权
公开(公告)号：EP3106224B1
公开(公告)日：2019-07-24
申请号：EP16174343.0
申请日：2016-06-14
申请人： Dionex Corporation
发明人： JAYARAMAN, Manikandan , POHL, Christopher A. , SAINI, Charanjit
IPC分类号： B01D15/36 , B01J39/20 , B01J39/26 , B01J39/04 , B01D15/20

7. 发明授权

EP2745904B1 HILIC/Anion-Exchange/Cation-Exchange Multimodal Media 有权
标题翻译：多式联运HILIC /阴离子交换/阳离子交换介质
公开(公告)号：EP2745904B1
公开(公告)日：2015-12-16
申请号：EP13198653.1
申请日：2013-12-19
申请人： Dionex Corporation
发明人： LIU, Xiaodong , CHEN, Jinhua , POHL, Christopher A.
IPC分类号： B01D15/38 , B01J43/00 , B01J20/28 , B01J20/32
CPC分类号： B01D15/3847 , B01J20/28097 , B01J20/288 , B01J20/3221 , B01J20/3285 , B01J20/3295 , B01J43/00 , B01D15/305 , B01D15/362 , B01D15/363 , B01D15/364

8. 发明公开

EP2783749A3 Epoxy chemistry derived materials as mixed mode chromatography media, method for their synthesis and use 有权
标题翻译：环氧化学物质物质混合物 - 色谱法，Verfahren zu ihrer Synthese und Verwendung
公开(公告)号：EP2783749A3
公开(公告)日：2014-10-29
申请号：EP14160383.7
申请日：2014-03-17
申请人： Dionex Corporation
发明人： LIU, Xiaodong , CAO, Liang , POHL, Christopher A.
IPC分类号： B01J20/32 , B01J20/286 , B01J20/289 , B01J39/20 , B01J41/20 , B01J39/26 , B01J20/281
CPC分类号： G01N30/482 , B01J20/289 , B01J20/3257 , B01J20/3259 , B01J20/3285 , B01J39/26 , B01J41/20 , B01J2220/54
摘要： This invention provides mixed-mode stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separation.
摘要翻译：本发明提供了混合模式固定相组合物，包含固定相的装置和体系以及使用环氧化物开环反应制备这些组合物的方法。还提供了使用本发明的固定相进行分离的方法。

9. 发明授权

EP3177915B1 A METHOD FOR REDUCING SUPPRESSOR NOISE 有权
公开(公告)号：EP3177915B1
公开(公告)日：2018-12-12
申请号：EP15753557.6
申请日：2015-08-07
申请人： Dionex Corporation
发明人： POHL, Christopher A. , SRINIVASAN, Kannan , OMPHROY, Brittany K.
IPC分类号： G01N30/96 , B01D15/36
CPC分类号： G01N30/96 , B01D15/361 , G01N2030/965
摘要： An electrolytic method for suppressing liquid eluent containing previously separated sample analyte anions, counterions to the sample anions, and non-sample anions suppressible to weak acids in an electrolytic device comprising a housing defining at least a sample stream flow channel and an ion receiving flow-through channel separated by an ion exchange bather. The sample stream flow channel includes an upstream channel portion and a downstream channel portion. A first current is applied across the upstream channel portion for substantially completely suppression. A second current is applied across the downstream channel portion at a magnitude of less than 10% of the magnitude of the first current.

10. 发明公开

EP3040722A1 CURRENT-EFFICIENT SUPPRESSOR AND PRETREATMENT DEVICE AND METHOD 有权
标题翻译： VORBEHANDLUNGSVORRICHTUNG UND-PERFAHREN的抗感染药物抑制剂
公开(公告)号：EP3040722A1
公开(公告)日：2016-07-06
申请号：EP15201964.2
申请日：2015-12-22
申请人： Dionex Corporation
发明人： SRINIVASAN, Kannan , LIN, Rong , POHL, Christopher A. , MADDEN, John Edward
IPC分类号： G01N30/96
CPC分类号： G01N30/48 , B01D15/08 , B01D15/36 , B01D61/46 , B01D61/52 , G01N30/96 , G01N2030/027 , G01N2030/488 , G01N2030/965
摘要： An apparatus for treating an aqueous sample stream includes analyte ions. The apparatus comprises an ion exchange barrier; a sample stream flow channel; an ion receiving stream flow channel adjacent to the sample stream flow channel and separated therefrom by said first ion exchange barrier. Stationary flow-through ion exchange packing is disposed in the sample flow channel of the same charge as the ion exchange barrier. The ion exchange packing comprises a mixture of a first ion exchange portion with strong ionizable groups and a second ion exchange portion with weak ionizable groups of the same charge. First and second electrodes are in electrical communication with the sample stream flow channel and ion receiving flow channel.
摘要翻译：用于处理含水样品流的装置包括分析物离子。该装置包括离子交换屏障; 样本流流通道; 离子接收流流动通道，其与样品流流动通道相邻并且由所述第一离子交换屏障分离。固定的流通离子交换填料设置在与离子交换屏障相同电荷的样品流动通道中。离子交换填料包括具有强电离基团的第一离子交换部分和具有相同电荷的弱电离基团的第二离子交换部分的混合物。第一和第二电极与样品流流动通道和离子接收流动通道电连通。

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