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1. 发明授权

US09326814B2 System and method for predicting lesion size shortly after onset of RF energy delivery 有权
标题翻译：用于预测射频能量发射开始后不久的病变大小的系统和方法
公开(公告)号：US09326814B2
公开(公告)日：2016-05-03
申请号：US12882780
申请日：2010-09-15
申请人： Ding Sheng He , Michael Bosnos , José M. Guillén-Rodríguez , Frank I. Marcus
发明人： Ding Sheng He , Michael Bosnos , José M. Guillén-Rodríguez , Frank I. Marcus
IPC分类号： A61B18/10 , A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2018/00357 , A61B2018/00577 , A61B2018/00702 , A61B2018/00869 , A61B2018/00875 , A61B2034/104
摘要： Lesion size or volume prediction shortly after the onset of an ablation procedure can inform or control the ablation procedure. The prediction and/or control is made without regard to an actual detected temperature in the vicinity of the ablation electrodes. As a consequence, the system has utility with irrigated catheter constructions and other situations in which local irrigation in the vicinity of an ablation site would otherwise interfere with a prediction or control scheme that solely relies upon temperature measurements.
摘要翻译：在消融手术开始之后不久的损伤尺寸或体积预测可以通知或控制消融手术。在不考虑消融电极附近的实际检测温度的情况下进行预测和/或控制。因此，该系统具有灌溉导管结构和其它情况，其中在消融部位附近的局部灌溉将干扰仅依赖于温度测量的预测或控制方案。

2. 发明申请

US20110066147A1 SYSTEM AND METHOD FOR PREDICTING LESION SIZE SHORTLY AFTER ONSET OF RF ENERGY DELIVERY 有权
标题翻译：射频能量传输之后短距离预测的系统和方法
公开(公告)号：US20110066147A1
公开(公告)日：2011-03-17
申请号：US12882780
申请日：2010-09-15
申请人： Ding Sheng He , Michael Bosnos , José M. Guillén-Rodríguez , Frank I. Marcus
发明人： Ding Sheng He , Michael Bosnos , José M. Guillén-Rodríguez , Frank I. Marcus
IPC分类号： A61B18/18 , G06N7/02
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2018/00357 , A61B2018/00577 , A61B2018/00702 , A61B2018/00869 , A61B2018/00875 , A61B2034/104
摘要： Lesion size or volume prediction shortly after the onset of an ablation procedure can inform or control the ablation procedure. The prediction and/or control is made without regard to an actual detected temperature in the vicinity of the ablation electrodes. As a consequence, the system has utility with irrigated catheter constructions and other situations in which local irrigation in the vicinity of an ablation site would otherwise interfere with a prediction or control scheme that solely relies upon temperature measurements.
摘要翻译：在消融手术开始之后不久的损伤尺寸或体积预测可以通知或控制消融手术。在不考虑消融电极附近的实际检测温度的情况下进行预测和/或控制。因此，该系统具有灌溉导管结构和其它情况，其中在消融部位附近的局部灌溉将干扰仅依赖于温度测量的预测或控制方案。

3. 发明授权

US06423057B1 Method and apparatus for monitoring and controlling tissue temperature and lesion formation in radio-frequency ablation procedures 有权
标题翻译：用于监测和控制射频消融程序中组织温度和病变形成的方法和装置
公开(公告)号：US06423057B1
公开(公告)日：2002-07-23
申请号：US09488878
申请日：2000-01-21
申请人： Ding Sheng He , Michael Bosnos , Frank Marcus
发明人： Ding Sheng He , Michael Bosnos , Frank Marcus
IPC分类号： A61B1804
CPC分类号： A61B18/1206 , A61B2017/00026 , A61B2017/00039 , A61B2017/00084 , A61B2018/00755 , A61B2018/00791 , A61B2018/00875
摘要： Impedance and capacitance-related parameters are monitored in the electrical circuit of a tissue-ablation apparatus wherein RF electrical power is administered at predetermined frequencies. Tissue temperature has been found to correlate well with low-frequency impedance, or with the resistive component of impedance at any frequency. Therefore, one or both of these parameters are calculated and tracked during the ablation procedure to estimate tissue temperature. Similarly, tissue lesion formation has been found to correlate well with changes in the capacitive component of tissue impedance. Thus, this parameter can be used to track tissue lesion formation during the ablation procedure. The ratio of tissue-to-blood interface with the ablation electrode is estimated by measuring impedance at a very low frequency and a very high frequency. The difference between these two values divided by the high-frequency value is taken to be a measure of such ratio. Alternatively, other electrical parameters indicative of changes in the capacitive component of the system may be measured and the ratio is calculated as a function of these changes with respect to a baseline value.
摘要翻译：在组织消融装置的电路中监测阻抗和电容相关参数，其中以预定频率施加RF电力。已经发现组织温度与低频阻抗或任何频率处的阻抗电阻分量良好相关。因此，在消融过程期间计算和跟踪这些参数中的一个或两个以估计组织温度。类似地，已经发现组织损伤形成与组织阻抗的电容分量的变化良好相关。因此，该参数可用于跟踪消融过程期间的组织损伤形成。通过在非常低的频率和非常高的频率下测量阻抗来估计组织与血液界面与消融电极的比例。将这两个值除以高频值之间的差值作为该比例的量度。或者，可以测量指示系统的电容分量变化的其它电参数，并且根据这些基线值的变化来计算该比值。

4. 发明授权

US06978184B1 Optimization method for cardiac resynchronization therapy 有权
标题翻译：心脏再同步治疗的优化方法
公开(公告)号：US06978184B1
公开(公告)日：2005-12-20
申请号：US10629881
申请日：2003-07-29
申请人： Frank I. Marcus , Ding Sheng He
发明人： Frank I. Marcus , Ding Sheng He
IPC分类号： A61B20060101 , A61B5/11 , A61N1/00 , A61N1/05 , A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61B5/1107 , A61B5/6869 , A61B5/7217 , A61N1/3627 , A61N1/36542 , A61N1/3682 , A61N1/3684
摘要： The patterns of contraction and relaxation of the heart before and during left ventricular or biventricular pacing are analyzed and displayed in real time mode to assist physicians to screen patients for cardiac resynchronization therapy, to set the optimal A-V or right ventricle to left ventricle interval delay, and to select the site(s) of pacing that result in optimal cardiac performance. The system includes an accelerometer sensor; a programmable pace maker, a computer data analysis module, and may also include a 2D and 3D visual graphic display of analytic results, i.e. a Ventricular Contraction Map. A feedback network provides direction for optimal pacing leads placement. The method includes selecting a location to place the leads of a cardiac pacing device, collecting seismocardiographic (SCG) data corresponding to heart motion during paced beats of a patient's heart, determining hemodynamic and electrophysiological parameters based on the SCG data, repeating the preceding steps for another lead placement location, and selecting a lead placement location that provides the best cardiac performance by comparing the calculated hemodynamic and electrophysiological parameters for each different lead placement location.
摘要翻译：以实时模式分析和显示左心室或双心室起搏前后心脏收缩和松弛的模式，以协助医师筛选患者心脏再同步治疗，将最佳AV或右心室设置为左心室间隔延迟，并选择导致最佳心脏性能的起搏部位。该系统包括加速度传感器; 可编程步调器，计算机数据分析模块，还可以包括分析结果的2D和3D视觉图形显示，即心室收缩图。反馈网络为最佳起搏线索位置提供了方向。所述方法包括选择放置心脏起搏装置的引线的位置，在患者心脏的起搏节拍期间收集对应于心脏运动的心脏断层图（SCG）数据，基于SCG数据确定血流动力学和电生理参数，重复前述步骤通过比较每个不同引线放置位置的计算血液动力学和电生理参数，选择提供最佳心脏性能的引导位置位置。

5. 发明授权

US09028486B2 Methods of using a catheter having a braided conductive member 有权
标题翻译：使用具有编织导电部件的导管的方法
公开(公告)号：US09028486B2
公开(公告)日：2015-05-12
申请号：US13414018
申请日：2012-03-07
申请人： Russell F. Collins , Gary S. Falwell , Eric A. Bene , Steven J. Burns , Denyse M. Collins , Charles A. Gibson , Ding Sheng He , Paul E. LeClair , Donald F. Patterson , Stephen W. Sagon , Pierre Jais
发明人： Russell F. Collins , Gary S. Falwell , Eric A. Bene , Steven J. Burns , Denyse M. Collins , Charles A. Gibson , Ding Sheng He , Paul E. LeClair , Donald F. Patterson , Stephen W. Sagon , Pierre Jais
IPC分类号： A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00797 , A61B2018/00821 , A61B2018/00946 , A61B2018/1497
摘要： Embodiments described herein relate to methods of using a catheter having a braided conductive member. One embodiment relates to a method for treating a condition of a patient that involves contacting an exterior wall of a blood vessel with the braided conductive member. Another embodiment relates to a method that involves contacting a wall of a blood vessel with the braided conductive member and controlling energy delivery to the braided conductive member based on at least one sensed temperature.
摘要翻译：本文所述的实施例涉及使用具有编织导电构件的导管的方法。一个实施方案涉及用于治疗患者的状况的方法，其涉及使血管的外壁与编织的导电构件接触。另一实施例涉及一种方法，其包括使血管的壁与编织的导电构件接触，并且基于至少一个感测到的温度控制向编织导电构件的能量传递。

6. 发明申请

US20120108950A1 BIOIMPEDANCE-ASSISTED PLACEMENT OF A MEDICAL DEVICE 有权
标题翻译：医疗设备的生物安全辅助放置
公开(公告)号：US20120108950A1
公开(公告)日：2012-05-03
申请号：US13283395
申请日：2011-10-27
申请人： Ding Sheng He , David J. Ciavarella , Eddie K. Burnside
发明人： Ding Sheng He , David J. Ciavarella , Eddie K. Burnside
IPC分类号： A61B5/053 , A61B5/055 , A61B8/00 , A61M25/00
CPC分类号： A61M25/0105 , A61B5/068 , A61B17/00234 , A61B34/20 , A61B2017/00026 , A61B2017/00331 , A61B2034/2051 , A61M25/01 , A61M2025/0166
摘要： A system and method for guiding a catheter or other medical device to a desired target destination within the vasculature of a patient via bioimpedance measurements is disclosed. The target destination in one embodiment includes placement of the catheter such that a distal tip thereof is disposed proximate the heart, e.g., the junction of the right atrium and superior vena cava. In one embodiment the method for guiding the catheter comprises introducing the catheter into a vessel of the patient, the catheter defining a lumen through which fluids can be infused into the vasculature of the patient. The catheter is advanced toward a target destination within the vasculature. A first impedance value based on intravascular detection of at least one electrical property related to a first tissue surface of the vessel is calculated to enable determination of the proximity of a distal end of the catheter to the target destination.
摘要翻译：公开了一种用于通过生物阻抗测量将导管或其他医疗装置引导到患者脉管系统内的期望目的地目的地的系统和方法。在一个实施例中的目标目的地包括导管的放置，使得其远侧末端设置在心脏附近，例如右心房和上腔静脉的连接处。在一个实施例中，用于引导导管的方法包括将导管引入患者的容器中，该导管限定了内腔，流体可以通过内腔输注到患者的脉管系统中。导管朝向脉管系统内的目标目标前进。计算基于与血管的第一组织表面相关的至少一个电性质的血管内检测的第一阻抗值，以使得能够确定导管的远端与目的地的接近度。

7. 发明授权

US08157796B2 Apparatus and methods for mapping and ablation in electrophysiology procedures 有权
标题翻译：电生理学过程中绘图和消融的装置和方法
公开(公告)号：US08157796B2
公开(公告)日：2012-04-17
申请号：US11978066
申请日：2007-10-26
申请人： Russell F. Collins , Gary S. Falwell , Eric A. Bene , Steven J. Burns , Denyse M. Collins , Charles A. Gibson , Ding Sheng He , Paul E. LeClair , Donald F. Patterson , Stephen W. Sagon , Pierre Jais
发明人： Russell F. Collins , Gary S. Falwell , Eric A. Bene , Steven J. Burns , Denyse M. Collins , Charles A. Gibson , Ding Sheng He , Paul E. LeClair , Donald F. Patterson , Stephen W. Sagon , Pierre Jais
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00797 , A61B2018/00821 , A61B2018/00946 , A61B2018/1497
摘要： An electrophysiology catheter and method of use for mapping and ablation procedures. The catheter includes a braided conductive member at its distal end that can be radially expanded. The catheter can be used in endocardial and epicardial mapping and ablation procedures.
摘要翻译：一种电生理学导管及其用于测绘和消融手术的方法。导管在其远端包括可以径向扩张的编织导电构件。该导管可用于心内膜和心外膜贴图和消融手术。

8. 发明申请

US20080281391A1 Mapping and Ablation Method for the Treatment of Ventricular Tachycardia 有权
标题翻译：心室心动过速治疗的绘图和消融方法
公开(公告)号：US20080281391A1
公开(公告)日：2008-11-13
申请号：US11597082
申请日：2005-05-17
申请人： David MacAdam , Ding Sheng He
发明人： David MacAdam , Ding Sheng He
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B5/042 , A61B2018/00214 , A61B2018/00839
摘要： An apparatus for mapping and/or ablating tissue includes a braided conductive member that that may be inverted to provide a ring-shaped surface. When a distal tip of the braided conductive member is retracted within the braided conductive member, the lack of a protrusion allows the ring-shaped surface to contact a tissue wall such as a cardiac wall. In an alternative configuration, the braided conductive member may be configured with the distal portion forming a proboscis that can be used to stably position the braided conductive member relative to a blood vessel, such as a ventricular outflow tract. The braided conductive member has a plurality of electronically active sites that may be accessed individually for stable mapping over a broad area for stable mapping or ablation to form broad and deep lesions.
摘要翻译：用于映射和/或消融组织的装置包括可被倒置以提供环形表面的编织导电构件。当编织导电构件的远侧末端缩回到编织导电构件内时，缺少突起允许环形表面接触诸如心脏壁的组织壁。在替代配置中，编织导电构件可构造成具有形成长鼻的远端部分，其可用于相对于诸如心室流出道的血管来稳定地定位编织导电构件。编织导电构件具有多个电子活性位点，其可以单独访问以在广泛区域上稳定映射以用于稳定的映射或消融以形成宽而深的损伤。

9. 发明申请

US20120165815A1 METHODS OF USING A CATHETER HAVING A BRAIDED CONDUCTIVE MEMBER 有权
标题翻译：使用具有导电性导电构件的导体的方法
公开(公告)号：US20120165815A1
公开(公告)日：2012-06-28
申请号：US13414018
申请日：2012-03-07
申请人： Russell F. Collins , Gary S. Falwell , Eric A. Bene , Steven J. Burns , Denyse M. Collins , Charles A. Gibson , Ding Sheng He , Paul E. LeClair , Donald F. Patterson , Stephen W. Sagon , Pierre Jais
发明人： Russell F. Collins , Gary S. Falwell , Eric A. Bene , Steven J. Burns , Denyse M. Collins , Charles A. Gibson , Ding Sheng He , Paul E. LeClair , Donald F. Patterson , Stephen W. Sagon , Pierre Jais
IPC分类号： A61B18/00
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00029 , A61B2018/00083 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00797 , A61B2018/00821 , A61B2018/00946 , A61B2018/1497
摘要： Embodiments described herein relate to methods of using a catheter having a braided conductive member. One embodiment relates to a method for treating a condition of a patient that involves contacting an exterior wall of a blood vessel with the braided conductive member. Another embodiment relates to a method that involves contacting a wall of a blood vessel with the braided conductive member and controlling energy delivery to the braided conductive member based on at least one sensed temperature.
摘要翻译：本文所述的实施例涉及使用具有编织导电构件的导管的方法。一个实施方案涉及用于治疗患者的状况的方法，其涉及使血管的外壁与编织的导电构件接触。另一实施例涉及一种方法，其包括使血管的壁与编织的导电构件接触，并且基于至少一个感测到的温度控制向编织导电构件的能量传递。

10. 发明授权

US07727229B2 Method and apparatus for altering conduction properties in the heart and in adjacent vessels 有权
标题翻译：用于改变心脏和相邻血管中的传导性质的方法和装置
公开(公告)号：US07727229B2
公开(公告)日：2010-06-01
申请号：US10475915
申请日：2002-03-15
申请人： Ding Sheng He , David MacAdam
发明人： Ding Sheng He , David MacAdam
IPC分类号： A61B18/18 , A61B5/04
CPC分类号： A61B18/1492 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/003 , A61B2018/00011 , A61B2018/00029 , A61B2018/00083 , A61B2018/00214 , A61B2018/00357 , A61B2018/00363 , A61B2018/00577 , A61B2018/00755 , A61B2018/00761 , A61B2018/00797 , A61B2018/00821 , A61B2018/00839 , A61B2018/00875 , A61B2018/1435 , A61B2034/2051 , A61B2218/002
摘要： Method and apparatus for treating conductive irregularities in the heart, particularly atrial fibrillation and accessory path arrythmias. An ablative catheter is positioned relative to an inter-atrial electrical pathway, or a vicinity of accessory paths such as the coronary sinus or fossa ovalis, and actuated to form a lesion that partially or completely blocks electrical conduction in at least one direction along the pathway.
摘要翻译：用于治疗心脏中的导电不规则物的方法和装置，特别是心房颤动和辅助路径性心律失常。烧蚀导管相对于心房间电路或邻近的附近路径（例如冠状窦或卵圆窝）定位并且被致动以形成部分地或完全阻挡沿着该路径的至少一个方向的电传导的病变。

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